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| 1 | Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis显示文摘 | Nagendra Singh Ashish Gurav Sathish Sivaprakasam Evan Brady Ravi Padia Huidong Shi Muthusamy Thangaraju Puttur D. Prasad Santhakumar Manicassamy David H. Munn Jeffrey R. Lee Stefan Offermanns Vadivel Ganapathy | 2014 | Immunity2014，，1： | 2 |
| 2 | Modulation of adaptive immunity with Toll-like receptors显示文摘 | Santhakumar Manicassamy Bali Pulendran | 2009 | Seminars in Immunology2009，，4： | 2 |
| 3 | The Role of the Charged Residues of the GP2 Helical Regions in Ebola Entry显示文摘The glycoprotein(GP) of Ebola is the sole structural protein that forms the spikes on the viral envelope. The GP contains two subunits,GP1 and GP2,linked by a disulfide bond,which are responsible for receptor binding and membrane fusion,respectively. In this study,the full length of GP gene of Ebola Zaire species,2028 base pairs in length,was synthesized using 38 overlapping oligonucleotides by multiple rounds of polymerase chain reaction(PCR) . The synthesized GP gene was shown to be efficiently expressed in mammalian cells. Furthermore,an efficient HIV-based pseudotyping system was developed using the synthetic GP gene,providing a safe approach to dissecting the entry mechanism of Ebola viruses. Using this pseudotyping system and mutational analysis,the role of the charged residues in the GP2 helical regions was examined. It was found that substitutions of the most charged residues in the regions did not adversely affect GP expression,processing,or viral incorporation,however,most of the mutations greatly impaired the ability of GP to mediate efficient viral infection. These results demonstrate that these charged residues of GP2 play an important role in GP-mediated Ebola entry into its host cells. We propose that these charged residues are involved in forming the intermediate conformation(s) of GP in membrane fusion and Ebola entry. | Haiqing Jiang Jizhen Wang Balaji Manicassamy Santhakumar Manicassamy Michael Caffrey Lijun Rong | 2009 | Virologica Sinica2009，24，2： | 2 |
| 4 | Programming dendritic cells to induce T (H) 2 and tolerogenic responses显示文摘 | Pulendran B Tang H Manicassamy S | 2010 | Nat Immunol2010，11，8： | 1 |
| 5 | Programming dendritic cells to induce T(H) 2 and tolerogenic responses显示文摘 | Pulendran B Tang H Manicassamy S | 2010 | Nat Immunol2010，11，8： | 1 |
| 6 | Toll-like receptor- mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI (3)K- mTOR-p70S6K pathway显示文摘 | Cao W Manicassamy S Tang H | 2008 | Nat Immunol2008，9，10： | 1 |
| 7 | Programming dendritic cells to induce T(H) 2 and tolerogenic responses 显示文摘 | Pulendran B Tang H Manicassamy S | 2010 | Nat Immunol2010，11，8： | 1 |
| 8 | Dendritic cell control of tolerogenic responses显示文摘 | Manicassamy S Pulendran B | 2011 | Immunol Rev2011，241，1： | 1 |
| 9 | Protein kinase Cθ-media-ted signals enhance CD4+T cell survival by Up-regulating Bcl-xL显示文摘 | Manicassamy S Gupta S Huang Z | 2006 | J Immunol2006，180，8： | 1 |
| 10 | Characterization of Marburg virus glycoprotein in viral entry 显示文摘 | Manicassamy B Wang J Rumschlag E | 2007 | Virology2007，358，1： | 1 |
| 11 | The critical role of protein kinase C - theta in Fas/Fas ligand - mediated apoptosis 显示文摘 | Manicassamy S Sun Z | 2007 | Journal of immunology2007，178，1： | 1 |
| 12 | Zaire Ebola virus entry into human dendritic cellsis insensitive to cathepsin L inhibition 显示文摘 | MARTINEZ 0 JOHNSON J MANICASSAMY B etal | 2010 | CellMicrobiol2010，12，2： | 1 |
| 13 | A critical role for protein kinase C-theta-mediated T cell survival in cardiac allograft rejection显示文摘 | Manicassamy S Yin D Zhang Z | 2008 | J Immunol2008，181，1： | 1 |
| 14 | Dendritic cell control oftolerogenic responses 显示文摘 | Manicassamy S and Pulendran B | 2011 | Immunol Rev2011，241，1： | 1 |
| 15 | Retinoic acid-dependent regulation of immune responses by dendritic cells and macrophages显示文摘 | Manicassamy S Pulendran B | 2009 | Seminars In Immunology2009，21，1： | 1 |
| 16 | Toll-like receptormediated induction of type Ⅰ interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI (3) K-mTOR-p70S6K pathway显示文摘 | Cao W Manicassamy S Tang H | | 0，，： | 1 |
| 17 | Toll-like receptor-mediated induction of type I interferon inplasmacytoid dendritic cells requires the rapamycin- sensitive PI(3)K-mTOR-p70S6K pathway显示文摘 | Cao W Manicassamy S Tang H | 2008 | Nat Immunol2008，9，10： | 1 |
| 18 | Programming dendritic ceils to induce T (H)2 and tolerogenic responses 显示文摘 | Pulendran B Tang H Manicassamy S | 2010 | NatImmunol2010，11，8： | 1 |
| 19 | Dendritic cell control of tolerogenic responses 显示文摘 | Manicassamy S Pulendran B | 2011 | Immunol Rev2011，241，1： | 1 |
| 20 | The critical role of protein kinase C-theta in Fas/Fas ligand-mediated apoptosis 显示文摘 | Manicassamy S Sun Z | 2007 | J Immunol2007，178，1： | 1 |
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