|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Naringenin prevents experimental liver fibrosis by blocking TGFβ-Smad3 and JNK-Smad3 pathways显示文摘AIM To study the molecular mechanisms involved in the hepatoprotective effects of naringenin(NAR)on carbon tetrachloride(CCl4)-induced liver fibrosis.METHODS Thirty-two male Wistar rats(120-150 g)were randomly divided into four groups:(1)a control group(n=8)that received 0.7%carboxy methyl-cellulose(NAR vehicle)1 m L/daily p.o.;(2)a CCl4 group(n=8)that received 400 mg of CCl4/kg body weight i.p.3 times a week for 8 wk;(3)a CCl4+NAR(n=8)group that received 400 mg of CCl4/kg body weight i.p.3times a week for 8 wk and 100 mg of NAR/kg body weight daily for 8 wk p.o.;and(4)an NAR group(n=8)that received 100 mg of NAR/kg body weight daily for 8 wk p.o.After the experimental period,animals were sacrificed under ketamine and xylazine anesthesia.Liver damage markers such as alanine aminotransferase(ALT),alkaline phosphatase(AP),γ-glutamyl transpeptidase(γ-GTP),reduced glutathione(GSH),glycogen content,lipid peroxidation(LPO)and collagen content were measured.The enzymatic activity of glutathione peroxidase(GPx)was assessed.Liver histopathology was performed utilizing Masson’s trichrome and hematoxylin-eosin stains.Zymography assays for MMP-9 and MMP-2 were carried out.Hepatic TGF-β,α-SMA,CTGF,Col-I,MMP-13,NF-κB,IL-1,IL-10,Smad7,Smad3,p Smad3 and p JNK proteins were detected via western blot.RESULTS NAR administration prevented increases in ALT,AP,γ-GTP,and GPx enzymatic activity;depletion of GSH and glycogen;and increases in LPO and collagen produced by chronic CCl4 intoxication(P<0.05).Liver histopathology showed a decrease in collagen deposition when rats received NAR in addition to CCl4.Although zymography assays showed that CCl4 produced an increase in MMP-9 and MMP-2gelatinase activity;interestingly,NAR administration was associated with normal MMP-9 and MMP-2 activity(P<0.05).The anti-inflammatory,antinecrotic and antifibrotic effects of NAR may be attributed to its ability to prevent NF-κB activation and the subsequent production of IL-1 and IL-10(P<0.05).NAR completely prevented the increase in TGF-β,α-SMA,CTGF,Col-1,and MMP-13 proteins compared with the CCl4-treated group(P<0.05).NAR prevented Smad3phosphorylation in the linker region by JNK since this flavonoid blocked this kinase(P<0.05).CONCLUSION NAR prevents CCl4 induced liver inflammation,necrosis and fibrosis,due to its antioxidant capacity as a free radical inhibitor and by inhibiting the NF-κB,TGF-β-Smad3 and JNK-Smad3 pathways. | Erika Hernández-Aquino Natanael Zarco Sael Casas-Grajales Erika Ramos-Tovar Rosa E Flores-Beltrán Jonathan Arauz Mineko Shibayama Liliana Favari Víctor Tsutsumi José Segovia Pablo Muriel | 2017 | World Journal of Gastroenterology2017，23，24： | 10 |
| 2 | 墨西哥地下水中的砷和氟化物显示文摘墨西哥各区含水层的监测结果表明,地下水砷浓度和氟浓度都高于饮用水标准,调查表明,污染物是原生的;而少数区域的监测结果表明,污染主要是由于对水特殊处理后,将一些有毒元素释放到地下水中所致。在墨西哥北部Comarca Lagunera,就砷对健康的影响进行了大量的研究,而且在这些区域还发现了高氟水。这些地方砷的来源问题仍有争议。天然的和人为排放的砷污染了采矿活动频繁区域的地下水。墨西哥中部Zimapan裂隙石灰岩含水层被富砷矿物污染。尾矿和富含烟气的沉积物的冶炼污染了浅层小颗粒含水层(granular aquifer)。在SanAntonio-El Triunfo采矿区、加利福尼亚南部Baja和San Luis Potosi州的Santa Maria de la Paz也报道砷污染的情况。水文地球化学和统计学手段调查表明,即便不采矿,毒砂氧化也可能污染水体,如墨西哥高原的Independencia含水层就是这样的实例。在Los Azufres、Los Humeros和Acoculco地热区也有高浓度的砷检出,在Aguascalientes、Los Azufres、Los Humeros和Acoculco州调查了氟斑牙的发病率。水中的氟化物导致酸性的火山岩分解。墨西哥大部分居民都饮用地下水。目前对墨西哥地质概况的调查表明,在所有的水富集区,必须把测定地下水砷和氟化物浓度的工作提到日程上来,进行学科间的研究,评价污染物的来源。 | M. A. Armienta · N. Segovia 葛秀珍(翻译) 张福存(校对) | 2009 | 水文地质工程地质技术方法动态2009，，3： | 2 |
| 3 | The different faces of shared autoimmunity显示文摘 | Rodrtguez - Reyna TS Alarern - Segovia D | 2006 | Autoimmun Rev2006，5，2： | 1 |
| 4 | Formation risk of toxic and other unwanted compounds in pressure - assisted thermally processed foods显示文摘 | Segovia Bravo K Ramirez R Durst R | 2012 | Journal of Food Science2012，77，1： | 1 |
| 5 | Push-and-pull regulation of the fusion pore by synaptotagmin-7 显示文摘 | Segovia M Ales E Montes MA | 2010 | Proc Natl Acad Sci USA2010，107，19： | 1 |
| 6 | Long-term (5 years) effects of bosentan in patients with pulmonary arterial hypertension 显示文摘 | Avellana P Segovia J Sufrate E Gómez-Bueno M García-Cosío Carmena M D García-Pavía P | 2011 | Rev Esp Cardiol2011，64，： | 1 |
| 7 | A decomposition into atoms of distribution on space of homogeneous type显示文摘 | Maci'as R A Segovia C A | 1979 | Adv in Math1979，33，： | 1 |
| 8 | Arsenic and fluoride in the groundwater of Mexico显示文摘 | Armienta M A Segovia N | 2008 | Environmental Geochemistry and Health2008，30，： | 1 |
| 9 | Higher order commutators for vector - valued Calderón - Zygmund oporators显示文摘 | Carlos Segovia Jose L Torrea | 1993 | Trans Amer Math Soc1993，336，： | 1 |
| 10 | Clinical characteristics and natural history of human immunodeficiency virus infection study in a Chilean population served at a multlprofessional pilot center显示文摘 | Wolff M Northland R Segovia J | 1995 | Rev Med Chil1995，123，： | 1 |
| 11 | Nucleus accumbens and effort-related functions:behavioral and neural markers of the interactions between adenosine A2A and dopamine D2 receptors显示文摘 | Farrar AM Segovia KN Randall PA | | 0，，04： | 1 |
| 12 | Application of PolarOrganic Chemical Integrative Sampler ( POCIS) to monitor emer-ging contaminants in tropical waters显示文摘 | BAYEN S SEGOVIA E LOH L L | 2014 | Science of the Total En-vironment2014，482，： | 1 |
| 13 | Vector- valued commutators and applications显示文摘 | Carles Segovia Jose L Torrea | 1989 | Indiana Univ Math J1989，，： | 1 |
| 14 | Influence of processing variables on mechanical characteristics of sunlight aged polyester-glass fiber composites 显示文摘 | SEGOVIA F FERRER C SALVADOR M D AMIGO V | 2001 | Polymer Degradation and Stability2001，71，： | 1 |
| 15 | Hypocalci- uria during pregnancy as a risk factor of preeclampsia显示文摘 | SEGOVIA B L VEGA I T VILLARREAL E C | 2004 | Ginecol Obstet Mex2004，72，： | 1 |
| 16 | Growth retardation in constitutionally short children is related both to low serum levels of insulin-like growth factor- I and to its reduced bioavailability显示文摘 | Lindgren BF Segovia B Lassarre C | 1996 | Growth Regul1996，6，： | 1 |
| 17 | Stress, neurotransmitters corti- costerone and body-brain integration 显示文摘 | Mora F Segovia G Del Areo A | 2012 | Brain Res2012，1476，： | 1 |
| 18 | Weighted norm inequalities for commtators of strongly singular intergrals显示文摘 | Garcia-Cuerva J Harboure E Segovia C | 1991 | Indiana Univ Math1991，40，： | 1 |
| 19 | Delayed engraftment of nonobese diabetic/severe combined immunodeficient mice transplanted with ex vivo-expanded human CD34^+ cord blood ceils 显示文摘 | Guenechea G Segovia JC Albella B | 1999 | Blood1999，93，3： | 1 |
| 20 | Oc- currence of priority pollutants in WWTP effluents and Mediterra- nean coastal waters of Spain 显示文摘 | Martf N Aguado D Segovia - Martinez L | 2011 | Marine Pollution Bulletin2011，62，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员