|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Polymorphism in the interleukin-17A promoter contributes to gastric cancer显示文摘AIM:To evaluate the contribution of the G-197A polymorphism in the interleukin-17(IL-17)promoter region to gastric cancer risk in an Iranian population.METHODS:We performed a case control study using samples from 161 individuals with gastric cancer and171 healthy controls.For each individual,the G-197A genotype was determined by restriction fragment length polymorphism analysis of polymerase chain reaction-amplified fragments.Statistical analyses were performed to determine whether any demographic or behavioral factors,infection with Helicobacter pylori(H.pylori),or a particular G-197A genotype was associated with gastric cancer risk.RESULTS:We found that the G-197A genotype wassignificantly associated with increased gastric cancer risk(P=0.001).Patients who were homozygous(AA)at position-197 were 2.9 times more likely to develop disease(95%CI:1.56-5.4;P=0.001).Furthermore,logistic regression analysis revealed that the presence of a single A allele increased the risk of gastric cancer up to 1.7-fold(95%CI:1.26-2.369;P=0.001).This association was observed for early stage gastric adenocarcinomas only,and was not linked to H.pylori infection.CONCLUSION:These results suggest that carrying one or more G-197A polymorphisms at position-197 in the IL-17 promoter region significantly increases gastric cancer risk in this patient population. | Alireza Rafiei Vahid Hosseini Ghasem Janbabai Abuzar Ghorbani Abulghasem Ajami Touraj Farzmandfar Maedeh Darzyani Azizi Jeremy J Gilbreath D Scott Merrell | 2013 | World Journal of Gastroenterology2013，19，34： | 7 |
| 2 | Inducible nitric oxide synthetase genotype and Helicobacter pylori infection affect gastric cancer risk显示文摘AIM:To investigate the association of the inducible nitric oxide synthetase(iNOS) C150T polymorphism with Helicobacter pylori(H.pylori) infection and gastric cancer(GC) risk in Iran.METHODS:In order to determine whether there was a correlation between iNOS genotype and GC in Iran,we conducted a case-control study using samples from 329 individuals.For each sample,the C150T iNOS polymorphism was genotyped by polymerase chain reaction(PCR) and restriction digestion.Patients were grouped by cancer presence,demographic and behavior characteristics,and H.pylori infection status.Statistical tests were conducted to determine whether any behavioral factors or a particular iNOS genotype was associated with GC in the study population.RESULTS:In this population,we found that smoking,hot beverage consumption,a familial history of GC and H.pylori infection status were significantly associated with GC development(P = 0.015,P < 0.001,P = 0.0034,and P < 0.015,respectively).The distribution of the C150T iNOS genotypes among the two study groups was not statistically significant alone,but was impacted by H.pylori infection status.When compared to the non-H.pylori infected group,cancer patients who had a heterozygous CT genotype and were also infected with H.pylori were 2.1 times more at risk of developing GC [odds ratio(OR) = 2.1,P = 0.03] while those with a homozygous TT genotype and infected with H.pylori were 5.0 times more at risk of developing GC(OR = 5.0,P = 0.029).In contrast,this association was not seen in patients in the control group.CONCLUSION:A CT or TT polymorphism at position 150 in the iNOS gene significantly increases the risk of GC and may be a marker for GC susceptibility. | Alireza Rafiei Vahid Hosseini Ghasem Janbabai Bahman Fazli Abulghasem Ajami Zahra Hosseini-khah Jeremy J Gilbreath D Scott Merrell | 2012 | World Journal of Gastroenterology2012，18，35： | 4 |
| 3 | Frequency of antibiotic resistance in Helicobacter pylori strains isolated from the northern population of Iran显示文摘 | Amin Talebi Bezmin Abadi Tarang Taghvaei Ashraf Mohabbati Mobarez Beth M. Carpenter D. Scott Merrell | 2011 | The Journal of Microbiology2011，，6： | 2 |
| 4 | The repeatability of superovulatory response and embryo recovery in sheep显示文摘 | Bari F Khalid M Wolf B Haresigh W Murray A Merrell B | 2001 | Theriogenology2001，56，1： | 1 |
| 5 | Continuing evolution in the approach to severe liver trauma显示文摘 | Reed RL Merrell RC Meyers WC | 1992 | Ann Surg1992，216，： | 1 |
| 6 | Drug metabolism al- terations in nonalcoholic fatty liver disease显示文摘 | Merrell MD Cherrington NJ | 2011 | Drug Metab Reviews2011，43，3： | 1 |
| 7 | pH-regulated gene ex- pression of the gastric pathogen Helicobacter pylori 显示文摘 | Merrell DS Goodrich ML Otto G | 2003 | Infe-ct Immun2003，71，6： | 1 |
| 8 | The Helicobacter pylori ferricuptake regulator ( Fur) is essential for growth undersodium chloride stress显示文摘 | Gancz H Merrell DS | 2011 | J Microbiol2011，49，2： | 1 |
| 9 | Toll-like receptor 9 agonists promote cellular invasion by increasing matrix metalloproteinase activity显示文摘 | Merrell MA Ilvesaro JM Lehtonen N | | 0，，07： | 1 |
| 10 | Gender differencesin self-concept among children and adolescents:A meta-a-nalysis of multidimensional studies显示文摘 | MERRELL K W | 1999 | School PsychologyQuarterly1999，，14： | 1 |
| 11 | Toll like receptor-9 agonists stimulate prostate cancer invasion in vitro显示文摘 | Ilvesaro J M Merrell M A Swain T M | 2007 | Prostate2007，67，7： | 1 |
| 12 | A genetic linkage mapd for Eucalyptus globules with candidate loci for wood,fibre,and floral traits显示文摘 | Thamarus K A Groom K Merrell J | 2002 | Theor Appl Genet2002，104，： | 1 |
| 13 | Relative frequency of peripheral odontogenic tumors: a study of 45 new cases and comparison with studies from the literature 显示文摘 | Buchner A Merrell PW Carpenter WM | 2006 | J Oral Pathol Med2006，35，7： | 1 |
| 14 | B-cell anergy: from transgenic models to naturally occurring anergic B cells 显示文摘 | Cambier JC Gauld SB Merrell KT | 2007 | Nat Rev Immunol2007，7，： | 1 |
| 15 | Identification of anergic B cells within a wild-type repertoire显示文摘 | Merrell KT Bertschop R Gautd SB | 2006 | Immunity2006，25，： | 1 |
| 16 | Telemedicine in surgery显示文摘 | Merrel RC | 2005 | Eur Surg2005，37，5： | 1 |
| 17 | Arthroscopic-assisted percutaneous reduction and screw fixation of displaced scaphoid fractures显示文摘 | Slade JF Lozano-Calderón S Merrell G | 2008 | J Hand Surg Eur Vol2008，33，3： | 1 |
| 18 | Two frame structure from motion using optical flow probability distributions for unmanned air vehicle obstacle avoidance显示文摘 | Lee Dah-Jye Merrell Paul Wei Zhao-yi | 2010 | Machine Vision and Applica- tions2010，21，3： | 1 |
| 19 | Continuing evolution in the approach to severe liver trauma显示文摘 | Merrell RC Meyers WC | 1992 | Ann Surg1992，216，： | 1 |
| 20 | Multi- frame structure from motion using optical flow probability distributions 显示文摘 | LEE D J MERRELL P C NELSON B E | 2009 | Neurocomputing2009，72，46： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员