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| 1 | Transactivation of the TIEG1 confers growth inhibition of transforming growth factor-β-susceptible hepatocellular carcinoma cells显示文摘AIM:To investigate the role of transforming growth factor(TGF)-β-inducible early gene 1(TIEG1) in TGF-β-induced growth inhibition in hepatocellular carcinoma(HCC) cells.METHODS:Human hepatocyte and HCC cell lines with varied susceptibilities to TGF-β1 were tested by methylthiazoletetrazolium(MTT) assay.The expression changes of Smad2,Smad3,Smad4,Smad7,TIEG1 and TIEG2 gene following treatment with TGF-β1 in a TGF-β-sensitive hepatocyte cell line(MIHA),a TGF-β-sensitive hepatoma cell line(Hep3B) and two TGF-β-insensitive hepatoma cell lines(HepG2 and Bel7404) were examined.SiRNA targeting TIEG1 was transfected into Hep3B cells and the sensitivity of cells to TGF-β1 was examined.Overexpression of TIEG1 was induced by lentiviral-mediated transduction in TGF-β1-resistant hepatoma cell lines(Bel7404 and HepG2).MTT assay and 4',6-Diamidino-2-phenylindole staining were used to identify cell viability and apoptosis,respectively.The expression level of stathmin was measured by reverse transcriptase polymerase chain reaction and Western-blotting analysis,and stathmin promoter activity by TIEG1 was monitored by a luciferase reporter gene system.RESULTS:TIEG1 was significantly upregulated by TGF-β1 in the TGF-β1-sensitive HCC cell line,Hep3B,but not in the resistant cell lines.The suppression of TIEG1 by siRNAs decreased the sensitivity of Hep3B cells to TGF-β1,whereas the overexpression of TIEG1 mediated growth inhibition and apoptosis in TGF-β1-resistant HCC cell lines,which resembled those of TGF-β1-sensitive HCC cells treated with TGF-β1.Our data further suggested that stathmin was a direct target of TIEG1,as stathmin was signif icantly downregulated by TIEG1 overexpression,and stathmin promoter activity was inhibited by TIEG1 in a dose-dependent manner.CONCLUSION:Our data suggest that transactivation of TIEG1 conferred growth inhibition of TGF-β-susceptible human HCC cells. | Lei Jiang Yiu-Kay Lai Jin-Fang Zhang Chu-Yan Chan Gang Lu Marie CM Lin Ming-Liang He Ji-Cheng Li Hsiang-Fu Kung | 2012 | World Journal of Gastroenterology2012，18，17： | 13 |
| 2 | Heme oxygenase-1 system and gastrointestinal inflammation:A short review显示文摘Heme oxygenase-1(HO-1) system catalyzes heme to biologically active products:carbon monoxide,biliverdin/bilirubin and free iron.It is involved in maintaining cellular homeostasis and many physiological and pathophysiological processes.A growing body of evidence indicates that HO-1 activation may play an important protective role in acute and chronic inflammation of gastrointestinal tract.This review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal inflammation studied to date.The ability to upregulate HO-1 by pharmacological means or using gene therapy may offer therapeutic strategies for gastrointestinal inflammation in the future. | Xiao Zhu Wen-Guo Fan Dong-Pei Li Hsiangfu Kung Marie CM Lin | 2011 | World Journal of Gastroenterology2011，17，38： | 9 |
| 3 | Extra-intestinal and long term consequences of Giardia duodenalis infections显示文摘Giardiasis is the most common waterborne parasitic infection of the human intestine worldwide.The etiological agent,Giardia duodenalis(syn.G.intestinalis,G.lamblia),is a flagellated,binucleated protozoan parasite which infects a wide array of mammalian hosts.Human giardiasis is a true cosmopolitan pathogen,with highest prevalence in developing countries.Giardiasis can present with a broad range of clinical manifestations from asymptomatic,to acute or chronic diarrheal disease associated with abdominal pain and nausea.Most infections are self-limiting,although re-infection and chronic infection can occur.Recent evidence indicating that Giardia may cause chronic post-infectious gastrointestinal complications have made it a topic of intense research.The causes of the post-infectious clinical manifestations due to Giardia,even after complete elimination of the parasite,remain obscure.This review offers a state-of-the-art discussion on the long-term consequences of Giardia infections,from extra-intestinal manifestations,growth and cognitive deficiencies,to post-infectious irritable bowel syndrome.The discussion also sheds light on some of the novel mechanisms recently implicated in the production of these postinfectious manifestations. | Marie CM Halliez André G Buret | 2013 | World Journal of Gastroenterology2013，19，47： | 8 |
| 4 | Heme oxygenase-1 system and gastrointestinal tumors显示文摘Heme oxygenase-1(HO-1) system catabolizes heme into three products:carbon monoxide,biliverdin/bilirubin and free iron.It is involved in many physiological and pathophysiological processes.A great deal of data has demonstrated the roles of HO-1 in the formation,growth and metastasis of tumors.The interest in this system by investigators involved in gastrointestinal tumors is fairly recent,and few papers on HO-1 have touched upon this subject.This review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal tumors studied to date.The implications for possible therapeutic manipulation of HO-1 in gastrointestinal tumors are also discussed. | Marie CM Lin Hsiangfu Kung | 2010 | World Journal of Gastroenterology2010，16，21： | 4 |
| 5 | Cancer gene therapy targeting angiogenesis:An updated review显示文摘Since the relationship between angiogenesis and tumor growth was established by Folkman in 1971, scientists have made efforts exploring the possibilities in treating cancer by targeting angiogenesis. Inhibition of angiogenesis growth factors and administration of angiogenesis inhibitors are the basics of anti- angiogenesis therapy. Transfer of anti-angiogenesis genes has received attention recently not only because of the advancement of recombinant vectors, but also because of the localized and sustained expression of therapeutic gene product inside the tumor after gene transfer. This review provides the up-to-date information about the strategies and the vectors studied in the field of anti-angiogenesis cancer gene therapy. | Ching-Chiu Liu Zan Shen Hsiang-Fu Kung Marie CM Lin | 2006 | World Journal of Gastroenterology2006，12，43： | 4 |
| 6 | Bone morphogenetic protein 2 and retinoic acid accelerate in vivo bone formation,osteoclast recruitment,and bone turnover显示文摘 | Cowan CM Aalami OO Shi YY Chou YF Mari C Thomas R Quarto N Nacamuli RP Contag CH Wu B Longaker MT | | 0，，： | 1 |
| 7 | Serum leptin and vascular risk factors in obstructive sleep apnea显示文摘 | Mary SM Karen SL Ho CM | 2000 | Chest2000，118，3： | 1 |
| 8 | Early Intervention in Low Birth Weight Premature Infants:Results at 18 Years of Age for the Infant Health and Development Program显示文摘 | Marie CM Jeanne BG Stephen L | 2006 | Pediatrics2006，117，3： | 1 |
| 9 | Polyphenols as su- peroxide dismutase modulators and ligands for estrogen receptors 显示文摘 | VINCENT F MARIE CM JOAO PT | 2004 | AnalChimActa2004，513，1： | 1 |
| 10 | Serum leptin and vascular risk factors in obstructive sleep apnea显示文摘 | Mary SM Karen SL Ho CM | 2000 | Chest2000，118，3： | 1 |
| 11 | Bone morphogenetic protein 2 and retinoic acid accelerate in vivo bone formation,osteoclast recruitment,and bone turnover显示文摘 | Cowan CM Aalami OO Shi YY Chou YF Mari C Thomas R Quarto N Nacamuli RP Contag CH Wu B Longaker MT | | 0，，： | 1 |
| 12 | Nucleic acid delivery with chitosan and its derivatives显示文摘 | Lai WF Marie CM L | | 0，，03： | 1 |
| 13 | Acute fructose administration improves Oral glucose tolerance in adults with type 2 diabetes显示文摘 | Mary CM Stephen ND Stephanie LM | 2001 | Diabetes Care2001，24，11： | 1 |
| 14 | Acute fructose administration decreases the glycemic response to an oral tolerance test in normal adults显示文摘 | Mary CM Alan DC Stephanie L M | 2000 | Clinical Endocrinology & Metabolism2000，85，12： | 1 |
| 15 | Serum leptin and vascular risk factors in obstructive sleep apnea显示文摘 | Mary SM Karen SL Ho CM | 2000 | Chest2000，118，： | 1 |
| 16 | Adipose-derived adult stromal cells heal critical-size mouse calvarial defects显示文摘 | Cowan CM Shi YY Aalami OO Chou YF Mari C Thomas R Quarto N Contag CH Wu B Longaker MT | | 0，，5： | 1 |
| 17 | The relationship of allergen-specific IgE levels and oral food challenge outcome 显示文摘 | Tamara TP Elizabeth CM Mary KCW | 2004 | J Allergy Clin Immunol2004，114，1： | 1 |
| 18 | Electrical and electrochemical behaviour of several LiFexCol-PO4 sol- id solutions as cathode materials for lithium ion batteries 显示文摘 | Ruffo R Mari CM Morazzoni F | 2007 | Ionics2007，13，： | 1 |
| 19 | Serum leptin and vascular risk factor in obstructive sleep apnea显示文摘 | Mary SM Karen SL Ho CM | 2000 | Chest2000，118，： | 1 |
| 20 | Orenstein Physical Activity and Cancer Prevention: Etiologic Evidence and Biological Mechanisms 显示文摘 | Christione M Friedenreich CM Marie R | 2002 | Nutr2002，132，11： | 1 |
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