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| 1 | 对明串珠菌及其他细菌的抑制效果显示文摘在从压榨间直到蔗汁澄清的蔗糖生产过程中,蔗汁中微生物活动是破坏蔗糖品质的一个重要因素。蔗糖损失和葡聚糖的形成通常与蔗汁中微生物引起的变质有关。多年来,这一直成为糖厂试图改善蔗糖品质时所面临的问题。本文以直接影响得糖率的微生物减少和相对纯度为指标,研究了不同杀菌方法在蔗汁中的效果。浓度为0.007%的S抑制剂显示了对某糖厂初压汁和混合汁中的微生物菌群的抗菌效应。在对照组中,12h后观察到4.8单位的纯度降低。加入S抑制剂后,只降低2个单位。且蔗汁的稳定性在3个样品中几乎完全一致。以S抑制剂处理的蔗汁保持深褐色和清新的气味,且pH与初始相比无显著变化,而未处理的蔗汁变浅褐色,产生很强的酒味,pH和纯度显著降低。这种稳定效应尚未被其他常用的糖用杀菌剂所报导。同样,本文证明了有可能通过使用S抑制剂来稳定混合汁。经S抑制剂处理后,游离的还原物质和多聚糖比不经处理的样品低6倍。这些结果表明,形成的葡聚糖以及随之形成的游离果糖减少。 | Georgina Michelena Aidin Martinez Graciela Cerutti Monica Coronel Antonio Bell Emilia Carrera Agustin Lopez-Murguia Roberto Portuondo Lazaro Mergarejo Frost M Steele 李宜海 | 2006 | 广西轻工业2006，22，4： | 3 |
| 2 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 3 | Virtual enterprise - organisation evolution and control显示文摘 | MARTINEZ M T FOULETIER P PARK K H | 2001 | Int J Production Economics2001，74，： | 3 |
| 4 | MeSH pesticide trace analysis using solid-phase extraction and gas chromatography with electron capture and tandem mass spectrometric detection in water samples显示文摘 | Martinez Vidal J L Pablos Espada M C Garrido Frenich A | | Jounal of Chromatography A0，，： | 2 |
| 5 | Resistance to β-lactam/elavulanate resistance in Escherichia coli 显示文摘 | Martinez J L Cercenado E Rodriguez-Creixems M | 1987 | Lancet1987，2，8573： | 2 |
| 6 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 7 | Study of photodegradation of the pefticide ethiofencarb in aqueous and non - aqueous media, by gas chromatograghy - mass spectrometry 显示文摘 | J Sanze - Asensio M Plaza - Medina M T Martinez - Soria M Perez -Clavijo | 1999 | Journal of Chromatograghy A1999，84，： | 2 |
| 8 | The bovine IFN-ω1 is biologically active and secreted at high levels in the yeast Pichia pastoris显示文摘 | Rodriguez M Martinez V Alazo K | 1998 | J Biotechnol1998，60，： | 2 |
| 9 | Assessment of metal contamination in donana national park (spain) using crayfish (proeamburus elarkia) 显示文摘 | Sanchez Lopez F J Gil Garcia M D Martinez Vidal J | 2004 | Environmental Monitoring and Assessment2004，，93： | 1 |
| 10 | Factors regulating spatial distribution of soil water content in small semiarid catchments显示文摘 | Gomez P A Martinez M M Albaladejo J | 2000 | Journal of Hydrology2000，253，： | 1 |
| 11 | Analytic relation between bulk moduli and lattice constants显示文摘 | Cohen M L Martinez G | 1987 | Phys Rev B1987，35，17： | 1 |
| 12 | A three-dimensional finite element analysis of the combined behavior of ligaments and menisci in the healthy human knee joint 显示文摘 | Pena E Calvo B Martinez M A | 2006 | Journal of Biomechanics2006，39，9： | 1 |
| 13 | Textural and physicochemical changes in salmon (Salmo salar) treated with commercial liquid smoke flavoudngs显示文摘 | MARTINEZ O SALMERON L GUILLEN M D | 2007 | Food Chemistry2007，100，2： | 1 |
| 14 | Textural and physicochemical changes in salmon (Salmo salar) treated with commercial liquid smoke flavourings显示文摘 | Martinez O Salmeron J Guillen M D | 2007 | Food Chemistry2007，100，2： | 1 |
| 15 | Fungicidal potential of methoxylated flavones from citrus for in vitro control of Colletotrichum loeosporioides, causal agent of anthracnose disease in tropical fruits 显示文摘 | Almada Ruiz E Martinez Tellez M A Hem ndez Alamos M M | 2003 | Pest Manag Sci2003，59，： | 1 |
| 16 | On the influence of psychrometric ambient conditions on cooling tower drift deposition 显示文摘 | LUCAS M MARTINEZ P J | 2010 | Heat and Mass Transfer2010，53，： | 1 |
| 17 | Evaluation of add-on devices for the prevention of phlebitis and other complications associated with the use of peripheral catheters in hospitalized adults:a randomised controlled study显示文摘 | Martinez JA Piazuelo M Almela M | 2009 | Hospital Infection2009，73，2： | 1 |
| 18 | NF-Y and Sp1 are involved in transcriptional regulation of rat SND p102 gene显示文摘 | RODRIGUEZ L OCHOA B MARTINEZ M J | 2007 | Biochem Biophys Res Commun2007，356，1： | 1 |
| 19 | Thermal cracking of coal residues: Kinetics of asphaltene decomposition显示文摘 | MARTINEZ M T BENITO A M CALLEJAS M A | 1997 | Fuel1997，76，9： | 1 |
| 20 | Introduction of a product family penalty function using physical programming显示文摘 | Messac A Martinez M P Simpson T W | 2002 | Transactions of ASME2002，124，2： | 1 |
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