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| 1 | 胱抑素C与肌酐在确定肾功能风险方面的作用显示文摘血肌酐联合胱抑素c确定估算的肾小球滤过率(estimatedglomerularfiltrationrate,eGFR),能够提高准确性,但其对不同人群慢性肾脏病检测、分期和风险分类的影响尚未确定。最近美国学者报告了一项荟萃分析,比较了胱抑素c与肌酐在确定肾功能风险方面的作用。 | Shlipak MG Matsushita K rnlv J 王建中 | 2013 | 中华肾病研究电子杂志2013，2，5： | 60 |
| 2 | Appendix is a priming site in the development of ulcerative colitis显示文摘AIM: The role of the appendix has been highlighted in the pathogenesis of ulcerative colitis (UC). The aims of this study were to elucidate the immuno-imbalances in the appendix of UC patients, and to clarify the role of the appendix in the development of UC.METHODS: Colonoscopic biopsy specimens of the appendix, transverse colon, and rectum were obtained from 86 patients with UC: active pancotitis (A-Pan; n = 15),active left-sided colitis (A-Lt; n = 25), A-Lt with appendiceal involvement (A-Lt/Ap; n = 10), inactive pancolitis (I-Pan;n = 14), and inactive left-sided colitis (I-Lt; n = 22),and from controls. In the isolated mucosal T cells, the CD4/CD8 ratio and proportion of activated CD4+ T cells were investigated, and compared with controls.RESULTS: In the appendix, the CD4/CD8 ratio significantly increased in A-Lt and A-Lt/Ap. The ratio in the appendix also tended to increase in A-Pan. In the rectum, the ratio significantly increased in all UC groups. Tn the appendix,the proportion of CD4+CD69+ (early activation antigen)T cells significantly increased in all UC groups. Tn the rectum, the proportion of CD4+CD69+ T cells significantly increased only in A-Pan. The proportion of CD4+HLADR+ (mature activation antigen) T cells significantly increased only in the rectum of A-Pan, but not in the other areas of any groups.CONCLUSION: The increased CD4/CD8 ratio and predominant infiltration of CD4+CD69+ T cells in the appendix suggest that the appendix is a priming site in the development of UC. | Mitsunobu Matsushita Hiroshi Takakuwa Yuji Matsubayashi Akiyoshi Nishio Susumu Ikehara Kazuichi Okazaki | 2005 | World Journal of Gastroenterology2005，11，31： | 9 |
| 3 | Prognostic significance of perioperative tumor marker levels in stage Ⅱ/Ⅲ gastric cancer显示文摘AIM To evaluate the prognostic significance of perioperative carcinoembryonic antigen(CEA) and carbohydrate antigen 19-9(CA19-9) levels in stage Ⅱ/Ⅲ gastric cancer.METHODS From a multi-institutional retrospective database compiled by integrating clinical data from nine institutions, data of 998 patients who underwent curative resection for stage Ⅱ/Ⅲ gastric cancer between 2010 and 2014 were retrieved and analyzed. The prognostic impact of the preoperative and postoperative levels and chronological changes in CEA, CA19-9 and their combination were evaluated. To test whether postoperative adjuvant chemotherapy alters the prognostic impact of perioperative CEA and CA19-9 levels, the hazard ratios for mortality were compared between patients who underwent surgery alone and patients who underwent surgery followed by adjuvant chemotherapy.RESULTS The prognostic impact of postoperative CEA and CA19-9 was superior to that of the preoperative levels. Multivariable analysis identified high postoperative CEA and CA19-9 levels as independent prognostic factors for overall survival.Disease-free survival rates clearly decreased in a stepwise manner in association with postoperative CEA and CA19-9 levels, and patients with high levels of both markers showed significantly poorer prognosis than other patient groups. When we analyzed perioperative changes in serum CEA and CA19-9 levels, patients with high levels before and after surgery had the worst disease-free survival rates among all patient groups. Patients with normalized CEA levels after surgery had a significantly lower disease-free survival rate than those with normal perioperative levels, whereas patients with normalized CA19-9 levels after surgery had equivalent survival to those with normal perioperative levels. The prognostic impact of high CEA levels was observably smaller in patients who underwent adjuvant chemotherapy than in patients who underwent surgery alone, whereas that of high CA19-9 was greater in patients who underwent adjuvant chemotherapy. High postoperative CEA levels were significantly associated with an increased prevalence of liver, lung and bone recurrences, and high postoperative CA19-9 levels were significantly associated with increased frequencies of lymph node and liver recurrences.CONCLUSION The evaluation of serum CEA and CA 19-9 levels both before and after surgery provides useful information for precise risk stratification after curative gastrectomy. | Yasuhito Suenaga Mitsuro Kanda Seiji Ito Yoshinari Mochizuki Hitoshi Teramoto Kiyoshi Ishigure Toshifumi Murai Takahiro Asada Akiharu Ishiyama Hidenobu Matsushita Chie Tanaka Daisuke Kobayashi Michitaka Fujiwara Kenta Murotani Yasuhiro Kodera | 2019 | World Journal of Gastrointestinal Oncology2019，11，1： | 7 |
| 4 | In vivo histological diagnosis for gastric cancer using endocytoscopy显示文摘AIM To examine usefulness of virtual biopsy using endocytoscopy by comparing the in vivo endocytoscopic and histopathological images of gastric cancers.METHODS Endocytoscopy was performed in 30 patients with early gastric cancer. Of these, 26 patients showed well differentiated adenocarcinomas, while 4 patients showed poorly differentiated adenocarcinomas(including one signet ring cell carcinoma). Cancerous and non-cancerous areas were observed after double staining with 0.05% crystal violet and 0.1% methylene blue. The endocytoscopic images obtained were evaluated by an expert endoscopist and an expert pathologist without knowledge of patient clinical data, and endocytoscopic and histopathological diagnoses were compared.RESULTS The endocytoscopic images of the cancerous area were assessed as evaluable in 25(83.3%) and 27(90%) patients by endoscopist A and pathologist B, respectively, and those of the non-cancerous area as evaluable in 28(93.3%) and 23(76.7%) patients by the endoscopist and pathologist, respectively. The sensitivity, specificity, and diagnostic accuracy of gastric cancer diagnosis using evaluable endocytoscopic images were 88.0% and 92.9%, and 90.6% by endoscopist A, and 88.9% and 91.3%, and 90.0% by pathologist B, respectively. Evaluation of the diagnostic concordance rate between the endoscopist and the pathologist by inter-observer agreement calculation revealed no significant difference between the two observers. The inter-observer agreement(κ-value) for endocytoscopic diagnosis was 0.745. CONCLUSION Endocytoscopy is useful for the differentiation of cancerous from non-cancerous gastric mucosa, making it a promising tool for virtual biopsy. | Issei Tsurudome Ryoji Miyahara Kohei Funasaka Kazuhiro Furukawa Masanobu Matsushita Takeshi Yamamura Takuya Ishikawa Eizaburo Ohno Masanao Nakamura Hiroki Kawashima Osamu Watanabe Masato Nakaguro Akira Satou Yoshiki Hirooka Hidemi Goto | 2017 | World Journal of Gastroenterology2017，23，37： | 5 |
| 5 | Risk factors for the development of post-endoscopic retrograde cholangiopancreatography pancreatitis in patients with asymptomatic common bile duct stones显示文摘BACKGROUND Previous studies have revealed that patients with asymptomatic common bile duct(CBD)stones are at a high risk of developing post-endoscopic retrograde cholangiopancreatography(ERCP)pancreatitis(PEP).However,no studies to date have addressed the risk factors for PEP in patients with asymptomatic CBD stones.AIM To examine the risk factors for PEP in patients with asymptomatic CBD stones.METHODS Using medical records of three institutions in Japan for 6 years,we identified a total of 1135 patients with choledocholithiasis including 967 symptomatic patients and 168 asymptomatic patients with native papilla who underwent therapeutic ERCP.We performed univariate and multivariate analyses to examine the risk factors for PEP in the 168 patients with asymptomatic CBD stones.RESULTS The overall incidence rate of PEP in all the patients with during study period was 4.7%(53/1135).Of the 168 patients with asymptomatic CBD stones,24(14.3%)developed PEP.In univariate analysis,precut sphincterotomy(P=0.009)and biliary balloon sphincter dilation(P=0.043)were significant risk factors for PEP.In multivariate analysis,precut sphincterotomy(P=0.002,95%CI:2.2-27.8,odds ratio=7.7),biliary balloon sphincter dilation(P=0.015,95%CI:1.4-17.3,odds ratio=4.9),and trainee endoscopists(P=0.048,95%CI:1.01-8.1,odds ratio=2.9)were significant risk factors for PEP.CONCLUSION ERCP for asymptomatic CBD stones should be performed by experienced endoscopists.When performing precut sphincterotomy or biliary balloon sphincter dilation in patients with asymptomatic CBD stones,the placement of a prophylactic pancreatic stent is strongly recommended to prevent PEP. | Hirokazu Saito Tatsuyuki Kakuma Ikuo Matsushita | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，10： | 5 |
| 6 | Studies on numerical site calibration over complex terrain for wind turbines显示文摘The estimation of wind turbine performance over complex terrain is very difficult because of the document of standard IEC61400-12 is adapted for flat or slightly complex topography.And the cost of constructing a meteorological mast is higher with scaling wind turbine up.We have proposed a numerical site calibration(NSC) technique in order to estimate the inflow velocity at the position of wind turbine by using CFD tool to calculate the flow field around the site.The present paper shows the problems for the procedure of NSC in which a commercial nonlinear CFD tool and the improvement method are used to gain a more accurate result.It is clarified that the wind turbine performance which is estimated by using the wind speed on the meteorological mast has a good result for annual energy production. | Daisuke MATSUSHITA Hikaru MATSUMIYA Yoshinori HARA Satoshi WATANABE Akinori FURUKAWA | 2010 | Science China(Technological Sciences)2010，53，1： | 4 |
| 7 | Identification of Naturally Occurring Polyamines as Root-Knot Nematode Attractants显示文摘Root-knot nematodes(RKNs;genus Meloidogyne)are a class of plant parasites that infect the roots of many plant species.It is believed that RKNs target certain signaling molecules derived from plants to locate their hosts;however,currently,no plant compound has been unambiguously identified as a universal RKN attractant.To address this question,we screened a chemical library of synthetic compounds for Meloidogyne incognita attractants.The breakdown product of aminopropylam ino-anthraquinone,1,3-diam inopropane,as well as its related compounds,putrescine and cadaverine,were found to attract M.incognita.After exam ining various polyamines,M.incognita were found to be attracted specifically by natural com pounds that possess three to five methylene groups between two terminal amino groups.Using cryo-TO F-SIM S/SEM,cadaverine was indeed detected in soybean root cortex cells and the surrounding rhizosphere,establishing a chemical gradient.In addition to cadaverine,putrescine and 1,3-diam inopropane were also detected in root exudate by HPLC-MS/MS.Furtherm ore,exogenously applied cadaverine is sufficient to enhance M.incognita infection of Arabidopsis seedlings.These results suggest that M.incognita is likely attracted by polyam ines to locate the appropriate host plants,and the naturally occurring polyamines have potential applications in agriculture in developing protection strategies for crops from RKN infection. | Morihiro Oota Allen Yi-Lun Tsai Dan Aoki Yasuyuki Matsushita Syuuto Toyoda Kazuhiko Fukushima Kentaro Saeki Kei Toda Laetitia Perfus-Barbeoch Bruno Favery Hayato Ishikawa Shinichiro Sawa | 2020 | Molecular Plant2020，13，4： | 4 |
| 8 | 冠状动脉钙化在高血压患者心血管病风险分层中的作用显示文摘研究者研究了冠状动脉钙化(coronary artery calcium,CAC)在成人高血压心血管病风险分层中的作用,包括符合收缩压干预试验(systolic blood pressure intervention trial,SPRINT)标准的患者。此外,研究者使用CAC来确定心血管病死亡率与SPRINT中标准降压组心血管病死亡率('SPRINT水平')相当的高血压成年患者,其可能受益于强化降压治疗。研究人群包括来自CAC研究联盟的高血压患者16 167例,其中6375例患者构成'SPRINT类似人群'。研究者按CAC分类(0,1~99,100~399,≥400)比较了多因素校正后的冠状动脉粥样硬化性心脏病(冠心病)和心血管病死亡风险比。 | 刘青(译) 叶鹏(摘、审校) Uddin SMI Mirbolouk M Kianoush S Orimoloye OA Dardari Z Whelton SP Miedema MD Nasir K Rumberger JA Shaw LJ Berman DS Budoff MJ McEvoy JW Matsushita K Blaha MJ Graham G | 2019 | 中华高血压杂志2019，27，5： | 3 |
| 9 | Practical image fusion method based on spectral mixture analysis显示文摘Conventional image fusion algorithm, such as IHS, SVR, PCS, etc., may show some defects in inheriting the higher-spectral information embedded in the original lower-spatial resolution MS image.A fusion method based on spectral mixture analysis(FSMA) was proposed in previous study, which has potential in solving this problem.While published results are limited to well-behaved simulated data where the endmembers are known a priori and the FSMA method will not work well when applying to real remotely sensed images because the estimated reflectance ranging in panchromatic band derived from MS bands cannot be treated as the real panchromatic values.In this paper, an improved image fusion method based on spectral mixture analysis(IFSMA) is proposed, in which the original FSMA method was extended to real remotely sensed images by modifying the objective function of the constrained nonlinear optimization expressions.It was compared with the original FSMA, Zhang's SVR, PCS and IHS method, and results indicated that the IFSMA method was superior to other methods in preserving the spectral and spatial information. | YANG Wei CHEN Jin MATSUSHITA Bunkei SHEN MiaoGen CHEN XueHong | 2010 | Science China(Information Sciences)2010，53，6： | 3 |
| 10 | Protocol analysis of designers using an interactive evolutionary computation显示文摘 | Weixin Huang Daisuke Matsushita Junzo Munemoto | 2012 | Frontiers of Architectural Research2012，1，1： | 3 |
| 11 | Azathioprine is essential following cyclosporine for patients with steroid-refractory ulcerative colitis显示文摘AIM: To evaluate long-term prognosis following cyclosporine treatment by examining the rate of surgery avoidance among cyclosporine responders.METHODS: We retrospectively reviewed clinical records for 29 patients diagnosed with severe steroid-refractory ulcerative colitis in our hospital from August 1997 to August 2008 and treated with cyclosporine by continuous intravenous infusion.All patients were treated with intravenous corticosteroids for more than 5 d prior to cyclosporine therapy.Administration was continued for up to 21 d under serum monitoring to maintain cyclosporine levels between 400 and 600 ng/mL.Clinical activity was assessed before and after cyclosporine therapy using the clinical activity index score,with a reduction of ≥ 5 considered to indicate a response.Among responders,we defined cases not requiring surgery for more than 5 years as exhibiting long-term efficacy of cyclosporine.Factors considered to be possibly predictive of long-term efficacy of cyclosporine were sex,age,disease duration,clinical activity index score,C-reactive protein level,hemoglobin level,disease extent,endoscopic findings,and clinical course.RESULTS: Cyclosporine was not discontinued due to side effects in any patient.Nineteen(65.5%) of 29 patients were considered responders.A statistically significant(P = 0.004) inverseas sociation wa s observed between an endoscopic finding of 'mucosal bleeding' and responsive cases.Fifteen(9 males,6 females) of these 19 patients were followed for 5 years or more,of whom 9(60%) exhibited long-termefficacy of cyclosporine.Of the 10 non-responders,9(90%) underwent surgery within 6 mo of cyclosporine therapy.None of the following factors had a significant impact on the long-term efficacy of cyclosporine: sex,age,duration of disease,clinical activity index score,C-reactive protein level,hemoglobin level,extent of disease,endoscopic findings,or clinical course.In contrast,a significant association was observed for maintenance therapy with azathioprine after cyclosporine therapy(P = 0.0014).CONCLUSION: Maintenance therapy with azathioprine might improve the long-term efficacy of continuously infused cyclosporine for severe steroid-refractory ulcerative colitis patients. | Nobuyuki Miyake Takafumi Ando Kazuhiro Ishiguro Osamu Maeda Osamu Watanabe Yutaka Hirayama Keiko Maeda Kazuhiro Morise Masanobu Matsushita Kazuhiro Furukawa Kohei Funasaka Masanao Nakamura Ryoji Miyahara Naoki Ohmiya Hidemi Goto | 2015 | World Journal of Gastroenterology2015，21，1： | 3 |
| 12 | Bone tissue engineering in osteoporosis显示文摘 | Franz Jakob Regina Ebert Anita Ignatius Takashi Matsushita Yoshinobu Watanabe Juergen Groll Heike Walles | 2013 | Maturitas2013，，2： | 2 |
| 13 | Evidence for apoptosis after intercerebral hemorrhage in rat striatum显示文摘 | Matsushita K Meng W Wang X | | 0，，： | 2 |
| 14 | Endoscopic retrograde cholangiopancreatography for bile duct stones in patients with a performance status score of 3 or 4显示文摘BACKGROUND As the aging population grows worldwide,the rates of endoscopic retrograde cholangiopancreatography(ERCP)for common bile duct stones(CBDS)in older patients with a poor performance status(PS)have been increasing.However,the data on the safety and efficacy of ERCP for CBDS in patients with a PS score of 3 or 4 are lacking,with only a few studies having investigated this issue among patients with poor PS.AIM To examine the safety and efficacy of ERCP for CBDS in patients with a PS score of 3 or 4.METHODS This study utilized a retrospective multi-centered design of three institutions in Japan for 8 years to identify a total of 1343 patients with CBDS having native papillae who underwent therapeutic ERCP.As a result,1113 patients with a PS 0-2 and 230 patients with a PS 3-4 were included.One-to-one propensity-score matching was performed to compare the safety and efficacy of ERCP for CBDS between patients with a PS 0-2 and those with a PS 3-4.RESULTS The overall ERCP-related complication rates in all patients and propensity score-matched patients with a PS 0-2 and 3-4 were 9.0%(100/1113)and 7.0%(16/230;P=0.37),and 4.6%(9/196)and 6.6%(13/196;P=0.51),respectively.In the propensity score-matched patients,complications were significantly more severe in the group with a PS 3-4 than in the group with a PS 0-2 group(P=0.042).Risk factors for complications were indications of ERCP and absence of antibiotics in the multivariate analysis.Therapeutic success rates,including complete CBDS removal and permanent biliary stent placement,in propensity score-matched patients with a PS 0-2 and 3-4 were 97.4%(191/196)and 97.4%(191/196),respectively(P=1.0).CONCLUSION ERCP for CBDS can be effectively performed in patients with a PS 3 or 4.Nevertheless,the indication for ERCP in such patients should be carefully considered with prophylactic antibiotics. | Hirokazu Saito Yoshihiro Kadono Takashi Shono Kentaro Kamikawa Atsushi Urata Jiro Nasu Haruo Imamura Ikuo Matsushita Tatsuyuki Kakuma Shuji Tada | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，4： | 2 |
| 15 | Tuberculous bronchial stenosis: treatment with balloon bronchoplasty显示文摘 | Nakamura K Terada N Matsushita T | 1991 | AJR Am J Roentgenol1991，157，6： | 2 |
| 16 | 利用小震震源机制解研究汶川地震后龙门山断裂带中段应力场时空演化显示文摘利用川西流动地震台阵观测资料,求解汶川地震后发生在龙门山断裂带中段地区的余震震源机制解,反演了相应的应力场,得到了应力场的时空演化特征。结果显示,小震震源机制以逆冲为主并含有一定数量的走滑和正断型地震,逆冲型地震的比重随时间明显增加。震源机制类型的空间分布与断层深部展布及区域速度结构具有相关性。应力张量反演结果显示早期余震各分区水平最大主压应力S_H方位主要分布在近EW—NWW范围内,沿小鱼洞—理县方向余震分支地壳浅部主压应力则沿NE-SW向,表明震后早期应力场主要受主震破裂传播引起的动态应力影响,S_H方位与破裂面特征密切相关。应力张量随时间的变化显示深部应力结构由逆冲、走滑混合向纯逆冲转变,表明深部区域通过走滑型地震来平衡初期应力释放造成的局部库仑应力,并逐渐恢复到接近背景应力场,浅部应力变化追随深部变化特征,显示出在时间上的滞后。 | 江敏 陈九辉 Yasuto Kuwahara Reiken Matsushita | 2018 | 地震地质2018，40，2： | 2 |
| 17 | Epinephrine sprayed on the papilla for prevention of post-ERCP pancreatitis显示文摘 | Mitsunobu Matsushita Hiroshi Takakuwa Naoto Shimeno Kazushige Uchida Akiyoshi Nishio Kazuichi Okazaki | 2009 | Journal of Gastroenterology2009，，1： | 2 |
| 18 | Novel hexagonal structure and ultrahigh strength of magnesium solid solution in the Mg–Zn–Y system显示文摘 | Akihisa Inoue Yoshihito Kawamura Mitsuhide Matsushita Kentaro Hayashi Junichi Koike | 2001 | Journal of Materials Research2001，，7： | 2 |
| 19 | Microbial production of pyrroloquinoline quinone显示文摘 | Ameyama M Hayashi M Matsushita K | 1984 | Agric Biol Chem1984，48，2： | 2 |
| 20 | SAP155-Mediated Splicing of FUSE-Binding Protein-Interacting Repressor Serves as a Molecular Switch for c-myc Gene Expression显示文摘 | Kazuyuki Matsushita Toshiko Kajiwara Mai Tamura Mamoru Satoh Nobuko Tanaka Takeshi Tomonaga Hisahiro Matsubara Hideaki Shimada Rei Yoshimoto Akihiro Ito Shuji Kubo Tohru Natsume David Levens Minoru Yoshida Fumio Nomura | 2012 | Molecular Cancer Research2012，，6： | 2 |
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