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| 1 | The clinical impact of bacterial biofilms显示文摘Bacteria survive in nature by forming biofilms on surfaces and probably most, if not all, bacteria (and fungi) are capable of forming biofilms. A biofilm is a structured consortium of bacteria embedded in a self-produced polymer matrix consisting of polysaccharide, protein and extracellular DNA. Bacterial biofilms are resistant to antibiotics, disinfectant chemicals and to phagocytosis and other components of the innate and adaptive inflammatory defense system of the body. It is known, for example, that persistence of staphylococcal infections related to foreign bodies is due to biofilm formation. Likewise, chronic Pseudomonas aeruginosa lung infections in cystic fibrosis patients are caused by biofilm growing mucoid strains. Gradients of nutrients and oxygen exist from the top to the bottom of biofilms and the bacterial cells located in nutrient poor areas have decreased metabolic activity and increased doubling times. These more or less dormant cells are therefore responsible for some of the tolerance to antibiotics. Biofilm growth is associated with an increased level of mutations. Bacteria in biofilms communicate by means of molecules, which activates certain genes responsible for production of virulence factors and, to some extent, biofilm structure. This phenomenon is called quorum sensing and depends upon the concentration of the quorum sensing molecules in a certain niche, which depends on the number of the bacteria. Biofilms can be prevented by antibiotic prophylaxis or early aggressive antibiotic therapy and they can be treated by chronic suppressive antibiotic therapy. Promising strategies may include the use of compounds which can dissolve the biofilm matrix and quorum sensing inhibitors, which increases biofilm susceptibility to antibiotics and phagocytosis. | Niels Hoiby Oana Ciofu Helle Krogh Johansen Zhi-jun Song Claus Moser Peter Ostrup Jenser Soren Molin Michael Givskov Tim Tolker-Nieisen Thomas Bjamsholt | 2011 | International Journal of Oral Science2011，3，2： | 48 |
| 2 | Noninvasive evaluation of hepatic fibrosis using acoustic radiation force-based shear stiffness in patients with nonalcoholic fatty liver disease显示文摘 | Mark L. Palmeri Michael H. Wang Ned C. Rouze Manal F. Abdelmalek Cynthia D. Guy Barry Moser Anna Mae Diehl Kathryn R. Nightingale | 2011 | Journal of Hepatology2011，，3： | 5 |
| 3 | TLR9 agonist enhances radiofrequency ablation-induced CTL responses, leading to the potent inhibition of primary tumor growth and lung metastasis显示文摘Radiofrequency ablation(RFA)is the most common approach to thermal ablation for cancer therapy.Unfortunately,its efficacy is limited by incomplete ablation,and further optimization of RFA is required.Here,we demonstrate that incubation at 65°C triggers more EG7 tumor cell death by necrosis than treatment at 45°C,and the 65°C-treated cells are more effective at inducing antigen-specific CD8^(+)cytotoxic T lymphocyte(CTL)responses after injection in mice than the 45°C-treated ones.Dendritic cells(DCs)that phagocytose 65°C-treated EG7 cells become mature with upregulated MHCII and CD80 expression and are capable of efficiently inducing effector CTLs in mouse tumor models.RFA(65°C)therapy of EG7 tumors induces large areas of tumor necrosis and stimulates CTL responses.This leads to complete regression of small(~100 mm^(3))tumors but fails to suppress the growth of larger(~350 mm^(3))tumors.The administration of the Toll-like receptor-9(TLR9)agonist unmethylated cytosine-phosphorothioate-guanine oligonucleotide(CpG)to DCs phagocytosing 65°C-treated EG7 cells enhances the expression of MHCII and CD40 on DCs as well as DC-induced stimulation of CTL responses.Importantly,the intratumoral administration of CpG following RFA also increases the frequencies of tumor-associated immunogenic CD11b−CD11c^(+)CD103^(+)DC2 and CD11b+F4/80+MHCII+M1 macrophages and increases CD4^(+)and CD8^(+)T-cell tumor infiltration,leading to enhanced CD4^(+)T cell-dependent CTL responses and potent inhibition of primary RFA-treated or distant untreated tumor growth as well as tumor lung metastasis in mice bearing larger tumors.Overall,our data indicate that CpG administration,which enhances RFA-induced CTL responses and ultimately potentiates the inhibition of primary tumor growth and lung metastasis,is a promising strategy for improving RFA treatment,which may assist in optimizing this important cancer therapy. | Aizhang Xu Lifeng Zhang Jingying Yuan Fatma Babikr Andrew Freywald Rajni Chibbar Michael Moser Wenjun Zhang Bing Zhang Zhaoying Fu Jim Xiang | 2019 | Cellular & Molecular Immunology2019，16，10： | 3 |
| 4 | Using LIDAR and ground truth for landslide recognition and characterization of geotechnical and morphological parameters in sedimentary rocks,a case study in Northern Bavaria (Germany)显示文摘The use of LIDAR-derived shaded relief maps led to the identification of all potential landslide areas in a hilly region in Northern Bavaria(1590 km^2), Germany. Every possible structure was investigated by field investigation which resulted in a detailed database of 1002 landslides within the study area. The analysis of geological, lithological, topographical and morphological properties(spatial ratio, lithological and geological setting, length/width distribution, material properties and slope angle) revealed characteristic appearances of the landslides and possible relationships between different aspects. Strong relations between the lithological setting, spatial ratio of the mapped landslides and distribution of slope angle could be observed. This study shows the value of high-resolution shaded relief maps for detecting and mapping landslides in a large area with comparatively little work and time in comparison to the traditional approach to mapping. It reveals that many landslides were not known before. Landslides are much more common in Northern Bavaria and have a higher influence on the denudation rate of the Franconian Alb than expected before. | WIEDENMANN Johannes ROHN Joachim MOSER Michael | 2017 | Journal of Mountain Science2017，14，8： | 2 |
| 5 | Evidence that thalidomide is effective in recurrent bleeding from watermelon stomach associated with liver cirrhosis显示文摘 | Stephan Moser Alexander Tischer Asia Karpi Michael Schleicher Susanne Stavjanik Michael Gschwantler | 2014 | Endoscopy2014，，： | 2 |
| 6 | Histologic Pathologies of the Myocardium in Septic Shock: A Prospective Observational Study显示文摘 | Christian A. Schmittinger Martin W. Dünser Christian Torgersen Günter Luckner Ingo Lorenz Stefan Schmid Michael Joannidis Patrizia Moser Walter R. Hasibeder Milo Halabi Christina M. Steger | 2013 | Shock2013，，4： | 1 |
| 7 | Electrochemical impedance spectroscopic analysis of dye-Sensitized solar cells显示文摘 | Wang Qing Moser Jacques-E Gratzel Michael | 2005 | J Phys Chem B2005，109，14： | 1 |
| 8 | Crohn’s disease, pregnancy, and birth weight显示文摘 | Michael A.J Moser Nanette B Okun Damon C Mayes Robert J Bailey | 2000 | The American Journal of Gastroenterology2000，，4： | 1 |
| 9 | Circulating Cytokine Levels Compared to Pain in Patients with Fibromyalgia A Prospective Longitudinal Study Over 6 Months显示文摘 | Wang H L Michael Moser | 2008 | J Rheumatol2008，35，： | 1 |
| 10 | Phenotype - specific CpG insland methylation events in a murine model of prostate cancer显示文摘 | Maria Camoriano Shannon R Morey Kinney Michael T Moser | 2008 | Cancer Research2008，1，68： | 1 |
| 11 | The state of the art in the analysis of two-dimensional gel electrophoresis images显示文摘 | Matthias Berth Frank Michael Moser | 2007 | Appl Microbiol Biotechnol2007，76，： | 1 |
| 12 | A stage specific calciumbinding protein expressed in eggs of Schistosoma mansoni 显示文摘 | Doris Moser Michael J Doenhoff | 1992 | Mol Biochem Parasitol1992，51，2： | 1 |
| 13 | Electrochemical impedance spectroscopic analysis of dye-sensitized solar Cells 显示文摘 | Wang Qing Moser Jacques-E Gratzel Michael | 2005 | J Phys Chem B2005，109，14： | 1 |
| 14 | Effect of anticoagulation on blood membrane interactions during hemodialysis显示文摘 | Roland Hofbauer Doris Moser Michael Frass | 1999 | Kidney Int1999，，56： | 1 |
| 15 | Five-year experience with donation after cardiac death kidney transplantation in a Canadian transplant program: Factors affecting outcomes 显示文摘 | Michael Moser Michael Sharpe Corinne Weemink | 2012 | Canadian Urological Association2012，6，6： | 1 |
| 16 | Charge carrier trapping and recombination dynamics in small semiconductor particles显示文摘 | Guido Rothenberger Jacques Moser Michael Graetzel | 1985 | J Am Chem Soc1985，107，26： | 1 |
| 17 | Building a Distributed E-Healthcare System Using SOA显示文摘 | Firat Kart Louise Moser P Michael Melliar-Smith | 2008 | The IEEE Computer Society2008，，6： | 1 |
| 18 | Photoelectrochemical studies on nanocrystalline hematite films显示文摘 | Ulrika Bjorkstbn Jacques Moser Michael Gratzel | 1994 | Chem Mater1994，6，： | 1 |
| 19 | Noninvasive evaluation of hepatic fibrosis using acoustic radiation force-based shear stiffness in patients with nonalcoholic fatty liver disease显示文摘 | Mark L. Palmeri Michael H. Wang Ned C. Rouze Manal F. Abdelmalek Cynthia D. Guy Barry Moser Anna Mae Diehl Kathryn R. Nightingale | 2011 | Journal of Hepatology2011，，3： | 1 |
| 20 | Political Risk and Export Promotion:Evidence from Germany显示文摘 | Christoph Moser Thorsten Nestmann Michael Wedow | | 0，，31： | 1 |
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