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| 1 | Polymorphism in the interleukin-17A promoter contributes to gastric cancer显示文摘AIM:To evaluate the contribution of the G-197A polymorphism in the interleukin-17(IL-17)promoter region to gastric cancer risk in an Iranian population.METHODS:We performed a case control study using samples from 161 individuals with gastric cancer and171 healthy controls.For each individual,the G-197A genotype was determined by restriction fragment length polymorphism analysis of polymerase chain reaction-amplified fragments.Statistical analyses were performed to determine whether any demographic or behavioral factors,infection with Helicobacter pylori(H.pylori),or a particular G-197A genotype was associated with gastric cancer risk.RESULTS:We found that the G-197A genotype wassignificantly associated with increased gastric cancer risk(P=0.001).Patients who were homozygous(AA)at position-197 were 2.9 times more likely to develop disease(95%CI:1.56-5.4;P=0.001).Furthermore,logistic regression analysis revealed that the presence of a single A allele increased the risk of gastric cancer up to 1.7-fold(95%CI:1.26-2.369;P=0.001).This association was observed for early stage gastric adenocarcinomas only,and was not linked to H.pylori infection.CONCLUSION:These results suggest that carrying one or more G-197A polymorphisms at position-197 in the IL-17 promoter region significantly increases gastric cancer risk in this patient population. | Alireza Rafiei Vahid Hosseini Ghasem Janbabai Abuzar Ghorbani Abulghasem Ajami Touraj Farzmandfar Maedeh Darzyani Azizi Jeremy J Gilbreath D Scott Merrell | 2013 | World Journal of Gastroenterology2013，19，34： | 7 |
| 2 | Inducible nitric oxide synthetase genotype and Helicobacter pylori infection affect gastric cancer risk显示文摘AIM:To investigate the association of the inducible nitric oxide synthetase(iNOS) C150T polymorphism with Helicobacter pylori(H.pylori) infection and gastric cancer(GC) risk in Iran.METHODS:In order to determine whether there was a correlation between iNOS genotype and GC in Iran,we conducted a case-control study using samples from 329 individuals.For each sample,the C150T iNOS polymorphism was genotyped by polymerase chain reaction(PCR) and restriction digestion.Patients were grouped by cancer presence,demographic and behavior characteristics,and H.pylori infection status.Statistical tests were conducted to determine whether any behavioral factors or a particular iNOS genotype was associated with GC in the study population.RESULTS:In this population,we found that smoking,hot beverage consumption,a familial history of GC and H.pylori infection status were significantly associated with GC development(P = 0.015,P < 0.001,P = 0.0034,and P < 0.015,respectively).The distribution of the C150T iNOS genotypes among the two study groups was not statistically significant alone,but was impacted by H.pylori infection status.When compared to the non-H.pylori infected group,cancer patients who had a heterozygous CT genotype and were also infected with H.pylori were 2.1 times more at risk of developing GC [odds ratio(OR) = 2.1,P = 0.03] while those with a homozygous TT genotype and infected with H.pylori were 5.0 times more at risk of developing GC(OR = 5.0,P = 0.029).In contrast,this association was not seen in patients in the control group.CONCLUSION:A CT or TT polymorphism at position 150 in the iNOS gene significantly increases the risk of GC and may be a marker for GC susceptibility. | Alireza Rafiei Vahid Hosseini Ghasem Janbabai Bahman Fazli Abulghasem Ajami Zahra Hosseini-khah Jeremy J Gilbreath D Scott Merrell | 2012 | World Journal of Gastroenterology2012，18，35： | 4 |
| 3 | Toll like receptor-9 agonists stimulate prostate cancer invasion in vitro显示文摘 | Ilvesaro J M Merrell M A Swain T M | 2007 | Prostate2007，67，7： | 1 |
| 4 | A genetic linkage mapd for Eucalyptus globules with candidate loci for wood,fibre,and floral traits显示文摘 | Thamarus K A Groom K Merrell J | 2002 | Theor Appl Genet2002，104，： | 1 |
| 5 | Multi- frame structure from motion using optical flow probability distributions 显示文摘 | LEE D J MERRELL P C NELSON B E | 2009 | Neurocomputing2009，72，46： | 1 |
| 6 | Treatment of scaphoid nonunion: quantitative meta - analysis of the literature显示文摘 | Merrell GA Wolf SW Slade J F | 2002 | Am J Hand Surg2002，27，： | 1 |
| 7 | Technique for percutaneous fixation of displaced and nondisplaced acute scaphnid fractures and select nonunions显示文摘 | Merrell G Slade J | 2008 | J Hand Surg Am2008，33，6： | 1 |
| 8 | Toll-like receptor 9 agonists promote cellular invasion by increasing matrix metalloproteinase activity显示文摘 | Merrell M A Ilvesaro J M Lehtonen N | 2006 | Mol Cancer Res2006，4，7： | 1 |
| 9 | The effects of compression garments on intermittent exercise performance and recovery on consecutive days 显示文摘 | DUFFIELD R EDGE J MERRELLS R | 2008 | Int J Sports Physiol Perform2008，3，4： | 1 |
| 10 | Change is good: Variations in common biological mecha- nisms inthe epsilonproteobacterial genera Campylobacter and Helicobacter 显示文摘 | GILBREATH J J CODY W L MERRELL D S | 2011 | Microbiology and Molecular Biology Review2011，75，1： | 1 |
| 11 | Interleukin (IL)-15 and IL-2 reciprocally regulate expression of the chemokine receptor CX3CR1 through selective NFAT1 and NFAT2-dependent mechanisms 显示文摘 | Barlic J McDermott DH Merrell MN | 2004 | J Biol Chem2004，279，48： | 1 |
| 12 | Continuum traffic simulation显示文摘 | Sewall J Wilkie D Merrell P | 2010 | Computer Graphics Forum2010，29，2： | 1 |
| 13 | Embryonic and fetal limb myogenic cells are derived from developmentally distinct progenitors and have different requirements for beta-catenin显示文摘 | Hutcheson D A Zhao J Merrell A | | 0，，： | 1 |
| 14 | Technique for percutaneous fixation of dis- placed and nondisplaeed acute scaphoid fractures and select non- unions 显示文摘 | Merrell G Slade J | 2008 | J Hand Surg Am2008，33，6： | 1 |
| 15 | Technique for percutaneous fixation of displaced and nondisplaced acute scaphoid fractures and select nonunions 显示文摘 | Merrell G Slade J | 2008 | J Hand Surg Am2008，33，6： | 1 |
| 16 | Random and site-specific mutagenesis of the Helicobacter pylori ferric uptake regulator provides insight into Fur structure-function relationships显示文摘 | Gilbreath J J Pich O Q Benoit S L Besold A N Cha J H Maier R J Michel S L Maynard E L Merrell D S | 2013 | Molecular Microbiology2013，89，2： | 1 |
| 17 | The effects of compression garments on intermittent exercise performance and recovery on consecutive days显示文摘 | DUFFIELD R EDGE J MERRELLS R | 2008 | Int J Sports Physiol Per- form2008，3，4： | 1 |
| 18 | Detailed real-time urban 3D reconstruction from video 显示文摘 | POLLEFEYS M NISTER D FRAHM J M AKBARZADEH A MORDOHAI P CLIPP B ENGELS C GALLUP D KIM S J MERRELL P SALMI C SINHA S TALTON B WANG L YANG Q STEWENIUS H YANG R WELCH G TOWLES H | 2007 | International Journal of Computer Vision2007，78，23： | 1 |
| 19 | Acute renal failure,oxalosis,and vitamin C supplementation:a case report and review of the literature显示文摘 | Mashour S Turner J F Jr Merrell R | 2000 | Chest2000，118，2： | 1 |
| 20 | Technique for percutaneous fixation of dis- placed and nondisplaced acute scaphoid fractures and select nonunions显示文摘 | Merrell G Slade J | 2008 | J Hand Surg Mn2008，33，6： | 1 |
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