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| 1 | Characterization of cytotoxic compound from mangrove derived fungi Irpex hydnoides VB4显示文摘Objective:To investigate the cytotoxic activity of endophytic fungi isolated from mangrove fungi.Methods:In the present study the DNA was isolated and the ITS region of 5.8s rRNA was amplified using specific primers ITS 1 and ITS4 and sequence was determined using automated sequencers.Blast search sequence similarity was found against the existing non redundant nucleotide sequence database thus,identified as Aspergilus flavus,Hyporcaea lixii,Aspergillus niger,Eutorium amstelodami,Irpex hydnoides and Neurospora crassa.Among the seven isolates, one fungi Irpex hydnoides was selected for further studies.The fungi were grown in sabouraud broth for five days and filtrate were separated and subjected to ethyl acetate for further studies. Results:Nearly half(49.25%) of the extracts showed activity(IC_(50) of 125 μ g/mL).These values were within the cutoff point of the National Cancer Institute criteria for cytotoxicity(IC_(50)<20 μ g/mL) in the screening of crude plant extracts.The GC MS analysis revealed that the active principals might be Tetradecane(6.26%) with the RT 8.606.Conclusions:It is clear from the present study that mangrove fungi with bioactive metabolites can be expected to provide high quality biological material for high throughout biochemical,anti cancer screening programmes.The results help us conclude that me potential of using metabolic engineering and post genomic approaches to isolate more novel bioactive compounds and to make their possible commercial application is not far off. | B Valentin Bhimba DA Agnel Defora Franco Geena Mary Jose Jibi Merin Mathew Elsa Lycias Joel | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，3： | 3 |
| 2 | Non-invasive vagus nerve stimulation in healthy humans reduces sympathetic nerve activity显示文摘 | Clancy JA Mary DA Witte KK | 2014 | Brain Stimul2014，7，6： | 1 |
| 3 | Management of single fetal demise in a muhiple gestation 显示文摘 | Jane CG Mary DA | 2004 | Obstet Gynecol Surv2004，59，4： | 1 |
| 4 | Asymptomatic dogs are highly competent to transmit Leishmania ( Leishmania ) infantum chagasi to the natural vector显示文摘 | Márcia Dalastra Laurenti Claudio Nazaretian Rossi Vania Lúcia Ribeiro da Matta Thaise Yumie Tomokane Carlos Eduardo Pereira Corbett Nágila Francinete Costa Secundino Paulo Filemon Paulocci Pimenta Mary Marcondes | 2013 | Veterinary Parasitology2013，，： | 1 |
| 5 | Phytochemical study guided by the myorelaxant activity of the crude extract, fractions and constituent from stem bark of Hymenaea courbaril L.显示文摘 | Gabrieli Penha Bezerra Roberto Wagner da Silva Góis Teresinha Silva de Brito Francisco José Batista de Lima Mary Anne Medeiros Bandeira Nirla Rodrigues Romero Pedro Jorge Caldas Magalh?es Gilvandete Maria Pinheiro Santiago | 2013 | Journal of Ethnopharmacology2013，，： | 1 |
| 6 | Influence of sterichindrance on the reactivity and kinetics of molten stateradical polymerization of binary bismaleimide-diamine systems 显示文摘 | Marie Florence Grenier Loustalot Louis Da Cunha | 1998 | Polymer1998，39，10： | 1 |
| 7 | Preoperative rectal tumor embolization as an adjunctive tool for bloodless abdominoperineal excision:A case report显示文摘BACKGROUND Abdominoperineal excision(APE)-related hemorrhage can be challenging due to difficult access to pelvic organs and the risk of massive blood loss.The objective of the present study was to demonstrate the use of preoperative embolization(PE)as a strategy for blood preservation in a patient with a large low rectal tumor with a high risk of bleeding,scheduled for APE.CASE SUMMARY A 56-year-old man presented to our institution with a one-year history of anal bleeding and rectal tenesmus.The patient was diagnosed with bulky adenocarcinoma limited to the rectum.As the patient refused any clinical treatment,surgery without previous neoadjuvant chemoradiation was indicated.The patient underwent a tumor embolization procedure,two days before surgery performed via the right common femoral artery.The tumor was successfully devascularized and no major bleeding was noted during APE.Postoperative recovery was uneventful and a one-year follow-up showed no signs of recurrence.CONCLUSION Therapeutic tumor embolization may play a role in bloodless surgeries and increase surgical and oncologic prognoses.We describe a patient with a bulky low rectal tumor who successfully underwent preoperative embolization and bloodless abdominoperineal resection. | Marley Ribeiro Feitosa Lucas Fernandes de Freitas Antonio Balestrim Filho Guilherme Seizem Nakiri Daniel Giansante Abud Ligia Magnani Landell Mariângela Ottoboni Brunaldi Jose Joaquim Ribeiro da Rocha Omar Feres Rogério Serafim Parra | 2020 | World Journal of Clinical Oncology2020，11，12： | 1 |
| 8 | Sympa- thetic neural hyperactivity and its normalization following unstable angi- na andac -ute myocardial infarction 显示文摘 | Graham LN Smith PA Stoker JB Mackintosh AF Mary DA | 2004 | C lin Sci (Lond)2004，106，： | 1 |
| 9 | Prediction of severity of coronary artery disease using slope of submaximal ST segment / heart rate relationship显示文摘 | Elamin MS Mary DA Smith DR | 1980 | Cardiovasc Res1980，14，： | 1 |
| 10 | Intracoronary ghrelin infusion decreases coronary blood fl ow in anesthetized pigs显示文摘 | Grossini E Molinari C Mary DA | 2007 | Endocrinology2007，148，2： | 1 |
| 11 | Single-unit sympa-thetic discharge : quantitative assessment in human hy-pertensive disease显示文摘 | Greenwood JP Stoker JB Mary DA | 1999 | Circulation1999，100，12： | 1 |
| 12 | Intracoro- nary intermedin 1-47 augments cardiac perfusion and function in anesthetized pigs: role of calcitonin receptors and beta-adrenoreceptor-mediated nitric oxide release显示文摘 | Grossini E Molinari C Mary DA | 2009 | J Appl Physiol2009，107，4： | 1 |
| 13 | Expression of Metalloproteinase 2 in the Cell Response to Porous Demineralized Bovine Bone Matrix显示文摘 | Thais Accorsi-Mendon?a Willian Fernando Zambuzzi Katiúcia Batista da Silva Paiva José Roberto Pereira Lauris Tania Mary Cestari Rumio Taga José Mauro Granjeiro | 2005 | Journal of Molecular Histology2005，，4： | 1 |
| 14 | The role of cognition in school refusal: an investigation of automatic thoughts and cognitive errors显示文摘 | Marie M Heyne DA de Heus P | 2012 | Behav Cogn Psyehother2012，40，3： | 1 |
| 15 | The activity of single vasoconstrictor nerve units in hypertension 显示文摘 | Mary DA Stoker JB | 2003 | Aeta physiol Seand2003，177，3： | 1 |
| 16 | Heart valve replacement with the Ionescu-Schiley pericardial xenodraft显示文摘 | Ionescu MI Tandon AP Mary DA | 1977 | J Thorac Cardiovasc Surg1977，73，1： | 1 |
| 17 | Accuracy of CA 125 in the diagnosis of ovarian tumors: A quantitative systematic review显示文摘 | Lidia Rosi Medeiros Daniela Dornelles Rosa Maria Inês da Rosa Mary Clarisse Bozzetti | 2008 | European Journal of Obstetrics and Gynecology2008，，： | 1 |
| 18 | Metoclopramide treatment in DBA patients:No complete response in a French prospective study显示文摘 | Leblanc TM Da Costa L Marie I | 2007 | Blood2007，109，5： | 1 |
| 19 | Heart valve replacement with the Ionescu-Shiley pericardial xenograft 显示文摘 | Ionescu MI Tandon AP Mary DA et al | 1977 | J Thorac Cardiovasc Surg1977，73，1： | 1 |
| 20 | Intracoronary genistein acutely increases coronary blood flow in anesthetized pigs through {beta}-adrenergic mediated nitric oxide release and estrogenic receptors 显示文摘 | Grossini E Molinari C Mary DA | 2007 | Endocrinology2007，10，1： | 1 |
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