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| 1 | Nonalcoholic fatty liver disease is associated with benign gastrointestinal disorders显示文摘AIM:To explore associations between nonalcoholic fatty liver disease(NAFLD)and benign gastrointestinal and pancreato-biliary disorders.METHODS:Patient demographics,diagnoses,and hospital outcomes from the 2010 Nationwide Inpatient Sample were analyzed.Chronic liver diseases were identified using International Classification of Diseases,the 9thRevision,Clinical Modification codes.Patients with NAFLD were compared to those with other chronic liver diseases for the endpoints of total hospital charges,disease severity,and hospital mortality.Multivariable stepwise logistic regression analyses to assess for the independent association of demographic,comorbidity,and diagnosis variables with the event of NAFLD(vs other chronic liver diseases)were also performed.RESULTS:Of 7800441 discharge records,32347(0.4%)and 271049(3.5%)included diagnoses of NAFLD and other chronic liver diseases,respectively.NAFLD patients were younger(average 52.3 years vs55.3 years),more often female(58.8%vs 41.6%),less often black(9.6%vs 18.6%),and were from higher income areas(23.7%vs 17.7%)compared to counterparts with other chronic liver diseases(all P<0.0001).Diabetes mellitus(43.4%vs 28.9%),hypertension(56.9%vs 47.6%),morbid obesity(36.9%vs 8.0%),dyslipidemia(37.9%vs 15.6%),and the metabolic syndrome(28.75%vs 8.8%)were all more common among NAFLD patients(all P<0.0001).The average total hospital charge($39607 vs$51665),disease severity scores,and intra-hospital mortality(0.9%vs6.0%)were lower among NALFD patients compared to those with other chronic liver diseases(all P<0.0001).Compared with other chronic liver diseases,NAFLD was significantly associated with diverticular disorders[OR=4.26(3.89-4.67)],inflammatory bowel diseases[OR=3.64(3.10-4.28)],gallstone related diseases[OR=3.59(3.40-3.79)],and benign pancreatitis[OR=2.95(2.79-3.12)]on multivariable logistic regression(all P<0.0001)when the latter disorders were the principal diagnoses on hospital discharge.Similar relationships were observed when the latter disorders were associated diagnoses on hospital discharge.CONCLUSION:NAFLD is associated with diverticular,inflammatory bowel,gallstone,and benign pancreatitis disorders.Compared with other liver diseases,patients with NAFLD have lower hospital charges and mortality. | Srinevas K Reddy Min Zhan H Richard Alexander Samer S El-Kamary | 2013 | World Journal of Gastroenterology2013，19，45： | 4 |
| 2 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 3 | Beta-7 integrin controls enterocyte migration in the small intestine显示文摘AIM:To hypothesize that beta-7 integrin affects cellularmigration of both,lymphocytes and enterocytes.METHODS:The nucleoside analog Brd U was ip injected in beta-7-deficient mice(C57BL/6-Itgbtmlcgn/J)of male gender and age-matched male C57BL/J J mice(wild type)4,20,or 40 h before analysis.The total small intestine was isolated,dissected,and used for morphometrical studies.Brd U-positive epithelial cells were numbered in at least 15 hemi-crypts per duodenum,jejunum,and ileum of each animal.The outer most Brd U-positive cell(cellmax)was determined per hemi-crypt,numerically documented,and statistically analysed.RESULTS:Integrins containing the beta-7-chain were exclusively expressed on leukocytes.In the small intestinal mucosa of beta-7 integrin-deficient mice the number of intraepithelial lymphocytes was drastically decreased.Moreover,the Peyer’s patches of beta-7integrin-deficient mice appeared hypoplastic.In beta-7integrin-deficient mice the location of cellmax was found in a higher position than it was the case for the controls.The difference was already detected at 4 h after Brd U application,but significantly increased with time(40 h after Brd U injection)in all small intestinal segments investigated,i.e.,duodenum,jejunum,and ileum.Migration of small intestinal enterocytes was different between the experimental groups measured by cellmax locations.CONCLUSION:The E-cadherin beta-7 integrin pathway probably controls migration of enterocytes within the small intestinal surface lining epithelial layer. | Elke Kaemmerer Paula Kuhn Ursula Schneider Thomas Clahsen Min Kyung Jeon Christina Klaus Julia Andruszkow Michael Hrer Sabine Ernst Angela Schippers Norbert Wagner Nikolaus Gassler | 2015 | World Journal of Gastroenterology2015，21，6： | 3 |
| 4 | Adult metaplastic hutch diverticulum with robotic-assisted diverticulectomy and reconstruction:A case report显示文摘BACKGROUND Hutch diverticulum arises from the compromised muscular development at the ureteral orifice.It is a congenital disease and extremely rare in adult,only accounting for about 3%occurrence worldwide.It can be either symptomatic or asymptomatic,and relies on image tools for diagnosis and preoperative planning.Indications for surgery are dependent on the complications from the diverticulum.Metaplasia is about 10%among those with hutch diverticulum,and it still has chances turning into malignancy,especially urothelial cell carcinoma.CASE SUMMARY A 27-year-old man was presented with frequently recurrent urinary tract infection for one year,and had suffered from intermittent right flank pain for 3 mo.No past medical histories were recorded before.No obvious abnormalities on laboratory data and urine examination were found.Under ultrasound,right hydronephrosis was seen and an anatomical abnormality was observed on intravenous pyelography.Further computed tomography urogram showed one diverticulum seated at superolateral side of right ureteral orifice.Cystoscopy was done and biopsy results showed focal metaplasia.After discussing with him,roboticassisted diverticulectomy with reconstruction was performed.Right hydronephrosis was greatly improved after surgery.He has completed his 1.5-year follow-ups,and no malignancies were seen from urine cytology and image of intravenous pyelography.CONCLUSION Robotic-assisted diverticulectomy and reconstruction to hutch diverticulum is a safe and efficient operation,providing several advantages over open and laparoscopic ones. | Che H Yang Yi S Lin Yen C Ou Wei C Weng Li H Huang Chin H Lu Chao Y Hsu Min C Tung | 2020 | World Journal of Clinical Cases2020，8，20： | 2 |
| 5 | Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling显示文摘 | Min J H Yang H Ivan M | 2002 | Science2002，296，5574： | 2 |
| 6 | Generation and characterization of a human nanobody against VEGFR-2显示文摘瞄准:Nanobody 是由一个单个 monomeric 变量抗体领域组成的抗体碎片,它能被用于许多 biotechnological 和治疗学的目的。这个工作的目的是从噬菌体显示器 library.Methods 对 VEGFR-2 domain3 (VEGFR D3 ) 孤立并且描绘人的信号域抗体:与与 VEGFR2 D3 的高亲密关系生产抗原特定的 recombinant nanobodies,液体阶段 panning 策略被用于 panning 的 all rounds。为 nanobody 表示和纯化,四 VEGFR2 堵住 D3 克隆是进 pETduet-biotin-MBP 表示向量的 subcloned。recombinant 蛋白质带了一个 MBP 标签由亲密关系层析便于纯化。Recombinant NTV (1-4 ) 在另外的胶化过滤层析步以后被获得。在 VEGFR2 D3 和 NTV (1-4 ) 之间的相互作用与基于光的 AlphaScreen 试金和 SPR 试金被估计。Anti-angiogenesis 效果在人的脐的静脉 endothelial 房间(HUVEC ) 被检验 .Results:在 AlphaScreen 试金, NTV1 (100 和 200 nmol/L ) 与 VEGFR2 D3 得到了最高有约束力的信号;NTV2 与 VEGFR2 D3 显示出中等相互作用;NTV3 和 NTV4 展出了有 VEGFR2 D3 的很少或没有相互作用。在 SPR 试金, NTV1 与一个平衡分离常数为 VEGFR2 D3 显示了一种高亲密关系(K 49 ± 的 D ) ; 1.8 nmol/L。NTV1 (1-1000 nmol/L ) dose-dependently 由 HUVECs.Conclusion 禁止了 HUVEC 和 endothelial 试管形成的增长:nanobody NTV1 是堵住 VEGFR2 的一个潜在的治疗学的候选人。这研究为指向 VEGFR2 的基于 nanobody 的癌症治疗学的开发提供新奇、有希望的策略。 | Lin MA Kai GU Cheng-hai ZHANG Xue-tao CHEN Yi JIANG Karsten MELCHER Juan ZHANG Min WANG H Eric XU | 2016 | Acta Pharmacologica Sinica2016，37，6： | 2 |
| 7 | Biochemical features of the adhesion G protein- coupled receptor CD97 related to its auto-proteolysis and HeLa cell attachment activities显示文摘CD97 属于经由一个 GPCR 解朊的地点(GPS ) 连接到 7TM 的长 ECD 描绘的粘附 GPCR 家庭并且在 modulating 房间移植和侵略起重要作用。CD97 (EGF1-5 ) 是在房间膜和细胞外的矩阵上认出特定的 ligand chondroitin 硫酸盐的 CD97 的拼接的变体。这研究的目的是阐明在蛋白质表示,汽车解朊作用和房间粘附,象领域一样的包括的表皮的生长因素(EGF ) , GPCR 导致 autoproteolysis (获得) 领域,以及 GPS mutagenesis 和 N-glycosylation 的 CD97 EGF1-5 isoform 的细胞外的分子的基础。两野类型(WT ) CD97-ECD 并且它的截断, GPS 变异, PNGase F-deglycosylated,和 N-glycosylation 地点变异形式被表示并且净化。蛋白质的汽车解朊作用与西方的弄污和 SDS 页被分析。散布的小角度 X 光检查(萨克斯风管) 并且分子的建模被用来决定适当地表示的受体的结构的侧面。潜在的 N-glycosylation 地点用 MS 被识别并且与 PNGase F 消化和 glyco 地点变化被调制。流动基于 cytometry 的 HeLa 房间附件试金被用于所有上述的 CD97 变体阐明 CD97-HeLa 相互作用的分子的基础。一个唯一的集中依赖者 GPS 汽车解朊作用每样品与最高的集中(4 mg/mL ) 在 CD97 EGF1-5 isoform 被观察,支持对为另外的 CD97 isoforms 的报导 intramolecular 机制不同的汽车解朊作用的分子间的机制是比更低的集中(0.1 mg/mL ) 快的自我劈开的大部分。N-glycosylation 作为另外的以前报导的 CD97 isoforms 以一个类似的方法影响了 CD97 EGF1-5 isoform 的汽车解朊作用。为 WT 和 deglycosylated CD97ECD 的萨克斯风管数据与分别地组成身体和柄的获得和 EGF 域揭示了像抹刀的形状。结构的建模自己为 GAIN 领域的表示的缺席显示了在 GAIN 和 EGF5 领域财务之间的一个潜在的相互作用,尽管 EGF5 获得在野类型的蛋白质同样被表示。为 HeLa 房间粘附,截断获得的形式显示出戏剧性地减少的有约束力的亲密关系。PNGase F-deglycosylated 和 GPS 变异也展出的形式与 WT CD97 相比减少了 HeLa 附件。然而, N-glycosylation mutagenesis 引起的既不 N-glycosylation mutagenesis 也不汽车解朊作用抑制影响了 CD97-HeLa 房间相互作用。PNGase 的 HeLa 有约束力的亲密关系的比较消化 F,变异 GPS 并且 N-glycosylation-mutated CD97 样品揭示了多样的调查结果,当调查 CD97 的 N-glycosylation 和汽车解朊作用时,建议 CD97 ECD 的函数为函数确认是建筑群,和各种各样的技术应该被利用避免单个途径的偏爱。CD97 EGF1-5 isoform 的集中依赖者汽车解朊作用的唯一的机制被描绘,建议从另外的以前报导的 CD97 isoforms 的是不同的分子间的机制。当 CD97 表达式和萨克斯风管数据揭示了在二域之间的一个潜在的相互作用, EGF5 和获得域多半与对方被联系。最后, GAIN 和 EGF 领域为 CD97-HeLa 粘附也是重要的,而 CD97 获得领域和 GPS 汽车解朊作用的 N-glycosylation 没为 HeLa 房间附件被要求。 | Li-yun YANG Xiao-fang LIU Yang YANG Lin-lin YANG Kai-wen LIU Yu-bo TANG Min ZHANG Min-jia TAN Shan-meiCHENG Ye-chun XU H uai-yu YANG Zhi-jie LIU Gao-jie SONG Wei HUANG | 2017 | Acta Pharmacologica Sinica2017，38，1： | 2 |
| 8 | Galectin-3:一种有助于各种脑肿瘤鉴别诊断的生物标记显示文摘 | Park S H Min H S Kim B 樊祥山(摘译) 张丽华(审校) | 2008 | 临床与实验病理学杂志2008，24，3： | 2 |
| 9 | Supply Chain Modeling:Past,Present and Future显示文摘 | MIN H ZHOU G | 2002 | Computers & Industrial Engineering2002，，43： | 1 |
| 10 | Isolation and character ization of novel H3N1 swine influenza viruses from pigs with re spiratory diseases in korea显示文摘 | Jin-Young S Min Suk S Eun H L | 2006 | Journal of Clinical microbiology2006，44，11： | 1 |
| 11 | Synthesis and characterization of bifunctional Au-Fe3O4 core-shell nanoparticles显示文摘 | Liu H L Wu J H Min J H | 2009 | J Nanosci Nanotech2009，9，： | 1 |
| 12 | Nucleation and Growth Behavior of Chromium Nitride Film Deposited on Various Substrates by Magnetron Sputtering显示文摘 | Kyung H N Yun M J | 2003 | Surf Coat Technol2003，171，： | 1 |
| 13 | Adjuvant effects of IL-1beta,IL-2,IL-8,IL-15,IFN-alpha,IFN-gamma TGF-beta and μLymphotactin on DNA vaccination against Eimeria acervulina显示文摘 | MIN W LILLEHOJ H S BURNSIDE J | 2001 | Vaccine2001，20，： | 1 |
| 14 | In Vitro Antiviral Activity of 1,2,3,4,6-Penta-O-galloyl-b-D-glucose against Hepatitis B Virus 显示文摘 | Min BS Jung H J Lee JS | 2006 | Biol Pharm Bull2006，29，10： | 1 |
| 15 | Study on properties of CaO-SiO2-B2O3 system glass-ceramic显示文摘 | Zhu H K Min L Zhou H Q | 2007 | Materials Research Bulletin2007，42，： | 1 |
| 16 | Agenetie algorithm approach to developing the multi - echelon reverse logistics network for product returns显示文摘 | Min H Ko H J Ko C S | 2006 | Omega2006，34，： | 1 |
| 17 | Inhibition of human immunodeficiency virus type 1 reverse transcriptase and ribonuclease H activities by constituents of Juglans mandshurica显示文摘 | MIN B S NAKAMURA N MIYASHIRO H KIM Y H HATTPRI M | 2000 | Chem Pharm Bull2000，48，2： | 1 |
| 18 | Supply Chain Modeling: Past, Present and Future 显示文摘 | Min H Zhou G | 2002 | Computers & Industrial Engineering2002，43，： | 1 |
| 19 | Structure of an HIF-1 alpha-pVHL complex: hydroxyproline recognition in signaling显示文摘 | Min JH Yang H Ivan M | 2002 | Science2002，296，5574： | 1 |
| 20 | Molecular, cellular,and functional characterization of chicken cytokines homologous to mammalian IL-15 and IL-2 显示文摘 | Lillehoj H S Min W Choi K D | 2001 | Vet Immunol Immunopathol2001，82，34： | 1 |
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