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| 1 | Management of hilar cholangiocarcinoma in the North of England: Pathology, treatment, and outcome显示文摘AIM: To assess the management and outcome of hilar cholangiocarcinoma (Klatskin tumor) in a single tertiary referral center.METHODS: The notes of all patients with a diagnosis of hilar cholangiocarcinoma referred to our unit for over an 8-year period were identified and retrospectively reviewed. Presentation, management and outcome were assessed.RESULTS: Seventy-five patients were identified. The median age was 64 years (range 34-84 years). Male to female ratio was 1:1. Eighty-nine percent of patients presented with jaundice. Most patients referred were under Bismuth classification 3a, 3b or 4. Seventy patients required biliary drainage, 65 patients required 152percutaneous drainage procedures, and 25 had other complications. Forty-one patients had 51 endoscopic drainage procedures performed (15 failed). Of these,36 subsequently required percutaneous drainage. The median number of drainage procedures for all patients was three, 18 patients underwent resection (24%), nine had major complications and three died post-operatively.The 5-year survival rate was 4.2% for all patients, 21%for resected patients and 0% for those who did not undergo resection (P = 0.0021). The median number of admissions after diagnosis in resected patients was two and three in non-resected patients (P<0.05).Twelve patients had external-beam radiotherapy, seven brachytherapy, and eight chemotherapy. There was no significant benefit in terms of survival (P = 0.46) or hospital admissions.CONCLUSION: Resection increases survival but carries the risk of significant morbidity and mortality.Percutaneous biliary drainage is almost always necessary and endoscopic drainage should be avoided if possible. | SD Mansfield O Barakat RM Charnley BC Jaques CB O'Suilleabhain PJ Atherton D Manas | 2005 | World Journal of Gastroenterology2005，11，48： | 37 |
| 2 | 《日用化学品安全评价技术创新——替代方法》专题一 国际化学品安全评价动物替代测试法规趋势显示文摘综述了国际化学品和化妆品动物替代测试的法规进展和趋势。重点介绍了在3R运动和体外科学技术的推动下,替代方法在化学品毒性测试中的验证和法规认可现状。讨论了替代技术在急性毒性、皮肤刺激/腐蚀、眼刺激/腐蚀、皮肤致敏、遗传毒性、内分泌干扰等毒理学终点的应用。最后提出了替代方法的发展不仅是法规趋同、市场一体、检测标准协调一致、动物福利认知进步的必然趋势,也是检测技术创新和日化企业应用难得的机遇。 | 瞿小婷 程树军 刘超 Claire Mansfield Troy Seidle | 2016 | 日用化学品科学2016，39，2： | 12 |
| 3 | 乳腺癌保乳整复手术显示文摘保乳整复手术是乳腺癌治疗中的一个基本组成部分。这种治疗方式可以切除大量的乳腺组织,提高美容效果,在使患者满意的同时保持良好的肿瘤学切除原则,减少再切除术和乳腺切除率,并有助于辅助放射治疗计划。我们复习了近年来各种不同保乳整复手术,并描述了在切除乳腺内不同位置肿瘤的技术应用以及选择不同技术时所考虑患者相关的具体因素。最后,对于这种外科手术类型的肿瘤学安全性的证据及并发症进行了讨论。 | Lucy Mansfield Avi Agrawal Ramsey I. Cutress | 2013 | 中国普通外科杂志2013，22，11： | 4 |
| 4 | Perturbation of Wood Cellulose Synthesis Causes Pleiotropic Effects in Transgenic Aspen显示文摘在树上的纤维素生合成的基因操作可以提供新奇卓见进树的生长和发展。探索这可能性,一棵白杨的 overexpression 第二等的联系墙的纤维素 synthase (PtdCesA8 ) 基因在转基因的白杨(Populus tremuloides L.) 被尝试并且出人意料地象它的内长的对应物一样导致了 transgene 的 silencing。转基因的白杨植物的主要的轴快速停止成长,并且弱树枝采用了一个哭泣的生长习惯。而且,转基因的植物开始开发了更小的叶子和一个不太广泛的根系统。几乎没象 10% 纤维素一样包含的转基因的白杨植物的第二等的木部(木头) 使正常化与典型地在正常白杨木头发现的 41% 纤维素相比弄干重量。在纤维素的这巨大的减小被木质素(35%) 和非有纤维质的多糖(55%) 的比例的增加在控制植物与 22% 木质素和 36% 非有纤维质的多糖相比伴随。生产的转基因的茎典型崩溃或改变了第二等的墙形态学并且极大地包含了的不规则的木部容器减少了水晶的纤维素的数量。这些结果在维持要求在树上建立垂直生长习惯的力量和结构的正直在第二等的木部以内表明第二等的墙纤维素的基本角色。 | Chandrashekhar R Joshi Shivegowda Thammannagowda Takeshi Fujino Ji-Qing Gou Utku Avci Candace H. Haigler Lisa M. McDonnell Shawn D. Mansfield Bemnet Mengesha Nicholas C. Carpita Darby Harris Seth DeBolt Gary F. Peter | 2011 | Molecular Plant2011，4，2： | 4 |
| 5 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 6 | A next-generation marker genotyping platform(AmpSeq)in heterozygous crops:a case study for marker-assisted selection in grapevine显示文摘Marker-assisted selection(MAS)is often employed in crop breeding programs to accelerate and enhance cultivar development,via selection during the juvenile phase and parental selection prior to crossing.Next-generation sequencing and its derivative technologies have been used for genome-wide molecular marker discovery.To bridge the gap between marker development and MAS implementation,this study developed a novel practical strategy with a semi-automated pipeline that incorporates trait-associated single nucleotide polymorphism marker discovery,low-cost genotyping through amplicon sequencing(AmpSeq)and decision making.The results document the development of a MAS package derived from genotyping-by-sequencing using three traits(flower sex,disease resistance and acylated anthocyanins)in grapevine breeding.The vast majority of sequence reads(⩾99%)were from the targeted regions.Across 380 individuals and up to 31 amplicons sequenced in each lane of MiSeq data,most amplicons(83 to 87%)had<10%missing data,and read depth had a median of 220–244×.Several strengths of the AmpSeq platform that make this approach of broad interest in diverse crop species include accuracy,flexibility,speed,high-throughput,low-cost and easily automated analysis. | Shanshan Yang Jonathan Fresnedo-Ramíre Minghui Wang Linda Cote Peter Schweitzer Paola Barba Elizabeth M Takacs Matthew Clark James Luby David C Manns Gavin Sacks Anna Katharine Mansfield Jason Londo Anne Fennell David Gadoury Bruce Reisch Lance Cadle-Davidson Qi Sun | 2016 | Horticulture Research2016，3，1： | 2 |
| 7 | Technical change and the rate of imitation显示文摘 | Mansfield E | 1996 | Econometrica1996，29，： | 1 |
| 8 | Academic research underlying industrial innovations:Sources,characteristics and financing显示文摘 | MANSFIELD E | 1995 | Review of Economics and Statistics1995，77，1： | 1 |
| 9 | How rapidly does new industrial technology leak out? 显示文摘 | Mansfield E | 1985 | Journal of Industrial Economics1985，，34： | 1 |
| 10 | Effect of magnitude of vertical whole-body vibration on absorbed power for the seated human body显示文摘 | MANSFIELD N J GRIFFIN M J | 1998 | Journal of Sound and Vibration1998，215，4： | 1 |
| 11 | The significance of natural and synthetic auxins in the control of stomatal movements 显示文摘 | Cox R C Snaith P J Mansfield TA | 1985 | Acta Horticulture1985，171，： | 1 |
| 12 | The R&D Tax Credit and Other Technology Policy Issues显示文摘 | Mansfield E | 1986 | The American Economic Review1986，76，2： | 1 |
| 13 | Transcription factor NF kappa B expression and postsurgical organ dysfunction显示文摘 | Foulds S Galustian C Mansfield AO | 2001 | Ann Surg2001，233，1： | 1 |
| 14 | International Technology Transfer:Forms,Resource Requirements and Policies显示文摘 | Mansfield E | 1975 | The American Economic Review1975，65，2： | 1 |
| 15 | Beyond Rescaling: Reintegrating the 'National' as a Dimension of Scalar Relations显示文摘 | B Mansfield | 2005 | Progress in Human Geography2005，29，4： | 1 |
| 16 | Patents and Innovation:An Empirical Study显示文摘 | Mansfield Edwin | 1986 | Management Science1986，32，2： | 1 |
| 17 | Concerning trend removal in electrochemical noise measurements显示文摘 | Mansfield F Sun Z Hsu C H | 2001 | Corrosion Science2001，43，： | 1 |
| 18 | Monte carlo studies of dendrimer macromolecule显示文摘 | MANSFIELD M L KLUSHINL Z | 1993 | Macromolecule1993，26，16： | 1 |
| 19 | Composition of R&D Expenditures:Relatlonship to Size of Firm,Concentration and Innovative Output显示文摘 | MANSFIELD E | 1981 | Renew of Economics and Statistics1981，，63： | 1 |
| 20 | Colour remediation of pulp mill effluent using purified fungal cellobiose dehydrogenase: Reaction optimisation and mechanism of degradation 显示文摘 | Wingate K G Stuthridge T Mansfield S D | 2005 | Bio- tech-nology and Bioengineering2005，90，1： | 1 |
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