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| 1 | Nonalcoholic fatty liver disease: An overview of current insights in pathogenesis, diagnosis and treatment显示文摘Estimates of people suffering from overweight (one billion) and obesity (300 million) are increasing. The accumulation of triglycerides in the liver, in the absence of excess alcohol intake, has been described in the early sixties. It was not until 1980, however, that Ludwig et al named this condition nonalcoholic steatohepatitis (NASH). Subsequently, nonalcoholic fatty liver disease (NAFLD) has been used as a general name for conditions ranging from simple steatosis through steatohepatitis to end-stage liver disease (cirrhosis). Many studies have demonstrated the significant correlation with obesity and insulin resistance. Other studies have revealed a signifi- cant correlation between hepatic steatosis, cardiovascu- lar disease and increased intima-media thickness. WHO estimated that at least two million patients will develop cirrhosis due to hepatic steatosis in the years to come. Longitudinal cohort studies have demonstrated that those patients with cirrhosis have a similar risk to devel- op hepatocellular carcinoma as those with other causes of cirrhosis. Taken all together, NAFLD has become the third most important indication for liver transplantation. There- fore, training programmes in internal medicine, gastroen- terology and hepatology should stress the importance of diagnosing this entity and treat properly those at risk for developing complications of portal hypertension and con- comittant cardiovascular disease. This review will focus on the clinical characteristics, pathophysiology, imaging tech- niques and the readily available therapeutic options. | Tim CMA Schreuder Bart J Verwer Carin MJ van Nieuwkerk Chris JJ Mulder | 2008 | World Journal of Gastroenterology2008，14，16： | 35 |
| 2 | Small bowel capsule endoscopy in 2007:Indications,risks and limitations显示文摘囊内视镜检查法有 revoluzionized 由提供一个可靠方法评估的小肠的学习,内视镜的联盟者,全部小肠。在最后六年里,几份报纸被出版了处于不同临床的条件探索这考试的可能的角色。在现在的时间囊,内视镜检查法通常被推荐为第三考试,在否定双向内视镜检查法以后,在有阴暗胃肠的流血的病人。证据的成长身体也处于象 Crohn 的疾病,乳糜泻,小肠息肉病症候群或小肠肿瘤那样的另外的临床的条件为这考试建议一个重要角色。这考试的主要复杂并发症是在以前未知的小肠苛评的地点的设备的保留。然而,也由于这个工具的技术限制主要有一些另外的开的问题(它没从遥控被驾驶,是不能的拿活体检视到 insufflate 空气,正确地缩放并且定位损害到 suck 液体或碎片并且到有时) 。最近发达的双汽球肠脓毒病,尽管侵略、耗时,由于它的能力指向了活体检视探索小肠的大部分并且拿,能克服囊内视镜检查法的一些限制。在现在预定,在临床的条件的多数(即阴暗官方补给的流血),赢的策略似乎是联合这二种技术探索小肠在一无痛苦,安全、完全的方法(与囊内视镜检查法)并且识别了定义并且对待损害(与两倍汽球肠寄生物)。 | Emanuele Rondonotti Federica Villa Chris JJ Mulder Maarten AJM Jacobs Roberto de Franchis | 2007 | World Journal of Gastroenterology2007，13，46： | 30 |
| 3 | 模拟氮沉降对克氏针茅草原土壤有机碳的短期影响显示文摘为更好地了解天然草地土壤有机碳对氮沉降增加的响应,2011年在内蒙古太仆寺旗的克氏针茅(Stipa krylovii)草原上开展了模拟氮沉降的控制实验,设置对照(CK)和5个模拟氮沉降(NO-3)处理,分别为2(N1)、5(N2)、10(N3)、25(N4)和50 g N m-2a-1(N5)。生长季末,采集每个样地中0—2 cm和2—10 cm深度土壤进行有机碳含量及组成的分析,并进行实验室矿化培养。结果表明,土壤颗粒态有机碳(POC)对氮添加响应敏感,N1和N2处理下的POC含量高于CK,N3、N4和N5处理则低于CK。5个模拟氮沉降处理下的矿质结合态有机碳(MOC)含量均高于对照,但差别不显著。不同氮沉降水平下0—2 cm土层的碳矿化潜势为N2>N1>N4>N3>CK>N5,且N1,N2,N3和N4处理均显著高于CK和N5;2—10 cm土层的碳矿化潜势为N2>N1>N3>CK>N4>N5,N1、N2和N3显著高于CK、N4及N5。不同施氮处理对群落净第一性生产力有明显影响,N5的净第一性生产力和地上生物量显著低于对照和其它施氮处理,N1的0—10 cm地下生物量显著高于对照和其它处理,N5的凋落物量显著高于对照。模拟氮沉降短期内对土壤总有机碳(SOC)含量无显著影响。 | 祁瑜 Mulder J 段雷 黄永梅 | 2015 | 生态学报2015，35，4： | 23 |
| 4 | Elastic band ligation of hemorrhoids:Flexible gastroscope or rigid proctoscope?显示文摘AIM: To compare rigid proctoscope and flexible endoscope for elastic band ligation of internal hemorrhoids. METHODS: Patients between 18 and 80 years old, with chronic complaints (blood loss, pain, itching or prolapse) of internal hemorrhoids of grade I-Ⅲ, were randomized to elastic band ligation by rigid proctoscope or flexible endoscope (preloaded with 7 bands). Patients were re- treated every 6 wk until the cessation of complaints. Evaluation by three-dimensional anal endosonography was performed. RESULTS: Forty-one patients were included (median age 52.0, range 27-79 years, 20 men). Nineteen patients were treated with a rigid proctoscope and twenty two with a flexible endoscope. Twenty-nine patients had grade I hemorrhoids, 9 patients had grade Ⅱ hemorrhoids and 3 patients had grade Ⅲ hemorrhoids. All patients needed a minimum of 1 treatment and a maximum of 3 treatments. A median of 4.0 bands was used in the rigid proctoscope group and a median of 6.0 bands was used in the flexible endoscope group (P < 0.05). Pain after ligation tended to be more frequent in patients treated with the flexible endoscope (first treatment: 3 vs 10 patients, P < 0.05). Three- dimensional endosonography showed no sphincter defects or alterations in submucosal thickness. CONCLUSION: Both techniques are easy to perform, well tolerated and have a good and fast effect. It is easier to perform more ligations with the flexible endoscope. Additional advantages of the flexible scope are the maneuverability and photographic documentation. However, treatment with the flexible endoscope might be more painful and is more expensive. | M Cazemier RJF Felt-Bersma MA Cuesta CJJ Mulder | 2007 | World Journal of Gastroenterology2007，13，4： | 12 |
| 5 | Gastroenterology in developing countries:Issues and advances显示文摘Developing countries shoulder a considerable burden of gastroenterological disease. Infectious diseases in particular cause enormous morbidity and mortality. Diseases which afflict both western and developing countries are often seen in more florid forms in poorer countries. Innovative techniques continuously improve and update gastroenterological practice. However, advances in diagnosis and treatment which are commonplace in the West, have yet to reach many developing countries. Clinical guidelines, based on these advances and collated in resource-rich environments,lose their relevance outside these settings. In this two-part review, we first highlight the global burden of gastroenterological disease in three major areas: diarrhoeal diseases, hepatitis B, and Helicobacter pylori . Recent progress in their management is explored, with consideration of future solutions. The second part of the review focuses on the delivery of clinical services in developing countries. Inadequate numbers of healthcare workers hamper efforts to combat gastroenterological disease. Reasons for this shortage are examined, along with possibilities for increased specialist training. Endoscopy services, the mainstay of gastroenterology in the West, are in their infancy in many developing countries. The challenges faced by those setting up a service are illustrated by the example of a Nigerian endoscopy unit. Finally, we highlight the limited scope of many clinical guidelines produced in western countries. Guidelines which take account of resource limitations in the form of 'cascades' are advocated in order to make these guidelines truly global. Recognition of the different working conditions facing practitioners worldwide is an important step towards narrowing the gap between gastroenterology in rich and poor countries. | Kate L Mandeville Justus Krabshuis Nimzing Gwamzhi Ladep Chris JJ Mulder Eamonn MM Quigley Shahid A Khan | 2009 | World Journal of Gastroenterology2009，15，23： | 8 |
| 6 | 海岸湿地在飓风防护中的价值显示文摘海岸湿地可以减少飓风对沿海群落的破坏作用。把1980年以来美国34次主要飓风在其袭击区所造成的单位国民生产总值损失的自然对数值作为因变量,风速和飓风袭击区湿地面积的自然对数值作为自变量,回归模型显示两者之间的差异极显著,说明了其相对损失的差别的60%。在上述模型中,每减少1 hm^2的湿地面积,来自特定风暴造成的风暴损害将平均增加33 000美元的损失(中值5000美元)。利用这个关系,把各年度不同强度飓风发生的概率考虑在内,我们以1km×1km为像素,以州为单元将湿地的年度价值绘制成图,湿地年度价值的变化范围为250~51 000美元/hm^2·a,平均价值为8240美元/hm^2·a(中值3230美元/hm^2·a),这显著高于以前估算的湿地价值。据估算,美国的海岸湿地目前能够提供的保护作用相当于232亿美元/a。在风暴防护中,海岸湿地是一种有价值的、能够自我维持的'水平堤防',并且能够提供垂直堤防所不能提供的许多其他的生态系统功能。对于人类社会来说,对沿海湿地的修复与维护是一种极其划算的战略性投资。 | Robert Costanza Octavio Pérez-Maqueo M. Luisa Martinez Paul Sutton Sharolyn J. Anderson Kenneth Mulder 唐晓宇(译) 王书磊(校) 张晓琴(校) | 2008 | AMBIO-人类环境杂志2008，37，4： | 8 |
| 7 | Double balloon endoscopy associated pancreatitis:A description of six cases显示文摘AIM:To perform a single-center analysis of all double balloon endoscopy (DBE) related cases of pancreatitis identified prospectively from a recorded DBE-complication database. METHODS:From November 2003 until January 2007, 603 DBE procedures were performed on 412 patients, with data on complications recorded in a database. The setting was a tertiary care center offering DBE. DBE was performed from the antegrade or retrograde route. Out-come measurements included age, gender, medication, indication, DBE-endoscope type, insertion depth, proce-dure duration, findings, interventions, post-procedural abdominal pain, and post-procedural hospitalization. RESULTS:This is the largest single-center study report-ing on post-DBE pancreatitis prospectively. Six patients (1.0%) developed post-DBE pancreatitis, all after antegrade DBE. There was no association with gender, duration of the procedure or type of endoscope. The mean age was 51.9 years (range 25-78). Four patients had severe pancreatitis. Of these, two had inflammatory signs in the body-tail region, one had pancreatitis in the tail region, and the total pancreas was involved in one. CONCLUSION:The incidence of post-DBE pancreatitis in our series is higher than previously reported. We found no relation with DBE-endoscope type. The inflammatory changes occurred in the body-tail region of the pancreas, suggesting that post-DBE pancreatitis is caused by repetitive mechanical strain on the pancreas. | Soeresh VA Jarbandhan Stijn JB van Weyenberg Willem M van der Veer Dimitri GN Heine Chris JJ Mulder Maarten AJM Jacobs | 2008 | World Journal of Gastroenterology2008，14，5： | 8 |
| 8 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 9 | IS6110限制性片段多态性分析标准方法的建立及其在结核分枝杆菌分子分型中的应用显示文摘目的建立IS6110限制性片段多态性分析(IS6110一RFLP)标准方法并评价该方法的分型能力。方法采用核酸提取、PCR、限制性内切酶分析、Southern杂交、琼脂糖凝胶电泳等技术,结合Gel—Proanalyzer3.1和BioNumerics(Version5.0)软件,对78株结核分枝杆菌插入序列IS6110-RFLP进行分析。结果确定标准化的IS6110-RFLP技术,包括核酸提取、PCR、限制性内切酶分析、Southern杂交、琼脂糖凝胶电泳等实验步骤及标化参数的相关数据分析软件的使用;采用该技术,将78株结核分枝杆菌分为75个不同的基因型,分别归属于11个基因簇,其中有52株归属于同一个基因簇,占菌株总数的66.7%(52/78)。结论建立标准化的IS6110-RFLP技术方案,该方法具有很强的基因分型和株水平鉴定能力,可用于结核病的病原学监测。 | 刘敬华 Kristin Kremer Christine Pourcel Arnout Mulder 刘志广 赵秀芹 万康林 | 2008 | 中华流行病学杂志2008，29，8： | 5 |
| 10 | 中国的酸化问题——一项基于重庆—广州森林监测点研究结果的评估显示文摘中国经济的快速增长一直伴随着污染的加剧。本文在现场观测和文献研究的基础上讨论了酸性降水及其先兆的范围和影响。目前酸性降水的主要原因是二氧化硫的排放,但氮氧化物的排放也在增加。中国污染最严重地区的硫化合物沉降比东欧和中欧经受严重污染的地区要高。中国南部很多地区的土壤和土壤水看来已经被酸化。这些地区的污染已经影响了森林和其他植物的生命力,特别是在位于和靠近城市地区的地方。地表水的酸化似乎在近期不会成为主要的区域性问题,但一些地区的河流,目前虽仅接受少量的酸沉降,却对酸化显得较敏感。 | Hans M. Seip Per Aagaard Valter Angell Odd Eilertsen ThorjφrnLarssen Espen Lydersen Jan Mulder Ivar P. Muniz Arne Semb 汤大钢 Rolf D. Vogt 肖劲松 赵大为 孔国辉 岳欣 | 1999 | AMBIO-人类环境杂志1999，28，6： | 5 |
| 11 | Efficacy of thioguanine treatment in inflammatory bowel disease: A systematic review显示文摘AIM To critically assess the available literature regarding the efficacy of thioguanine treatment in inflammatory bowel disease(IBD) patients, irrespective of the(hepato-) toxicity profile.METHODS A systematic literature search of the MEDLINE database using Pub Med was performed using the keywords 'thioguanine', '6-TG', 'thioguanine', 'inflammatory bowel disease', 'IBD', 'Crohn's disease', 'Ulcerative colitis' and 'effectiveness' in order to identify relevant articles published in English starting from 2000. Reference lists of the included articles were crosschecked for missing articles. Reviewed manuscripts concerning the effectiveness of thioguanine treatment in IBD were reviewed by the authors and the data were extracted. Data were subsequently analyzed with descriptive statistics. Due to the lack of standardized outcomes, a formal meta-analysis was not performed.RESULTS A total of 11 applicable studies were found that involved the effectiveness of thioguanine therapy in IBD. Eight studies were conducted in a prospectivemanner, in the remaining three studies, data was collected retrospectively. In total, 353 IBD-patients(225 patients with Crohn's disease, 119 with ulcerative colitis and nine with unclassified IBD) with prior azathioprine/mercaptopurine resistance and/or intolerance(n = 321) or de novo thioguanine administration(n = 32) were included for analysis, of which 228(65%) had clinical improvement on thioguanine therapy, based on standard IBD questionnaires, biochemical parameters or global physician assessments. Short-term results were based on 268 treatment years(median follow-up 9 mo, range 3-22 mo) with a median daily dose of 20 mg(range 10-80 mg). Discontinuation, mostly due to adverse events, was reported in 72 patients(20%). CONCLUSION The efficacy of thioguanine therapy in IBD patients intolerant to conventional thiopurine therapy is observed in 65%, with short term adverse events in 20% of patients. | Berrie Meijer Chris JJ Mulder Godefridus J Peters Adriaan A van Bodegraven Nanne KH de Boer | 2016 | World Journal of Gastroenterology2016，22，40： | 5 |
| 12 | 先天性心脏病中的肺动脉高压:来自一项荷兰注册研究的流行病学结果显示文摘背景:与先天性心脏病有关的肺动脉高压(PAH),通常是大量体循环向肺循环分流的结果,常常导致右室心力衰竭和早期死亡。本研究旨在确定一项先天性心脏病国家注册研究所登记成年患者中的PAH患病率,评价患者特征和PAH之间的关系。 | Duffels M.G.J. Engelfriet P.M. Berger R.M.F. B.J.M. Mulder 韩瑞娟 | 2007 | 世界核心医学期刊文摘(心脏病学分册)2007，，11： | 4 |
| 13 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 14 | Application of the Nutrient Cycling Model NuCM to a Forest Monitoring Site Exposed to Acidic Precipitation in China显示文摘The nutrient cycling model NuCM is one of the most detailed models for simulating processes that influence nutrient cycling in forest ecosystems. A field study was conducted at Tieshanping, a Masson pine (Pinus massoniana Lamb.) forest site, in Chongqing, China, to monitor the impacts of acidic precipitation on nutrient cycling. NuCM simulations were compared with observed data from the study site. The model produced an approximate fit with the observed data. It simulated the mean annual soil solution concentrations in the two simulation years, whereas it sometimes failed to reproduce seasonal variation. Even though some of the parameters required by model running were measured in the field, some others were still highly uncertain and the uncertainties were analyzed. Some of the uncertain parameters necessary for model running should be measured and calibrated to produce a better fit between modeled results and field data. | ZHU Jian-Hua YU Peng-Tao T. A. SOGN WANG Yan-Hui J. MULDER | 2008 | Pedosphere2008，18，6： | 4 |
| 15 | Colonic work-up after incomplete colonoscopy: significant new findings during follow-up显示文摘 | M. Neerincx J. Terhaar sive Droste C. Mulder M. R?kers J. Bartelsman R. Loffeld H. Tuynman R. Brohet R. van der Hulst | 2010 | Endoscopy2010，，09： | 4 |
| 16 | Anal plugs and retrograde colonic irrigation are helpful in fecal incontinence or constipation显示文摘AIM: To evaluate the feasibility, clinical effect and predicting factors for favorable outcome of treatment with anal plugs in fecal incontinence and retrograde colonic irrigation (RCI) in patients with fecal incontinence or constipation. METHODS: Patients who received treatment with an anal plug or RCI between 1980 and 2005 were investigated with a questionnaire. RESULTS: Of the 201 patients (93 adults, 108 children), 101 (50/) responded. Adults: anal plugs (8), five stopped immediately, one stopped after 20 mo and two used it for 12-15 mo. RCI (40, 28 fecal incontinence, 12 constipation), 63/ are still using it (mean 8.5 years), 88/ was satisfied. Younger adults (< 40 years) were more satisfied with RCI (94 / vs 65/, P = 0.05). Children: anal plugs (7), 5 used it on demand for an average of 2.5 years with satisfactory results, one stopped immediately and one after 5 years. RCI (26 fecal incontinence, 22 constipation), 90/ are still using it (mean time 6.8 years) and felt satisfi ed. Children tend to be more satisfi ed (P = 0.001). Besides age, no predictive factors for success were found. There was no difference in the outcome between patients with fecal incontinence or constipation. CONCLUSION: RCI is more often applied than anal plugs and is helpful in patients with fecal incontinence or constipation, especially for younger patients. Anal plugs can be used incidentally for fecal incontinence, especially in children. | Marcel Cazemier Richelle JF Felt-Bersma Chris JJ Mulder | 2007 | World Journal of Gastroenterology2007，13，22： | 4 |
| 17 | Are faecal markers good indicators of mucosal healing in inflammatory bowel disease?显示文摘AIM: To review the published literature concerning the accuracy of faecal inflammatory markers for identifying mucosal healing. METHODS: Bibliographical searches were performed in MEDLINE electronic database up to February 2015,using the following terms: 'inflammatory bowel disease','Crohn′s disease','ulcerative colitis','faecal markers','calprotectin','lactoferrin','S100A12','endoscop*','mucosal healing','remission'. In addition,relevant references from these studies were also included. Data were extracted from the published papers including odds ratios with 95%CI,P values and correlation coefficients. Data were grouped together according to each faecal marker,Crohn's disease or ulcerative colitis,and paediatric compared with adult study populations. Studies included in this review assessed mucosal inflammation by endoscopic and/or histological means and compared these findings to faecal marker concentrations in inflammatory bowel diseases(IBD) patient cohorts. Articles had to be published between 1990 and February 2015 and written in English. Papers excluded from the review were those where the faecal biomarker concentration was compared between patients with IBD and controls or other disease groups,those where serum biomarkers were used,those with a heterogeneous study population and those only assessing post-operative disease. RESULTS: The available studies show that faecal markers,such as calprotectin and lactoferrin,are promising non-invasive indicators of mucosal healing. However,due to wide variability in study design,especially with regard to the definition of mucosal healing and evaluation of marker cut offs,the available data do not yet indicate the optimal roles of these markers. Thirty-six studies published between 1990 and 2014 were included. Studies comprised variable numbers of study participants,considered CD(15-164 participants) or UC(12-152 participants) separately or as a combined group(11-252 participants). Eight reports included paediatric patients. Several indices were used to document mucosal inflammation,encompassing elevenendoscopic and eight histologic grading systems. The majority of the available reports focused on faecal calprotectin(33 studies),whilst others assessed faecal lactoferrin(13 studies) and one study assessed S100A12. Across all of the biomarkers,there is a wide range of correlation describing the association between faecal markers and endoscopic disease activity(r values ranging from 0.32 to 0.87,P values ranging from < 0.0001 to 0.7815). Correlation coefficients are described in almost all studies and are used more commonly than outcome measures such as sensitivity,specificity,PPV and/or NPV. Overall,the studies that have evaluated faecal calprotectin and/or faecal lactoferrin and their relationship with endoscopic disease activity show inconsistent results. CONCLUSION: Future studies should report the results of faecal inflammatory markers in the context of mucosal healing with clear validated cut offs. | Gudula JAM Boon Andrew S Day Chris J Mulder Richard B Gearry | 2015 | World Journal of Gastroenterology2015，21，40： | 4 |
| 18 | 法洛四联症患者肺动脉瓣置换后自体移植物功能的长期随访显示文摘Aims: To analyse the long-term outcomes after pulmonary valve replacement(PVR) in patients with a previous correction for tetralogy of Fallot. Methods and results: In a retrospective study, 158 adult patients with a diagnosis of tetralogy of Fallot, who had undergone a PVR after initial total correction in childhood, were identified from the CONCOR(CONgenital CORvitia) registry. All patients underwent 175 PVRs between June 1986 and June 2005. To analyse the predictors for homograft dysfunction and adverse events(death, reoperations, balloon angioplasty), Cox-regression analysis was performed. Overall freedom from significant homograft dysfunction was 66%after 5 years and 47%after 10 years. We could not identify predictors for combined homograft dysfunction. Event-free survival was 78%at 10 years and 68%at 15 years after PVR. Both early significant pulmonary regurgitation(PR)(HR 6.8, P=0.017) and pulmonary stenosis(PS)(HR 4.0, P=0.037) after surgery were associated with adverse events. When analysing direct post-operative PR or PS,we observed that in patients with severe, pre-operative PR, right ventricular aneurysm/patch resection resulted in a lower post-operative PR(mean difference grade 0.38±0.14, P=0.01). Less significant post-operative PS was associated with a higher diameter of the homograft(HR 0.37, P=0.006). Conclusion: While 47%of the patients in our study were free from homograft dysfunction at 10 years after PVR, event-free survival after PVR remained fairly good(78%). Significant residual lesions directly after surgery influenced event-free survival. A smaller diameter of the pulmonary homograft and severe pre-surgical PR were related to early homograft dysfunction after surgery. | Oosterhof T. Meijboom F.J. Vliegen H.W. B.J.M. Mulder 郭俊 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，，12： | 4 |
| 19 | Coeliac disease in Dutch patients with Hashimoto’s thyroiditis and vice versa显示文摘AIM: To define the association between Hashimoto’s thyroiditis and coeliac disease in Dutch patients. METHODS: A total of 104 consecutive patients with Hashimoto’s thyroiditis underwent coeliac serological tests (antigliadins, transglutaminase and endomysium antibodies) and HLA-DQ typing. Small intestinal biopsy was performed when any of coeliac serological tests was positive. On the other hand, 184 patients with coeliac disease were subjected to thyroid biochemical (thyroid stimulating hormone and free thyroxine) and thyroid serological tests (thyroglobulin and thyroid peroxidase antibodies). RESULTS: Of 104 patients with Hashimoto’s thyroiditis, sixteen (15%) were positive for coeliac serology and five patients with documented villous atrophy were diagnosed with coeliac disease (4.8%; 95% CI 0.7-8.9). HLA-DQ2 (and/or -DQ8) was present in all the five and 53 patients with Hashimoto’s thyroiditis (50%; 95% CI 43-62). Of 184 patients with coeliac disease, 39 (21%) were positive for thyroid serology. Based on thyroid biochemistry, the 39 patients were subclassified into euthyroidism in ten (5%; 95% CI 2-9), subclinicalhypothyroidism in seven (3.8%; 95% CI 1.8-7.6), and overt hypothyroidism (Hashimoto’s thyroiditis) in 22 (12%; 95% CI 8-16). Moreover, four patients with coeliac disease had Graves’ disease (2%; 95% CI 0.8-5) and one patient had post-partum thyroiditis. CONCLUSION: The data from a Dutch population confirm the association between Hashimoto’s thyroiditis and coeliac disease. Screening patients with Hashimoto’s thyroiditis for coeliac disease and vice versa is recom- mended. | Muhammed Hadithi Hans de Boer Jos WR Meijer Frans Willekens Jo A Kerckhaert Roel Heijmans Amado Salvador Pea Coen DA Stehouwer Chris JJ Mulder | 2007 | World Journal of Gastroenterology2007，13，11： | 4 |
| 20 | Prevalence and prognosis of synchronous colorectal cancer: A Dutch population-based study显示文摘 | Sanna A. Mulder Ries Kranse Ronald A. Damhuis Johannes H.W. de Wilt Rob J.Th. Ouwendijk Ernst J. Kuipers Monique E. van Leerdam | 2011 | Cancer Epidemiology2011，，5： | 3 |
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