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| 1 | 乳腺癌组织中TP和TS及DPD mRNA表达与预后的关系显示文摘目的 探讨乳腺癌组织中胸苷酸化酶 (TP)、胸苷酸合成酶 (TS)和二氢嘧啶脱氢酶(DPD)mRNA表达水平及其与预后的关系。方法 采用real time定量PCR技术检测经过微选的 9例正常乳腺组织和 86例乳腺癌组织TP、TS和DPD的mRNA表达水平。结果 肿瘤组织中TP、TS和DPDmRNA表达水平中位数分别为 16 .5 4 ,0 .38和 2 .74 ,正常乳腺组织分别为 11.75 ,0 .2 5和 8.33,差异均无显著性 (P >0 .0 5 )。除年龄与DPD表达呈负相关外 ,TP、TS和DPDmRNA表达与肿瘤体积、淋巴结转移、组织学分级、临床分期均无相关性。TP、DPD高表达组和低表达组之间 ,无瘤生存期和总生存期差异均无显著性。TS高表达组和低表达组无瘤生存期差异无显著性 (P =0 .0 6 9) ;平均总生存期分别为 5 9.0 0和 70 .30个月 ,差异有显著性 (P =0 .0 4 96 )。结论 仅检测TSmRNA对判断乳腺癌预后有参考价值 ,同时检测TP、TS和DPD具有更好的预测价值。 | 李惠翔 Suo ZH 张云汉 Bjrn Risberg Mats G Karlsson Jahn M Nesland | 2004 | 中华肿瘤杂志2004，26，11： | 9 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Mapping aboveground biomass and its prediction uncertainty using LiDAR and field data, accounting for tree-level allometric and LiDAR model errors显示文摘Background: The increasing availability of remotely sensed data has recently challenged the traditional way of performing forest inventories, and induced an interest in model-based inference. Like traditional design-based inference, model-based inference allows for regional estimates of totals and means, but in addition for wall-to-wall mapping of forest characteristics. Recently Light Detection and Ranging(LiDAR)-based maps of forest attributes have been developed in many countries and been well received by users due to their accurate spatial representation of forest resources. However, the correspondence between such mapping and model-based inference is seldom appreciated. In this study we applied hierarchical model-based inference to produce aboveground biomass maps as well as maps of the corresponding prediction uncertainties with the same spatial resolution. Further, an estimator of mean biomass at regional level, and its uncertainty, was developed to demonstrate how mapping and regional level assessment can be combined within the framework of model-based inference.Results: Through a new version of hierarchical model-based estimation, allowing models to be nonlinear, we accounted for uncertainties in both the individual tree-level biomass models and the models linking plot level biomass predictions with LiDAR metrics. In a 5005 km2 large study area in south-central Sweden the predicted aboveground biomass at the level of 18 m×18 m map units was found to range between 9 and 447 Mg·ha^-1. The corresponding root mean square errors ranged between 10 and 162 Mg·ha^-1. For the entire study region, the mean aboveground biomass was 55 Mg·ha^-1 and the corresponding relative root mean square error 8%. At this level 75%of the mean square error was due to the uncertainty associated with tree-level models.Conclusions: Through the proposed method it is possible to link mapping and estimation within the framework of model-based inference. Uncertainties in both tree-level biomass models and models linking plot level biomass with LiDAR data are accounted for, both for the uncertainty maps and the overall estimates. The development of hierarchical model-based inference to handle nonlinear models was an important prerequisite for the study. | Svetlana Saarela AndréWästlund Emma Holmström Alex Appiah Mensah Sören Holm Mats Nilsson Jonas Fridman Göran Ståhl | 2020 | Forest Ecosystems2020，7，3： | 3 |
| 4 | Biomarkers of Coagulation, Inflammation, and Angiogenesis are Independently Associated with Preeclampsia显示文摘 | Roland Boij Judit Svensson Kristina Nilsson‐Ekdahl Kerstin Sandholm Tomas L. Lindahl Elzbieta Palonek Mats Garle G?ran Berg Jan Ernerudh Maria Jenmalm Leif Matthiesen | 2012 | Am J Reprod Immunol2012，，3： | 2 |
| 5 | Numerical simulation of axi - symmetric fire plumes : accuracy and limitations 显示文摘 | MAT G QUINTIERE J G | 2003 | Fire Safety Journal2003，38，： | 1 |
| 6 | Assodation between surges of follicle stimulating hormone and the emergence of follicular waves in heifers显示文摘 | Adams G P Matted R L Kastellc J Pt | 2002 | J Reprod Fertil2002，94，： | 1 |
| 7 | Dependence of stimulated Brillouin scattering in multimode fibers on beam quality,pulse duration,and coherence length显示文摘 | Lopez Q M Sheila G Sverker H | 2003 | Journal of Optical Society of America B2003，20，3： | 1 |
| 8 | Environmental Brownian noise suppresses explosions in populations dynamics显示文摘 | Mat X Marion G Renshaw E | 2002 | Stochastic Process Appl2002，97，： | 1 |
| 9 | Process considerations and economic evaluation of two-stepsteam pretreatment for production of fuel ethanol from softwood显示文摘 | Wingren A Soderstrolm J Mats G | 2004 | Biotechnol Prog2004，20，5： | 1 |
| 10 | Scalability of multiwavelength switching networks: Crosstalk analysis显示文摘 | Popp L C Mats G | 1999 | Journal of lightwave technology1999，17，1： | 1 |
| 11 | Cytokine Response in Cerebrospinal Fluid after Brith Asphyxia显示文摘 | Karin S Mats B Katarina G | 1998 | Pediatr Res1998，43，6： | 1 |
| 12 | Expression of Iipoprotein lipase in ovaries of the guinea pig 显示文摘 | Laura C Mats G Manuel R | 1990 | Biol Reprod1990，42，： | 1 |
| 13 | A first-order statistical method for channel estimation 显示文摘 | G Tong Zhou Mats Viberg Tomos McKeley | 2003 | IEEE Signal Processing Letters2003，10，： | 1 |
| 14 | Universal computation in simple one-dimensional cellular automata 显示文摘 | Kristian Lindgren Mats Nordahl G | 1990 | Complex Systems1990，4，： | 1 |
| 15 | Randomized controlled trial of cogni- tive behavioral therapy vs standard treatment to prevent recur- rent cardiovascular events in patients with coronary heart disease 显示文摘 | Mats G Gunilla B Bengt V | 2011 | Arch Intern Med2011，171，2： | 1 |
| 16 | Lubricant replenishment in rolling bearing contacts显示文摘 | Leonid G Mats G L Piet M L | 2008 | STLE Trans2008，51，： | 1 |
| 17 | Deep modulation technique for optical phase detection显示文摘 | G Heinzel F Guzmán Cervantes A F García Matín | 2010 | Opt Express2010，，4： | 1 |
| 18 | Bile Acid Synthesis in Humans Has a Rapid Diurnal Variation That Is Asynchronous With Cholesterol Synthesis显示文摘 | Cecilia G?lman Bo Angelin Mats Rudling | 2005 | Gastroenterology2005，，5： | 1 |
| 19 | Stabilization of chaos by proportional pulses in the system variables 显示文摘 | G UE MEZ J | 1994 | Phys Rev Lett1994，72，： | 1 |
| 20 | Inferences on the common mean of several inverse Gaussian populations 显示文摘 | YE R D MAT F WANG S G | 2010 | Computational Statistics and Date Analysis2010，54，： | 1 |
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