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| 1 | microRNA-181b targets MLK2 in HL-60 cells显示文摘microRNAs(miRNAs) play critical roles in many different cellular processes,including metabolism,apoptosis,differentiation and development.We showed miR-181b to be highly expressed in acute myeloid leukemia(AML).Furthermore,miR-181b contributed to proliferation of AML cells by targeting MLK2.Our results demonstrated that miR-181b plays an important role in the biology of AML and may be useful in developing therapies targeting miRNAs. | CHEN Hong1,CHEN Qun2,FANG Ming3 & MI Yan1 1 The First Affiliated Hospital of Harbin Medical University,Harbin 150101,China 2 Harbin Acheng District People’s Hospital,Harbin 150300,China 3 Graduate Department of Harbin Medical University,Harbin 150001,China | 2010 | Science China(Life Sciences)2010，53，1： | 20 |
| 2 | Differences in atheroma between Caucasian and Asian subjects with anterior stroke:A vessel wall MRI study显示文摘Background and purpose While extracranial carotid artery stenosis is more common among Caucasians and intracranial artery stenosis is more common among Asians,the differences in atherosclerotic plaque characteristics have not yet been extensively examined.We sought to investigate plaque location and characteristics within extracranial carotid and intracranial arteries in symptomatic Caucasians and Chinese using vessel wall MRI.Methods Subjects with recent anterior circulation ischaemic stroke were recruited and imaged at two sites in the USA and China using similar protocols.Both extracranial carotid and intracranial arteries were reviewed to determine plaque location and characteristics.Results The prevalence of extracranial carotid plaque in Caucasians and Chinese was 73.1%and 49.1%,respectively(p=0.055).Prevalence of intracranial plaque was 38.5%and 69.1%in Caucasians and Chinese,respectively(p=0.02).Furthermore,42% of Caucasians and 16%of Chinese had high-risk plaque(HRP)features(intraplaque haemorrhage,luminal surface disruption)in the extracranial carotid artery(p=0.03).The prevalence of HRP features in intracranial arteries was not significantly different between the two cohorts(4%vs 11%;p=0.42).Conclusions Differences in the location and characteristics of cerebrovascular atherosclerosis were identified by vessel wall MRI in US Caucasian and Chinese subjects with recent anterior circulation ischaemic stroke.Extracranial carotid plaques with HRP features were more common in Caucasians.Intracranial plaques were more common in Chinese subjects,but no significant difference between the two cohorts in intracranial HRP prevalence was found.Larger studies using vessel wall imaging to investigate racial differences in cerebrovascular disease may inform underlying mechanisms of HRP development and may ultimately help guide appropriate therapy. | Hiroko Watase Mi Shen Binbin Sui Peiyi Gao Dong Zhang Jie Sun Niranjan Balu Daniel S Hippe Gail P Jarvik Xihai Zhao Rui Li Shuo Chen Chun Yuan Thomas S Hatsukami | 2021 | Stroke & Vascular Neurology2021，6，1： | 4 |
| 3 | Frequency and prognostic role of mucosal healing in patients with Crohn's disease and ulcerative colitis after one-year of biological therapy显示文摘AIM:To assess the endoscopic activity before and after a one-year period of biological therapy and to evaluate the frequency of relapses and need for retreatment after stopping the biologicals in patients with Crohn’s disease(CD)and ulcerative colitis(UC).METHODS:The data from 41 patients with CD and 22 patients with UC were assessed.Twenty-four CD patients received infliximab,and 17 received adalimumab.The endoscopic severity of CD was quantified with the simplified endoscopic activity score for Crohn’s disease in CD and with the Mayo endoscopic subscore in UC.RESULTS:Mucosal healing was achieved in 23 CD and7 UC patients.Biological therapy had to be restarted in78%of patients achieving complete mucosal healing with CD and in 100%of patients with UC.Neither clinical remission nor mucosal healing was associated with the time to restarting the biological therapy in either CD or UC.CONCLUSION:Mucosal healing did not predict sustained clinical remission in patients in whom the biological therapies had been stopped. | Klaudia Farkas Péter László Lakatos Mónika Szcs va Pallagi-Kunstár Anita Bálint Ferenc Nagy Zoltán Szepes Noémi Vass Lajos S Kiss Tibor Wittmann Tamás Molnár | 2014 | World Journal of Gastroenterology2014，20，11： | 2 |
| 4 | 定期运动有助于改善高血压患者蛋白质稳态、炎症和血管活性显示文摘体育锻炼是一种公认的非药物控制血压的策略,除了降低血压外,运动还能对高血压患者的炎症特征、自主功能、内皮功能和抗氧化状态产生积极的影响。但其对高血压患者的蛋白质稳态的影响尚不清楚。已有动物研究表明,运动训练干预可以改善蛋白质质量控制机制,但在动物模型中报告的积极作用仍有待于在人类身上得到证实。本研究旨在根据报告的运动习惯,评估患高血压成年人的蛋白质稳态,生活质量以及炎症、氧化应激和血管活性生物标记物状态。 | Teixeira M Gouveia M Duarte A Ferreira M Simões MI Conceição M Silva G Magalhães S Ferreira R Nunes A Vieira SI Ribeiro F 周卫(译) 叶鹏(审校) | 2020 | 中华高血压杂志2020，28，12： | 2 |
| 5 | Intraarticular hyaluronans:a review of product-specific safety profiles显示文摘 | Hamburger MI Lakhanpal S Mooar PA | | Seminars in Arthritis and Rheumatism0，，： | 2 |
| 6 | 循环脂肪因子与超声心动图测量的心脏结构和功能的关系:基于社区的队列研究显示文摘脂肪因子介导与肥胖相关的心脏代谢风险,但它们在肥胖相关心力衰竭的发病机制中的作用仍然不确定。von Jeinsen等调查了社区样本中循环脂肪因子浓度与超声心动图测量的心功能和结构指标之间的关联。研究纳入3514名Framingham心脏研究参与者(平均年龄40岁,53.8%为女性). | 刘莉 叶鹏 von Jeinsen B Short MI Xanthakis V Carneiro H Cheng S Mitchell GF Vasan RS | 2018 | 中华高血压杂志2018，26，8： | 2 |
| 7 | Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients显示文摘AIM:To investigate the interaction of interleukin-23 receptor(IL23R)(rs1004819 and rs2201841),autophagy-related 16-like 1(ATG16L1)(rs2241880), caspase recruitment domain-containing protein 15 (CARD15)genes,and IBD5 locus in Crohn's disease(CD) patients. METHODS:A total of 315 unrelated subjects with CD and 314 healthy controls were genotyped.Interactions and specific genotype combinations of a total of eight variants were tested.The variants of IBD5locus(IGR2198a_1 rs11739135 and IGR2096a_1 rs12521868),CARD15(R702W rs2066845 and L1007fs rs2066847),ATG16L1(rs2241880)and IL23R (rs1004819,rs2201841)genes were genotyped by PCR-RFLP,the G908R(rs2066844)in CARD15 was determined by direct sequencing. RESULTS:The association of ATG16L1 T300A with CD was confirmed[P=0.004,odds ratio(OR)=1.69, 95%CI:1.19-2.41],and both IL23R variants were found to represent significant risk for the disease(P= 0.008,OR=2.05,95%CI:1.20-3.50 for rs1004819 AA;P<0.001,OR=2.97,95%CI:1.65-5.33 for rs2201841 CC).Logistic regression analysis of pairwise interaction of the inflammatory bowel disease (IBD)loci indicated that IL23R,ATG16L1,CARD15 and IBD5(IGR2198a_1)contribute independently to disease risk.We also analysed the specific combina- tions by pair of individual ATG16L1,IL23R rs1004819, rs2201841,IGR2198a_1,IGR2096a_1 and CARD15 genotypes for disease risk influence.In almost all cases,the combined risk of susceptibility pairs was higher in patients carrying two different risk-associated gene variants together than individuals with just one polymorphism.The highest OR was found for IL23R rs2201841 homozygous genotype with combination of positive CARD15 status(P<0.001,OR=9.15,95% CI:2.05-40.74). CONCLUSION:The present study suggests a cumulative effect of individual IBD susceptibility loci. | Veronika Csngei Luca Járomi EnikSáfrány Csilla Sipeky Lili Magyari Bernadett Faragó Judit Bene Noémi Polgár Lilla Lakner Patrícia Sarlós Márta Varga Béla Melegh | 2010 | World Journal of Gastroenterology2010，16，2： | 2 |
| 8 | Worldwide time trends in the prevalence of symptoms of asthma, allergic rhino- conjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys 显示文摘 | Asher MI Montefort S Bjorksten B | 2006 | Lancet2006，368，： | 1 |
| 9 | Troy/Taj and its role in CNS axon regeneration显示文摘 | Mi S | 2008 | Cytokine Growth Factor Rev2008，19，34： | 1 |
| 10 | Serum paraoxonase after myocardial infarction显示文摘 | Ayub A Mackness MI Arrol S | 1999 | ArteriosclerThmmb vasc Biol1999，19，2： | 1 |
| 11 | 显示文摘 | Matsui S Fu MI Havase M | 2001 | J Cardiovasc Pharmacol2001，38，1： | 1 |
| 12 | Application of proliferation ( PCNA ) immunostaining in gastric carcinoma显示文摘 | Jain S Filipe MI Hall PA | 1990 | J Pathol1990，161，3： | 1 |
| 13 | New filtration process cuts contaminants from offshore produced water 显示文摘 | Mi S A Henry L R Darlington J W | 1998 | Oil and Gas Journal1998，96，44： | 1 |
| 14 | LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG- induced experimental autoimmune encephalomyelitis 显示文摘 | Mi S Hu B Hahm K | 2007 | Nat Med2007，13，10： | 1 |
| 15 | Endothelial cell colonization and angiogenic potential of combined nano- and micro -fibrous scaffolds for bone tissue engineering 显示文摘 | Santos MI Tuzlakoglu K Fuchs S | 2008 | Biomaterials2008，29，32： | 1 |
| 16 | Asymmetric chitosan membranes prepared by dry/wet phase separation:a new type of wound dressing for controlled antibacterial release显示文摘 | Mi F L Wu Y B Shyu S S | 2003 | J Memb Sci2003，212，12： | 1 |
| 17 | Vancomycin-resitant enterocoeei in a Chinese hospital 显示文摘 | Li S Zhang Z Mi ZH | 2007 | Curr Microbio12007，55，2： | 1 |
| 18 | Genetic variation of the prevailing porcine respiratory and reproductive syndrome viruses occurring on a pig farm upon vaccination显示文摘 | I. Kiss L. Sámi S. Kecskeméti K. Hanada | 2006 | Archives of Virology2006，，11： | 1 |
| 19 | EULA R/PReS endorsed con- sensus critena for the classification of childhood vasculitldes 显示文摘 | Ozen S Ruperto N Dillon MI | 2006 | Ann Rheum DIS2006，65，7： | 1 |
| 20 | The formation of a tissue-engineered cornea using plastically compressed collagen scaffolds and limbal stem cells显示文摘 | Mi S Connon CJ | | 0，，： | 1 |
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