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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation显示文摘PTEN 肿瘤 suppressor 是在调整 phosphatidylinositol-3-kinase (PI3K ) 有一个中央角色的类脂化合物磷酸酶信号 transduction 串联。不过, PTEN 活动被在房间调整的机制需要进一步的说明。尽管以前的研究证明了 PTEN 的 ubiquitination 能调制它的稳定性和 subcellular 本地化,在 PTEN 功能的最批评的方面的 ubiquitination 的角色,它的磷酸酶活动,充分没被探讨。这里,我们识别 PTEN 的新奇 E3 ubiquitin ligase,沤手指蛋白质(RFP ) ,那能支持 PTEN 的不正常的 polyubiquitinations。这些 ubiquitinations 不导致 PTEN 不稳定性或本地化,但是相当显著地禁止 PTEN 磷酸酶活动因此调制它的能力调整 PI3K 信号 transduction 串联。确实, RFP overexpression 在 AKT 激活上减轻调停 PTEN 的禁止的效果;相反,调停 RNAi 内长的 RFP 击倒提高 PTEN 的能力压制 AKT 激活。而且, PTEN 的调停 RFP 的 ubiquitination 禁止小道表示的 PTEN 依赖的激活并且也压制它的能力导致 apoptosis。我们的调查结果在控制 PTEN 表明调停 RFP 的 ubiquitination 的一个关键角色活动。 | James T Lee Jing Shan Jiayun Zhong Muyang Li Brenda Zhou Amanda Zhou Ramon Parsons Wei Gu | 2013 | Cell Research2013，23，4： | 5 |
| 3 | Resistance switching for RRAM applications显示文摘Resistive random access memory (RRAM or ReRAM) is a non-volatile memory (NVM) technology that consumes minimal energy while offering sub-nanosecond switching. In addition, the data stability against high temperature and cycling wear is very robust, allowing new NVM applications in a variety of markets (au- tomotive, embedded, storage, RAM). Based on sudden conduction through oxide insulators, the characteristics of RRAM technology have still yet to be fully described. In this paper, we present our current understanding of this very promising technology. | CHEN Frederick T LEE HengYuan CHEN YuSheng HSU YenYa ZHANG LiJie CHEN PangShiu CHEN WeiSu GU PeiYi LIU WenHsing WANG SuMin TSAI ChenHan SHEU ShyhShyuan TSAI MingJinn HUANG Ru | 2011 | Science China(Information Sciences)2011，54，5： | 3 |
| 4 | Inhibition of extracellular signal-regulated kinase enhances Ischemia/Reoxygenation-induced apoptosis in cultured cardiac myocytes and exaggerated reperfusion injury in isolated peffusod heart 显示文摘 | Yue T L Wang C Gu J L | 2000 | Circ Res2000，86，6： | 2 |
| 5 | Meshless method: An overview and recent developments显示文摘 | Belytschko T Lu Y Y Gu L | 1996 | Computer Methods Appl Mech Engrg1996，139，： | 2 |
| 6 | Chemical and pharmacological evaluation of Hypericum perforation extracts显示文摘KEY WORDS Hypericum perforation; High pressure liquid chromatography; serotonin uptake inhibitors; tree radicals; antioxidants; hyperforin; hypericin; quercetin; rutinABSTRACTAIM: To determine the concentrations of chemical characteristic to extracts of leaves and flowers of Hypericum perforatnm (St John’s wort) in a number of selected samples and, following chemical characterization, to investigate the effects of these extracts on several pharmacological properties including effects of the extracts on inhibition of 5-hydroxytryptamine (5-HT) uptake and on an-tioxidant properties. METHODS: The samples were analyzed for the presence of characteristic chemicals by high performance liquid chromatography (HPLC) directly coupled to ultraviolet wavelength absorbance and positive or negative mode electrospray mass spectrometric detection. The effects of extracts on 5-HT uptake were determined by quantifying 3H-5-HT incorporation into rat hip-pocampal prisms. Estimates of effects of extracts on free radical | B Duff SLOLEY Liana J URICHUK LING Lei GU Lie-Dong Ronald T COUTTS Peter K T PANG Jacqueline J SHAN | 2000 | Acta Pharmacologica Sinica2000，21，12： | 2 |
| 7 | Cortical neurogenesis in adult rats after transient middle cerebral artery occlusion显示文摘 | Jiang W Gu WG Brannstrom T | 2001 | Stroke2001，32，： | 2 |
| 8 | A New Implementation of the Element-Free Galerkin Method显示文摘 | Belytschko T Lu YY Gu L | 1994 | Comput Methods Appl Mech Engrg1994，113，： | 1 |
| 9 | Element-free Galerkin methods显示文摘 | LiuY Y Gu L | 1994 | International Journal for Numerical Methods in Engineering1994，37，： | 1 |
| 10 | A point interpolation method for two-dimension solids显示文摘 | Gu Y T | 2001 | International Journal for Numerical Methods in Engineering2001，50，： | 1 |
| 11 | Divergent tumor necrosis factor receptor-related remodeling responses in heart failure:role of nuclear factor-kappa B and inflammatory activation显示文摘 | Hamid T Gu Y Ortines R V | 2009 | Circulation2009，119，10： | 1 |
| 12 | Pneumonia in acute respiratory distress syndrome 显示文摘 | Meduri GU Reddy RC Stanley T | 1998 | Am J Respir Crit CareMed1998，158，5： | 1 |
| 13 | Mechanisms involved in development of resistance to adenovirus-mediated proapoptotic gene therapy in DLD1 human colon cancer cell line显示文摘 | Zhang L Gu J Lin T | 2002 | Gene Ther2002，9，18： | 1 |
| 14 | Tumor suppressor PTEN inhibition of cell invasion,migration,and growth:differential involvement of focal adhension kinase and p130Cas显示文摘 | Tamura M Gu J Kakino T | 1999 | Cancer Res1999，59，2： | 1 |
| 15 | Metabolite concentration rati- os in thalami of patients with migraine and trigeminal neu- ralgia measured with 1 H-MRS 显示文摘 | Gu T Ma XX Xu YH | 2008 | Neurol Res2008，30，3： | 1 |
| 16 | Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer显示文摘 | Reiter RE Gu Z Watabe T | 1998 | Proceedings of the National Academy of Sciences of the United States of America1998，95，4： | 1 |
| 17 | To,z'oplasma gondii immune mapped protein 1 (TglMP1) is a novel vaccine candidate against toxoplasmosis 显示文摘 | Gu Lei T Yang 1) | 2012 | Vaccine2012，30，22： | 1 |
| 18 | A state of the art review on microbi- al fuel cells: A promising technology for wastewater treatment and bioenergy 显示文摘 | Du Z Li H Gu T | 2007 | Biotechnol Adv2007，25，： | 1 |
| 19 | Element free Galerkin methods显示文摘 | Belytschko T Lu Y Y Gu L | | 0，，： | 1 |
| 20 | On the design of two-dimensional cellular metals for combined heat dissipation and structural load capacity显示文摘 | Gu S Lu T Evans A | | 0，，： | 1 |
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