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| 1 | Efficacy of thymol against Echinococcus granulosus protoscoleces显示文摘 | M. Celina Elissondo Clara M. Albani Liesel Gende Martín Eguaras Guillermo Denegri | 2008 | Parasitology International2008，，2： | 1 |
| 2 | Biochemical and energy dynamics during larval development of the mussel Mytilus galloprovincialis (Lamarck,1819)显示文摘 | Clara Sánchez-Lazo Inés Martínez-Pita | | 0，，358： | 1 |
| 3 | Efficacy of thymol against Echinococcus granulosus protoscoleces显示文摘 | M. Celina Elissondo Clara M. Albani Liesel Gende Martín Eguaras Guillermo Denegri | 2008 | Parasitology International2008，，2： | 1 |
| 4 | Analysis of energy use and CO 2 emission in service industries: Evidence from Sweden显示文摘 | Clara Inés Pardo Martínez Semida Silveira | 2012 | Renewable and Sustainable Energy Reviews2012，，7： | 1 |
| 5 | Application of the experimental design of experiments(Do E)for the determination of organotin compounds in water samples using HS-SPME and GC-MS/MS显示文摘 | Clara Coscollà Santiago Navarro-Olivares Pedro Martí | 2014 | Talanta2014，119，： | 1 |
| 6 | Influence of Livestock Soil Eutrophication on Floral Composition in the Pyrenees Mountains显示文摘Livestock behaviour in the Pyrenees includes free grazing and a long resting period that provokes the accumulation of dung and urine in some places,so-called camping areas. The aims of this study were (i) to analyze any change in floral composition,and in nutritional and chemical contents of plants in a livestock camping area; and (ii) to relate the floral composition with soil chemical properties. In a linear transect,five sampling zones were established,from the centre of the camping area to the surrounding Nardus stricta-dominant pasture. The above ground plant biomass and the topsoil were sampled in each zone with 6 replicates per zone. Plant species were classified and weighed to calculate above ground biomass,nutritional and chemical contents,and Shannon diversity and evenness indices. Additionally,soils were sampled in two periods,at the beginning and at the end of grazing period. Soil available nutrients (nitrate,ammonium,phosphorus,potassium,calcium and magnesium),total nitrogen,organic carbon and pH were measured. Plant chemical contents (protein,lignin and others) were significantly related to the proportions of grasses,legumes and other plants; so,the protein content is positively correlated with legumes plant biomass while lignin content is negatively correlated with grasses. Both plant and soil nutrients increased linearly towards the centre of the camping area. However,the relationship among plant species richness,diversity and evenness relative to its position along the studied transect was bell-shaped. From the outskirts to the centre of the camping area,plants with low nutrient demand were progressively replaced by those with medium and high nutrients demand and by pioneers. Nardus stricta-dominant pasture has low plant diversity and plant nutrient content as well as a poor soil nutrient availability. The presence of the camping area introduced patches with more soil nutrients and new species in the large spatial scale. However at a small spatial scale,the strong soil nutrient concentration into the centre of the camping area reduced floral composition again. To ensure positive effects of camping areas on plant diversity,and to manage more effectively the nutrients returned to the soil,a reduction in the stocking rate should be pursued. | BADíA David MARTí Clara SáNCHEZ José Ramón FILLAT Federico AGUIRRE Javier GóMEZ Daniel | 2008 | Journal of Mountain Science2008，5，1： | 1 |
| 7 | Opposing roles of plant laticifer cells in the resistance to insect herbivores and fungal pathogens显示文摘More than 12,000 plant species(ca.10%of flowering plants)exude latex when their tissues are injured.Latex is produced and stored in specialized cells named“laticifers”.Laticifers form a tubing system composed of rows of elongated cells that branch and create an internal network encompassing the entire plant.Laticifers constitute a recent evolutionary achievement in ecophysiological adaptation to specific natural environments;however,their fitness benefit to the plant still remains to be proven.The identification of Euphorbia lathyris mutants(pil mutants)deficient in laticifer cells or latex metabolism,and therefore compromised in latex production,allowed us to test the importance of laticifers in pest resistance.We provided genetic evidence indicating that laticifers represent a cellular adaptation for an essential defense strategy to fend off arthropod herbivores with different feeding habits,such as Spodoptera exigua and Tetranychus urticae.In marked contrast,we also discovered that a lack of laticifer cells causes complete resistance to the fungal pathogen Botrytis cinerea.Thereafter,a latex-derived factor required for conidia germination on the leaf surface was identified.This factor promoted disease susceptibility enhancement even in the non-latex-bearing plant Arabidopsis.We speculate on the role of laticifers in the coevolutionary arms race between plants and their enemies. | Lourdes Castelblanque Javier García-Andrade Clara Martínez-Arias Juan J.Rodríguez Francisco J.Escaray Ernestina Aguilar-Fenollosa Josep A.Jaques Pablo Vera | 2021 | Plant Communications2021，2，3： | 0 |
| 8 | Functional Heterogeneity of Cancer-Associated Fibroblasts from Human Colon Tumors Shows Specific Prognostic Gene Expression Signature显示文摘 | Mercedes Herrera Abul B.M.M.K. Islam Alberto Herrera Paloma Martín Vanesa García Javier Silva Jose M. Garcia Clara Salas Ignacio Casal Antonio García de Herreros Félix Bonilla Cristina Pe?a | 2013 | Clinical Cancer Research2013，，21： | 2 |
| 9 | 超加工食品与全因死亡的关联:SUN前瞻性队列研究显示文摘目的评估食用超加工食品与全因死亡的关联。方法前瞻性队列研究。背景西班牙Seguimiento Universidad de Navarra(SUN)大学毕业生队列,1999-2018年。参与者1999年12月-2014年2月对19899位(女性12113位,男性7786位)年龄为20~91岁的受试者的膳食和饮品消耗情况每2年进行1次随访,根据NOVA分级标准对食品的加工程度进行分类,利用已经确证的136项食品频率问卷进行评价。主要结局测量利用多变量Cox比例风险模型评估能量校正的超加工食品食用量(分为4个水平:低、中低、中高、高)与全因死亡的关系。结果在全部200432人年的随访期间发生了335例死亡。与食用低水平超加工食品的受试者相比,食用高水平超加工食品的受试者其全因死亡的风险较高(多变量校正危险比为1.62,95%可信区间为1.13~2.33),并且具有显著剂量依赖性(趋势P=0.005)。每多吃一份超加工食品,其全因死亡的风险相比增加18%(校正危险比为1.18,95%可信区间为1.05~1.33)。结论食用较多超加工食品(每日大于4份)与全因死亡风险提高62%独立相关。而每多吃一份超加工食品,全因死亡的风险增加18%。研究注册ClinicalTrials.gov NCT02669602。 | Gómez-Donoso Clara Anaïs Rico-Campà Miguel A Martínez-González Ismael Alvarez-Alvarez Raquel de Deus Mendonça Carmen de la Fuente-Arrillaga Clara Gómez-Donoso Maira Bes-Rastrollo 霍永丰(译) | 2020 | 英国医学杂志中文版2020，23，1： | 0 |
| 10 | Effective use of FibroTest to generate decision trees in hepatitis C显示文摘AIM:To assess the usefulness of FibroTest to forecast scores by constructing decision trees in patients with chronic hepatitis C.METHODS:We used the C4.5 classification algorithm to construct decision trees with data from 261 patients with chronic hepatitis C without a liver biopsy.The FibroTest attributes of age,gender,bilirubin,apolipoprotein,haptoglobin,α2 macroglobulin,and γ-glutamyl transpeptidase were used as predictors,and the FibroTest score as the target.For testing,a 10-fold cross validation was used.RESULTS:The overall classification error was 14.9%(accuracy 85.1%).FibroTest's cases with true scores of F0 and F4 were classified with very high accuracy(18/20 for F0,9/9 for F0-1 and 92/96 for F4) and the largest confusion centered on F3.The algorithm produced a set of compound rules out of the ten classification trees and was used to classify the 261 patients.The rules for the classification of patients in F0 and F4 were effective in more than 75% of the cases in which they were tested.CONCLUSION:The recognition of clinical subgroups should help to enhance our ability to assess differences in fibrosis scores in clinical studies and improve our understanding of fibrosis progression. | Dana Lau-Corona Luís Alberto Pineda Héctor Hugo Avilés Gabriela Gutiérrez-Reyes Blanca Eugenia Farfan-Labonne Rafael Núez-Nateras Alan Bonder Rosalinda Martínez-García Clara Corona-Lau Marco Antonio Olivera-Martínez Maria Concepción Gutiérrez-Ruiz Guillermo Robles-Díaz David Kershenobich | 2009 | World Journal of Gastroenterology2009，15，21： | 2 |
| 11 | Infection during Natural Orifice Transluminal Endoscopic Surgery Peritoneoscopy: A Randomized Comparative Study in a Survival Porcine Model显示文摘 | Carlos Guarner-Argente Mireia Beltrán Graciela Martínez-Pallí Ricard Navarro-Ripoll M. àngels Martínez-Zamora Henry Córdova Jaume Comas Cristina Rodríguez de Miguel Antonio Rodríguez-D’Jesús Manel Almela Clara Hernández-Cera Antonio M. Lacy Gloria Fernánd | 2011 | The Journal of Minimally Invasive Gynecology2011，，6： | 1 |
| 12 | Impact of an Evidence-Based Bundle Intervention in the Quality-of-Care Management and Outcome of Staphylococcus aureus Bacteremia显示文摘 | Luis E. López-Cortés Maria Dolores del Toro Juan Gálvez-Acebal Elena Bereciartua-Bastarrica María Carmen Fari?as Mercedes Sanz-Franco Clara Natera Juan E. Corzo José Manuel Lomas Juan Pasquau Alfonso del Arco María Paz Martínez Alberto Romero Miguel A. Mu | 2013 | Clinical Infectious Diseases2013，，9： | 1 |
| 13 | Precision medicine in sepsis and septic shock:From omics to clinical tools显示文摘Sepsis is a heterogeneous disease with variable clinical course and several clinical phenotypes.As it is associated with an increased risk of death,patients with this condition are candidates for receipt of a very well-structured and protocolized treatment.All patients should receive the fundamental pillars of sepsis management,which are infection control,initial resuscitation,and multiorgan support.However,specific subgroups of patients may benefit from a personalized approach with interventions targeted towards specific pathophysiological mechanisms.Herein,we will review the framework for identifying subpopulations of patients with sepsis,septic shock,and multiorgan dysfunction who may benefit from specific therapies.Some of these approaches are still in the early stages of research,while others are already in routine use in clinical practice,but together will help in the effective generation and safe implementation of precision medicine in sepsis. | Juan Carlos Ruiz-Rodriguez Erika P Plata-Menchaca Luis Chiscano-Camón Adolfo Ruiz-Sanmartin Marcos Pérez-Carrasco Clara Palmada Vicent Ribas Mónica Martínez-Gallo Manuel Hernández-González Juan J Gonzalez-Lopez Nieves Larrosa Ricard Ferrer | 2022 | World Journal of Critical Care Medicine2022，11，1： | 0 |
| 14 | Cardiovascular prevention in elderly patients显示文摘In recent decades,life expectancy has been increasing significantly.In this scenario,health interventions are ne-cessary to improve prognosis and quality of life of elderly with cardiovascular risk factors and cardiovascular disease.However,the number of elderly patients included in clinical trials is low,thus current clinical practice guidelines do not include specific re-commendations.This document aims to review prevention recommendations focused in patients≥75 years with high or very high cardiovascular risk,regarding objectives,medical treatment options and also including physical exercise and their inclusion in cardiac rehabilitation programs.Also,we will show why geriatric syndromes such as frailty,dependence,cognitive impair-ment,and nutritional status,as well as comorbidities,ought to be considered in this population regarding their important pro-gnostic impact. | Clara Bonanad Rosa Fernández-Olmo Sergio García-Blas Jose Antonio Alarcon Pablo Díez-Villanueva Carmen Rus Mansilla Héctor García-Pardo Pablo Toledo Ana Ayesta Eva Pereira Antoni Carol Almudena Castro-Conde Carmen de Pablo-Zarzoso Manuel Martínez-Sellés Vicente Arrarte Raquel Campuzano Albert Ariza-Solé | 2022 | Journal of Geriatric Cardiology2022，19，5： | 0 |
| 15 | Historical Scope of Seasonal Influenza A and B Infections in Cuba and Their Impact on Mortality in the Elderly,1983-2005显示文摘Background:Influenza causes high mortality in the elderly.Its behavior has not been studied regularly in tropical and subtropical countries,like Cuba.The purposes of this study were to understand the circulation type and subtype of the influenza virus and to obtain evidence of their relationship with underlying P&I deaths in persons aged 65 years or older.Methods:A retrospective study was carried out with 7,252 positive sera from influenza A(H3N2),A(H1N1)or from type B by hemagglutination inhibition assay from 1983-1984 and 2004-2005 seasons,which created three series with the type/subtype prevalence percentages corresponding to the total of positive cases.The relationship between mortality by pneumonia and influenza in people aged 65 years or more was determined by calculating its mean rates when the type/subtype prevalence was above the median or not.Results:The circulation pattern of these viruses in Cuba was defined,and predominance of A(H3N2)in the 77%of seasons was corroborated.The mean rate of mortality increased 24.4%(p<0.001)when any pair of virus was above its medians and for the subtype A(H3N2)the increase was of 14.6%(p<0.05).Conclusions:For the first time the Health Authorities of Cuba received a“native”pattern on the circulation of influenza viruses in the period studied,showing increases in mortality for underlying pneumonia and influenza in people aged 65 years or older when the A(H3N2)or any pair of viruses were above their means and underscoring the need for better prevention measures and vaccination programs for elderly people in our country. | Oropesa Fernández Suset Gonzalez Ochoa Edilberto Alonso Ismell Savón Valdés Clara Armas Luisa Arencibia García Amely Gonzalez Munoz Grehete Martínez Motas Isabel Hernández Espinosa Bárbara Gonzalez Baéz Gelsys Roque Arrieta Rosmery | 2019 | Journal of US-China Medical Science2019，16，1： | 0 |
| 16 | DLST mutations in pheochromocytoma and paraganglioma cause proteome hyposuccinylation andmetabolic remodeling显示文摘Dear Editor,Of all human tumors,pheochromocytomas and paragangliomas(PPGLs)have the highest heritability rate.Over 15%of PPGLs harbor mutations in genes encoding tricarboxylic acid(TCA)cycle-related enzymes that cause oncometabolite accumulation and drive tumorigenesis via metabolic adaptation to hypoxia and global hypermethylation[1].The dihydrolipoamide S-succinyltransferase(DLST)gene was recently described as a new PPGL susceptibility gene[2]. | Sara Mellid Fernando García Luis Javier Leandro-García Alberto Díaz-Talavera Ángel Mario Martínez-Montes Eduardo Gil Bruna Calsina María Monteagudo Rocío Letón Juan María Roldán-Romero María Santos Javier Lanillos Carlos Valdivia Natalia Martínez-Puente Javier de Nicolás-Hernández Scherezade Jiménez Manuel Pérez-Martínez Emiliano Honrado Javier Coloma Ana Cerezo Clara María Santiveri Manel Esteller Ramón Campos-Olivas Eduardo Caleiras Cristina Montero-Conde Cristina Rodríguez-Antona Javier Muñoz Mercedes Robledo Alberto Cascón | 2023 | Cancer Communications2023，43，7： | 0 |
| 17 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
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