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| 1 | In vitro effect of pantoprazole on lower esophageal sphincter tone in rats显示文摘AIM:To investigate the in vitro effects of pantoprazole on rat lower esophageal sphincter(LES)tone.METHODS:Rats weighing 250-300 g,provided by the Yeditepe University Experimental Research Center(Yü-DETAM),were used throughout the study.They were anesthetized before decapitation.LES tissues whose mucosal lining were removed were placed in a stan-dard 30-mL organ bath with a modif ied Krebs solution and continuously aerated with 95% oxygen-5% carbon dioxide gas mixture and kept at room temperature.The tissues were allowed to stabilize for 60 min.Sub-sequently,the contractile response to 10-6 mol/L carba-chol was obtained.Different concentrations of freshly prepared pantoprazole were added directly to the tis-sue bath to generate cumulative concentrations of 5×10-6 mol/L,5×10-5 mol/L,and 1.5×10-4 mol/L.Activi-ties were recorded on an online computer via a 4-channeltransducer data acquisition system using the software BSL PRO v 3.7,which also analyzed the data.RESULTS:Pantoprazole at 5×10-6 mol/L caused a small,but statistically insignif icant,relaxation in the car-bachol-contracted LES(2.23% vs 3.95%).The 5×10-5 mol/L concentration,however,caused a signif icant relax-ation of 10.47% compared with the control.1.5×10-4 mol/L concentration of pantoprazol caused a 19.89% relaxation in the carbachol contracted LES(P<0.001).CONCLUSION:This is the fi rst study to demonstrate that pantoprazole has a relaxing effect in isolated LESs.These results might have signif icant clinical implications for the subset of patients using proton pump inhibitors who do not receive full symptomatic alleviation from gastroesophageal reflux disease. | Mustafa Duman Mahmut zer Enver Rean Yeliz Demirci Ali E Atιcι Tahsin Dalgι Erdal B Bostancι Ece Gen | 2011 | World Journal of Gastroenterology2011，17，46： | 3 |
| 2 | Endoscopic submucosal dissection in gastric lesions: the 100 cases experience from a tertiary reference center in West显示文摘 | Fatih Aslan Emrah Alper Cem Cek&imath c Derya Arslan Yurtlu Nese Ek&imath nc&imath Mahmut Arabul Belkis Unsal Yoshimasa M&imath ura Hironori Yamamoto | 2014 | Scandinavian Journal of Gastroenterology2014，，3： | 1 |
| 3 | Surgical treatment of hydatid disease of the hver (review of 304cases)显示文摘 | Abmet AB Mahmut B Fehmi C | 1999 | Arch Surg1999，16，2： | 1 |
| 4 | Spacial specificity of H2O2-generating oxalate oxidase gene expression during wheat embryo germination显示文摘 | ANDREW C CUMING | 1998 | The Plant Journal1998，15，2： | 1 |
| 5 | Spatial and temporal changes of soil salinity in a cotton field irrigated with low-quality water显示文摘 | Mahmut C Cevat K | 2003 | Journal of Hydrology2003，272，： | 1 |
| 6 | Spacial specificity of H2O2-generating oxalate oxidase gene expression during wheat embryo germination显示文摘 | MAHMUT C ANRE C CUMING | 1998 | The plant Journal1998，15，2： | 1 |
| 7 | Treatment of textile wastewaters by electrocoagulation using iron and aluminum electrodes显示文摘 | MEHMET K ORHAN T C MAHMUT B | 2003 | Journal of Hazardous Materials2003，100，123： | 1 |
| 8 | Heavy metal pollution of surface soil in the thrace region, turkey 显示文摘 | MAHMUT C | 2006 | Environmental Mo- nitoring and Assessment2006，119，： | 1 |
| 9 | Prostate cancer and adiponec- tin 显示文摘 | Serdar G Mahmut I Y Kayser C | 2005 | Urology2005，65，6： | 1 |
| 10 | Surgical treatment of hydatid disease of the liver (review of 304 cases) 显示文摘 | 1,Ahmet AB Mahmut B Fehmi C | 1999 | Arch Surg1999，134，2： | 1 |
| 11 | Spacial specificity of H2O2-generating oxalate oxidase gene expression during wheat embryo germination显示文摘 | Mahmut C Andrew C Cuming | 1998 | The plant Journal1998，15，2： | 1 |
| 12 | Surgical treatment of hydatid dis- ease of the fiver显示文摘 | Abmet AB Mahmut B Fehmi C | 1999 | Arch1999，16，2： | 1 |
| 13 | Surgical treatment of hydatid disease of the liver(review of 304 casas)显示文摘 | Ahmet AB Mahmut B Fehmi C | 1999 | Arch Sarg1999，134，2： | 1 |
| 14 | Spatial and temporal changes of soil salinity in a cotton field irrigation with low-quality water显示文摘 | Mahmut C Cevat K | 2003 | Journal of Hydrology2003，272，： | 1 |
| 15 | Elevated plasma adva- nced oxidation protein products in children with Henoch-Scht~n- lein purpura显示文摘 | Nurcan K Mahmut C Murat E | 2011 | Pediatric Nephrol2011，26，： | 1 |
| 16 | Value of a Put option to the Risk-averse Newsvendor显示文摘 | Youhaa C Mahmut P | 2007 | IIE Transactions2007，39，5： | 1 |
| 17 | EMT, the cytoskeleton, and cancer cell invasion显示文摘 | Mahmut Y Gerhard C | 2009 | Cancer Metastasis Rev2009，28，12： | 1 |
| 18 | Operating costanalysis of electrocoagulation of textile dye wastewater显示文摘 | MAHMUT B MEHMET K ORHAN T C | 2004 | Separation and Purification Technology2004，37，： | 1 |
| 19 | Genetic differentiation between red deer from different sample sites on the Tianshan Mountains (Cervus elaphus), China显示文摘 | Zhou C L RisMat T Mahmut H | 2014 | Mitochondrial DNA2014，6，28： | 1 |
| 20 | EMT,the cytoskeleton,and cancer cell inva- sion显示文摘 | Mahmut Y Gerhard C | 2009 | Cancer Metastasis Rev2009，28，12： | 1 |
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