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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | 新型低密度脂蛋白胆固醇评估对全球血脂异常指南中次级靶标非高密度脂蛋白胆固醇和载脂蛋白B应用的影响显示文摘血脂异常指南通常推荐非高密度脂蛋白胆固醇(non-high-density lipoprotein-cholesterol,non-HDL-C)和载脂蛋白B(apolipoprotein B,apoB)作为主要靶点低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)的次要靶点。 | Sathiyakumar V Park J Quispe R Elshazly MB Michos ED Banach M Toth PP Whelton SP Blumenthal RS Jones SR Martin SS 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，4： | 4 |
| 3 | Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial显示文摘 | Ronald P DeMatteo Karla V Ballman Cristina R Antonescu Robert G Maki Peter WT Pisters George D Demetri Martin E Blackstein Charles D Blanke Margaret von Mehren Murray F Brennan Shreyaskumar Patel Martin D McCarter Jonathan A Polikoff Benjamin R Tan Kouros | 2009 | The Lancet2009，，9669： | 2 |
| 4 | Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2R[gamma]c-deficient mice显示文摘 | Sarry Jean-Emmanuel Murphy Kathleen Perry Robin Sanchez Patricia V Secreto Anthony Keefer Cathy Swider Cezary R Strzelecki Anne-Claire Cavelier Cindy Récher Christian Mansat-De Mas Véronique Delabesse Eric Danet-Desnoyers G Carroll Martin | 2011 | Journal of Clinical Investigation2011，，1： | 2 |
| 5 | Infrared, blue and ultraviolet upconversion emissions in Yb3+:Tm3+-doped fluoroindate glasses 显示文摘 | Martin I R Rodriguez V D Lavin V | 1999 | Spectrochimica Acta Part A1999，55，： | 2 |
| 6 | Engineering of a- Si : H device stability by suitable design of interface 显示文摘 | Martins R Ferreira I Silva V | 2002 | Solar Energy Material & Solar Cells2002，，： | 1 |
| 7 | Phosphorus diagenesis in lake sediments:investigation using fractionation techniques显示文摘 | Michael R P Martin T A Eric L V | 1995 | Mar Freshwater Res1995，46，： | 1 |
| 8 | Globai estimates of ambient fine particulate matter concentrations from satellite-based aerosol optical depth: Development and application显示文摘 | VAN DONKELAAR A MARTIN R V BRAUER M | 2010 | Environ Health Perspectives2010，118，6： | 1 |
| 9 | Reverse engineering of geometric models—an introduction显示文摘 | Tamás Várady Ralph R Martin Jordan Cox | 1997 | Computer-Aided Design1997，，4： | 1 |
| 10 | Global estimates of ambient fine particulate matter concentrations from satellite-based aerosol optical depth: development and application显示文摘 | DONKELAAR A V MARTIN R V BRAUER M | 2010 | Environment Health Perspectives2010，118，6： | 1 |
| 11 | Biological effects of magnetic fluids toxicity studies 显示文摘 | Lacava Z G M Azevedo R B Martins E V | 1999 | J Magn Magnetic Mater1999，201，： | 1 |
| 12 | A review of production planning and scheduling models in the semiconductor industry part Ⅱ: shop-floor control 显示文摘 | Uzsoy R L C Martin V L A | 1994 | IIE Transactions1994，26，5： | 1 |
| 13 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 14 | Abdominal obesi-ty is associated with microalbuminuria and an elevated cardio-vascular risk profile in patients with hypertension 显示文摘 | Martin T Jan Christian R Bobby V | 2009 | VaseHealth Risk Manag2009，5，4： | 1 |
| 15 | Development of N,P and S-containing multifunctional additives for lubricants显示文摘 | Sarin R Tuli D K Martin V | 1997 | Lubr Eng1997，53，5： | 1 |
| 16 | Fatigue behavior of the equine third metacarpus: mechanical property analysis 显示文摘 | Gibson V A Stover S M Martin R B | 1995 | J Orthop Res1995，13，6： | 1 |
| 17 | Synthesis of mesoporous Al2O3 macrospheres using the biopolymer chitosan as a template:a novel active catalyst system for CO2 reforming of methane显示文摘 | FAIARDO H V MARTINS A O DE ALMEID R M | 2005 | Materials Letters2005，59，： | 1 |
| 18 | Effects of lateseason nitrogen fertilizer on irrigated soybean yield and composition 显示文摘 | Wesley T L Lamond R E Martin V L | 1998 | Journal of Production Agriculture1998，11，3： | 1 |
| 19 | Evaluation of the cosmetic significance of external dacryocystorhinostomy scars显示文摘 | SHARMA V MARTIN P A BENGER R | 2005 | Am J Ophthalmol2005，140，3： | 1 |
| 20 | The use of mechanical restraint and seclusion in patients with sehlzophrenia:a comparison of tile practice in Germany and Switzerland 显示文摘 | Martin V Bernhardsgrutter R Goebel R | 2007 | Clin pratt epidemol ment heahh2007，3，： | 1 |
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