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| 1 | Twenty-four hour intra-arterial infusion of 5-fluorouracil,cisplatin,and leucovorin is more effective than 6-hour infusion for advanced hepatocellular carcinoma显示文摘AIM: To evaluate the time dependence of intra-arterial 5-fluorouracil (5-FU) therapy for advanced hepatocellular carcinoma (aHCC). METHODS: Thirty-seven adult Japanese patients who had aHCC and liver cirrhosis were treated with combined intra-arterial 5-FU, cisplatin (CDDP), and leucovorin (LV). The Japan Integrated Staging score (JIS score) of each patient was 3 or more. The patients were divided into two groups, after which the 15 patients in group S were treated with 6-h infusion chemotherapy (LV at 12 mg/h, CDDP at 10 mg/h, and 5-FU at 250 mg/m2 per 4 h) and the 22 patients in group L were treated with 24-h infusion chemotherapy (LV at 12 mg/h, CDDP at 10 mg/h, and 5-FU at 250 mg/m2 per 22 h). Continuous infusion chemotherapy was performed via the proper hepatic artery every 5 d for 4 wk using an implanted drug reservoir. RESULTS: The percentages of patients with a partial response after 4 wk of chemotherapy were 6.7% in group S and 31.8% in group L. The survival of group L was significantly better than that of group S, with the median survival time being 496 d in group L and 226 d in group S (P < 0.05). CONCLUSION: Continuous 24-h intra-arterial infusion is more effective for aHCC and can markedly prolong survival time as compared to 6-h infusion. | Hidenari Nagai Masahiro Kanayama Katsuya Higami Kouichi Momiyama Akiko Ikoma Naoki Okano Katsuhiko Matsumaru Manabu Watanabe Koji Ishii Yasukiyo Sumino Kazumasa Miki | 2007 | World Journal of Gastroenterology2007，13，2： | 6 |
| 2 | Insulin-like growth factor Ⅱ and insulin-like growth factor binding protein Ⅱ expression in hepatoblastoma显示文摘 | Akmal SN Yun K Higami Y | 1995 | Hum Pathol1995，26，3： | 1 |
| 3 | Histologic and physiologic e- valuation of skeletonized internal thoracic m'tery harvesting with an ul- trasonic scalpel 显示文摘 | Higami T Maruo M Yamashita T | 2010 | J Thorac Cardiovasc Surg2010，120，6： | 1 |
| 4 | Aging increases dnase gamma,an apoptosis-related endonuclease in rat liver nuclei:effect of dietary restriction显示文摘 | Tanaka K Higami Y Tsuchiya T | 2004 | Exp Gerontol2004，39，2： | 1 |
| 5 | Cerebral metabolic impairment in patients with obstructive sleep apnoea: an independent association of obstructive sleep apnoea with white matter change 显示文摘 | Kamba M Inoue Y Higami S | 2001 | J Neurol Neurosurg Psychiatry2001，71，： | 1 |
| 6 | Is lung cancer resection indicated in patients with idiopathic pulmonary fibrosis显示文摘 | Watanabe A Higami T Ohori S | | 0，，： | 1 |
| 7 | Age-related changes in cerebral lactate metabolism in sleep-disordered breathing 显示文摘 | Kamba M Inoue Y Higami S | 2003 | Neumbiol Aging2003，24，： | 1 |
| 8 | Is video-assisted thoracoscopic surgery a feasible approach for clinical N0 and postoperatively pathological N2 non-small cell lung cancer?显示文摘 | Atsushi Watanabe Taijiro Mishina Syunsuke Ohori Tetsuya Koyanagi Shinji Nakashima Tohru Mawatari Yoshihiko Kurimoto Tetsuya Higami | 2008 | European Journal of Cardio-Thoracic Surgery2008，，5： | 1 |
| 9 | Cerebral metabolic impairment in patients with obstructive sleep apnoea: an independent association of obstructive sleep apnoea with white matter change 显示文摘 | Kamba M Inoue Y Higami S | 2001 | J Neurol Neurosurg Psychiatry2001，71，3： | 1 |
| 10 | Age-related changes in cerebral lactate metabolism in sleep--disordered breathing显示文摘 | Kamba M lnoue Y Higami S | 2003 | Neurobiol Aging2003，24，5： | 1 |
| 11 | Aging accelerates but life-long dietary restriction suppresses apoptosis-related Fas expression on hepatocytes显示文摘 | Higami Y Shimokawa I Tomita M | 1997 | Am JPathol1997，151，： | 1 |
| 12 | How Infant Mortality Was Reduced in the Early Twentieth Century in Osaka显示文摘 | Emiko Higami Ken'ichi Tomob | 2014 | Journal of Sociology Study2014，4，5： | 1 |
| 13 | Is lung cancer resection indicated in patients with idiopathic pulmonary fibrosis?显示文摘 | Watanabe A Higami T Ohori S | 2008 | J Thorac Cardiovasc Surg2008，136，5： | 1 |
| 14 | Adipose tissue energy metabolism:al- tered gene expression profile of mice subjected to long-term caloric restric- tion显示文摘 | Higami Y Pugh TD Page GP | 2004 | FASEB J2004，18，2： | 1 |
| 15 | Intravascular maligant lymphomatisis: a case of T-cell lymphoma probably associated with human T-cell lymphotropic virus显示文摘 | Shimokawa I Higami Y Sakai H | 1991 | Human Pathol1991，22，2： | 1 |
| 16 | Test Cost Reduction for Logic Circuits 显示文摘 | Higami Y | 2005 | Systems and Computers in Japan Reduction of Test Data Volume and Test Application Time2005，36，6： | 1 |
| 17 | Cerebral metabolic impairment in patients with obstructive sleep apnoea:an independent association of obstructive sleep apnoea with white matter change显示文摘 | Kamba M Inoue Y Higami S | 2001 | J Neurol Neurosurg Psychiatry2001，71，3： | 1 |
| 18 | VEGF and bFGF mRNA are expression in ethylnitrosourea-induced experimental rat gliomas显示文摘 | Okimoto T Shimokawa I Higami Y | 1997 | Cell Mol Neurobiol1997，17，1： | 1 |
| 19 | Retrospective analysis of the relationship between HUS incidence and antibiotics among patients with Escherichia coli O157 enterocolitis in the Sakai outbreak显示文摘 | Higami S Nishimoto K Kawamura T | 1998 | Kansenshogaku Zasshi1998，72，3： | 1 |
| 20 | Acute cerebral arterial embolism following pemetrexed and carboplatintreatment in non?small?cell lung cancer: A case report显示文摘 | Masayuki Takeda Takehiko Kobayashi Satoshi Marumo Yoshihiko Koshimo Takashi Teranishi Yuichi Higami Motokazu Kato | 2013 | Molecular and Clinical Oncology2013，，5： | 1 |
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