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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Assessment of metal contamination in donana national park (spain) using crayfish (proeamburus elarkia) 显示文摘 | Sanchez Lopez F J Gil Garcia M D Martinez Vidal J | 2004 | Environmental Monitoring and Assessment2004，，93： | 1 |
| 3 | Textural and physicochemical changes in salmon (Salmo salar) treated with commercial liquid smoke flavoudngs显示文摘 | MARTINEZ O SALMERON L GUILLEN M D | 2007 | Food Chemistry2007，100，2： | 1 |
| 4 | Textural and physicochemical changes in salmon (Salmo salar) treated with commercial liquid smoke flavourings显示文摘 | Martinez O Salmeron J Guillen M D | 2007 | Food Chemistry2007，100，2： | 1 |
| 5 | Two-microphone multi-speaker localization based on a laplacian mixture model显示文摘 | Cobos M Lopez J J and Martinez D | 2010 | Digital Signal Processing2010，21，1： | 1 |
| 6 | Immunobiology of vasoactive intestinal peptide (VIP) 显示文摘 | Pozo D Delgado M Martinez M | 2000 | Immunol Today2000，21，1： | 1 |
| 7 | Computational prediction of novel components of lung transcription networks 显示文摘 | Martinez M J Smith A D Li B L | 2007 | Bioinformatics2007，23，1： | 1 |
| 8 | Obstructive sleep apnea and resistant hypertension: a case-control study 显示文摘 | Gonalves SC Martinez D Gus M | 2007 | Chest2007，132，6： | 1 |
| 9 | Deterruination of photoirradiated high polar benzoylureas in tomato by HPLC with luminol chemiluminescence detection显示文摘 | Martinez Galera M Gil Gareia M D Santiago Valverde R | 2008 | Talanta2008，76，4： | 1 |
| 10 | Structural studies of the polysaccharide isolated from Spondias purpurea gum exudate显示文摘 | PINTO G L D MARTINEZ M MENDOZA J A | 1996 | Carbohydr Res1996，290，： | 1 |
| 11 | Regulation of DNA binding and transactivation in P53 by nuclear localization and phosphorylation显示文摘 | Martinez J D Craven M T Joseloff E | 1997 | Oncogene1997，14，21： | 1 |
| 12 | Effects of plasma oxidation on the surface and interracial properties of carbon fibers/polycarbonate composites 显示文摘 | MONLES M M A MARTINEZ A A TASCON J M D | 2001 | Carbon2001，39，7： | 1 |
| 13 | Severity classification on the Hamilton Depression Rating Scale显示文摘 | Zimmerman M Martinez JH Young D | 2013 | J Affect Disord2013，150，2： | 1 |
| 14 | Inversion of Rayleigh wave phase and group velocities by simulated annealing显示文摘 | Martinez M D Lana X Olarte J | 2000 | Phys Earth Planet Inter2000，122，： | 1 |
| 15 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
| 16 | Occurrence of antifouling biocides in the spanish medi terranean marine environment显示文摘 | MARTINEZ K FERRER I HERNANDO M D | 2001 | Environmental tech nology2001，22，5： | 1 |
| 17 | 显示文摘 | Marrero LOpez D Martin Sedeno M C Pena Martinez J | 2010 | J Power Sources2010，195，： | 1 |
| 18 | Microstructure evolution associated with adiabatic shear bands and shear band failure in baUistic plug formation in Ti-6A1-4V targets 显示文摘 | Murr L E Ramirez A C Gaytan S M Lopez M I Martinez E Y Hernandez D H Martinez E | 2009 | Materials Science and Engineering A2009，516，： | 1 |
| 19 | Texture profile analysis of meat products treated with commercial liquid smoke flavourings显示文摘 | Martinez O Salmeron J Guillen M D | | 0，，06： | 1 |
| 20 | Community genomics among stratified microbial assemblages in the ocean's interior显示文摘 | DeLong E F Preston C M Mincer T Rich V Hallam S J Frigaard N U Martinez A Sullivan M B Edwards R Brito B R Chisholm S W Karl D M | | 0，，5760： | 1 |
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