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| 1 | Hepatic echinococcosis:Clinical and therapeutic aspects显示文摘Echinococcosis or hydatid disease(HD)is a zoonosis caused by the larval stages of taeniid cestodes belonging to the genus Echinococcus.Hepatic echinococcosis is a life-threatening disease,mainly differentiated into alveolar and cystic forms,associated with Echinoccus multilocularis(E.multilocularis)and Echinococcus granulosus(E.granulosus)infection,respectively.Cystic echinococcosis(CE)has a worldwide distribution,while hepatic alveolar echinococcosis(AE)is endemic in the Northern hemisphere,including North America and several Asian and European countries,like France,Germany and Austria.E.granulosus young cysts are spherical,unilocular vesicles,consisting of an internal germinal layer and an outer acellular layer.Cyst expan-sion is associated with a host immune reaction and the subsequent development of a fibrous layer,called the pericyst;old cysts typically present internal septations and daughter cysts.E.multilocularis has a tumorlike,infiltrative behavior,which is responsible for tissue destruction and finally for liver failure.The liver is the main site of HD involvement,for both alveolar and cystic hydatidosis.HD is usually asymptomatic for a long period of time,because cyst growth is commonly slow;the most frequent symptoms are fatigue and abdominal pain.Patients may also present jaundice,hepatomegaly or anaphylaxis,due to cyst leakage or rupture.HD diagnosis is usually accomplished with the combined use of ultrasonography and immunodiagnosis;furthermore,the improvement of surgical techniques,the introduction of minimally invasive treatments[such as puncture,aspiration,injection,re-aspiration(PAIR)]and more effective drugs(such as benzoimidazoles)have deeply changed life expectancy and quality of life of patients with HD.The aim of this article is to provide an up-todate review of biological,diagnostic,clinical and therapeutic aspects of hepatic echinococcosis. | Giuseppe Nunnari Marilia R Pinzone Salvatore Gruttadauria Benedetto M Celesia Giordano Madeddu Giulia Malaguarnera Piero Pavone Alessandro Cappellani Bruno Cacopardo | 2012 | World Journal of Gastroenterology2012，18，13： | 72 |
| 2 | Laparoscopic hysterectomy as optimal approach for 5400 grams uterus with associated polycythemia: A case report显示文摘BACKGROUND Uterine myomas are the most common benign gynecological soft tissue tumors in women but polycythemia associated with these tumors is rare.Polycythemia is significantly associated with risk of venous thromboembolism(VTE),which is further increased in case of a large pelvic mass and obesity.Here we report the surgical challenges in the case of an obese patient with a giant fibromatous uterus and associated polycythemia.CASE SUMMARY A 42-year-old obese woman was referred to our department for treatment for a huge fibromatous uterus.She suffered of pelvic pressure and abdominal distension and reported severe dyspnea from several months.Laboratory analyses including hemoglobin(Hb)19.2 g/dL and hematocrit(Hct)59.7%were indicative of polycythemia.Arterial blood gas analysis showed arterial oxygen pressure(pO2)of 81.5 mmHg.Abdominal computed tomography confirmed a giant fibromatous uterus measuring 28.2 cm×17 cm×25 cm.To reduce the thromboembolic risk,the patient underwent low molecular weight heparin,phlebotomy twice before surgery,and we opted for a laparoscopic hysterectomy.The uterus weighed 5400 g and the histology confirmed a diagnosis of leiomyoma.We did not find increased erythropoietin levels in the supernatant of the myomatous uterine tissue.There were no complications.On postoperative day 1,the Hb and the Hct levels normalized to 13.3 g/dL and 41.7%,respectively.Arterial blood gas analysis after surgery showed a pO2 of 144.7 mmHg.These results suggested the diagnosis of myomatous erythrocytosis syndrome.The patient was discharged on the second postoperative day in very good condition with no symptoms.CONCLUSION We believe this is the first reported laparoscopic hysterectomy in a patient with a giant uterus,polycythemia and obesity.Multiple VTE risk factors warranted a laparoscopic approach. | Antonio Macciò Giacomo Chiappe Fabrizio Lavra Elisabetta Sanna Romualdo Nieddu Clelia Madeddu | 2019 | World Journal of Clinical Cases2019，7，19： | 5 |
| 3 | Contrast-enhanced ultrasound Liver Imaging Reporting and Data System:Lights and shadows in hepatocellular carcinoma and cholangiocellular carcinoma diagnosis显示文摘BACKGROUND Contrast-enhanced ultrasound(CEUS)is considered a secondary examination compared to computed tomography(CT)and magnetic resonance imaging(MRI)in the diagnosis of hepatocellular carcinoma(HCC),due to the risk of misdiagnosing intrahepatic cholangiocarcinoma(ICC).The introduction of CEUS Liver Imaging Reporting and Data System(CEUS LI-RADS)might overcome this limitation.Even though data from the literature seems promising,its reliability in real-life context has not been well-established yet.AIM To test the accuracy of CEUS LI-RADS for correctly diagnosing HCC and ICC in cirrhosis.METHODS CEUS LI-RADS class was retrospectively assigned to 511 nodules identified in 269 patients suffering from liver cirrhosis.The diagnostic standard for all nodules was either biopsy(102 nodules)or CT/MRI(409 nodules).Common diagnostic accuracy indexes such as sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)were assessed for the following associations:CEUS LR-5 and HCC;CEUS LR-4 and 5 merged class and HCC;CEUS LR-M and ICC;and CEUS LR-3 and malignancy.The frequency of malignant lesions in CEUS LR-3 subgroups with different CEUS patterns was also determined.Inter-rater agreement for CEUS LI-RADS class assignment and for major CEUS pattern identification was evaluated.RESULTS CEUS LR-5 predicted HCC with a 67.6%sensitivity,97.7%specificity,and 99.3%PPV(P<0.001).The merging of LR-4 and 5 offered an improved 93.9%sensitivity in HCC diagnosis with a 94.3%specificity and 98.8%PPV(P<0.001).CEUS LR-M predicted ICC with a 91.3%sensitivity,96.7%specificity,and 99.6%NPV(P<0.001).CEUS LR-3 predominantly included benign lesions(only 28.8%of malignancies).In this class,the hypo-hypo pattern showed a much higher rate of malignant lesions(73.3%)than the iso-iso pattern(2.6%).Inter-rater agreement between internal raters for CEUS-LR class assignment was almost perfect(n=511,k=0.94,P<0.001),while the agreement among raters from separate centres was substantial(n=50,k=0.67,P<0.001).Agreement was stronger for arterial phase hyperenhancement(internal k=0.86,P<2.7×10-214;external k=0.8,P<0.001)than washout(internal k=0.79,P<1.6×10-202;external k=0.71,P<0.001).CONCLUSION CEUS LI-RADS is effective but can be improved by merging LR-4 and 5 to diagnose HCC and by splitting LR-3 into two subgroups to differentiate iso-iso nodules from other patterns. | Gianpaolo Vidili Marco Arru Giuliana Solinas Diego Francesco Calvisi Pierluigi Meloni Assunta Sauchella Davide Turilli Claudio Fabio Antonio Cossu Giordano Madeddu Sergio Babudieri Maria Assunta Zocco Giovanni Iannetti Enza Di Lembo Alessandro Palmerio Delitala Roberto Manetti | 2022 | World Journal of Gastroenterology2022，28，27： | 3 |
| 4 | l -Carnitine: An adequate supplement for a multi-targeted anti-wasting therapy in cancer显示文摘 | Sílvia Busquets Roberto Serpe Míriam Toledo Angélica Betancourt Enrica Marmonti Marcel Orpí Fabrizio Pin Eva Capdevila Clelia Madeddu Francisco J. López-Soriano Giovanni Mantovani Antonio Macciò Josep M. Argilés | 2012 | Clinical Nutrition2012，，6： | 2 |
| 5 | Deregulation of microRNA-503 Contributes to Diabetes Mellitus–Induced Impairment of Endothelial Function and Reparative Angiogenesis After Limb Ischemia显示文摘 | Andrea Caporali Marco Meloni Christine V?llenkle Desiree Bonci Graciela B. Sala-Newby Roberta Addis Gaia Spinetti Sergio Losa Rachel Masson Andrew H. Baker Reuven Agami Carlos le Sage Gianluigi Condorelli Paolo Madeddu Fabio Martelli Costanza Emanueli | 2011 | Circulation2011，，3： | 2 |
| 6 | Angiogenesis therapy with human tissue kallikrein for the treatment of ischemic diseases 显示文摘 | Emanueli G Madeddu P | 2004 | Arch Mal Coeur2004，97，6： | 1 |
| 7 | Human tissue kallikrein:a new bullet for the treatment of ischemia显示文摘 | Emanuelia C Madeddu P | 2003 | Curr Pharm Des2003，9，7： | 1 |
| 8 | Intracoronary deliv-ery of hematopoietic bone marrow stem cells and luminal loss of the in-farct-related artery in patients with recent myocardial infarction显示文摘 | Mansour S Madeddu C Vanderheyden M et a1 | 2006 | Am Coll Cardiol2006，47，8： | 1 |
| 9 | Antioxidant agents are effective in inducing lymphocyte progression through cell cycle in advanced cancer patients:assessment of the most important laboratory indexes of cachexia and oxidative stress显示文摘 | Mantovani G Maccio A Madeddu C | 2003 | J Mol Med2003，81，10： | 1 |
| 10 | Therapeutic angiogenesis and vasculogenesis for tissue regeneration显示文摘 | Madeddu P | | 0，，： | 1 |
| 11 | BDNF down-regulates the caspase-3 pathway in injuried genicullo-cortical neurons显示文摘 | Madeddu F Naska S Bozzi Y | 2004 | Neuroreport2004，15，13： | 1 |
| 12 | Angiogenesis therapy with human tissue kallikrein for the treatment of ischemic diseases显示文摘 | Emanueli C Madeddu P | | 0，，06： | 1 |
| 13 | Angiogenesis therapy with human tissue kallikrein for the treatment of ischemic disease显示文摘 | Emanueli C Madeddu P | 2004 | Arch Mal Coeur2004，97，6： | 1 |
| 14 | Tenofovir renal safety in HIV-infected patients : Results from the SCOLTA Project 显示文摘 | Madeddu G Bonfanti P de Socio GV | 2008 | Biomed Pharmacother2008，62，1： | 1 |
| 15 | Human tissue kallikrein: a new bullet for the treatment of ischemia 显示文摘 | Emanuelia C Madeddu P | 2003 | Curr Pharm Des2003，9，7： | 1 |
| 16 | Reactive oxygen species, antioxidant mechanisms, and serum cytokine levels in cancer patients: impact of an antioxidant treatment显示文摘 | Mantovani G Maccio A Madeddu C | 2003 | J Environ Pathol Toxicol Oncol2003，22，1： | 1 |
| 17 | Acute ACE inhibition ca- use plasma extravasation in mice that is mediated by bradykinin and substance P显示文摘 | Emanueli C Grady EF Madeddu P | 1998 | Hypertension1998，31，6： | 1 |
| 18 | Angiogenesis therapy with human tissue kallikrein for the treatment of ischemic diseases 显示文摘 | Emanueli C Madeddu P | 2004 | Arch Mal Coeur Vaiss2004，97，： | 1 |
| 19 | Phase Ⅱ nonrandomized study of the efficacy and safety of COX-2 inhibitor celecoxib on patients with cancer cachexia显示文摘 | Mnntovani G Maccio A Madeddu C | 2010 | J Mol Med (Berl)2010，88，1： | 1 |
| 20 | Transplantation of low dose CD34+ KDR+ cells promotes vascular and muscular regeneration in ischemic limbs显示文摘 | Madeddu P Emanueli C Pelosi E | 2004 | FASEB J2004，18，14： | 1 |
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