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| 1 | Treatment of hepatocellular carcinoma: Steps forward but still a long way to go显示文摘Hepatocellular carcinoma(HCC) is the fifth most common malignancy and the third cause of tumor associated deaths worldwide. HCC incidence rates are increasing in many parts of the world including developing and developed countries. Potentially curative treatments for HCC are resection and liver transplantation, but these are only suitable for patients with small tumors, meeting strict pre-defined criteria, or well-compensated liver disease. Early diagnosis of HCCcan be achieved by surveillance of at-risk populations. For patients with non-resectable disease treatments modalities include loco-ablative and systemic therapies. In this review we focus on treatment options in HCC and their allocation. Although significant research is in progress, to this date, the results are unsatisfactory with limited long-term survival. In the fight against this deadly disease, there is still a long way to go. | Liat Mlynarsky Yoram Menachem Oren Shibolet | 2015 | World Journal of Hepatology2015，7，3： | 13 |
| 2 | Gender-associated differences in urea breath test for Helicobacter pylori infection referrals and results among dyspeptic patients显示文摘AIM: To verify whether there is a gender difference in the 13C-urea breath test results in a large cohort. METHODS: The test results of dyspeptic patients referred for 13C-urea breath testing between January and December, 2007 were evaluated. Testing was carried out at the health insurance organization branches and evaluated at a central laboratory in Israel. RESULTS: Of a total of 28 746 test results, 18 122 (63.04%) were from females and 10 624 (36.95%) from males. Overall, 10 188 (35.4%) results [expressed as delta over baseline (DOB)] were positive (DOB 13C > 5), 18,326 (63.7%) were negative (DOB 13C < 3.5) and 232 (0.8%) were borderline (DOB 13C 3.5-5). There was a significant difference between the total positive rate among females and males (34.8% vs 37.2%, respectively, P = 0.0003). The mean test value was increased by approximately 10 units for females compared to males (P < 0.01) and this difference was consistent for all age groups (i.e., between 10-80 years of age, P < 0.01). CONCLUSION: More females were referred to 13C-urea breath testing. More males had positive results. The mean test values were significantly higher among females of all age groups, possibly representing an increased bacterial load among females and suggesting gender-associated differences in Helicobacter pylori host interactions. | Menachem Moshkowitz Noya Horowitz Anat Beit-Or Zamir Halpern Erwin Santo | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，3： | 4 |
| 3 | Role of colonoscopy in patients with persistent acute diverticulitis显示文摘AIM: To identify patients with persistent acute diverticulitis who might benefit from an early colonoscopy during their first hospitalization. METHODS: All patients hospitalized between July 2000 and December 2006 for acute diverticulitis who underwent colonoscopy were included in the study. Patients were followed during hospitalization and after discharge. Patients were considered to have a persistent course of acute diverticulitis if symptoms continued after 1 wk of conventional treatment with Ⅳ antibiotics, or if symptoms recurred within 2 mo after discharge. Patients were considered to benefit from an early colonoscopy if the colonoscopy was therapeutic or if it changed a patient’s outcome. RESULTS: Three hundred and six patients were hospitalized between July 2000 and December 2006 with the diagnosis of acute diverticulitis. Two hundred and twenty four of these were included in the study group. Twenty three patients (10.3%) fulfilled the criteria for a persistent course of acute diverticulitis. Of them, four patients (17.4%) clearly benefited from an early colonoscopy; these patients’ clinical course is described. None of the patients with a regular non-persistent course demonstrated any benefit from colonoscopy. CONCLUSION: Early colonoscopy detected other significant pathology, which accounted for the clinical presentation in 17% of patients with persistent acute diverticulitis. Therefore, we believe an early colonoscopy should be considered in all patients with a persistent clinical course. | Adi Lahat Henit Yanai Emad Sakhnini Yoram Menachem Simon Bar-Meir | 2008 | World Journal of Gastroenterology2008，14，17： | 2 |
| 4 | Avoidance of Phrasal Verbs—A Case for Contrastive Analysis显示文摘 | Menachem Dagut Batia Laufer | 1985 | Studies in Second Language Acquisition1985，，1： | 2 |
| 5 | Chronic Urticaria can be Triggered by Eradication of H elicobacter pylori显示文摘 | Eli Magen Menachem Schlesinger Israel Hadari | 2012 | Helicobacter2012，，1： | 2 |
| 6 | Gastroesophageal reflux disease symptoms:Prevalence,sociodemographics and treatment patterns in the adult Israeli population显示文摘AIM: To evaluate the prevalence and sociodemographics of gastroesophageal reflux disease (GERD) symptoms and to identify treatment patterns among GERD patients. METHODS: A telephone survey of a representative sample of the adult Israeli population was conducted. The questionnaire included detailed sociodemographics, history of GERD symptoms and the various treatments used. RESULTS: The survey included 2027 subjects. Twice weekly, once weekly and monthly GERD symptoms were reported by 8.4%, 12.5% and 21.5% of subjects, respectively. There was no difference in prevalence between men and woman; however, GERD symptoms were significantly more prevalent within the older age group and lower socioeconomic status. Among those reporting weekly symptoms, a quarter did not use any kind of therapy and another quarter used various traditional remedies (e.g. soda, milk, almonds, etc.). Antacids were used by 35.1%, H2 blockers by 13.2% and PPIs by 17.5%. CONCLUSION: We found that 12.5% of the adult Israeli population experience weekly GERD symptoms. GERD prevalence and sociodemographics are similar to those described in other Western countries, and treatment is still suboptimal. | Menachem Moshkowitz Noya Horowitz Zamir Halpern Erwin Santo | 2011 | World Journal of Gastroenterology2011，17，10： | 2 |
| 7 | Science andtechnology for water purification in the coming decades显示文摘 | Mark A S Paul W B Menachem E | 2008 | Nature2008，452，： | 1 |
| 8 | Double blind, placebo-controlled trial of topiramate as add- on therapy in patients with refractory partial seizures显示文摘 | Ben menachem E Henrisken O Dam M | 1996 | Epilepsia1996，37，： | 1 |
| 9 | Augmentation of natural and antibody-dependent cell-mediated cytotoxicity by pure human leukocyte interferon显示文摘 | Ronald B. Herberman John R. Ortaldo Menachem Rubinstein Sidney Pestka | 1981 | Journal of Clinical Immunology1981，，3： | 1 |
| 10 | The Bacillus thuringiensis delta - endotoxin CrylC as a potential bioinsecticide in plants 显示文摘 | DROR AVISAR HAVIVA EILENBERG MENACHEM KELLER | 2009 | Plant Science2009，，176： | 1 |
| 11 | Colloid mobilization and transport in groundwater显示文摘 | Ryan J N Menachem Elimelech | 1996 | Colloids Surface A1996，，107： | 1 |
| 12 | Long - term safety of perampanel and seizure outcomes in refractory partial - onset seizures and secondarily generalized seizures: results from phase HI extension study 307 显示文摘 | Krauss GL Perucca E Ben - Menachem E | 2014 | Epilepsia2014，55，7： | 1 |
| 13 | Functional groups and degradation of cotton oxidized by hypochlorite显示文摘 | Lewin Menachem Epstein Joseph | 1962 | Journal of Polymer Science1962，58，： | 1 |
| 14 | Improved graphite anode for lithium-ion batteries-chemically bonded solid electrolyte interface and nanochannel formation显示文摘 | PELED E MENACHEM C BARTOW D | 1996 | J Electrochem Soc1996，143，1： | 1 |
| 15 | Aggregation and deposition kinetics of fullerene (C-60) nanoparicles 显示文摘 | Kai Loon Chen Menachem Elimelech | 2006 | Langmuir2006，22，10： | 1 |
| 16 | Ad- sorption kinetics and reversibility of linear plasmid DNA on silica surfaces: Influence of alkaline earth and transition metal ions显示文摘 | Thanh H Nguyen Kai Loon Chen Menachem Elimelech | 2010 | Biomacromolecules2010，11，5： | 1 |
| 17 | Mast cells and autoimmunity显示文摘 | Menachem Rottem Yoseph A. Mekori | 2004 | Autoimmunity Reviews2004，，1： | 1 |
| 18 | A switch to high-flux helixonee membranes reverse suppressed interferon-γ production in patients on low-flux dialysis显示文摘 | Gerhard L Daniela N Menachem R | 2003 | Blood Purification2003，21，： | 1 |
| 19 | The Preterm Prediction Study: Toward a multiple-marker test for spontaneous preterm birth显示文摘 | Robert L. Goldenberg Jay D. Iams Brian M. Mercer Paul J. Meis Atef Moawad Anita Das Menachem Miodovnik Peter J. VanDorsten Steve N. Caritis Gary Thurnau Mitchell P. Dombrowski | 2001 | American Journal of Obstetrics and Gynecology2001，，3： | 1 |
| 20 | Double -blind,placebo-control trial of topiamate as add-on therapy in patients with refractory partial seizures显示文摘 | BEN - MENACHEM E HENRIKSEN O DAM M | 1996 | Epilepsia1996，37，6： | 1 |
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