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| 1 | Management of hilar cholangiocarcinoma in the North of England: Pathology, treatment, and outcome显示文摘AIM: To assess the management and outcome of hilar cholangiocarcinoma (Klatskin tumor) in a single tertiary referral center.METHODS: The notes of all patients with a diagnosis of hilar cholangiocarcinoma referred to our unit for over an 8-year period were identified and retrospectively reviewed. Presentation, management and outcome were assessed.RESULTS: Seventy-five patients were identified. The median age was 64 years (range 34-84 years). Male to female ratio was 1:1. Eighty-nine percent of patients presented with jaundice. Most patients referred were under Bismuth classification 3a, 3b or 4. Seventy patients required biliary drainage, 65 patients required 152percutaneous drainage procedures, and 25 had other complications. Forty-one patients had 51 endoscopic drainage procedures performed (15 failed). Of these,36 subsequently required percutaneous drainage. The median number of drainage procedures for all patients was three, 18 patients underwent resection (24%), nine had major complications and three died post-operatively.The 5-year survival rate was 4.2% for all patients, 21%for resected patients and 0% for those who did not undergo resection (P = 0.0021). The median number of admissions after diagnosis in resected patients was two and three in non-resected patients (P<0.05).Twelve patients had external-beam radiotherapy, seven brachytherapy, and eight chemotherapy. There was no significant benefit in terms of survival (P = 0.46) or hospital admissions.CONCLUSION: Resection increases survival but carries the risk of significant morbidity and mortality.Percutaneous biliary drainage is almost always necessary and endoscopic drainage should be avoided if possible. | SD Mansfield O Barakat RM Charnley BC Jaques CB O'Suilleabhain PJ Atherton D Manas | 2005 | World Journal of Gastroenterology2005，11，48： | 37 |
| 2 | T cell responses to allogeneic human mesenchymal stem cells: immunogenicity, tolerance, and suppression显示文摘 | Elena Klyushnenkova Joseph D Mosca Valentina Zernetkina Manas K Majumdar Kirstin J Beggs Donald W Simonetti Robert J Deans Kevin R McIntosh | 2005 | Journal of Biomedical Science2005，，1： | 2 |
| 3 | Effect of sodium tungstate on visual evoked potentials in diabetic rats显示文摘AIM: To evaluate the effect of sodium tungstate on visual evoked potentials(VEPs) in diabetic rats.· METHODS: Wistar rats were randomly divided into three groups as normal control, diabetic control and diabetic rats treated with sodium tungstate. Diabetes was induced by single intraperitoneal injection of streptozotocin(50 mg/kg). Sodium tungstate [40 mg/(kg·d)]was administered for 12 wk and then VEPs were recorded.Additionally, thiobarbituric acid reactive substance(TBARS) levels were measured in brain tissues.·RESULTS: The latencies of P1, N1, P2, N2 and P3 waves were significantly prolonged in diabetic rats compared with control group. Diabetes mellitus caused an increase in the lipid peroxidation process that was accompanied by changes in VEPs. However, prolonged latencies of VEPs for all components returned to control levels in sodium tungstate-treated group. The treatment of sodium tungstate significantly decreased brain TBARS levels and depleted the prolonged latencies of VEP components compared with diabetic control group.· CONCLUSION: Sodium tungstate shows protective effects on visual pathway in diabetic rats, and it can be worthy of further study for potential use. | Mehmet Bulut Bariszgür Dnmez Nihai ztürk Gksum Basaranlar Ceren Kencebay Manas Narin Derin Semir zdemir | 2016 | International Journal of Ophthalmology(English edition)2016，9，5： | 2 |
| 4 | 7-Substituted 2-phenyl-benzofurans as ERβ selective ligands显示文摘 | COLLINI M D KAUFMAN D H MANAS E S | 2004 | Bioorg Med Chem Lett2004，14，19： | 1 |
| 5 | Influence of aggregate structure and matrix infiltration on the dispersion behavior of carbon black agglomerates显示文摘 | Li Q Feke D L Manas Z I | 1995 | Rubb Chem Technol1995，68，5： | 1 |
| 6 | Ischemic cholangiopathy after liver transplantation from controlled non-heart-beating donors-a single-center experience显示文摘 | KACZMAREK B MANAS M D JAQUES B C | 2007 | Transplant Proe2007，39，9： | 1 |
| 7 | Analysis of power requirements and dispersion quality in batch compounding using a dispersion model for single agglomerates显示文摘 | Bohin F Feke D L Manas Z I | 1995 | Rubb Chem Technol1995，69，1： | 1 |
| 8 | Deleterious role of IFNgamma in a toxic model of central nervous system demyelination 显示文摘 | Mana P Linares D Fordham S | 2006 | Am J Pathol2006，168，5： | 1 |
| 9 | Optimal treatment for hepatocellular carcinoma in the cirrhotic liver显示文摘 | White S A Manas D M Farid S G | 2009 | Ann R Coil Surg Engl2009，91，7： | 1 |
| 10 | Identification of novel estrogen re- ceplor antagonists显示文摘 | Shao D Berrodin TJ Manas E | 2004 | The Journal of Steroid Biochemistry and Molecular Biolo~''2004，88，45： | 1 |
| 11 | Synthesis and characterization of diorganotin(Ⅳ)complexes of tetradentate Schiff bases crystal structure of n-Bu2Sn(Vanophen)显示文摘 | Dilip K D Manas K S Mrina1 K D eta1 | 1999 | Polyhedron1999，18，： | 1 |
| 12 | Analysis of the Formation of Bound Poly (Dimethylsiloxane) on Silica显示文摘 | Levresse P Feke D L Manas Zloczower I | 1998 | Polymer1998，39，17： | 1 |
| 13 | Strongly subspectral paris in C50+10n and C60+12n fullerenes via a common generic graph显示文摘 | KAKAI D MANAS B ASOK K | 1991 | Phy Chem1991，，1： | 1 |
| 14 | Fluid flow analysis of magnetorheologieal abrasive flow finishing (MRAFF) process显示文摘 | MANAS D JAIN V K GHOSHDASTIDAR P S | 2008 | International Journal of Machine Tools & Manufacture2008，48，： | 1 |
| 15 | Inactivation of lysozyme by ultrasonic waves under pressure at different temperatures 显示文摘 | Manas P Mufioz B Sanz D | 2006 | Enzyme and Microbial Technology2006，39，6： | 1 |
| 16 | QoS-guaranteed bandwidth shifting and redistribution in mobile cloud environment显示文摘 | SUDIP M SNIGDLA D MANAS K | 2014 | IEEE Transacions on Cloud Computing2014，2，2： | 1 |
| 17 | Potentially fatal haemobilia due toinappropriateuse of an expanding biliary stent 显示文摘 | Rai R Rose J Manas D | 2011 | World JGastroenterol2011，9，10： | 1 |
| 18 | Acyl- guanidines as small-molecule fl-secretase inhibitors 显示文摘 | COLE D C MANAS E S STOCK J R | 2006 | J Med Chem2006，49，21： | 1 |
| 19 | Inactivation of lysozyme by ultrasonic waves under pressure at different temperatures 显示文摘 | Manas P Munoz B Sanz D S | 2006 | Enzyme and Microbial Technology2006，39，： | 1 |
| 20 | Cyclosporine withdrawal from a mycophenolate mofetil-containing immunosuppressive regimen in stable kidney transplant recipients: a randomized, controlled study显示文摘 | Abramowicz D Manas D Lao M | 2002 | Transplantation2002，74，12： | 1 |
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