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| 1 | DNA甲基化和E-cadherin基因甲基化与胃癌关系研究进展显示文摘目的:总结DNA甲基化和E-cadherin基因甲基化与胃癌关系的研究现状。方法:应用PubMed及万方数据知识服务平台检索系统,以'胃癌、DNA甲基化、E-钙黏蛋白基因和CpG岛'等为关键词,检索1979-01-2013-05的相关文献,共检索到英文文献2 093篇,中文文献672篇。纳入标准:1)关键词包括胃癌及DNA甲基化;2)文中包括E-钙黏蛋白基因启动子区CpG岛甲基化。剔除标准:1)非E-钙黏蛋白基因启动子区CpG岛的甲基化;2)关键词有E-钙黏蛋白但文中无甲基化描述。符合纳入标准的中文文献56篇,英文文献43篇,根据剔除标准剔除中文文献46篇,英文文献23篇,最后纳入分析30篇文献。结果:DNA甲基化在基因表达、调控过程中发挥重要作用,其功能紊乱在恶性肿瘤形成过程中具有重要作用,与胃癌的发生密切相关。E-cadherin基因能抑制肿瘤细胞的浸润和转移,E-cadherin基因启动子区CpG岛甲基化是胃肠道肿瘤E-cadherin基因失活的主要原因,可引起E-cadherin表达下降或缺失,与胃癌的发生、浸润、转移和预后密切相关。结论:DNA甲基化和E-cadherin基因甲基化与胃癌的形成、浸润和转移等关系密切,但其要成为胃癌防治的靶点仍需进一步研究。 | 李新源 郭亚民 吴新民 | 2014 | 中华肿瘤防治杂志2014，21，12： | 9 |
| 2 | Perspectives on new biomarkers in gastric cancer: Diagnostic and prognostic applications显示文摘Gastric cancer is considered one of the most deadly tumors worldwide. Even with the decline in its incidence, the mortality rate of this disease has remained high, mainly due to its late diagnosis and to the lack of precise prognostic markers. The main purpose of this review is to present genetic, epigenetic and proteomic molecular markers that may be used in a diagnostic and prognostic manner and to discuss the pros and cons of each type of marker for improving clinical practice. In this sense, we observed that the use of genetic markers, especially mutations and polymorphisms, should be carefully considered, as they are strongly affected by ethnicity. Proteomic-based markers show promise, but the higher costs of the associated techniques con-tinue to make this approach expensive for routine use. Alternatively, epigenetic markers appear to be very promising, as they can be detected in bodily fluids as well as tissues. However, such markers must be used carefully because epigenetic changes may occur due to environmental factors and aging. Despite the advances in technology and its access, to date, there are few defined biomarkers of prognostic and diagnostic use for gastric tumors. Therefore, the use of a panel of several approaches(genetic, epigenetic and proteomic) should be considered the best alternative for clinical practice. | Danilo do Rosário Pinheiro Wallax Augusto Silva Ferreira Mariceli Baia Leo Barros Mariana Diniz Araújo Symara Rodrigues-Antunes Bárbara do Nascimento Borges | 2014 | World Journal of Gastroenterology2014，20，33： | 4 |
| 3 | 胃癌患病风险基因研究进展显示文摘胃癌是我国常见的恶性肿瘤,其致病因素涉及环境及遗传等多种因素的相互作用。本文对胃癌患病风险有关的代谢酶相关基因、解毒酶基因、免疫相关基因、DNA修复基因、原癌基因及抑癌基因的研究进展作一综述。 | 李龙 李静 郑燕芳 张积仁 | 2014 | 肿瘤防治研究2014，41，5： | 4 |
| 4 | CDH1 C-160A基因多态性与胃肠道肿瘤危险性的Meta分析显示文摘目的:综合评价上皮钙黏着蛋白基因CDH1C-160A基因多态性同大肠癌与胃癌危险性的关系。方法:通过PubMed等数据库检索文献,获得有关上皮钙黏着蛋白基因CDH1C-160A多态性同大肠癌与胃癌危险性关系的研究结果,并进行Meta分析。所有文献均采用病例对照研究或者巢式病例对照研究,以OR值为效应指标,对文献进行评价筛选、异质性检验。利用Meta分析软件RevMan5.0对各研究原始结果进行统计处理,并计算合并OR值及其95%可信区间。结果:Meta分析共纳入23项研究,累计病例6659例,对照17739例。CC&CA与AA基因型比较,OR值为OR=0.89(95%CI:0.81~0.97),Z值为:2.63。结论:上皮钙黏着蛋白基因CDH1C-160A多态性同胃肠道肿瘤危险性有统计学关联。 | 陈德钦 田俊 | 2011 | 数理医药学杂志2011，24，6： | 0 |
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