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| 1 | A pilot study of the modulation of sirtuins on arylamine N-acetyltransferase 1 and 2 enzymatic activity显示文摘Arylamine N-acetyltransferase(NAT; E.C. 2.3.1.5) enzymes are responsible for the biotransformation of several arylamine and hydrazine drugs by acetylation. In this process, the acetyl group transferred to the acceptor substrate produces NAT deacetylation and, in consequence, it is susceptible of degradation. Sirtuins are protein deacetylases, dependent on nicotine adenine dinucleotide,which perform post-translational modifications on cytosolic proteins. To explore possible sirtuin participation in the enzymatic activity of arylamine NATs, the expression levels of NAT1, NAT2,SIRT1 and SIRT6 in peripheral blood mononuclear cells(PBMC) from healthy subjects were examined by flow cytometry and Western blot. The in situ activity of the sirtuins on NAT enzymatic activity was analyzed by HPLC, in the presence or absence of an agonist(resveratrol) and inhibitor(nicotinamide) of sirtuins. We detected a higher percentage of positive cells for NAT2 in comparison with NAT1, and higher numbers of SIRT1t cells compared to SIRT6 in lymphocytes. In situ NAT2 activity in the presence of NAM inhibitors was higher than in the presence of its substrate, but not in the presence ofresveratrol. In contrast, the activity of NAT1 was not affected by sirtuins. These results showed that NAT2 activity might be modified by sirtuins. | Eneida Turiján-Espinoza Rául Alejandro Salazar-González Edith Elena Uresti-Rivera Gloria Estela Hernández-Hernández Montserrat Ortega-Juárez Rosa Milán Diana Portales-Pérez | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 7 |
| 2 | 水通道蛋白对人体皮肤重要性的研究显示文摘目的探讨水通道蛋白(AQPs)在人皮肤表皮上的功能和表达。方法免疫组化法检测30名30~40岁健康的白人女性大腿皮肤AQP3、Claudin-1和CD44表达。检测10名21~60岁亚洲健康妇女的前臂内侧AQP3表达与光暴露关系。结果在人表皮中,AQP3从基底层到粒层均有表达,但在角质层下方开始消失,AQP3和Claudin-1的表达与一种透明质酸盐受体CD44的表达呈负相关。对20~80岁之间的健康女性皮肤间接免疫荧光研究也发现,在衰老和长期慢性光暴露时皮肤AQP3表达会明显减少。结论人类皮肤供水系统缺陷可能与年龄有关,水通道蛋白在维持皮肤正常生理功能等方面具有重要意义。 | Frédéric Bonté Emmanuelle Noblesse Miléne Juan Jean Marc Verbawatz Marc Dumas | 2009 | 中华皮肤科杂志2009，42，5： | 4 |
| 3 | Magnetic Resonance Imaging Surveillance Detects Early-Stage Pancreatic Cancer in Carriers of a p16-Leiden Mutation显示文摘 | Hans F.A. Vasen Martin Wasser Anneke van Mil Rob A. Tollenaar Marja Konstantinovski Nelleke A. Gruis Wilma Bergman Frederik J. Hes Daniel W. Hommes G. Johan A. Offerhaus Hans Morreau Bert A. Bonsing Wouter H. de Vos tot Nederveen Cappel | 2011 | Gastroenterology2011，，3： | 3 |
| 4 | Therapeutic ERCP: A Review of 64 Cases.显示文摘Sixty-four patients receiving therapeutic ERCP were reported. The patients were divided into three groups. Group 1, endoscopic sphincterotomy (n = 28); Group 2, Nasobiliary catheter (n = 25); Group 3, Biliary endoprosthesis (n=11). | Cheng Hongyan et al. Dept Radiol, Orient Hapatobiliary Surgery Hospital, Second Mil Med Uni, Shanghai 200433. | 1995 | Chinese Medical Journal1995，，9： | 2 |
| 5 | Mucosal healing effect of mesalazine granules in naproxen-induced small bowel enteropathy显示文摘AIM:To investigate the effect of mesalazine granules on small intestinal injury induced by naproxen using capsule endoscopy (CE).METHODS:This was a single center,non-randomized,open-label,uncontrolled pilot study,using the PillCam SB CE system with RAPID 5 software.The Lewis Index Score (LIS) for small bowel injury was investigated to evaluate the severity of mucosal injury.Arthropathy patients with at least one month history of daily naproxen use of 1000 mg and proton pump inhibitor co-therapy were screened.Patients with a minimum LIS of 135 were eligible to enter the 4-wk treatment phase of the study.During this treatment period,3 × 1000 mg/d mesalazine granules were added to ongoing therapies of 1000 mg/d naproxen and 20 mg/d omeprazole.At the end of the 4-wk combined treatment period,a second small bowel CE was performed to re-evaluate the enteropathy according to the LIS results.The primary objective of this study was to assess the mucosal changes after 4 wk of mesalazine treatment.RESULTS:A total of 18 patients (16 females),ranging in age from 46 to 78 years (mean age 60.3 years) were screened,all had been taking 1000 mg/d naproxen for at least one month.Eight patients were excluded from the mesalazine therapeutic phase of the study for the following reasons:the screening CE showed normal small bowel mucosa or only insignificant damages (LIS < 135) in five patients,the screening esophagogastroduodenoscopy revealed gastric ulcer in one patient,capsule technical failure and incomplete CE due to poor small bowel cleanliness in two patients.Ten patients (9 female,mean age 56.2 years) whose initial LIS reached mild and moderate-to-severe enteropathy grades (between 135 and 790 and ≥ 790) entered the 4-wk therapeutic phase and a repeat CE was performed.When comparing the change in LIS from baseline to end of treatment in all patients,a marked decrease was seen (mean LIS:1236.4 ± 821.9 vs 925.2 ± 543.4,P=0.271).Moreover,a significant difference between pre-and post-treatment mean total LIS was detected in 7 patients who had moderate-tosevere enteropathy gradings at the inclusion CE (mean LIS:1615 ± 672vs 1064 ± 424,P=0.033).CONCLUSION:According to the small bowel CE evaluation mesalazine granules significantly attenuated mucosal injuries in patients with moderate-to-severe enteropathies induced by naproxen. | István Rácz Milán Szalai Valéria Kovács Henriett Regczi Gyngyi Kiss Zoltán Horváth | 2013 | World Journal of Gastroenterology2013，19，6： | 2 |
| 6 | A research agenda for improving national Ecological Footprint accounts显示文摘 | Justin Kitzes Alessandro Galli Marco Bagliani John Barrett Gorm Dige Sharon Ede Karlheinz Erb Stefan Giljum Helmut Haberl Chris Hails Laurent Jolia-Ferrier Sally Jungwirth Manfred Lenzen Kevin Lewis Jonathan Loh Nadia Marchettini Hans Messinger Krista Mil | 2008 | Ecological Economics2008，，7： | 2 |
| 7 | Septicarthritis of the knee in adults:treatment by arthroscopy or arthroomy显示文摘 | Wirtdc Marthm Mil tnero | 2001 | Int Orthop2001，25，： | 1 |
| 8 | Risks and complications of transrectal ultrasound guided prostate biopsy,A prospective study and review of the literature显示文摘 | Rodriguez LV Terris MIL | | 0，，02： | 1 |
| 9 | Emerging approaches,challenges and opportunities in life cycle assessment显示文摘 | Hel weg S Milái Canals L | 2014 | Science2014，344，6188： | 1 |
| 10 | Insect secretions in plants显示文摘 | MILS P W | 1968 | Annual Review of Phytopathology1968，，6： | 1 |
| 11 | Distributed Rate and Power Control for CDMA Uplink显示文摘 | Zhao Wen-tao Mil u | 2004 | IEEE Transactions on Communications2004，14，9： | 1 |
| 12 | MicroRNA-1 and -499 regulate differentiation and proliferation in human-derived cardio myocyte progenitor cells 显示文摘 | Sluijter JP van Mil A van Vliet P | 2010 | Arterioscler Thromb Vase Biol2010，30，4： | 1 |
| 13 | Wnt signal ing in smooth muscle cel s and its role in cardiovascular disorders显示文摘 | Mil C George SJ | | 0，，02： | 1 |
| 14 | Intracel ular IFN-γand IL-2 expression monitoring as surrogate markers of the risk of acute rejection and personal drug response in de novo liver transplant recipients显示文摘 | Mil án O Rafael-Valdivia L Torrademé E | | 0，，02： | 1 |
| 15 | Measurement of endo-tracheal tube cuff leak to predict postextubation stridor and need for reintubation显示文摘 | Sandhu R S Pasquale M D Mil er K | | 0，，06： | 1 |
| 16 | A Note on the Shift to a Service‐Based Economy and the Consequences for Regional Growth显示文摘 | TeresaGarcia‐Milá Therese J.McGuire | 2002 | Journal of Regional Science2002，，2： | 1 |
| 17 | Acute rheumatic fever and poststrepto- coccal reactive arthritis reconsidered 显示文摘 | van der Helm - van Mil AH | 2010 | Curr Opin Rheumatol2010，4，： | 1 |
| 18 | circulating microRNAs as novel minimal y invasive biomarkers for breast cancer显示文摘 | Heneghan H M Mil er N Lowery A J | | 0，，03： | 1 |
| 19 | Isolation and expansion of human glioblastoma multiforme tumor cel s using the neurosphere assay显示文摘 | Azari H Mil ette S Ansari S | | 0，，56： | 1 |
| 20 | The effects of polyacrytic acid, acetylsalicylic acid and salicytic acid on resistance of cucumber to Collectotrichum lagenarium显示文摘 | Mils P R Wood R K S | 1984 | Phytopathologische Zeitschrift1984，111，34： | 1 |
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