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| 1 | Medical treatment for sphincter of oddi dysfunction:Can it replace endoscopic sphincterotomy?显示文摘AIM:To report the results of a medical management of sphincter of oddi dysfunction(SOD) after an intermediate follow-up period.METHODS:A total of 59 patients with SOD(2 men and 57 women,mean age 51 years old) were included in this prospective study.After medical treatment for one year,the patients were clinically re-evaluated after an average period of 30 mo.RESULTS:The distribution of the patients according to the Milwaukee's classification was the following:11 patients were type 1,34 were type 2 and 14 were type 3.Fourteen patients underwent an endoscopic sphincterotomy(ES) after one year of medical treatment.The median intermediate follow-up period was 29.8 ± 3 mo(3-72 mo).The initial effectiveness of the medical treatment was complete,partial and poor among 50.8%,13.5% and 35%,respectively,of the patients.At the end of the follow-up period,37 patients(62.7%) showed more than 50% improvement.The rate of improvement in patients who required ES was not significantly different compared with the patients treated conservatively(64.2% vs 62.2%,respectively).CONCLUSION:Our study confirms that conservative medical treatment could be an alternative to endoscopic sphincterotomy because,after an intermediate follow-up period,the two treatments show the same success rates. | Véronique Vitton Salah Ezzedine Jean-Michel Gonzalez Mohamed Gasmi Jean-Charles Grimaud Marc Barthet | 2012 | World Journal of Gastroenterology2012，18，14： | 9 |
| 2 | 在缺血性卒中后新表达的由SUR1调控的NCCa-ATP通道介导脑水肿显示文摘中枢神经系统的病理状况(如卒中和脑外伤)通常因脑水肿而有所加剧。研究人员最近在缺血的星形胶质细胞发现了一种非选择性的阳离子通道,即NCCa—ATP通道。这种通道由磺酰脲受体1(SUR1)调控,在ATP耗竭时开放,并且这种开放会造成细胞毒性水肿。在本文中,作者通过建立啮齿类动物中风模型来评估这种通道机制的参与过程。 | J Marc Simard Mingkui Chen Kirill V Tarasov | 2006 | 国际内科双语杂志(中英文)2006，6，6： | 4 |
| 3 | Tenecteplase Reperfusion therapy in Acute ischaemic Cerebrovascular Events-Ⅱ (TRACE Ⅱ): rationale and design显示文摘Background and purpose Tenecteplase(TNK)is a promising agent for treatment of acute ischaemic stroke(AIS).We hypothesised that recombinant human TNK tissue-type plasminogen activator(rhTNK-tPA)is non-inferior to rt-PA in achieving excellent functional outcome at 90 days,when administered within 4.5 hours of ischaemic stroke onset.Methods and design Tenecteplase Reperfusion therapy in Acute ischemic Cerebrovascular Events(TRACE)is a phase Ⅲ,multicentre,prospective,randomised,open-label,blinded-end point non-inferiority study.Patients eligible for intravenous thrombolysis therapy are randomised to rhTNK-tPA 0.25 mg/kg(single bolus)to a maximum of 25 mg or rt-PA 0.9 mg/kg(10%bolus+90%infusion/1 hour)to a maximum of 90 mg.Medications considered necessary for the patient’s health may be given at the discretion of the investigator during 90-day follow-up.Study outcomes The primary study outcome is excellent functional outcome defined as modified Rankin Scale(mRS)0–1 at 90 days.Secondary efficacy outcomes include favourable functional outcome defined as mRS≤2 at 90 days,ordinal distribution of mRS and major neurological improvement on the National Institutes of Health Stroke Scale.Safety outcomes are symptomatic intracranial haemorrhage within 36 hours and death from any cause.Discussion There is no completed registration study of TNK in AIS worldwide.TRACE Ⅱ strives to provide evidence for a new drug application for rhTNK-tPA in AIS within 4.5 hours through a well-designed and rigorously executed randomised trial in China. | Shuya Li Bruce C V Campbell Lee H Schwamm Marc Fisher Mark Parsons Hao Li Yuesong Pan Yongjun Wang | 2022 | Stroke & Vascular Neurology2022，7，1： | 2 |
| 4 | NT-3 Expression from Engineered Olfactory Ensheathing Glia Promotes Spinal Sparing and Regeneration显示文摘 | Marc J R Dane B L Seok V L | 2005 | Brain2005，，128： | 1 |
| 5 | Cloned plasmid DNA fragments as calibrators for controlling GMOs: Different real-time duplex quantitative PCR methods显示文摘 | ISABEL T ERIK V B MARC D L | 2004 | Anal Bioanal Chem2004，378，5： | 1 |
| 6 | Biodiversity and identification of sour- dough lactic acid bacteria 显示文摘 | LUC D V MARC V | 2007 | Food Microbiology2007，24，2： | 1 |
| 7 | Low-dose spinal anaesthesia for Caesarean section to prevent spinal-induced hypotension 显示文摘 | Eva R Marc V | 2008 | Curr Opini Anaesthesiol2008，21，： | 1 |
| 8 | Photodegradation of lincomycin in aqueous solution显示文摘 | Di Paola A Addamo M Augugliaro V García-López E Loddo V Marcì G Palmisano L | | 0，，： | 1 |
| 9 | Real-time quantitative PCR detection of genetically modified maximizer maize and roundup ready soybean in some representative foods显示文摘 | MARC V HANS P FRANCOIS G | 1999 | J Agric Food Chem1999，47，： | 1 |
| 10 | Characterization and classification of matrix effects in biological samples analyses显示文摘 | Ivano Marchi Véronique Viette Flavia Badoud Marc Fathi Martial Saugy Serge Rudaz Jean-Luc Veuthey | 2009 | Journal of Chromatography A2009，，25： | 1 |
| 11 | Modelling the growth kinetics of Listeria as a function of temperature,pH and organic acid concentration显示文摘 | Le Marc Y Huchet V Bourgeois CM | 2002 | International Journal of Food Microbiology2002，73，： | 1 |
| 12 | Differences in gene expression profiles of diabetic and nondiabetic patients undergoing cardiopulmonary bypass and cardioplegic arrest显示文摘 | Pierre V Marc R Tanveer A K | 2004 | Circulation2004，110，2： | 1 |
| 13 | Superoxide dismutase and stress tolerance显示文摘 | Chris B Marc V H Did I | 1992 | Ann Rev Plant Physoil Plant Mol Bid1992，43，： | 1 |
| 14 | A stepwise multi- scaled landscape typology and charaeterisation for trans- regional integration, applied on the federal state of Belgium显示文摘 | Veerle V E Marc A | 2009 | Landscape and UrbanPlanning2009，3，91： | 1 |
| 15 | 查看详情显示文摘 | Iojoiu C Abadie Marc J.M Harabagiu V Pinteala M.and Simionescu Bogdan C | | 0，，： | 1 |
| 16 | Role of surgery in the treatment of primary pulmonary B-cel lymphoma显示文摘 | Frederic V E Elie F Marc P | | 0，，01： | 1 |
| 17 | Forecasting of pre- processed daily solar radiation time series using neural networks 显示文摘 | CHRISTOPHE P CYRIL V MARC M | 2010 | Solar Energy2010，84，12： | 1 |
| 18 | Foaming proterties of egg white protein affected by heat or high pressure treatment显示文摘 | Lesel V P Ann V L Marc E H | | 0，，04： | 1 |
| 19 | Why are some individuals resistant to the cardioprotective effects of aspirin? Coud it be thromboxame A2显示文摘 | Marc K Perry V | 2002 | Circulation2002，105，4： | 1 |
| 20 | Superoxide dismutase and stress tolerance显示文摘 | CHRIS B MARC V M DIRK I | 1992 | Annual Review Plant Physiol and Plant Molecular Biology1992，43，： | 1 |
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