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| 1 | 肾素抑制剂阿利吉仑对低钙喂饲小鼠松质骨的作用显示文摘低钙饮食导致骨吸收增强,可诱发骨量的流失[1],严重的则可导致骨质疏松。近年来有研究发现,肾素-血管紧张素系统( RAS )存在于骨组织并参与骨代谢疾病的发病过程[2-3]。由于骨组织RAS的活性升高,其活性肽血管紧张素II(AngII)的生成增加,AngⅡ作为RAS的最重要的活性物质[4]通过调控骨代谢致骨量流失[5]。阿利吉仑( Aliskiren)是一种新研制的可口服的具有直接抑制肾素活性的新型长效降压药物[6]。阿利吉仑通过抑制RAS首步肾素的活性,可以有效抑制血管紧张素原向血管紧张素I的转化[7],继而有效减少 RAS活性肽 AngII的生成[8]。本实验以肾素抑制剂阿利吉仑为研究对象,探讨其对低钙饮食小鼠松质骨的作用。 | 张方怡 Gebru Yoseph 黄文秀 张岩 | 2014 | 中国药理学通报2014，30，10： | 4 |
| 2 | Oral administration of a non-absorbable plant cellexpressed recombinant anti-TNF fusion protein induces immunomodulatory effects and alleviates nonalcoholic steatohepatitis显示文摘AIM To evaluate the immunomodulatory effect of oral administration of PRX-106 in the high-fat diet model.METHODS For 22 wk, C57BL/6 HFD-fed mice received daily oral treatments with BY-2 cells expressing recombinant antitumor necrosis factor alpha fusion protein(PRX-106). Mice were followed for serum liver enzyme and triglyceride levels, liver histology and intrahepatic and systemic FACS.RESULTS The orally administered non-absorbable PRX-106 w a s b i o l o g i c a l l y a c t i v e. A l t e r e d d i s t r i b u t i o n o f CD4+CD25+Fox P3+ between the liver and spleen and an increase in the intrasplenic-to-intrahepatic CD4+CD25+Fox P3+ ratio and a decrease in the intrasplenic-to-intrahepatic CD8+CD25+Fox P3+ ratio were observed. An increase in intrahepatic NKT cells and a decrease in the intrasplenic-to-intrahepatic NKT ratio were noted. Assessment of the CD4-to-CD8 ratios showed sequestration of CD8+ lymphocytes in the liver. These effects were associated with a decrease in serum triglyceride levels, decrease in the aspartate aminotransferase levels, serum glucose levels, and HOMA-IR score. A decrease in hepatic triglycerides content was observed in the high dose-treated mice.CONCLUSION Orally administered PRX-106 shows biological activity and exerts an immunomodulatory effect, alleviating liver damage. The data suggest that PRX-106 may provide an oral immunotherapy for nonalcoholic steatohepatitis. | Yaron Ilan Ami Ben Ya'acov Yehudit Shabbat Svetlana Gingis-Velitski Einat Almon Yoseph Shaaltiel | 2016 | World Journal of Gastroenterology2016，22，39： | 3 |
| 3 | 中国与埃塞俄比亚维和官兵心理健康状况的比较显示文摘目的 探讨中国与埃塞俄比亚维和官兵心理健康的差异。方法 用中国军人心理健康量表(CMMHS)对中国与埃塞俄比亚维和官兵的心理健康状况进行评估。结果中国维和后官兵的CMMHS总分[(48.90±21.15)分]、因子分的焦虑[(6.04±2.97)分、恐怖(3.92±2.14)分、精神病性(9.53±4.46)分]等均高于埃塞俄比亚维和官兵[分别为(28.78±3.97)分、(3.57±1.56)分、(2.44±1.30)分、(5.58±1.94)分,均P〈0.01]。除L因子分外,中国和埃塞俄比亚维和官兵3次测量的CMMHS各因子分均较中国军人常模显著增高(P〈0.01)。结论中国与埃塞俄比亚维和官兵的心理健康水平有明显不同,且两国维和官兵的心理健康水平均明显下降。 | 张理义 郭健 徐志熊 陈春霞 崔雪莲 Amsalu Yoseph | 2008 | 中国行为医学科学2008，17，1： | 2 |
| 4 | Performance and yield stability of maize hybrids in stress-prone environments in eastern Africa显示文摘Identification and deployment of high-yielding and stress-tolerant maize hybrids adapted to stress-prone agro-ecologies is important for improving the food security and livelihoods of smallholder farmers in eastern Africa.The objectives of this study were to(i)assess the performance of maize hybrids under well-watered and drought stress conditions;(ii)evaluate grain yield stability of 65 intermediate-maturing and 55 early-maturing hybrids in 24 well-watered locations and seven drought stress locations;and(iii)identify representative and/or discriminative testing locations for increasing genetic gains for the target traits.There were significant differences for grain yield among early-and intermediatematuring hybrids tested under well-watered and drought stress environments.Among the early-maturing hybrids,the top 10 hybrids produced 46.8%–73.9%and 31.2%–42.1%higher mean grain yields than the best commercial check under drought and well-watered conditions,respectively.Among the intermediate-maturing hybrids,the top 10 hybrids produced 25.2%–47.7%and 8.5%–13.5%higher grain yield than commercial checks under drought stress and well-watered conditions,respectively,suggesting improvement in the levels of drought tolerance in both early-and intermediate-maturing hybrids.GGE biplot analysis and a bi-segmented regression linear method identified specific early-maturing and intermediate-maturing hybrids that performed well under both well-watered and drought stress conditions.These hybrids could be recommended for commercial production in eastern Africa.Kakamega in Kenya was found to be the most representative and highly discriminating site among well-watered testing locations,while Kabuku in Tanzania was the least representative of test locations.For testing under drought stress conditions,Kiboko in Kenya was identified as the most representative location.This information could be useful for allocating resources and streamlining CIMMYT maize hybrid testing in eastern Africa. | Wender Santos Rezende Yoseph Beyene Stephen Mugo Eric Ndou Manje Gowda Julius Pyton Sserumaga Godfrey Asea Ismail Ngolinda McDonald Jumbo Sylvester O.Oikeh Michael Olsen Aluízio Borém Cosme Damião Cruz Boddupalli M.Prasanna | 2020 | The Crop Journal2020，8，1： | 2 |
| 5 | Piezoelectrically actuated miniature peristaltic pump 显示文摘 | YOSEPH B C CHANG Z S | 2001 | SPIE-Int Soc Opt Eng2001，327，4： | 1 |
| 6 | Residue Detection for Real-time Removal of Paint From Metallic Surfaces显示文摘 | Yoseph Bar-Cohen Xiaoqi Bao Benjamin Dolgin etc | 2001 | Advanced Nondestructive Evaluation for Structural and Biological Health Monitoring2001，7，： | 1 |
| 7 | Modeling and Computer Simulation of Ultrasonic/Sonic Driller/Corer (USDC)显示文摘 | Bao Xiaoqi Yoseph Bar-Cohen Chang Zensheu | 2003 | IEEE Transactions of Ultrasonics Sonics and Frequency Control2003，50，9： | 1 |
| 8 | Mast cells and autoimmunity显示文摘 | Menachem Rottem Yoseph A. Mekori | 2004 | Autoimmunity Reviews2004，，1： | 1 |
| 9 | Dynamic CO2 ther apy in periodic breathing: a modeling study to determine optimal timing and dosage regimes 显示文摘 | Yoseph M Willson K Charlotte H | 2009 | J Appl Physiol2009，107，： | 1 |
| 10 | The Cardiac Insufficiency Bisoprolol Study II显示文摘 | Amit Segev Yoseph A Mekori | 1999 | The Lancet1999，，9161： | 1 |
| 11 | Dynamic C02 therapy in periodic breathing : a modeling study to determine optimal timing and dosage regimes显示文摘 | Yoseph Mebrate Keith Willson Charlotte H | 2009 | J Appl Physiol2009，107，3： | 1 |
| 12 | Radiocarben dating of porewater - corretion for diffusion and diagenetic progress 显示文摘 | Sivan Orit Herut Barak Yechieli Yoseph | 2001 | Radiocarbon2001，43，2： | 1 |
| 13 | Occurrence of a variant of cucumber green mottle mosaic virus in Israel 显示文摘 | Antigus Y Pearslman M Ben -Yoseph R e t al | 1990 | Phyto- parasitica1990，18，1： | 1 |
| 14 | Modeling and Computer Simulation of Ultrasonic/Sonie Driller/Corer ( US- DC) 显示文摘 | Xiaoqi Ban Yoseph Bar-Cohen Zensheu Chang | 2003 | IEEE transactions of Ultrasonic Sonic and frequency control2003，50，： | 1 |
| 15 | Emerging NDT technologies and challenges at the beginning of the third millennium, Part 1 显示文摘 | Yoseph Bar Cohen | 2000 | Materials Evaluation2000，37，1： | 1 |
| 16 | Trabecular bone deterioration at the greater trochanter ol mice with unilateral obstructive nephropathy显示文摘 | Sa-Sa Gu Yan Zhang Xi Chen Teng-Yue Diao Yoseph Gebru Man-Sau Wong | 2013 | Asian Journal of Andrology2013，15，4： | 1 |
| 17 | Emerging NDT technologies and challenges at the beginning of the third millennium, Part 2 显示文摘 | Yoseph Bar Cohen | 2000 | Materials Evaluation2000，37，2： | 1 |
| 18 | The tumor suppressor p53 down - regulates glucose transporters Glut - 1 and Glut4 gene expression 显示文摘 | Schwartzenberg- Bar- Yoseph F Armoni M Kamieli E | 2004 | 64(7) :2627 -26332004，64，7： | 1 |
| 19 | 极端环境下的钻井--对地球和其他行星的穿透与取样显示文摘钻井技术的发展总是趋向低成本、高效率以及自动化。在某些情况下,比如在遥远的行星上钻井,由于通讯的延时,需要钻井技术的高度智能;在地球的某些地方钻井会遇到石油、岩浆以及冰层等不同温度与性质的物质材料,这些严酷的环境都要求我们开拓新的钻探技术。 | Yoseph Bar-Cohen 赵树森 | 2010 | 国外科技新书评介2010，，4： | 1 |
| 20 | An Algorithm for Vec- tor Quantizer Design 显示文摘 | YOSEPH L Buzo A GRAY R M | 1980 | IEEE Tran Commun1980，28，1： | 1 |
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