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| 1 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 2 | The implementation of an improved NPML absorbing boundary condition in elastic wave modeling显示文摘在向前当模特儿的有弹性的波浪,吸收边界条件(ABC ) 被用来从模型截断边界减轻不希望得到的思考。完美地匹配的层(PML ) 证明了是最好的可得到的 ABC。然而,传统的切开 PML (SPML ) ABC 有一些严肃的劣势:例如,全球 SPML ABC 要求更多计算记忆,尽管实现是容易的。本地 SPML ABC 的实现也有一些困难,自从边和角落必须被考虑。因为卷绕旋转,传统的非切开的完美地匹配的层(NPML ) ABC 有复杂计算。在这篇论文,基于 ABC 与复杂转移频率的拉长函数(CFS ) 相结合的非切开的完美地匹配的层(NPML ) ,我们为与简单计算方程,小存储器要求,和容易的编程吸收边界条件的 PML 介绍一个新奇数字实现方法。 | Qin Zhen Lu Minghui Zheng Xiaodong Yao Yao Zhang Cai Song Jianyong | 2009 | Applied Geophysics2009，6，2： | 21 |
| 3 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 4 | Early Serum HBsAg Kinetics as Predictor of HBsAg Loss in Patients with HBeAg-Negative Chronic Hepatitis B after Treatment with Pegylated Interferonα-2a显示文摘Hepatitis B surface antigen(HBsAg)loss is an ideal treatment endpoint for patients with chronic hepatitis B(CHB).We investigated the predictive value of on-treatment HBsAg levels for HBsAg loss in hepatitis B e antigen(HBe Ag)-negative CHB patients who received 120-week PEG-IFNα-2a treatment.Serum HBV DNA,HBsAg,and anti-HBs levels were assayed at baseline and every 3 months during the treatment.Of 81 patients,12 achieved HBsAg loss,20 achieved HBsAg\100 IU/mL,and 49 maintained HBs Ag C 100 IU/mL.HBsAg loss rate was only 3.7%at 48 weeks,while it reached to 11.1%and 14.8%after treatment of 96 weeks and 120 weeks.The cutoff HBs Ag levels at 12 weeks predicting HBsAg loss at 96 weeks and 120 weeks of treatment were 400 IU/mL and 750 IU/mL,with AUC 0.725 and 0.722,positive predictive value(PPV)29.41%and 30.56%,and negative predictive value(NPV)93.75%and 97.78%,respectively.The cutoff HBsAg levels at 24 weeks predicting HBsAg loss at 96 weeks and 120 weeks of treatment were 174 IU/m L and 236 IU/mL respectively,with AUC 0.925 and 0.922,PPV 40.0%and 46.15%,and both NPV 100%.The predictive ability of the cutoff HBsAg levels at 24 weeks was better than that at 12 weeks for HBs Ag loss at either 96 or 120 weeks(χ~2=3.880,P=0.049 andχ~2=4.412,P=0.036).These results indicate that extended therapy is critical to HBsAg loss in HBe Ag-negative CHB patients during PEG-IFN treatment,and the HBsAg level at 24 weeks can be used to predict HBsAg loss during tailoring PEG-IFN therapy. | Minghui Li Lu Zhang Yao Lu Qiqi Chen Huihui Lu Fangfang Sun Zhan Zeng Gang Wan Linqing Zhao Yao Xie | 2021 | Virologica Sinica2021，36，2： | 15 |
| 5 | Experimental study on the mechanical and failure behaviors of deep rock subjected to true triaxial stress:A review显示文摘It has become an inevitable trend of human development to seek resources from the deep underground.However,rock encountered in deep underground engineering is usually in an anisotropic stress state(σ_(1)>σ>σ_(3))due to the influences of geological structures and engineering disturbances.It is therefore essential to study the mechanical,seepage,and dynamic disaster behaviors of deep rock under true triaxial stress to ensure the safe operation of deep rock engineering and the efficient exploitation of deep resources.In recent years,experimental techniques and research on true triaxial rock mechanics have achieved fruitful results that have promoted the rapid development of deep rock mechanics;thus,it is necessary to systematically review and summarize these developments.This work first introduced several typical true triaxial testing apparatus and then reviewed the corresponding research progress on rock deformation,strength,failure mode,brittleness,and energy as well as the 3D volumetric fracturing(dynamic disaster)properties of deep rocks under true triaxial stress.Then,several commonly used true triaxial rock strength criteria and their applicability,the permeability characteristics and mathematical models of deep reservoir rocks,and the disaster-causing processes and mechanisms of disturbed volumetric fracturing(rockburst,compound dynamic disasters)in deep rock engineering were described.This work may provide an essential reference for addressing the true triaxial rock mechanics issues involved in deep rock engineering,especially regarding the stability of surrounding rock at depth,disaster prevention and control,and oil and gas exploitation. | Heping Xie Jun Lu Cunbao Li Minghui Li Mingzhong Gao | 2022 | International Journal of Mining Science and Technology2022，32，5： | 13 |
| 6 | SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs显示文摘Dietary microRNAs have been shown to be absorbed by mammals and regulate host gene expression,but the absorption mechanism remains unknown.Here,we show that SIDT1 expressed on gastric pit cells in the stomach is required for the absorption of dietary microRNAs.SIDT1-deficient mice show reduced basal levels and impaired dynamic absorption of dietary microRNAs.Notably,we identified the stomach as the primary site for dietary microRNA absorption,which is dramatically attenuated in the stomachs of SIDT1-deficient mice.Mechanistic analyses revealed that the uptake of exogenous microRNAs by gastric pit cells is SIDT1 and low-pH dependent.Furthermore,oral administration of plant-derived miR2911 retards liver fibrosis,and this protective effect was abolished in SIDT1-deficient mice.Our findings reveal a major mechanism underlying the absorption of dietary microRNAs,uncover an unexpected role of the stomach and shed light on developing small RNA therapeutics by oral delivery. | Qun Chen Fan Zhang Lei Dong Huimin Wu Jie Xu Hanqin Li Jin Wang Zhen Zhou Chunyan Liu Yanbo Wang Yuyan Liu Liangsheng Lu Chen Wang Minghui Liu Xi Chen Cheng Wang Chunni Zhang Dangsheng Li Ke Zen Fangyu Wang Qipeng Zhang Chen-Yu Zhang | 2021 | Cell Research2021，31，3： | 10 |
| 7 | Effect of Zhuyeshigao granule on tumor necrosis factor-α and inter leukins serum protein levels in rats with radiation esophagitis显示文摘OBJECTIVE: To investigate the effects of Zhuyeshigao granule(ZSG) on tumor necrosis factor-α(TNF-α), interleukin-1(IL-1), IL-2, IL-6, and IL-8 in rats with radiation esophagitis.METHODS: Fifty Wistar rats were randomly divided into five groups(10 rats in each group): control(without radiation), saline-treated, and low,medium, and high-dose ISG-treated groups. Rats were given normal saline(10 mL/kg) or 1.15, 2.3,or 4.6 g/kg ZSG by intragastric administration once a day for 7 days. A rat model of radiation esophagitis was established by local irradiation of Co60(490.25 cGy/min, totaling 30 Gy). The administration of ZSG was continued for another 7 days and on the 7th day post-irradiation, inferior vena cava blood was collected.The serum was separated, and TNF-α, IL-1, IL-2, IL-6, and IL-8 protein levels were determined.RESULTS: Inflammatory response factors were found in the serum of each group. However, levels in ZSG-treated groups were significantly lower than inthesaline-treatedgroup(P<0.05).CONCLUSION: ZSG may prevent the development of radiation esophagitis, perhaps by inhibiting the generation and release of the inflammatory responsefactorsTNF-α,IL-1,IL-2,IL-6,andIL-8. | Junzhang Lu Chen Wang Xiutang Cao Minghui Yang Hong Zhao Yi Liu | 2014 | Journal of Traditional Chinese Medicine2014，34，3： | 8 |
| 8 | Characteristics of air pollution by polychlorinated dibenzo-p-dioxins and dibenzofurans in the typical industrial areas of Tangshan City,China显示文摘The ambient air in vicinity of different industrial sources for PCDD/PCDFs was sampled by TSP/PM 10 active samplers and passive PUF disk samplers in Tangshan City,a metropolis containing clusters of various industrial plants.The ΣTEQ concentrations of ΣPCDD/ΣPCDFs ranged from 44.2 to 394.1 fg I-TEQ/m 3 with an average of 169.9 fg I-TEQ/m 3.2,3,4,7,8-PeCDF was the dominant contributor to TEQ,contributing 41% (12% to 55%),while 1,2,3,4,6,7,8-HpCDF,OCDD and OCDF were the major congeners for the total concentrations.The ratios of PCDF/PCDD reached 2.54 on average,suggesting that de novo synthesis in thermal processes played an important role to the airborne pollution of PCDD/PCDFs.The similarities congener profiles indicated that TSP and PM 10 active sampling methods are comparable for the determination of the PCDD/PCDFs in ambient air,and the ratios of concentrations determined by the two methods suggested that the PCDD/PCDFs tended to stay in fine particles.It was found that 2,3,7,8-TCDF and OCDD were the dominating congeners in the passive PUF disks samples.Through principal components analysis,the coke industry was suggested to be a relatively high potential emission source for PCDD/PCDFs in the ambient air of Tangshan,which was possibly formed by de novo synthesis mechanism.In this study,the atmospheric impacts to the environment from different industrial sources could be ranked as follows (from high to low):coking,iron sintering,steel making,power generation and chlorinate alkali chemical production industries. | Zhiyuan Ren Bing Zhang Pu Lu Cheng Li Lirong Gao Minghui Zheng | 2011 | Journal of Environmental Sciences2011，23，2： | 8 |
| 9 | Study of self-focusing in underwater waveguide by time reversal method显示文摘Acoustic wave time reversal self-focusing in underwater waveguide is studied.The acoustic wave time reversal is theoretically and experimentally investigated in a half-infinitefluid medium and a shallow fluid layer placed on a hard half-infinite solid medium,respectively,The ray approach method is adopted to study the far field of the acoustic field in theory,and the ultrasonic experiments have been carried out in laboratory to model the underwater waveguide.It is shown by theoretical and experimental results that the focusing gain can be improved by 12dB or more. | ZHANG Bixing WANG Chenghao LU Minghui (Institute of Acoustics, The Chinese academy of sciences Beijing 100080) | 2003 | Chinese Journal of Acoustics2003，22，1： | 7 |
| 10 | Tailoring the mechanical anisotropy of sintered NdFeB magnets by Pr-Cu grain boundary reconstruction显示文摘Pr_(83)Cu_(17)(wt%) grain boundary reconstruction was applied to prepare sintered NdFeB magnets. The effects of addition amount and annealing on the bending strength were investigated. The results show that Pr_(83)Cu_(17) can not only effectively enhance the bending strength, but also change the mechanical anisotropy in two directions parallel and perpendicular to c-axis. The bending strength perpendicular to c-axis reaches 404 MPa in 10 wt% addition magnet, higher than 348 MPa along parallel direction. This change is attributed to the preferred distribution of boundary phases, i.e., ductile(Nd,Pr)-Fe-Cu phase along perpendicular direction to c-axis and(Nd,Pr)-Fe phase along parallel direction. Moreover, the Cu migration during 480 ℃ annealing is found to be related to this boundary phase distribution. | Minghui Tang Xiaoqian Bao Xuejiao Zhang Xing Mu Kechao Lu Jiheng Li Xuexu Gao | 2019 | Journal of Rare Earths2019，37，4： | 7 |
| 11 | Isorhapontigenin protects against doxorubicin-induced cardiotoxicity via increasing YAP1 expression显示文摘As an effective anticancer drug, the clinical limitation of doxorubicin(Dox) is the time-and dose-dependent cardiotoxicity. Yes-associated protein 1(YAP1) interacts with transcription factor TEA domain 1(TEAD1) and plays an important role in cell proliferation and survival. However, the role of YAP1 in Dox-induced cardiomyopathy has not been reported. In this study, the expression of YAP1 was reduced in clinical human failing hearts with dilated cardiomyopathy and Dox-induced in vivo and in vitro cardiotoxic model. Ectopic expression of Yap1 significantly blocked Dox-induced cardiomyocytes apoptosis in TEAD1 dependent manner. Isorhapontigenin(Isor) is a new derivative of stilbene and responsible for a wide range of biological processes. Here, we found that Isor effectively relieved Doxinduced cardiomyocytes apoptosis in a dose-dependent manner in vitro. Administration with Isor(30 mg/kg/day, intraperitoneally, 3 weeks) significantly protected against Dox-induced cardiotoxicity in mice. Interestingly, Isor increased Dox-caused repression in YAP1 and the expression of its target genes in vivo and in vitro. Knockout or inhibition of Yap1 blocked the protective effects of Isor on Dox-induced cardiotoxicity. In conclusion, YAP1 may be a novel target for Dox-induced cardiotoxicity and Isor might be a new compound to fight against Dox-induced cardiotoxicity by increasing YAP1 expression. | Panxia Wang Minghui Wang Yuehuai Hu Jianxing Chen Yanjun Cao Cui Liu Zhongkai Wu Juan Shen Jing Lu Peiqing Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 7 |
| 12 | Hybrid metal-insulator-metal structures on Si nanowires array for surface enhanced Raman scattering显示文摘Surface enhanced Raman scattering(SERS)is an efficient technique to detect low concentration molecules.In this work,periodical silicon nanowires(Si NWs)integrated with metal-insulator-metal(MIM)layers are employed as SERS substrates.Laser interference lithography(LIL)combined with reactive ion etching(RIE)is used to fabricate large-area periodic nanostructures,followed by decorating the MIM layers.Compared to MIM disks array on Si surface,the SERS enhancement factor(EF)of the MIM structures on the Si NWs array can be increased up to 5 times,which is attributed to the enhanced electric field at the boundary of the MIM disks.Furthermore,high density of nanoparticles and nanogaps serving as hot spots on sidewall surfaces also contribute to the enhanced SERS signals.Via changing the thickness of the insulator layer,the plasmonic resonance can be tuned,which provides a new localized surface plasmon resonance(LSPR)characteristic for SERS applications. | Kaichen Xu Chentao Zhang Tzu Hsiao Lu Puqun Wang Rui Zhou Rong Ji Minghui Hong | 2017 | 光电工程2017，44，2： | 6 |
| 13 | STUDY ON TYPHOON DISASTER LOSS AND RISK PREDICTION AND BENEFIT ASSESSMENT OF DISASTER PREVENTION AND MITIGATION显示文摘Based on the meteorological monitoring data of Typhoon Nesat and Haitang in Fujian Province in 2017, the data of the typhoon disaster situation and third-party evaluation of typhoon disaster prevention and mitigation benefit were investigated. By using the mean value anomaly estimation method in the similarity analysis method, it is estimated that typhoon Nesat and Haitang will cause direct economic losses of 0.8 ~ 1.8 billion yuan, and the typhoon disaster risk index evaluation model is used. The disaster risk pre-assessment of Typhoon Nesat and Haitang is carried out. The results of the study and analysis show that the pre-assessment results of Typhoon Nesat and Haitang are basically consistent with the actual disaster situation. The disaster loss was reduced to the minimum. According to the third party evaluation and investigation, it was concluded that the contribution rate of reducing economic benefits was 75% in Fujian Province for preventing and landing double typhoons Nesat and Haitang. Mainly reflected in the ship return to the port to avoid the wind, geological hazards prone to the site construction and cage culture danger removal reinforcement and other links; The contribution rate of reducing casualties is 86, mainly reflected in fishermen disembarkation and personnel transfer to safety emergency shelter and other links. The benefit of this double typhoon disaster prevention and mitigation in Fujian Province is about 0.6 billion yuan to reduce the direct economic loss. According to the investigation, the overall satisfaction of the double typhoon meteorological service is 91.0 points. Typhoon early warning information service convenience satisfaction is 91.4 points, early warning information accuracy satisfaction is 87.2 points, government departments strong anti-Taiwan disaster reduction organization, linkage departments participate in disaster prevention and mitigation high. However, there is a gap between public awareness and participation in typhoon disasters. | LIN YANG CHUNRONG CAO DEHUI WU HONGHUA QIU MINGHUI LU LING LIU | 2018 | Tropical Cyclone Research and Review2018，7，4： | 4 |
| 14 | COORDINATING PRICING, ORDERING AND ADVERTISING FOR PERISHABLE PRODUCTS OVER AN INFINITE HORIZON显示文摘众多的实验研究证明那个做广告的努力能在两个现在和将来的时期刺激需求,并且在定价之间有一个相互作用,为决定做广告并且订。这些决定怎么并且什么与对方一起交往在定价上做广告并且订的效果是决定?理解这个相互作用,我们考虑在一个稳定的市场卖一个容易腐烂的产品并且动态地决定联合的订,定价和做广告的策略的一个书报摊贩类型公司。这个问题与做广告的 carryover 效果和价格敏感的需求作为一个无限的地平线书报摊贩问题被建模。我们描绘最佳的定价,做广告并且盘点策略和他们的比较静电干扰,并且考虑没有做广告的效果,这条政策怎么不同于传统的途径。我们证明最佳的有效做广告水平 monotonically 在以前的时期,和因此最佳的策略与有效做广告水平正在增加(做广告,定价,库存水平) 全球性长远来说收敛到稳定的状态。我们数字地证明最佳的政策能收获重要利润,它强调订的做广告开车和定价策略的重要性。 | Ye Lu Minghui Xu Yimin Yu | 2018 | Journal of Systems Science and Systems Engineering2018，27，1： | 3 |
| 15 | Using coupling slabs to tailor surface-acoustic-wave band structures in phononic crystals consisting of pillars attached to elastic substrates显示文摘The propagation of surface acoustic waves(SAWs) in two-dimensional phononic crystals(PnCs) with and without coupling-enhancement slabs was theoretically investigated using a three-dimensional finite element method.Different piezoelectric substrates,for example,lithium niobate(LiNbO_3),gallium nitride(GaN),and aluminium nitride(A1N),were taken into account.Compared to the PnCs without coupling-enhancement slabs,the coupling between each pillar and its nearest neighbor was largely enhanced in the presence of slabs.The bandwidth of the first directional band gap increased markedly compared with its initial value for the PnCs without a slab(within square symmetry).In addition,with increasing thicknesses of the slabs bonded between neighboring pillars,the first directional band-gap and second directional band gap of the PnCs tend to merge.Therefore,the structure with coupling-enhancement slabs can be used as an excellent electrical band elimination filter for most electro-SAW devices,offering a new strategy to realize chip-scale applications in electroacoustic signal processing,optoacoustic modulation,and even SAW microfluidic devices. | Heng Zhang SiYuan Yu FuKang Liu Zhen Wang MingHui Lu XiaoBo Hu YanFeng Chen XianGang Xu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，4： | 3 |
| 16 | Structural Evolution of the Eastern Qiulitagh Fold and Thrust Belt,Northern Tarim Basin,China显示文摘东方 Qiulitagh 褶层和戳带(EQFTB ) 是活跃 Kuqa 褶层的部分和北 Tarim 盆的戳带。地震思考侧面与地质的表面和练习数据是综合的检验变丑和 EQFTB 的结构风格,特别地第纳干扰器的 deformational 历史 2 煤气的地。地震解释建议 Dongqiu 8 是双结构在被动房顶戳下面开发了的外套,它在中新世的 Jidike 形成从一根尖端线产生了,并且脚底推进从在 Kuqatawu 背斜下面向西延长的一样的 Jidike 形成 evaporite 地区被开始。Dongqiu 5 是在 EQFTB 的西方的部分的弹出式结构,也在 Jidike 形成 evaporite 下面发展了。在 EQFTB 的很轻轻的地下室剧降和陡峭的蘸的地志的斜坡建议 Jidike 形成盐提供有效去耦。在 EQFTB 的强壮的变丑向南显得发展了进一步,在 evaporite 可能正在缺乏的一个区域。自从上新世, EQFTB 在 evaporite 上向南远移动了并且到达了 Yaken 区域。恢复一张平衡剖面图建议越过 EQFTB 的最小的弄短是超过 7800 m。假设这弄短发生在 5.3 妈期间预定平底锅,弄短的率是约 1.47 公里 / 年。 | YANG Minghui JIN Zhijun LU Xiuxiang SUN Dongsheng TANG Xuan PENG Gengxin LEI Ganglin | 2009 | Acta Geologica Sinica(English Edition)2009，83，2： | 2 |
| 17 | Approximate-model Based Estimation Method for Dynamic Response of Forging Processes显示文摘Many high-quality forging productions require the large-sized hydraulic press machine(HPM) to have a desirable dynamic response. Since the forging process is complex under the low velocity, its response is difficult to estimate. And this often causes the desirable low-velocity forging condition difficult to obtain. So far little work has been found to estimate the dynamic response of the forging process under low velocity. In this paper, an approximate-model based estimation method is proposed to estimate the dynamic response of the forging process under low velocity. First, an approximate model is developed to represent the forging process of this complex HPM around the low-velocity working point. Under guaranteeing the modeling performance, the model may greatly ease the complexity of the subsequent estimation of the dynamic response because it has a good linear structure. On this basis, the dynamic response is estimated and the conditions for stability, vibration, and creep are derived according to the solution of the velocity. All these analytical results are further verified by both simulations and experiment. In the simulation verification for modeling, the original movement model and the derived approximate model always have the same dynamic responses with very small approximate error. The simulations and experiment finally demonstrate and test the effectiveness of the derived conditions for stability, vibration, and creep, and these conditions will benefit both the prediction of the dynamic response of the forging process and the design of the controller for the high-quality forging. The proposed method is an effective solution to achieve the desirable low-velocity forging condition. | LEI Jie LU Xinjiang LI Yibo HUANG Minghui ZOU Wei | 2015 | Chinese Journal of Mechanical Engineering2015，28，3： | 2 |
| 18 | Toward an Ecological Civilization:China’s Progress as Documented by the Second National General Survey of Pollution Sources显示文摘The relationship between environmental quality and economic growth has been a hot topic for decades.After years of rapid industrialization and urbanization,China’s environmental challenges are approaching a turning point.Following the principles of ecological civilization construction,China is on its way to maintaining high-quality and green economic development.On 10 June 2020,the Chinese Government reported the key findings of the Second National General Survey of Pollution Sources(fiscal year 2017),which provides strong quantitative evidence of progress toward ecological civilization.In terms of our comparison between the two National General Surveys in 2007 and 2017,it was found that environmental pollution,measured in terms of many wastewater and air emission pollutant discharges,is decreasing despite the steady growth in economic activities—and at a noticeably fast pace.Other national and local governments can adopt some of China’s ecological civilization practices,within their own individual contexts. | Minghui Xie Huabo Duan Peng Kang Qi Qiao Lu Bai | 2021 | Engineering2021，7，9： | 2 |
| 19 | First principles study of CuAlO_2 doping with S显示文摘We study the electronic properties of CuAlO2 doped with S by the first principles calculations and find that the band gap of CuAlO2 is reduced after the doping.At the same time,the effective masses are also reduced and the density of states could cross the Fermi level.These results show that the conductivity of CuAlO2 could be enhanced by doping the impurities of S,which needs to be further studied. | GAO HaiGen 1,ZHOU Jian 1,2* & LU MingHui 1 1 National Laboratory of Solid State Microstructures and Department of Materials Science and Engineering,Nanjing University,Nanjing 210093,China 2 Group of Computational Condensed Matter Physics,National Laboratory of Solid State Microstructures and Department of Physics,Nanjing University,Nanjing 210093,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，7： | 2 |
| 20 | Arabidopsis immune-associated nucleotide-binding genes repress heat tolerance at the reproductive stage by inhibiting the unfolded protein response and promoting cell death显示文摘Plants are vulnerable to heat stress,especially during reproductive development.The heat shock response(HSR)in the cytosol and nucleus,as well as the unfolded protein response(UPR)in the endoplasmic reticulum(ER),are two mechanisms that enable plants to survive heat stress.Excessive heat or ER stresses lead to cell death when the UPR cannot repair stress damage,but the means by which cell survival or death is determined remains unclear.In this study,we used a genome-wide association study(GWAS)to identify that a cluster of five Immune-associated nucleotide-binding protein(IAN)genes(IAN2 to IAN6)is responsible for variation in heat tolerance at the reproductive stage in Arabidopsis thaliana.These IAN genes have both unique and overlapping functions in the negative regulation of heat tolerance,and their loss of function singly or in combination confers increased heat tolerance,measured by a lower number of barren siliques and a higher seedling survival rate under heat.The loss of rice IAN1 gene function also leads to enhanced heat tolerance,suggesting a conserved function of plant IANs.Transcriptome analysis revealed enhanced expression of HSR and UPR genes,as well as reduced cell death,under heat and ER stress in the mutant of IAN6,a major effect member in Arabidopsis.Furthermore,the IAN proteins were found to promote cell death induced by heat stress,ER stress,and cell death-inducing molecules.Thus,the Arabidopsis IAN genes repress heat tolerance,probably through the HSR and UPR and by enhancing the cell death pathway.The IAN2 to IAN6 proteins are partially localized to the ER,suggesting a direct role in the UPR and UPR-mediated cell death.In addition,a natural IAN6 variant from more heat-tolerant Arabidopsis accessions confers greater heat tolerance and induces less cell death compared with the natural variant from less heat-tolerant accessions.The heat-tolerant IAN6 variant is associated with a higher maximum temperature of the warmest month at its collection sites compared with the heat-sensitive variant.Taken together,these results reveal an important role of Arabidopsis IAN2 to IAN6 genes in the regulation of the HSR,UPR,and cell death,and suggest that their natural variations have adaptive functions in heat tolerance. | Shan Lu Tianquan Zhu Zhixue Wang Lilin Luo Shuai Wang Minghui Lu Yongmei Cui Baohong Zou Jian Hua | 2021 | Molecular Plant2021，14，2： | 2 |
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