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| 1 | Therapeutic options for HER-2 positive breast cancer: Perspectives and future directions显示文摘During the last 15 years we have witnessed an unprecedented expansion in the drugs developed to target human epidermal growth factor receptor-2(HER-2) positive breast cancer. Trastuzumab, pertuzumab, adotrastuzumab emtansine and lapatinib are currently food and drug administration(FDA)-approved for the treatment of breast cancer patients with HER-2 overexpressed. However, given the amount of information gathered from years of uninterrupted clinical research, it is essential to have periodic updates that succinctly recapitulate what we have learnt over these last years and help us to apply that information in our daily practice. This review will pursue that objective. We will summarize the most relevant and updated informationrelated to the state of the art management of HER-2 positive breast cancer in all the clinical scenarios including the adjuvant, neoadjuvant and metastatic settings. But we will also critically appraise that literature in order to highlight some key clinical concepts that should not be overlooked. Lastly, this review will also point out some of the most promising strategies that are currently being tested and may soon become available. | Gonzalo Recondo Jr Enrique Dìaz Canton Màximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Clinical Oncology2014，5，3： | 7 |
| 2 | Advances and new perspectives in the treatment of metastatic colon cancer显示文摘During the last decade we have witnessed an unprec-edented outburst of new treatment approaches for the management of metastatic colon cancer.Anti-angio-genic drugs,epidermal growth factor receptor blockers and multi-kinase inhibitors have all resulted in small but consistent improvement in clinical outcomes.However,this progress has paradoxically leaded us into new chal-lenges.In many cases the clinical development was done in parallel and the lack of head-to-head compari-son evolved into circumstances where several valid new'standards of care'are available.Even though desir-able in essence,the availability of many options as well as different possible combinations frequently leaves the busy clinician in the difficult situation of having to choose between one or the other,sometimes without solid evidence to support each decision.In addition,progress never stops and new agents are continuously tested.For these reason this review will try to summa-rize all the clinical trials that constitute the theoretical framework that support our daily practice but will also procure the reader with rational answers to common clinical dilemmas by critically appraising the current literature.Lastly,we will provide with a compilation of promising new agents that may soon become our next line of defense against this deadly disease. | Gonzalo Recondo Jr Enrique Díaz-Cantón Máximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Gastrointestinal Oncology2014，6，7： | 2 |
| 3 | Building geometric fealure based maps for indoor service robots 显示文摘 | RODRIGUEZ L D MATIA F GALAN R | 2006 | Robotics and Autonomous Systems2006，54，7： | 1 |
| 4 | Expression of tolerance for Meloidogyne graminicola in rice euhivars as affected by soil type and flooding显示文摘 | Soriano I R S Prot J C Matias D M | 2000 | Journal of nematology2000，，32： | 1 |
| 5 | Two members of the thioredoxin-h family interact with the kinase domain of a Brassica S-locus receptor kinase 显示文摘 | Bower M S Matias D D Femandes-carvalho E Mazzurco M Gu T Rothstein A J and Goring D R | 1996 | Plant Cell1996，8，： | 1 |
| 6 | Two members of the thioredoxin-H family interact with the kinase domain of a Brassica S-locus receptor kinase显示文摘 | Bower MS Matias D D Fernandes Carvalho E | 1996 | The Plant Cell1996，8，： | 1 |
| 7 | Analysis of one-dimensional photonic band gap structures with a liquid crystal defect towards development of fiber-optic tunable wavelength filters显示文摘 | Villar I D Matias I R Arregui F J | 2003 | Optics Express2003，11，3： | 1 |
| 8 | Optimization of sensitivity in long period fiber gratings with overlay deposition显示文摘 | Ignacio D V Ignacio R Matias I R | 2005 | Optics Express2005，13，1： | 1 |
| 9 | Analysis of one dimensional photonic hand gap structures with a liquid crystal defect towards development of fiber-optic tunable wavelength filter显示文摘 | VILLAR I D MATIAS I R ARREGUI F J | 2003 | Opt Exp2003，11，5： | 1 |
| 10 | Does the RIFLE Classification Improve Prognostic Value of the APACHE Ⅱ Score in Critically Ⅲ Patients? 显示文摘 | WAHRHAFTIG K M CORREIA L C MATIAS D | 2013 | lnt J Nephrol2013，40，： | 1 |
| 11 | Characterization of olive oil produced with a new enzyme processing aid显示文摘 | Ranalli A Matia G D | 1997 | J Am Oil Chem Soc1997，，9： | 1 |
| 12 | Recent Treatment Advances and Novel Therapies in Pancreas Cancer: A Review显示文摘 | Matias E. Valsecchi Enrique Díaz-Cantón Máximo Vega Susan J. Littman | 2014 | Journal of Gastrointestinal Cancer2014，，2： | 1 |
| 13 | Evidence for natural resistance towards trifloxystrobin in Fusarium graminearum 显示文摘 | Tiphaine D Matias P Friederike P | 2011 | Eur J Plant Pathol2011，130，： | 1 |
| 14 | Enhancement of sensitivity in long-period fiber gratings with deposition of low-refrac- tive-index materials 显示文摘 | VILLAR I D MATIAS I R ARREGUI F 1 | 2005 | Optics Letters2005，30，23： | 1 |
| 15 | Aneuploidies detection in miscarriages and fetal deaths using multiplex ligation-dependent probe amplification: an alternative for speeding up results?显示文摘 | Berta Carvalho Sofia Dória Carla Ramalho Otília Brand?o Mário Sousa Alexandra Matias Alberto Barros Filipa Carvalho | 2010 | European Journal of Obstetrics and Gynecology2010，，2： | 1 |
| 16 | Antimicrobial plant extracts encapsulated into polymeric beads for potential ap- plication on the skin显示文摘 | RIJO P MATIAS D FERNANDES A S | 2014 | Polymers2014，6，2： | 1 |
| 17 | Fiber-Optic multiple-wavelength filter based on one-dimensional photonic bandgap structures with defects显示文摘 | Matias I R Arregui F J | 2004 | IEEE Journal of Lightwave Technology2004，22，： | 1 |
| 18 | Extending the limits of feature-based SLAM with B-splines显示文摘 | Pedraza L Rodriguez-Losada D Matia E | 2009 | IEEE Transactions on Robotics2009，25，2： | 1 |
| 19 | An im proved bit parallel exact maximum clique algorithm显示文摘 | San Segundo P Matia F Rodriguez-Losada D | 2013 | Optimi- zation Letters2013，，： | 1 |
| 20 | Two members of the thioredoxin-h family interact with the kinase domain of a Brassica S locus receptor kinase显示文摘 | BOWER M S MATIAS D D FERNANDES-CARVALHO E MAZZURCO M GU T ROTHSTEIN S | 1996 | Plant Cell1996，8，： | 1 |
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