|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Is hepatic arterial infusion chemotherapy effective treatment for advanced hepatocellular carcinoma resistant to transarterial chemoembolization?显示文摘AIM:To evaluate the effectiveness of hepatic arterial infusion chemotherapy(HAIC) for advanced hepatocellular carcinoma(HCC) resistant to transarterial chemoembolization(TACE).METHODS:This study was conducted on 42 patients who received HAIC for advanced HCC between 2001and 2010 at our hospital.5-fluorouracil(5-FU) was administered continuously for 24 h from day 1 to day 5 every 2-4 wk via an injection reservoir.Intra-arterial cisplatin or subcutaneous interferon was administered in combination with the 5-FU.The patients enrolled in this retrospective study were divided into two groups according to whether or not they fulfilled the criteria for resistance to TACE proposed by the Japan Society of Hepatology in 2010(written in Japanese);one group of patients who did not fulfill the criteria for TACE resistance(group A,n = 23),and another group who fulfilled the criteria for TACE resistance(group B,n = 19).We compared the outcomes in terms of the response and survival rates between the two groups.RESULTS:Both the response rate and tumor suppression rate following HAIC were significantly superior in group A than in group B(response rate:48% vs 16%,P = 0.028,tumor suppression rate:87% vs 53%,P = 0.014).Furthermore,both the progression-free survival rate and survival time were significantly superior in group A than in group B(3-,6-,12-,and 24-mo = 83%,70%,29% and 20% vs 63%,42%,16% and 0%,respectively,P = 0.040,and 9.8 mo vs 6.2 mo,P = 0.040).A multivariate analysis(Cox proportional hazards regression model) showed that resistance to TACE was an independent predictor of poor survival(P = 0.007).CONCLUSION:HAIC administrating 5-FU was not effective against advanced HCC resistant to TACE.Other tools for treatment,i.e.,molecular-targeting agents may be considered for these cases. | Hiroyuki Kirikoshi Masato Yoneda Hironori Mawatari Koji Fujita Kento Imajo Shingo Kato Kaori Suzuki Noritoshi Kobayashi Kensuke Kubota Shin Maeda Atsushi Nakajima Satoru Saito | 2012 | World Journal of Gastroenterology2012，18，16： | 9 |
| 2 | Serum manganese superoxide dismutase and thioredoxin are potential prognostic markers for hepatitis C virus-related hepatocellular carcinoma显示文摘AIM:To evaluate the clinical significance of oxidative stress markers in patients with hepatitis C virus(HCV)related hepatocellular carcinoma(HCC).METHODS:Sixty-four consecutive patients who were admitted to Kagoshima University Medical and Dental Hospital were enrolled in this retrospective study.All patients had chronic liver disease(CLD) due to infection with HCV.Thirty patients with HCV-related HCC,34 with HCV-related CLD without HCC(non-HCC),and 20 healthy volunteers(HVs) were enrolled.Possible associations between serum manganese superoxide dismutase(MnSOD) and thioredoxin(TRX) levels and clinical parameters or patient prognosis were analyzed over a mean follow-up period of 31.7 mo.RESULTS:The serum MnSOD levels were significantly higher in patients with HCV-related HCC than in patients without HCC(P = 0.03) or HVs(P < 0.001).Similarly,serum TRX levels were also significantly higher in patients with HCV-related HCC than in patients without HCC(P = 0.04) or HVs(P < 0.01).However,serum levels of MnSOD and TRX were not correlated in patients with HCC.Among patients with HCC,the overall survival rate(OSR) was lower in patients with MnSOD levels ≥ 110 ng/mL than in patients with levels < 110 ng/mL(P = 0.01),and the OSR tended to be lower in patients with TRX levels < 80 ng/mL(P = 0.05).In addition,patient prognosis with HCC was poorest with serum MnSOD levels ≥ 110 ng/mL and serum TRX levels < 80 ng/mL.Furthermore,a multivariate analysis using a Cox proportional hazard model and serum levels of five factors(MnSOD,prothrombin time,serum albumin,serum α-fetoprotein(AFP),and serum des-γ-carboxy prothrombin) revealed that MnSOD levels ≥ 110 ng/mL(risk ratio:4.12,95% confidential interval:1.22-13.88,P = 0.02) and AFP levels ≥ 40 ng/mL(risk ratio:6.75;95% confidential interval:1.70-26.85,P < 0.01) were independent risk factors associated with a poor patient prognosis.CONCLUSION:Serum MnSOD and TRX levels are potential clinical biomarkers that predict patient prognosis in HCV-related HCC. | Tsutomu Tamai Hirofumi Uto Yoichiro Takami Kouhei Oda Akiko Saishoji Masashi Hashiguchi Kotaro Kumagai Takeshi Kure Seiichi Mawatari Akihiro Moriuchi Makoto Oketani Akio Ido Hirohito Tsubouchi | 2011 | World Journal of Gastroenterology2011，17，44： | 7 |
| 3 | Hyperresponsivity to Low-Dose Endotoxin during Progression to Nonalcoholic Steatohepatitis Is Regulated by Leptin-Mediated Signaling显示文摘 | Kento Imajo Koji Fujita Masato Yoneda Yuichi Nozaki Yuji Ogawa Yoshiyasu Shinohara Shingo Kato Hironori Mawatari Wataru Shibata Hiroshi Kitani Kenichi Ikejima Hiroyuki Kirikoshi Noriko Nakajima Satoru Saito Shiro Maeyama Sumio Watanabe Koichiro Wada Atsus | 2012 | Cell Metabolism2012，，1： | 2 |
| 4 | Retrovirus - mediated herpes simplex virus thymidine kinase gene transduction renders human thyroid carcinoma cell lines sensitive to ganciclovir and radiation in vitro and in vivo显示文摘 | Nishihara E Nagayama Y Mawatari F | 1997 | Endocrinology1997，138，11： | 1 |
| 5 | High sensitivity C-reactive protein is an independent clinical feature of nonalcoholic steatohepatitis(NASH)and also of the severity of fibrosis in NASH显示文摘 | Yoneda M Mawatari H Fujita K | 2007 | J Gastroenter o2007，42，7： | 1 |
| 6 | Clinical fea- tures of hepatitis C virus carriers with persistently normal alanine aminotransferase levels 显示文摘 | Hirofumi Uto Seiich Mawatari Kotaro Kumagai | 2012 | Hepat Mon2012，12，2： | 1 |
| 7 | Utilization of variant-type of human alpha-fetoprotein promoter in gene therapy targeting for hepatocellular carcinoma 显示文摘 | Ishikawa H Nakata K Mawatari F | 1999 | Gene Ther1999，6，4： | 1 |
| 8 | Prognostic factors for myasthenic crisis after transstemal thymectomy in patients with myasthenia gravis显示文摘 | Watanabe A Watanabe T Obama T Mawatari T | 2004 | J Thorac Cardiovasc Surg2004，127，3： | 1 |
| 9 | Angiotensiniidecreases glucose uptake by downregulation of glutl inthe cell membrane of the vascular smooth muscle cellline alO 显示文摘 | Masori M Hamamoto A Mawatari K | 2007 | J Cardiovasc Pharmacol2007，50，3： | 1 |
| 10 | Compound K, a meta-bolite of ginsenosides,induces cardiac protection mediatednitricoxide via Akt/PI3K pathway 显示文摘 | Tsutsumi YM Tsutsumi R Mawatari K | 2011 | Life Sciences2011，88，： | 1 |
| 11 | RPHPLC assay method for quantitating 6-mercaptopurine and its methylated and non- methylated metabolites in a single sample显示文摘 | Mawatari H Kato Y Nishimura S | 1998 | J Chromatogr B1998，716，12： | 1 |
| 12 | Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with nonalcoholic fatty liver disease (NAFLD) 显示文摘 | Yoneda M Yoneda M Mawatari H | 2007 | Dig Liver Dis2007，13，2： | 1 |
| 13 | Nitric oxide-cGMP signaling regulates axonal elongation during optic nerve regeneration in the goldfish in vitro and in vivo 显示文摘 | Koriyarna Y Yasuda R Homma K Mawatari K Nagashima M Sugitani K | 2009 | J Neurochem2009，110，3： | 1 |
| 14 | Is video-assisted thoracoscopic surgery a feasible approach for clinical N0 and postoperatively pathological N2 non-small cell lung cancer?显示文摘 | Atsushi Watanabe Taijiro Mishina Syunsuke Ohori Tetsuya Koyanagi Shinji Nakashima Tohru Mawatari Yoshihiko Kurimoto Tetsuya Higami | 2008 | European Journal of Cardio-Thoracic Surgery2008，，5： | 1 |
| 15 | Surgery for metastatic lung tumors at our department during the last ten years显示文摘 | MAWATARI T WATANABE A OHSAWA H | 2003 | Kyobu Geka2003，56，1： | 1 |
| 16 | Gastric undifferentiated carcinoma with diffuse c-kit overexpression and focal neuroendocrine differentiation显示文摘 | Daisuke Mori Michiaki Akashi Koichi Baba Kiyoto Morito Masami Shibaki Michinori Hashimoto Akashi Nakamura Seiko Mawatari Seiji Sato | 2013 | Pathology - Research and Practice2013，，2： | 1 |
| 17 | The phytoestrogen ginsensoside Re activates potassium channels of vascular smooth muscle cells through PI3K/Akt and nitric oxide pathways显示文摘 | Nakaya Y Mawatari K Takahashi A Harada N Hata A Yasui S | 2007 | J Med Invest2007，54，34： | 1 |
| 18 | Growth-associated protein-43(GAP-43) is a biochemical marker for the whole pe- riod of fish optic nerve regeneration显示文摘 | Kaneda M Nagashima M Mawatari K | 2010 | Adv Exp Med Biol2010，664，： | 1 |
| 19 | Serum carcinoembryonic antigen concentration doubling time correlates with tumor biology and life expectancy in patients with recurrent gastrointestinal carcinoma 显示文摘 | Korenaga D Saeki H Mawatari K | 1997 | Arch Surg1997，132，2： | 1 |
| 20 | The Effect of Subtenon Triamcinolone Acetonide Injection for Diabetic Macular Edema on Retinal and Choroidal Circulation显示文摘 | Yuki Mawatari Tomoyo Koga Junko Inumaru Akira Hirata Mikiko Fukushima Hidenobu Tanihara | 2005 | American Journal of Ophthalmology2005，，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员