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| 1 | Over-expression of heat shock protein 27 attenuates doxorubicin-induced cardiac dysfunction in mice显示文摘 | Liu,L Zhang,X Qian,B Min,XY Gao,X Li,CF Cheng,YL Huang,J | 2007 | 南京医科大学学报(自然科学版)2007，27，11： | 15 |
| 2 | Novel functional proteins interact with midkine in hepatic cancer cells显示文摘BACKGROUND: Midkine is a heparin-binding growth factor that promotes the proliferation, survival, migration and differentiation of various target cells. Midkine plays an important role in tumorigenesis and tumor progression, and is overexpressed in many human malignant tumors. Patients with high tumor midkine expression frequently have a worse prognosis than those with low expression. The present study was designed to investigate the interaction network of midkine in hepatic cancer cells, and to elucidate its role in hepatocellular carcinoma. METHODS: DNA encoding full-length midkine was cloned into pDBLeu vector to serve as bait in yeast two-hybrid screening to identify interacting proteins. Candidate proteins were examined on SC-Leu-Trp-His+3-AT (20 mmol/L) plates and assayed for X-gal activity, then sequenced and classified according to the GenBank. Finally, identified proteins were expressed by the in vitro expression system pCMVTnT, and protein interactions were confirmed by co-immunoprecipitation. RESULTS: Using the yeast two-hybrid system, we found 6 proteins that interacted with midkine: NK-kappa-B inhibitor alpha (I-κ-B-α), Dvl-binding protein naked cuticle 2, granulin, latent active TGF-β binding protein 3, latent active TGF-β binding protein 4, and phospholipid scramblase 1. In vitro co-immunoprecipitation demonstrated that all identified proteins directly interacted with midkine.CONCLUSION: The identification of midkine-interacting proteins in hepatic cancer cells indicates that midkine is a multifunctional factor that may participate in cell migration, differentiation, and proliferation, and is also associated with the multicellular response feedback during the development of hepatocellular carcinoma. | Qiang Yan, Hui-Lian Huang, Xing Yao, Jing Li, Li-Qin Li, Jing Zhong, Li-Shan Min, Li-Cheng Dai and Shu-Sen Zheng Department of Hepatobiliary and Pancreatic Surgery, Huzhou Central Hospital (Yan Q and Yao X) Huzhou Key Laboratory of Molecular Medicine, Affiliated Central Hospital of Huzhou Teachers College (Huang HL, Li J, Li LQ, Zhong J, Min LS and Dai LC), Huzhou 313000, China Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China (Yan Q and Zheng SS) | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 7 |
| 3 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 4 | Theory for constructing generalized synchronization and synchronization and applications显示文摘 | ZHANG X D MIN L Q | 2000 | Journal of University of Science and Technology Beijing2000，，7： | 1 |
| 5 | Phase stability and magnetism of Ni3A1 显示文摘 | Xu J X MIN B I FREEMAN A J | 1990 | Physical Review B: Condensed Matter1990，41，8： | 1 |
| 6 | Tench farming in Chi- na: present status and future prospects 显示文摘 | Wang J X Min W Q E Guan M | 2006 | Aquaculture2006，，2006： | 1 |
| 7 | Liver transplantation:changing goals in immunosuppression显示文摘 | McMaster P Gunson B Min X | 1998 | Transplant Proc1998，30，5： | 1 |
| 8 | Serum response factor is overexpressed in esophageal squamous cell carcinoma and promotes Eca109 cell proliferation and invasion显示文摘 | Xi H Hong X Min Z | 2012 | Oncol Let2012，5，： | 1 |
| 9 | Anterior corpectomy versusposterior laminoplasty for multilevel cervical myelopathy : asystematic review and meta - analysis 显示文摘 | Liu X Min S Zhang H | 2014 | Eur Spine J2014，23，2： | 1 |
| 10 | Facile one-step synthesis of inorganic-framework molecularly imprinted TiO2/WO3nanocomposite and its molecular recognitive photocatalytic degradation of target contaminant显示文摘 | LUO X B DENG F MIN L J | 2013 | Environmental Science and Technology2013，47，13： | 1 |
| 11 | Microstructure and mechanical properties of Mg-Al based alloy with calcium and rare earth additions显示文摘 | Du W W Sun Y S Min X G | | 0，，： | 1 |
| 12 | Parameter Sensitiv- ity Examination and Discussion of PEM Fuel Cell Sim- ulation Model Validation 显示文摘 | Min C H He Y L Liu X L | 2006 | Journal of Power Sources2006，160，1： | 1 |
| 13 | An investigation on synthesis and photocatalytic activity of polyaniline sensitized nanocrystalline TiO2 composites显示文摘 | Min S X Wang F Han Y Q | 2007 | J Mater Sci2007，42，： | 1 |
| 14 | Performance of SIMO FM- DCSK UWB system based on chaotic pulse cluster signals 显示文摘 | WANG L MIN X CHEN G | 2011 | IEEE Transactions on Circuits and System2011，58，9： | 1 |
| 15 | Border malaria in china: knowl- edge and use of personal protection by minority populations and implications for malaria control:a questionnarie-based survey显示文摘 | Moore SJ Min X Hill N | 2008 | BMC Public Health2008，8，： | 1 |
| 16 | The glioma-associated oncogene homolog 1 promotes epithelial-mesenchymal transition in human esophageal squamous cell cancer by inhibiting E-cadherin via Snail显示文摘 | Min S Xiaoyan X Fanghui P | 2013 | Cancer Gene Ther2013，20，7： | 1 |
| 17 | FunSecKB: the Fungal Secretome Knowl- edge Base显示文摘 | Lure G Min X J | 2011 | Database2011，2011，： | 1 |
| 18 | Influence of acetamiprid on soil enzymatic activities and respiration 显示文摘 | Yao X H Min H Lu Z H | 2006 | European Journal of Soil Biology2006，42，2： | 1 |
| 19 | Mechanical pleurodesis does not reduce recurrence of spontaneous pneumothorax: a randomized tri- al显示文摘 | Min X Huang Y Yang Y | 2014 | Ann Thorac Surg2014，98，5： | 1 |
| 20 | Nanobactcria:a polliblc ctiology for type III prostatitis 显示文摘 | Shen X Min g A Li X ct al | 2010 | Urol2010，184，1： | 1 |
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