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| 1 | Autophagy in colorectal cancer:An important switch from physiology to pathology显示文摘Colorectal cancer(CRC) remains a leading cause of cancer death in both men and women worldwide.Among the factors and mechanisms that are involved in the multifactorial etiology of CRC,autophagy is an important transformational switch that occurs when a cell shifts from normal to malignant.In recent years,multiple hypotheses have been considered regarding the autophagy mechanisms that are involved in cancer.The currently accepted hypothesis is that autophagy has dual and contradictory roles in carcinogenesis,but the precise mechanisms leading to autophagy in cancer are not yet fully defined and seem to be context dependent.Autophagy is a surveillance mechanism used by normal cells that protects them from the transformation to malignancy by removing damaged organelles and aggregated proteins and by reducing reactive oxygen species,mitochondrial abnormalities and DNA damage.However,autophagy also supports tumor formation by promoting access to nutrients that are critical to the metabolism and growth of tumor cells and by inhibiting cellular death and increasing drug resistance.Autophagy studies in CRC have focused on several molecules,mainly microtubule-associated protein 1 light chain 3,beclin 1,and autophagy related 5,with conflicting results.Beneficial effects were observed for some agents that modulate autophagy in CRC either alone or,more often,in combination with other agents.More extensive studies are needed in the future to clarify the roles of autophagy-related genes and modulators in colorectal carcinogenesis,and to develop potential beneficial agents for the prognosis and treatment of CRC. | Florin Burada Elena Raluca Nicoli Marius Eugen Ciurea Daniel Constantin Uscatu Mihai Ioana Dan Ionut Gheonea | 2015 | World Journal of Gastrointestinal Oncology2015，7，11： | 15 |
| 2 | Implementing a DIKW model on a deep mine cooling system显示文摘The South African mining industry has been experiencing increasing economic pressure. Deep mines also suffer from very hot workplaces, which leads to safety risks. These factors place stress on managers to reach their production targets while providing safe workplace conditions. The data information knowledge wisdom(DIKW) model, also known as the wisdom hierarchy, was implemented on a deep mine cooling system. This study aims to show that a simple model such as the DIKW model can assist managers in improving their deep mine cooling system's performance. The study found that the DIKW approach is a suitable approach for use on mine cooling systems to facilitate operational improvements.Applying the DIKW approach to a case study on a mine cooling system created substantial awareness and facilitated a cooling duty improvement of 55% which relates to an increase of 5.3 MW of refrigeration. The results of this study indicate that the DIKW approach may be a suitable approach to optimise management on deep mines using their existing infrastructure. | Jan Gabriel Pretorius Marc John Mathews Philip Maré Marius Kleingeld Johann van Rensburg | 2019 | International Journal of Mining Science and Technology2019，29，2： | 14 |
| 3 | Nat Biotechnol:将人星形胶质细胞重编程为多巴胺能神经元,有助治疗帕金森病显示文摘帕金森病是一种主要影响运动系统的神经退行性疾病。它的特征在于大脑中的多巴胺能神经元(dopaminergic neuron)渐进性丧失。尽管当前的疗法旨在补充多巴胺水平,但是没有一种疗法能够恢复这些丢失的细胞。如今。在一项新的研究中,来自瑞典、奥地利、西班牙和美国的研究人员开发出一种方法:将神经胶质细胞(glialcell)转化为活性的多巴胺能神经元,并且所产生的多巴胺能神经元能够部分恢复帕金森病模式小鼠的运动功能。这项概念验证研究可能为开发出一种治疗这种疾病的新方法铺平道路。 | Pia Rivetti di Val Cervo, Elisa Martín-Montañez, Enrique M Toledo, Gioele La Manno, Sara Padrell Sánchez, Sten Linnarsson Ernest Arenas Roman A Romanov, Christian Pifl Tibor Harkany Roman A Romanov, Giada Spigolon, Débora Masini, Michael Feyder, Tibor Harkany Gilberto Fisone Elisa Martín-Montañez Yi-Han Ng Marius Wernig | 2017 | 现代生物医学进展2017，17，17： | 11 |
| 4 | Machine-learned interatomic potentials by active learning:amorphous and liquid hafnium dioxide显示文摘We propose an active learning scheme for automatically sampling a minimum number of uncorrelated configurations for fitting the Gaussian Approximation Potential(GAP).Our active learning scheme consists of an unsupervised machine learning(ML)scheme coupled with a Bayesian optimization technique that evaluates the GAP model.We apply this scheme to a Hafnium dioxide(HfO2)dataset generated from a“melt-quench”ab initio molecular dynamics(AIMD)protocol.Our results show that the active learning scheme,with no prior knowledge of the dataset,is able to extract a configuration that reaches the required energy fit tolerance.Further,molecular dynamics(MD)simulations performed using this active learned GAP model on 6144 atom systems of amorphous and liquid state elucidate the structural properties of HfO2 with near ab initio precision and quench rates(i.e.,1.0 K/ps)not accessible via AIMD.The melt and amorphous X-ray structural factors generated from our simulation are in good agreement with experiment.In addition,the calculated diffusion constants are in good agreement with previous ab initio studies. | Ganesh Sivaraman Anand Narayanan Krishnamoorthy Matthias Baur Christian Holm Marius Stan Gábor Csányi Chris Benmore Álvaro Vázquez-Mayagoitia | 2020 | npj Computational Materials2020，，1： | 10 |
| 5 | 反置式肩关节成形术:择期手术的当前趋势显示文摘反置式肩关节成形术(reverse shoulder arthroplasty, RSA)在近些年才被广泛认可为一种成功术式,但是其概念很早就已出现。20世纪70年代初,为了应对治疗肩袖撕裂性肩关节病(cufftear arthropathy,CTA)所面临的挑战,出现了一些反置式肩关节成形装置,但均以失败告终。Grammont医生团队自1985年至1995年,为治疗CTA设计并提出了现代成功的反置式人工肩关节假体。内移和远置肩关节旋转中心是Grammont反置式肩关节假体最为突出的设计原则。RSA手术数量在过去十年中呈指数级增长,目前适应证除了CTA以外,还包括巨大不可修复性肩袖撕裂、肱骨近端骨折或骨折后遗症、炎症性肩关节病、肩胛盂形态异常引起的骨关节炎、解剖型全肩或半肩失败后翻修以及肩部肿瘤。RSA的绝对禁忌症包括感染、完全性腋神经瘫痪、神经性肩关节病以及严重肩胛盂骨侵蚀或缺损。随着RSA应用的迅速增长,术后并发症和再手术量明显增加。RSA手术并发症可以分为非特异性并发症、与RSA相关的特异性并发症以及与假体品牌相关的特殊并发症。RSA手术中对肩胛盂骨缺损的处理极具挑战性,目前处理方法有三种:肩胛盂不对称打磨和使用外移的肩胛盂假体,肩胛盂植骨,以及使用加强型肩胛盂基座。近年来,随着3D打印技术的广泛应用,对RSA患者进行术前个体化定制假体植入辅助工具以进行精准外科治疗,并已经开始了商品化应用。骨科医生应当选择好RSA的手术适应证,把握其手术要领和技术细节,努力学习并掌握新技术,降低RSA手术并发症并提高其临床疗效。 | 陆博 Marius M. Scarlat | 2018 | 中华骨科杂志2018，38，10： | 7 |
| 6 | A review:applications of the phase field method in predicting microstructure and property evolution of irradiated nuclear materials显示文摘Complex microstructure changes occur in nuclear fuel and structural materials due to the extreme environments of intense irradiation and high temperature.This paper evaluates the role of the phase field method in predicting the microstructure evolution of irradiated nuclear materials and the impact on their mechanical,thermal,and magnetic properties.The paper starts with an overview of the important physical mechanisms of defect evolution and the significant gaps in simulating microstructure evolution in irradiated nuclear materials.Then,the phase field method is introduced as a powerful and predictive tool and its applications to microstructure and property evolution in irradiated nuclear materials are reviewed.The review shows that(1)Phase field models can correctly describe important phenomena such as spatial-dependent generation,migration,and recombination of defects,radiation-induced dissolution,the Soret effect,strong interfacial energy anisotropy,and elastic interaction;(2)The phase field method can qualitatively and quantitatively simulate two-dimensional and three-dimensional microstructure evolution,including radiation-induced segregation,second phase nucleation,void migration,void and gas bubble superlattice formation,interstitial loop evolution,hydrate formation,and grain growth,and(3)The Phase field method correctly predicts the relationships between microstructures and properties.The final section is dedicated to a discussion of the strengths and limitations of the phase field method,as applied to irradiation effects in nuclear materials. | Yulan Li Shenyang Hu Xin Sun Marius Stan | 2017 | npj Computational Materials2017，，1： | 6 |
| 7 | Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma: Subanalyses of a phase III trial显示文摘 | Jordi Bruix Jean-Luc Raoul Morris Sherman Vincenzo Mazzaferro Luigi Bolondi Antonio Craxi Peter R. Galle Armando Santoro Michel Beaugrand Angelo Sangiovanni Camillo Porta Guido Gerken Jorge A. Marrero Andrea Nadel Michael Shan Marius Moscovici Dimitris Vo | 2012 | Journal of Hepatology2012，，4： | 6 |
| 8 | Effects of Staged Injection on Supersonic Mixing and Combustion显示文摘The three-dimensional (3D) reacting flow in a staged supersonic combustor is examined numerically. In order to obtain the optimum stream-wise vortices, a swept ramp injector is chosen as the second-stage wall injection combined with the first-stage central strut injection. The performance of the two-staged injection is compared with that of a one-staged injection, while the strut is kept installed in both cases. The two-staged injections can make full use of the residual oxygen near the wall and release more heat. The second-stage injection further downstream avoids the strong shock waves in the isolator and results in a rising wall pressure and good burning effects after the wall injection. Therefore, it allows more fuel to be injected into the supersonic combustor without causing thermal choking. Parallel injection from the second-stage swept ramp shows low total pressure loss and the best burning efficiency, compared with the other injection angles. | HOU Lingyun Bernhard WEIGAND Marius BANICA | 2011 | Chinese Journal of Aeronautics2011，24，5： | 6 |
| 9 | Operational concepts of HVDC in the context of security assessment in the German transmission grid显示文摘Because of the realization of HVDC connections parallel to the synchronous grid in Germany, operational concepts become more important in the context of system security aspects. In this article commonly known concepts are analyzed regarding their suitability for the German transmission system. Therefore, an approach for the analysis was developed and exemplary results are given using this approach. Under consideration of the overall system, the concepts of reducing losses in combination with minimizing(n-1)-warnings or-indications^1 as well as the sole minimization of(n-1)-warnings and-indications are the most reasonable approaches. However, under grid security aspects best results can be achieved by reducing operational limits and therefore, by the minimization of(n-1)-warnings. | Annika Klettke Marius Sieberichs Albert Moser | 2019 | Global Energy Interconnection2019，2，2： | 5 |
| 10 | Smart Transformer-based Medium Voltage Grid Support by Means of Active Power Control显示文摘In the last decades the voltage regulation has been challenged by the increase of power variability in the electric grid,due to the spread of non-dispatchable generation sources.This paper introduces a Smart Transformer(ST)-based Medium Voltage(MV)grid support by means of active power control in the ST-fed Low Voltage(LV)grid.The aim of the proposed strategy is to improve the voltage profile in MV grids before the operation of On-Load Tap Changer in the primary substation transformer,which needs tens of seconds.This is realized through reactive power injection by the AC/DC MV converter and simultaneous decrease of the active power consumption of voltage-dependent loads in ST-fed LV grid,controlling the ST output voltage.The last feature has two main effects:the first is to reduce the active power withdrawn from MV grid,and consequently the MV voltage drop caused by the active current component.At the same time,higher reactive power injection capability in the MV converter is unlocked,due to the lower active power demand.As result,the ST increases the voltage support in MV grid.The analysis and simulation results carried out in this paper show improvements compared to similar solutions,i.e.the only reactive power compensation.The impact of the proposed solution has been finally evaluated under different voltage-dependence of the loads in the LV grid. | Stefano Giacomuzzi Marius Langwasser Giovanni De Carne Giuseppe Buja Marco Liserre | 2020 | CES Transactions on Electrical Machines and Systems2020，4，4： | 5 |
| 11 | 厚壳贻贝分离蛋白提取、氨基酸组成及理化特性研究显示文摘以厚壳贻贝脂溶性物质提取后的副产品-贻贝粉为原料,采用等电点沉淀法,结合乙醇/水脱酚及透析分离提取厚壳贻贝蛋白并对其氨基酸组成及理化特性进行研究。最终得到分离蛋白的蛋白含量为93.8%,氨基酸组成在提取前后无显著性变化,必需氨基酸含量丰富,约为总氨基酸的36%,其中赖氨酸、亮氨酸、苯丙氨酸、苏氨酸和缬氨酸含量较高,均可达到FAO/WHO推荐值。厚壳贻贝分离蛋白具有较好的溶解性,其持水性、吸油性以及起泡性均优于大豆分离蛋白和鸡蛋蛋白,但乳化性不及大豆分离蛋白和鸡蛋蛋白。研究结果表明,厚壳贻贝蛋白可作为一种良好的蛋白质资源,通过优化提取方法及对其理化特性研究的深入,可极大提高厚壳贻贝脂溶性物质提取后的副产品-贻贝粉的综合利用。 | 张乾元 MARIUS Nzekebaloudou 张兰 李铎 | 2012 | 食品工业科技2012，33，24： | 4 |
| 12 | Efficiency of HAART in the prevention of mother to children HIV-1 transmission at Saint Camille medical centre in Burkina Faso,West Africa显示文摘Objective:To evaluate efficiency of HAART in the prevention of mother to child HIV transmission.Methods:A longitudinal study was conducted on 1 300 women attending the antenatal service at Saint Camille Medical Centre from September 2010 to July 2011.The HIV status of mothers was determined by rapid tests and EUSA.Discordant results were confirmed by real-time PCR.PCR was used to determine HIV status of children born from HIV-positive mothers.Results:Among 1 300 pregnant women tested for HIV,378 were seropositive.Mothers were predominantly housewives(69.7%),and their mean age was(28.32±0.15) years.The overall prevalence of HIV transmission from mother to child was 4.8%(18/378).This prevalence differed significantly from 0.0%(0/114) to 6.8%(18/264) in children born from mothers under HAART and those with mothers under New Prophylactic Protocol(ACT + 3TC + NVP),respectively(P< 0.01).Children’s mortality rate during the medical follow up was 1.3%(5/378).Among 16 women with HIV dubious status by ELISA,the Real Time PCR confirmed 2/16(12.5%) as HIV positive. Conclusions:The protocol of prevention of mother to children HIV transmission(PMTCT) is effective.The rate of HIV vertical transmission is significantly reduced.Early diagnosis determined by PCR of children born from HIV- positive mother is necessary and recommended in the context of PMTCT in Burkina Faso.We also found that PCR is an effective tool to confirm HIV status in pregnant women. | Laure Stella Ghoma Linguissi Cyrille Bisseye Tani Sagna Bolni Marius Nagalo Djeneba Ouermi Florencia W Djigma Salvatore Pignatelli Joseph D Sia Virginio Pietra Remy Moret Jean Baptiste Nikiema Jacques Simpore | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，12： | 4 |
| 13 | CuO/分子筛夹心型吸附剂-催化剂的合成和性质显示文摘以硝酸铜水溶液(浓度50.0g/L)浸渍母体分子筛(NaA,CaA,NaX和CaX)2h,干燥1h并在450℃焙烧6h后制得CuO/分子筛夹心型吸附剂-催化剂.活性组分(CuO)在母体分子筛上沉积的涂层厚度约1mm.采用原子吸收光谱、X射线衍射、红外光谱和差示扫描量热等技术对母体分子筛、浸渍介质和吸附剂-催化剂进行了表征.将该吸附剂-催化剂用于醇(甲醇、丙醇和丁醇)蒸气的催化氧化,催化活性实验在固定床石英反应器中于100~350℃下进行,测定了生成的副产物及其在空气流中的浓度.结果表明,在200~250℃时生成的副产物量最多.CuO/分子筛催化剂的使用寿命为120d,在此期间,该吸附剂-催化剂对醇氧化成CO2和H2O具有活性.随着醇分子量的增加和醇初始浓度的降低,起燃温度和完全氧化温度降低. | Marius BRAZLAUSKAS Saulius KITRYS | 2008 | 催化学报2008，29，1： | 4 |
| 14 | Sectoral agglomeration economies in a panel of European regions显示文摘 | Marius Brülhart Nicole A. Mathys | 2008 | Regional Science and Urban Economics2008，，4： | 4 |
| 15 | 中国骨科SCI论文3年现状分析显示文摘目的:了解和分析近3年中国骨科国际论文的发展现状,分布情况和主要特点。方法:使用Web of Science网站检索近3年SCI收录的中国骨科论文,根据论文数,按照科研机构和来源期刊进行排序;通过引用频次排序,获取引用数高的论文,并进行分析。结果:近3年分别有1238篇,1264篇和1225篇来自中国的骨科论文被SCI数据库收录,上海交通大学(n=75)和Eur Spine J(n=114)为发表中国论文数量最多的机构和杂志。纳入的143篇高引论文中,发表最多的研究类型为临床论著(n=70)和系统综述/meta分析(n=50)。高引临床论著涉及最多的主题为'膝',高引系统综述/meta分析最多主题为'脊柱'。结论:2015—2017年,上海交通大学和Eur Spine J发表最多中国骨科SCI论文;高引论文中,涉及最多的主题为'脊柱'和'膝',论文类型分布不均衡,主要集中在临床论著和系统综述。 | 孙静 Marius M Scarlat 李银平 胡永成 | 2018 | 中国中西医结合外科杂志2018，24，3： | 3 |
| 16 | An evaluation framework for energy aware buildings using statistical model checking显示文摘Cyber-physical systems are to be found in numerous applications throughout society.The principal barrier to develop trustworthy cyber-physical systems is the lack of expressive modelling and specification formalisms supported by efficient tools and methodologies.To overcome this barrier,we extend in this paper the modelling formalism of the tool UPPAAL-SMC to stochastic hybrid automata,thus providing the expressive power required for modelling complex cyber-physical systems.The application of Statistical Model Checking provides a highly scalable technique for analyzing performance properties of this formalisms.A particular kind of cyber-physical systems are Smart Grids which together with Intelligent,Energy Aware Buildings will play a major role in achieving an energy efficient society of the future.In this paper we present a framework in UPPAAL-SMC for energy aware buildings allowing to evaluate the performance of proposed control strategies in terms of their induced comfort and energy profiles under varying environmental settings(e.g.weather,user behavior etc.).To demonstrate the intended use and usefulness of our framework,we present an application to the Hybrid Systems Verification Benchmark. | DAVID Alexandre DU DeHui LARSEN Kim G. MIKUCIONIS Marius SKOU Arne | 2012 | Science China(Information Sciences)2012，55，12： | 3 |
| 17 | Mapping forest age using National Forest Inventory,airborne laser scanning,and Sentinel-2 data显示文摘Background:The age of forest stands is critical information for forest management and conservation,for example for growth modelling,timing of management activities and harvesting,or decisions about protection areas.However,area-wide information about forest stand age often does not exist.In this study,we developed regression models for large-scale area-wide prediction of age in Norwegian forests.For model development we used more than 4800 plots of the Norwegian National Forest Inventory(NFI)distributed over Norway between latitudes 58°and 65°N in an 18.2 Mha study area.Predictor variables were based on airborne laser scanning(ALS),Sentinel-2,and existing public map data.We performed model validation on an independent data set consisting of 63 spruce stands with known age.Results:The best modelling strategy was to fit independent linear regression models to each observed site index(SI)level and using a SI prediction map in the application of the models.The most important predictor variable was an upper percentile of the ALS heights,and root mean squared errors(RMSEs)ranged between 3 and 31 years(6%to 26%)for SI-specific models,and 21 years(25%)on average.Mean deviance(MD)ranged between^(−1) and 3 years.The models improved with increasing SI and the RMSEs were largest for low SI stands older than 100 years.Using a mapped SI,which is required for practical applications,RMSE and MD on plot level ranged from 19 to 56 years(29%to 53%),and 5 to 37 years(5%to 31%),respectively.For the validation stands,the RMSE and MD were 12(22%)and 2 years(3%),respectively.Conclusions:Tree height estimated from airborne laser scanning and predicted site index were the most important variables in the models describing age.Overall,we obtained good results,especially for stands with high SI.The models could be considered for practical applications,although we see considerable potential for improvements if better SI maps were available. | Johannes Schumacher Marius Hauglin Rasmus Astrup Johannes Breidenbach | 2020 | Forest Ecosystems2020，7，4： | 3 |
| 18 | Kirchhoff叠前时间偏移在南阳油田复杂构造成像中的应用(英文)显示文摘Kirchhoff叠前时间偏移比常规偏移具有方法简单、运算速度快以及可操作性强,而且可以应用到2-D和3-D地震数据偏移成像。Kirchhoff叠前时间偏移是高频近似条件下的偏移算法,可以利用射线跟踪技术可以获得地震波旅行时间,沿着该射线路径传播的时间积分求和来实现偏移成像。由于射线跟踪算法适应于横向变速介质,因此,Kirchhoff叠前时间偏移也适应横向变速介质。我们将该方法应用于南阳油田复杂构造的成像,该区构造产状不仅陡,断层也多,偏移结果表明Kirchhoff叠前时间偏移在该区可以获得较好的地震成像效果. | Ekoro Marius Blanchard 顾汉明 | 2007 | 工程地球物理学报2007，4，5： | 3 |
| 19 | Testing the robustness of particle-based separation models for the magnetic separation of a complex skarn ore显示文摘Physical separation processes are best understood in terms of the behaviour of individual ore particles.Yet,while different empirical particle-based separation modelling approaches have been developed,their predictive performance has never been tested under variable process conditions.Here,we investigated the predictive performance of a state-of-the-art particle-based separation model under variable feed composition for a laboratory-scale magnetic separation of a skarn ore.Two scenarios were investigated:one in which the mass flow of the different processing streams could be measured and one in which it had to be estimated from data.In both scenarios,the predictive models were sufficiently general to predict the process outcomes of new samples of variable composition.Nevertheless,the scenario in which mass flow could be measured was4%more precise in predicting mass balances.The process behaviour of minerals present at concentrations above 0.1%by weight could be accurately predicted.Our findings indicate the potential use of this method to minimize the costs of metallurgical testwork while providing in-depth understanding of the recovery behaviour of individual ore particles.Moreover,the method may be used to establish powerful tools to forecast mineral recoveries for partly new ore types at a running mining operation. | Lucas Pereira Max Frenzel Markus Buchmann Marius Kern Raimon Tolosana-Delgado K.Gerald van den Boogaart Jens Gutzmer | 2022 | International Journal of Mining Science and Technology2022，32，3： | 3 |
| 20 | Evidence of insecticide resistance selection in wildmosquitoes due to agricultural pesticide use显示文摘Background:The wetlands used for some agricultural activities constitute productive breeding sites for many mosquito species.Thus,the agricultural use of insecticide targeting other pests may select for insecticide resistance in malaria mosquitoes.The purpose of this study is to clarify some knowledge gaps on the role of agrochemicals in the development of insecticide resistance in malaria vectors is of utmost importance for vector control.Methods:Using the CDC bottle test and the log-probit analysis,we investigated for the first time the resistance levels ofAnopheles coluzzii mosquitoes to neonicotinoids,insecticides used exclusively for crop protection in C?te d’Ivoire.The study was conducted in two agricultural regions(Tiassale and Gagnoa)and one non-agricultural region(Vitre)between June and August 2017 using clothianidin,acetamiprid and imidacloprid.Results:Mosquito populations from Tiassale and Gagnoa(agricultural settings)were determined to be resistant to acetamiprid with mortality rates being<85%at 24 h post-exposure.In Vitre(non-agricultural area)however,the mosquito population was susceptible to acetamiprid.In all three localities,mosquito populations were resistant to imidacloprid(mortality rates were 60%in Vitre,37%in Tiassale,and 13%in Gagnoa)and completely susceptible to clothianidin(100%mortality).An.coluzzii represented 100%of mosquito collected in Gagnoa,86%in Tiassale and 96%in Vitre.Conclusions:This study provides strong evidence that agricultural use of insecticides can cause insecticide resistance in malaria vector populations.Insecticide resistance driven by agrochemical usage should be considered when vector control strategies are developed. | Chouaibou Seidou Mouhamadou Sarah Souline de Souza Behi Kouadio Fodjo Marius Gonse Zoh Nestor Kesse Bli Benjamin Guibehi Koudou | 2019 | Infectious Diseases of Poverty2019，8，4： | 3 |
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