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| 1 | NAT2 polymorphism in Omani gastric cancer patients-risk predisposition and clinicopathological associations显示文摘AIM: To study whether N-acetyltransferase 2 (NAT2) genotypes and phenotypes are associated with increased risk factor for gastric cancer in Omani patients and to study the clinico-pathological correlations and the prognostic signifi cance of NAT2.METHODS: Genomic DNA was extracted from peripheral blood of 100 gastric cancer patients and 100 control subjects. NAT2 genotyping was performed using DNA sequencing. The prognostic significance of NAT2 and other clinicopathological features was assessed by univariate and multivariate analyses.RESULTS: We observed no significant association between NAT2 genotypes and phenotypes and gastric cancer risk. The NAT2 phenotype polymorphisms and gastric cancer risk predisposition were not modified by concomitant H pylori infection and smoking. There was no significant association between NAT2 and clinicopathological features, and NAT2 had no independent prognostic signifi cance.CONCLUSION: In the current study, NAT2 genotypes and phenotypes are not associated with gastric cancer risk predisposition. Moreover NAT2 phenotypes had no clinicopathological associations or prognostic signif icance. | Mansour S Al-Moundhri Mohamed Al-Kindi Maryam Al-Nabhani Bassim Al-Bahrani Ikram A Burney Ali Al-Madhani Shyam S Ganguly Misbah Tanira | 2007 | World Journal of Gastroenterology2007，13，19： | 5 |
| 2 | Association of E-cadherin (CDH1) gene polymorphisms and gastric cancer risk显示文摘AIM:To investigate the associations between CDH1 gene polymorphisms and gastric cancer(GC) risk predisposition.METHODS:We analyzed four CDH1 polymorphisms(+54 T>C,-160 C>A,-616 G>C,-3159 T>C) in an Omani population,by extraction of genomic DNA from the peripheral blood of 192 patients with GC and 170 control participants and performed CDH1 genotyping using DNA sequencing.RESULTS:CDH1-160-AA genotype was associated with an increased risk of GC(OR = 3.6,95% CI:1.1-11.8)(P = 0.03).There was no significant association between the other polymorphisms and GC risk.The haplotype analysis of +54 T>C,-160 C>A,-616 G>C,-3159 T>C genotypes revealed that the OR of CCGC and CAGC haplotypes was 1.5(95% CI:0.7-3.5) and 1.5(95% CI:0.2-3.0),but did not reach statistical significance.CONCLUSION:The current study suggests that the-160 AA genotype was associated with an increased risk of GC in Oman. | Mansour S Al-Moundhri Manal Al-Khanbashi Mohammed Al-Kindi Maryam Al-Nabhani Ikram A Burney Abdulaziz Al-Farsi Bassim Al-Bahrani | 2010 | World Journal of Gastroenterology2010，16，27： | 4 |
| 3 | Differing profiles of people diagnosed with acute and chronic hepatitis B virus infection in British Columbia,Canada显示文摘AIM To describe the characteristics of people diagnosed with acute and chronic hepatitis B virus(HBV) infection in British Columbia(BC).METHODS We used data from the BC Hepatitis Testers Cohort(BCHTC),which includes all individuals tested for hepatitis C virus(HCV) or human immunodeficiency virus(HIV) or those diagnosed with HBV or active tuberculosis in BC since 1990.These data were integrated with prescription drug,medical visit,hospitalization and mortality data.HBV cases were classified as acute or chronic according to provincial guidelines.We compared characteristics of individuals by HBV infection group(acute,chronic and negative).Factors associated with acute or chronic HBV infection were assessed with multinomial logistic regression models in comparison to the HBV negative group.RESULTS46498 of the 1058056 eligible BC-HTC participants were diagnosed with HBV infection.4.3% of HBV positive individuals were diagnosed with acute HBV infections while 95.7% had chronic infections.Problematic alcohol use,injection drug use,and HIV or HCV co-infection were more common among individuals diagnosed with acute HBV compared to those with chronic infections and HBV negative individuals.In multivariable multinomial logistic regression models,we observed significant associations between acute or chronic HBV diagnosis and being male,age at HBV diagnosis or birth cohort,South and East Asian ethnicity,HCV or HIV infection,and injection drug use.The odds of acute HBV decreased with increasing age among people who inject drugs,while the opposite was true for chronic HBV.Persons with acute HBV were predominantly White(78%) while those with chronic HBV were mostly East Asian(60%).Relative to Whites,East Asians had 12 times greater odds of being diagnosed with chronic HBV infection.These odds increased with increasing socioeconomic deprivation.CONCLUSION Differences in the profiles of people diagnosed with acute and chronic HBV infection necessitate differentiated screening,prevention,care and treatment programs. | Mawuena Binka Zahid A Butt Stanley Wong Mei Chong Jane A Buxton Nuria Chapinal Amanda Yu Maria Alvarez Maryam Darvishian Jason Wong Gina McGowan Mikhail Torban Mark Gilbert Mark Tyndall Mel Krajden Naveed Z Janjua | 2018 | World Journal of Gastroenterology2018，24，11： | 3 |
| 4 | Infectious diseases in the aftermath of monsoon flooding in Pakistan显示文摘Pakistan is ranked 9th in terms of flood-affected countries worldwide.In the summer of 2010,the northern province of Khyber-Pakhtunkhwa received more than 312 mm of rain in a 56 hour period.This resulted in over 1 600 deaths across the region.In addition,over 14 million people were directly affected by this record-breaking deluge.Flood affected regions serve as ideal breeding grounds for pathogens,leading to the spread of diseases.The poor standards of hygiene in camps set up for individuals displaced by the floods also contribute to this.It is essential that those involved in relief efforts are aware of the epidemiology of diseases that have historically seen a sudden upsurge after natural disasters.Keeping this in mind,we conducted a simple review of literature.An extensive literature search was conducted using the PubMed data base and online search engines.Articles published in the last 20 years were considered along with some historical articles where a background was required.Seven major diseases were identified to increase substantially in the aftermath of natural disasters.They were then classified into acute and sub-acute settings.Diarrhea,skin&eye infections and leptospirosis were identified in the acute setting while malaria,leishmaniasis,respiratory infections and hepatitis were identified in the sub-acute setting. | Maryam Baqir Zain A Sobani Amyn Bhamani Nida Shahab Bham Sidra Abid Javeria Farook M Asim Beg | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，1： | 2 |
| 5 | Review: Knowledge management and knowledge management systems: conceptual foundations and research issues 显示文摘 | MARYAM A DOROTHY E L | 2001 | Management Information Systems Quarterly2001，25，1： | 1 |
| 6 | The efficacy of -opical diphency-prone in the treament of alopecia areata 显示文摘 | Maryam A Hassan S Farshad F | 2009 | Indian Dematol2009，54，1： | 1 |
| 7 | Effectiveness of educational programs based on Pender's theory on the health and symptoms in patients with obsessive-compulsive disorder显示文摘 | Maryam R Tahereh A Leila N | 2012 | Life Science2012，9，4： | 1 |
| 8 | Casting the Net : A Multimodal Network Perspective on User-System Interactions 显示文摘 | GERALD C K MARYAM A | 2008 | Information Systems Research2008，19，3： | 1 |
| 9 | Risk factors of lymph edema in breast cancer patients显示文摘 | Shahpar H Atieh A Maryam A | 2013 | Int J Breast Cancer2013，2013，64： | 1 |
| 10 | Serum uric acid level in patients with relapsing-remitting multiple sclerosis 显示文摘 | Fereshteh A Mohammadali B Maryam A | 2013 | Journal of Clinical Neuroscience2013，20，5： | 1 |
| 11 | PPARγ signaling and metabolism: the good, the bad and the future 显示文摘 | Maryam A Jae MS Nasun H | 2013 | Nat Med2013，19，5： | 1 |
| 12 | Review:knowledge management and knowledge management systems:conceptual foundations and research issues显示文摘 | Maryam A Dorothy E L | 2001 | Management Information Systems Quarterly2001，25，1： | 1 |
| 13 | Pruritus in hemodialysis patients显示文摘 | Maryam A Mohammad-Reza G Nasrin S | 2005 | BMC Dermatology2005，5，： | 1 |
| 14 | Automatic denoising of single-trial evoked potentials 显示文摘 | Maryam A Rodrigo Q Q | 2013 | Neurolmage2013，66，10： | 1 |
| 15 | Review: Knowledge Management and Knowledge Management Systems:Conceptual Foundations and Research Issues显示文摘 | Maryam A Dorothy E L | 2001 | Management Information Systems Quarterly2001，25，1： | 1 |
| 16 | Knowledge integration in virtual teams : The potential role of KMS显示文摘 | MARYAM A AMRIT T | 2002 | Journal of the American Society for Information Science and Technology2002，53，12： | 1 |
| 17 | Leisure Time Physical Activity and Its Determinants among Adults in Tehran 显示文摘 | AMIR A M MARYAM D PARVIN M | 2011 | Tehran Lipid and Glucose StudyInt J Prev Med2011，2，4： | 1 |
| 18 | Recanalization therapy for acute ischemic stroke, part 1: surgical emboletomy and cheemical thtombolysis 显示文摘 | Aaeed A Maryam R Michael F | 2011 | Neurosurg Rev2011，34，11： | 1 |
| 19 | Determing of Factors Influencing the Success and Failure of HospitaI Information System and Their Evaluation Methods:A Systematic Review显示文摘 | Farahnaz S Khalil K Maryam A | 2013 | lran Red Cres Med2013，15，2： | 1 |
| 20 | Performance comparison oftime slot allocation schemes in TDD-CDMA multihopcellular networks 显示文摘 | Maryam A Hong Peter H | 2012 | Wireless Personal Communica-tions2012，62，3： | 1 |
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