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| 1 | Oral pharmacological treatment for patent ductus arteriosus in premature neonates with hemodynamic repercussions显示文摘Objective: To evaluate the efficacy of oral indomethacin, ibuprofen, and paracetamol in oral dosage form on patent ductus arteriosus(PDA) in premature neonates with significant clinical and hemodynamic repercussions(CHRs) and to determine the effect of these respective treatments on renal function.Methods: A retrospective study of cases of PDA in premature neonates in the Neonatal Intensive Care Unit was conducted. The treatments consisted of indomethacin[0.2 mg/(kg$d), 3-day cycle], ibuprofen [10 mg/(kg$d) followed by 5 mg/(kg$d), 3-day cycle], and paracetamol(15 mg/kg every 6 h, 5-day cycle). The drugs were administered as an oral solution. The following variables were considered: gestational age,newborn weight at birth, Apgar score, diuresis, serum creatinine and urea levels, and serum electrolyte levels(sodium and potassium).Results: Treatment with indomethacin presented efficacy of 87.5% in closure of the ductus with a mean outcome period of 3.5 d. In premature neonates with CHRs and contraindications for indomethacin, the initial treatment with either ibuprofen or paracetamol failed to close the ductus. However, when this treatment was followed by indomethacin, closure occurred in 66.7% of the neonates, with an outcome period of9.66 d. The initial treatment with one cycle of ibuprofen followed by one or two cycles of paracetamol failed to close the ductus.Conclusions: Oral indomethacin was effective for closure of the PDA in premature neonates with severe CHRs. Oral paracetamol or ibuprofen for PDA closure in premature neonates with severe CHRs and contraindications for indomethacin was ineffective.However, results in clinical improvements of neonates allowed the subsequent use of indomethacin and successful closure of the ductus. A significant reduction of diuresis occurred in neonates who were treated with indomethacin, either as a first-line treatment or after the failure of ibuprofen or paracetamol. | Clarissa de Albuquerque Botura Bruno Ambrósio da Rocha Thiely Balensiefer Franciele Queiroz Ames Ciomar Aparecida Bersani-Amado Roberto Kenji Nakamura Cuman | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，11： | 4 |
| 2 | Endometrial leuke-mia inhibitory factor as a predictor of pregnancy after in vitrofertilization显示文摘 | Serafini P Rocha AM Osorio CT | 2008 | Int J Gynaecol Obstet2008，102，1： | 1 |
| 3 | Anticancer, antichemotactic and antimicrobial activities of marine sponges collected off the coast of Santa Catarina, southern Brazil显示文摘 | Noel R Monks Clea Lerner Amélia T Henriques Fabiane M Farias Elfrides E.S Schapoval Edna S Suyenaga Adriana B da Rocha Gilberto Schwartsmann Beatriz Mothes | 2002 | Journal of Experimental Marine Biology and Ecology2002，，1： | 1 |
| 4 | Effect of Sodium Alendronate on Alveolar BoneResorption in Experimental Periodontitis in Rats显示文摘 | Menezes AM Rocha FA Chaves HV | 2005 | J Periodontol2005，76，11： | 1 |
| 5 | Lack of association between Helicobaeter pylori infection with dupA-positive strains and gastroduodenal diseases in Brazilian patients显示文摘 | Gomes LI Rocha GA Rocha AM | | 0，，3： | 1 |
| 6 | dupA polymorphlsms and risk of Helicohacter pylori-aasociated diseases显示文摘 | Queiroz DM Rocha GA oeha AM | | 0，，03： | 1 |
| 7 | The role of the Hoxa10/HOXA10 gene in the etiology of endometriosis and its related infertility:a review显示文摘 | Zanatta A Rocha AM Carvalho FM | 2010 | J Assist Reprod Genet2010，27，12： | 1 |
| 8 | The levels o1 IL-17A and ofthe cytokines involved in Th17 cell commitment are increased inpatients with chronic immune thrombocytopenia显示文摘 | Rocha AM Souza C Rocha G A | 2011 | Haematologi-ca2011，96，10： | 1 |
| 9 | IL1RN polymorphic gene and CagA positive status independently increase the risk of noncardia gastric careinoma显示文摘 | Rocha GA Guerra JB Rocha AM | 2005 | Int Caneer2005，115，5： | 1 |
| 10 | Effect of sodium alendronate on alveolar bone resorption in experimental periodontitis in rats显示文摘 | Menezes AM Rocha FA Chaves HV | 2005 | J Periodontal2005，76，11： | 1 |
| 11 | The levels of IL - 17A and of the cytokines involved in Thl7 cell commitment are increased in patients with chronic immune throm- bocytopenia显示文摘 | Rocha AM Souza C Rocha GA | 2011 | Haematologica2011，96，10： | 1 |
| 12 | Dynamic medium containing growth differentiation factor9and FSH maintains survival and promotes in vitro growth of caprine preantral follicles after long-term in vitro culture显示文摘 | Lves AM Chaves RN Rocha RM et a1 | 2013 | Reprod Fertil Dev2013，25，： | 1 |
| 13 | Gemcitabine doublets in advanced pancreatic cancer: should we move on?显示文摘 | Rocha Lima CM Flores AM | 2006 | J Clin Oncol2006，24，3： | 1 |
| 14 | Unintended consequences of Helicobacter pylori infection in children in developing coun- tries:iron deficiency, diarrhea, and growth retardation 显示文摘 | Queiroz DiM Rocha AM Crabtree JE | 2013 | Gut Microbes2013，4，49： | 1 |
| 15 | The role of (he HoxalO/HOXAIO gene in the etiology of endomettiosis and its related infer-tility: a review 显示文摘 | Zanatta A Rocha AM Carvalho FM | 2010 | J Assist Reprod Genet2010，27，12： | 1 |
| 16 | The levels of IL - 17A and of the cytokines involved in Th17 cell commitment are increased in patients with chronic immune thrombocytopenia 显示文摘 | Rocha AM Souza C Rocha GA | 2011 | Haematologica2011，96，10： | 1 |
| 17 | Seroprevalence of Helicobacter pylori in children of low socioeconomic level in Belo Horizonte,Brazil显示文摘 | Oliviera AM Queiroz DM Rocha GA Mendes EN | 1994 | Am J Gastroenterol1994，89，12： | 1 |
| 18 | Autonomic nervous system modulation affects the inflammatory immune response in mice with acute Chagas disease显示文摘 | Machado MP Rocha AM de Oliveira LF | 2012 | Exp Physiol2012，97，11： | 1 |
| 19 | The levels of IL-17Aand of the cytokines involved in Th17cell commitment are increased in patients with chronic immune thrombocytopenia显示文摘 | Rocha AM Souza C Rocha GA | 2011 | Haematologica2011，96，： | 1 |
| 20 | The role of the HoxalO/HOXAIO gene in the etiology of endometriosis and its relatedinfertility:a review显示文摘 | Zanatta A Rocha AM Carvalho FM | 2010 | J Assist Reprod Genet2010，27，12： | 1 |
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