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| 1 | 维生素D对心力衰竭患者全因死亡率的影响:4000U/d维生素D口服3年随机临床试验结果显示文摘循环25-羟基维生素D[25-hydroxyvitamin D,25(OH)D]〈75nmol/L与死亡率风险的非线性增加相关。这种低25(OH)D水平在心力衰竭患者中很常见。因此,Zittermann等进行研究检查口服维生素D补充剂能否降低晚期心力衰竭患者的死亡率。 | 刘莉 叶鹏 Zittermann A Ernst JB Prokop S Fuchs U Dreier J Kuhn J Knabbe C Birschmann I Schulz U Berthold HK Pilz S Gouni-Berthold I Gummert JF Dittrich M Brgermann J | 2017 | 中华高血压杂志2017，25，10： | 7 |
| 2 | 标准辅助化疗基础上增加塞来昔布或安慰剂对Ⅲ期结肠癌患者无复发生存的疗效对比研究:CALGB/SWOG 80702(Alliance)随机对照研究显示文摘背景:既往观察性和随机对照研究已表明阿司匹林和环氧化酶-2(COX-2)抑制剂可降低肠道息肉和肠癌的发生风险。COX-2抑制剂塞来昔布治疗非转移性结肠癌的效果尚未明确。目的:本研究旨在明确FOLFOX辅助化疗基础上增加塞来昔布是否能提高Ⅲ期结肠癌患者的无复发生存率。方法:本研究为在美国、加拿大的654个中心开展的采用2×2析因设计的Ⅲ期临床研究,从2010年6月至2015年11月共纳入2526例Ⅲ期结肠癌患者,随访时间截止为2020年8月10日。以化疗时长和是否接受塞来昔布治疗作为2个随机因素,入组患者被随机分配接受3个月或6个月的FOLFOX辅助化疗(每两周1次)及随机接受联合3年塞来昔布(400 mg QD,n=1263)或安慰剂(n=1261)治疗。主要终点测量指标为3年无复发生存率(DFS),次要终点测量指标包括总生存、不良反应及心血管特异性不良事件。本次仅报道以是否接受塞来昔布治疗的随机分组研究结果。结果:入组患者平均年龄(61±11)岁,1134例(44.9%)为女性,最终2524例被纳入初步分析。患者治疗方案依从性(即接受塞来昔布或安慰剂治疗2.75年以上或持续治疗至复发、死亡或不可接受的不良事件)在塞来昔布组和安慰剂组分别为70.8%和69.9%。经过6年中位随访期,塞来昔布组和安慰剂组各有337例和363例患者出现疾病复发或死亡,3年无复发生率分别为76.3%和73.4%(疾病复发或死亡风险比HR=0.89,95%CI:0.76~1.03,P=0.12)。塞来昔布治疗对DFS的影响不会因辅助化疗时长(3个月或6个月)而存在差异(交互作用P=0.61)。两组5年生存率分别为84.3%和81.6%(死亡风险比HR=0.86,95%CI:0.72~1.04,P=0.13)。任何级别的高血压病发生率在塞来昔布组和安慰剂组分别为14.6%和10.9%,而2级或以上肌酐水平升高的发生率在两组分别为1.7%和0.5%。结论:对于Ⅲ期结肠癌患者,在标准辅助化疗的基础上联合3年塞来昔布治疗与安慰剂比较,对患者无复发生存率的改善不明显。 | 邱萌 MEYERHARDT J A SHI Q FUCHS C S | 2021 | 结直肠肛门外科2021，27，3： | 6 |
| 3 | Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial显示文摘 | Charles S Fuchs Jiri Tomasek Cho Jae Yong Filip Dumitru Rodolfo Passalacqua Chanchal Goswami Howard Safran Lucas Vieira dos Santos Giuseppe Aprile David R Ferry Bohuslav Melichar Mustapha Tehfe Eldar Topuzov John Raymond Zalcberg Ian Chau William Campbell | 2014 | The Lancet2014，，9911： | 3 |
| 4 | Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial显示文摘 | Charles S Fuchs Jiri Tomasek Cho Jae Yong Filip Dumitru Rodolfo Passalacqua Chanchal Goswami Howard Safran Lucas Vieira dos Santos Giuseppe Aprile David R Ferry Bohuslav Melichar Mustapha Tehfe Eldar Topuzov John Raymond Zalcberg Ian Chau William Campbell | 2014 | 2014 (9911)2014，，9911： | 2 |
| 5 | Differential expression of cell surface and dense granule-associated Neospora caninum proteins in tachyzoites and bradyzoites 显示文摘 | Fuchs N Sonda S Gottstein B | 1998 | Parasitol1998，84，： | 1 |
| 6 | Breakage of tolerance to hidden cyto plasmic epitopes of the acetylcholine receptor in experimental autoimmune myasthenia gravis显示文摘 | Feferman T Im SH Fuchs S | 2003 | Neuroimmunol2003，140，12： | 1 |
| 7 | Ex vivo generated regulatory T cells modulate experimental autoimmune myasthenia gravis 显示文摘 | Aricha R Feferman T Fuchs S | 2008 | J Immunol2008，180，4： | 1 |
| 8 | Sonographic evaluation of ACL rupture signs compared to arthroscopic findings in acutely injured knees显示文摘 | Fuchs S Chylarecki C | 2002 | Ultrasound Med Biol2002，28，2： | 1 |
| 9 | Interspecies comparison of neuroglobin, cytoglobin and myoglobin: sequence evolution and candidate regulatory elements显示文摘 | WYSTUB S EBNER B FUCHS C | 2004 | Cytogenet Genome Res2004，105，1： | 1 |
| 10 | Transendocardial delivery of autologous bone marrow enhances collateral perfusion and regional function in pigs with chronic experimental myocardial ischemia显示文摘 | Fuchs S Baffour R Zhou YF | 2001 | J Am Coll Cardiol2001，37，6： | 1 |
| 11 | Therapeutic interventions for enhancing collateral development by administration of growth factors:basic principles, early results and potential hazards 显示文摘 | EPSTEIN S E FUCHS S ZHOU Y F | 2001 | Cardiovasc Res2001，49，： | 1 |
| 12 | Th ree-dimensional solution structure of the complex of A-bungarotoxin with a library-derivedpep tide 显示文摘 | Tall Scherf Mo she Balass Sara Fuch s | 1997 | P roe N atl A cad Sei USA1997，94，12： | 1 |
| 13 | Microstructural evaluation of as - solidified and heat - treated γ- TiA1 based powders 显示文摘 | Fuchs G E Hayden S Z | 1992 | Materials Science and Engineering A1992，152，1： | 1 |
| 14 | Endothelial cell colonization and angiogenic potential of combined nano- and micro -fibrous scaffolds for bone tissue engineering 显示文摘 | Santos MI Tuzlakoglu K Fuchs S | 2008 | Biomaterials2008，29，32： | 1 |
| 15 | Nonmyeloablative bone marrow transplantation from partially HLA-mismatched related donors using posttransplantation cyclophosphamide显示文摘 | P.V O'Donnell L Luznik R.J Jones G.B Vogelsang M.S Leffell M Phelps P Rhubart K Cowan S Piantadosi E.J Fuchs | 2002 | Biology of Blood and Marrow Transplantation2002，，7： | 1 |
| 16 | Detoxification of patulin and ochratoxin A,two abundant mycotoxins,by lactic acid bacteria显示文摘 | Fuchs S Sontag G Stidl R | | 0，，04： | 1 |
| 17 | Management of Cervical Intraepithelial Neoplasia 2 in Adolescent and Young women显示文摘 | Fuchs K Weitzen S Wu L | 2007 | J pediatr Adolesc Gynecol2007，20，5： | 1 |
| 18 | Preservation of cranial nerve function following Gamma Knife radiosurgery for henign skull base meningiomas: experience in 121 patients with follow-up of 5 to 9-8 years 显示文摘 | Eustacchio S TrummerM Fuchs I | 2002 | Acta Neurochir2002，84，： | 1 |
| 19 | A family of vectors for surface display and production of antibodies显示文摘 | Dübel S Breitling F Fuchs P | 1993 | Gene1993，128，1： | 1 |
| 20 | Scale-up of dialysis fermentation for high celldensity cultivation of Escherichia coli显示文摘 | FUCHS C KOSTER D WIEBUSCH S etal | 2002 | Journal of Biotechnology2002，，93： | 1 |
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