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| 1 | Therapeutic options for HER-2 positive breast cancer: Perspectives and future directions显示文摘During the last 15 years we have witnessed an unprecedented expansion in the drugs developed to target human epidermal growth factor receptor-2(HER-2) positive breast cancer. Trastuzumab, pertuzumab, adotrastuzumab emtansine and lapatinib are currently food and drug administration(FDA)-approved for the treatment of breast cancer patients with HER-2 overexpressed. However, given the amount of information gathered from years of uninterrupted clinical research, it is essential to have periodic updates that succinctly recapitulate what we have learnt over these last years and help us to apply that information in our daily practice. This review will pursue that objective. We will summarize the most relevant and updated informationrelated to the state of the art management of HER-2 positive breast cancer in all the clinical scenarios including the adjuvant, neoadjuvant and metastatic settings. But we will also critically appraise that literature in order to highlight some key clinical concepts that should not be overlooked. Lastly, this review will also point out some of the most promising strategies that are currently being tested and may soon become available. | Gonzalo Recondo Jr Enrique Dìaz Canton Màximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Clinical Oncology2014，5，3： | 7 |
| 2 | Role of human papillomavirus in oropharyngeal squamous cell carcinoma: A review显示文摘Human papillomavirus(HPV) has been implicated in the pathogenesis of a subset of oropharyngeal squamous cell carcinoma. As a result, traditional paradigms in relation to the management of head and neck squamous cell carcinoma have been changing. Research into HPVrelated oropharyngeal squamous cell carcinoma is rapidly expanding, however many molecular pathological and clinical aspects of the role of HPV remain uncertain and are the subject of ongoing investigation. A detailed search of the literature pertaining to HPV-related oropharyngeal squamous cell carcinoma was performed and information on the topic was gathered. In this article, we present an extensive review of the current literature on the role of HPV in oropharyngeal squamous cell carcinoma, particularly in relation to epidemiology, risk factors, carcinogenesis, biomarkers and clinicalimplications. HPV has been established as a causative agent in oropharyngeal squamous cell carcinoma and biologically active HPV can act as a prognosticator with better overall survival than HPV-negative tumours. A distinct group of younger patients with limited tobacco and alcohol exposure have emerged as characteristic of this HPV-related subset of squamous cell carcinoma of the head and neck. However, the exact molecular mechanisms of carcinogenesis are not completely understood and further studies are needed to assist development of optimal prevention and treatment modalities. | Robbie SR Woods Esther M O'Regan Susan Kennedy Cara Martin John J O'Leary Conrad Timon | 2014 | World Journal of Clinical Cases2014，2，6： | 5 |
| 3 | 妊娠期高血压免疫因子、肿瘤坏死因子α、血管紧张素Ⅱ1型受体自身抗体对妊娠可溶性fms样酪氨酸1和可溶性Endoglin产物的影响显示文摘最近研究发现先兆子痫中血管新生因子、可溶性fms样酪氨酸激酶(sFlt-1)和可溶性Endoglin(sEn-doglin)不平衡;然而尚不清楚它们过度分泌的启动机制。方法:长期给予怀孕大鼠肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)或抗血管紧张素Ⅱ受体的自身抗体(AT1-AA),测定其循环和胎盘的sFlt-1和(或)sEndoglin以确定这些因素的免疫调节作用。 | Parrish MR Murphy SR Rutland S Wallace K Wenzel K Wallukat G Keiser S Ray LF Dechend R Martin JN Granger JP La Marca B 黄晓斌 | 2010 | 中华高血压杂志2010，18，12： | 5 |
| 4 | 新型低密度脂蛋白胆固醇评估对全球血脂异常指南中次级靶标非高密度脂蛋白胆固醇和载脂蛋白B应用的影响显示文摘血脂异常指南通常推荐非高密度脂蛋白胆固醇(non-high-density lipoprotein-cholesterol,non-HDL-C)和载脂蛋白B(apolipoprotein B,apoB)作为主要靶点低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)的次要靶点。 | Sathiyakumar V Park J Quispe R Elshazly MB Michos ED Banach M Toth PP Whelton SP Blumenthal RS Jones SR Martin SS 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，4： | 4 |
| 5 | Advances and new perspectives in the treatment of metastatic colon cancer显示文摘During the last decade we have witnessed an unprec-edented outburst of new treatment approaches for the management of metastatic colon cancer.Anti-angio-genic drugs,epidermal growth factor receptor blockers and multi-kinase inhibitors have all resulted in small but consistent improvement in clinical outcomes.However,this progress has paradoxically leaded us into new chal-lenges.In many cases the clinical development was done in parallel and the lack of head-to-head compari-son evolved into circumstances where several valid new'standards of care'are available.Even though desir-able in essence,the availability of many options as well as different possible combinations frequently leaves the busy clinician in the difficult situation of having to choose between one or the other,sometimes without solid evidence to support each decision.In addition,progress never stops and new agents are continuously tested.For these reason this review will try to summa-rize all the clinical trials that constitute the theoretical framework that support our daily practice but will also procure the reader with rational answers to common clinical dilemmas by critically appraising the current literature.Lastly,we will provide with a compilation of promising new agents that may soon become our next line of defense against this deadly disease. | Gonzalo Recondo Jr Enrique Díaz-Cantón Máximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Gastrointestinal Oncology2014，6，7： | 2 |
| 6 | Ahernate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism显示文摘 | Heilbronn LK Smith SR Martin CK | 2005 | Am J Clin Nutr2005，81，： | 1 |
| 7 | Adiponectin is present in human milk and is associated with maternal factors 显示文摘 | Martin LJ Woo JO Oeraghty SR | 2006 | Am J Clin Nutr2006，83，5： | 1 |
| 8 | Mutations in COQ4,an essential component of coenzyme Q biosynthesis,cause lethal neonatal mitochondrial encephalomyopathy显示文摘 | Chung WK Martin K Jalas C Braddock SR Juusola J Monaghan KG | 2015 | J Med Genet2015，52，： | 1 |
| 9 | Denosumab for prevention of fractures in postmenopausal womenwith osteoporosis显示文摘 | Cummings SR San Martin J McClung MR | 2009 | N Engl J Med2009，361，： | 1 |
| 10 | C-reactive protein level and traditional vascular risk factors in the prediction of carotid stenosis显示文摘 | Mullenix PS Steele SR Martin M J | 2007 | Arch Surg2007，142，11： | 1 |
| 11 | The N-terminus of the fragile X mental retardation protein contains a novel domain involved in dimerization and RNA binding显示文摘 | ADINOLFI S RAMOS A MARTIN SR | 2003 | Biochemistry2003，42，10： | 1 |
| 12 | Denosumab for prevention of fractures in postmenopausal women with osteoporosis显示文摘 | Cummings SR San Martin J McClung MR et ai | 2009 | Obestetrical&Gynecdogical Survey2009，64，12： | 1 |
| 13 | Enhanced estrogen receptor (ER) alpha, ERbB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivation 显示文摘 | Martin LA Farmer I Johnston SR | 2003 | J Biol Chem2003，278，30： | 1 |
| 14 | Adiponectin is present inhuman milk and is associated with maternal factors显示文摘 | Martin LJ Woo JG Geraghty SR | 2006 | The Ameri-can journal of clinical nutrition2006，83，5： | 1 |
| 15 | Denosumab for prevention of fractures in postmenopausal women with osteoporosis显示文摘 | Cummings SR San Martin J McClung MR | 2009 | N Engl J Med2009，361，8： | 1 |
| 16 | Quality improvement guidelines for diagnostic arteriography显示文摘 | Dariushnia SR Gill AE Martin LG | 2014 | J Vase Interv Radiol2014，25，12： | 1 |
| 17 | Therapeutic implications of an enriched cancer stem - like cell population in a human osteosarcoma cell line显示文摘 | Martins -Neves SR Lopes AO Do Carmo A | 2012 | BMC Cancer2012，12，： | 1 |
| 18 | CD4 mimetics sensitize HIV-l-infected cells to ADCC 显示文摘 | Richard J Veillette M Brassard N Iyer SS Roger M Martin L Pazgier M Schon A Freire E Routy JP SmithAB 3rd Park J Jones DM Courter JR Melillo BN Kaufmann DE Hahn BH Permar SR Haynes BF MadaniN Sodroski JG Finzi A | 2015 | Proc Natl Acad Sci USA2015，112，20： | 1 |
| 19 | Denosumab for prevention of fractures in postmenopausal women with osteoporosis 显示文摘 | Cummings SR San Martin J McClung MR | 2009 | N Engl J Med2009，361，8： | 1 |
| 20 | Focused high-risk population screening for carotid arterial stenosis after radiation therapy for head and neck cancer显示文摘 | Steele SR Martin M J Mullenix PS | 2004 | Am J Surg2004，187，： | 1 |
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