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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | An apparently new transmissible disease of cattle显示文摘 | OLAFSON P MAC C A FOX F H | 1946 | Cornell Vet1946，36，： | 1 |
| 3 | The crystal chemistry of manganese-bearing elbaite显示文摘 | Burns P C Mac Donald D J Hawthorne F C | 1994 | Can Mineral1994，32，： | 1 |
| 4 | Diffusion tensor imaging reliably detects experimental traumatic axonal injury and indicates approximate time of injury显示文摘 | Mac Donald C L Dikranian K Bayly P | 2007 | J Neurosci2007，27，11： | 1 |
| 5 | Criteria used by venture capitalists to evaluate new venture proposals显示文摘 | MAC MILLAN I C SIEGEL R NARASIMHA P N | 1986 | Journal of Business venturing1986，1，1： | 1 |
| 6 | Application of biosafety principles in blood establishments显示文摘 | Grumet F C Mac Pherson J L Hoppe P A | 1988 | Transfusion1988，28，5： | 1 |
| 7 | Synthesis, thermal, mechanical and rheological properties of multi- wall carbon nanotube/waterborne polyurethane nanocom- posite显示文摘 | KUAN H C MAC C M CHANG W P | 2005 | Composites Science and Technology2005，65，11： | 1 |
| 8 | An improved technique for the in situ detection of DNA after polymerase chain reaction application显示文摘 | NUOVO G J GALLERY F MAC C P | 1991 | American Journal of Pathology1991，139，： | 1 |
| 9 | A com-parison of methods to test mediation and other intervening vari-able effects显示文摘 | Mac Kinnon D P Lockwood C M Hoffman J M | 2002 | Psychological Methods2002，7，： | 1 |
| 10 | Decomposition of nitrous oxide over Co-zeolite catalysts:Role of zeolite structure and active site显示文摘 | ZHANG X Y SHEN Q HE C MAC Y CHENG J LIU Z M HAO Z P | 2012 | Catal Sci Technol2012，2，6： | 1 |
| 11 | 查看详情显示文摘 | Marques R S Mac Leod T C O Yoshida I V P Mano V Assis M D Schiavon M A | | 0，，： | 1 |
| 12 | Synthesis, thermal, mechanical and rheological properties of multiwall carbon nanotube/waterbome polyurethane nanocomposite 显示文摘 | KUAN H C MAC C M CHANG W P | 2005 | Composites Science and Technology2005，65，1112： | 1 |
| 13 | Promotional effects and mechanism of second cations on activity and stability of Co-MOR for nitrous oxide decomposition:UV-Vis spectroscopy and EXAFS analysis 显示文摘 | ZHANG X Y SHEN Q HE C MAC Y LIU Z T HAO Z P | 2013 | Chem Eng J2013，226，： | 1 |
| 14 | Synthesis, thermal, mechanical and rheological properties of multiwall carbon nanotube/waterborne polyurethane nanocomposite 显示文摘 | KUAN H C MAC C CHANG W P | 2005 | Composites Science and Technology2005，65，1112： | 1 |
| 15 | Ultrasonography in patients with chronic liver disease:its usefulness in the diagnosis of cirrhosis显示文摘 | Macías Rodríguez M A Rendón Unceta P Navas Relinque C | | 0，，4： | 1 |
| 16 | Fresh cucumber flavor in refrigerated pickles:comparison of sensory and instrumental analysis显示文摘 | Palma H C Mac Feeters R F Fleming H P | 2002 | Journal of Agricultural and Food Chemistry2002，50，17： | 1 |
| 17 | Diffusion tensor imaging reliably detects experimental traumatic axonal injury and indicates approximate time of injury显示文摘 | Mac Donald C L Dikranian K Bayly P | 2007 | J Neurosci2007，27，11： | 1 |
| 18 | The distribuion of heavery metal between the principal components of digested sewage sludge 显示文摘 | Mac Nicol R C Beckett P H | 1989 | War Res1989，23，2： | 1 |
| 19 | Lipschitz functions on spaces of homogeneous type显示文摘 | Macías P Segovia C | | 0，，： | 1 |
| 20 | A critical review of construct indicators and measurement model misspecification in marketing and consumer research显示文摘 | Jarvis C B Mac Kenzie S B Podsakoff P M | 2003 | Journal of Consumer Research2003，30，2： | 1 |
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