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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Nutritional therapy for hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the most frequent primary liver cancer and presents together with cirrhosis in most cases.In addition to commonly recognized risk factors for HCC development,such as hepatitis B virus/hepatitis C virus infection,age and alcohol/tobacco consumption,there are nutritional risk factors also related to HCC development including high intake of saturated fats derived from red meat,type of cooking(generation of heterocyclic amines)and contamination of foods with aflatoxins.On the contrary,protective nutritional factors include diets rich in fiber,fruits and vegetables,n-3 polyunsaturated fatty acids and coffee.While the patient is being evaluated for staging and treatment of HCC,special attention should be paid to nutritional support,including proper nutritional assessment and therapy by a multidisciplinary team.It must be considered that these patients usually develop HCC on top of long-lasting cirrhosis,and therefore they could present with severe malnutrition.Cirrhosisrelated complications should be properly addressed and considered for nutritional care.In addition to traditional methods,functional testing,phase angle and computed tomography scan derived skeletal muscle index-L3 are among the most useful tools for nutritional assessment.Nutritional therapy should be centered on providing enough energy and protein to manage the increased requirements of both cirrhosis and cancer.Supplementation with branched-chain amino acids is also recommended as it improves response to treatment,nutritional status and survival,and finally physical exercise must be encouraged and adapted to individual needs. | Astrid Ruiz-Margáin Berenice M Román-Calleja Paulina Moreno-Guillén JoséA González-Regueiro DeyaniraKúsulas-Delint Alejandro Campos-Murguía Nayelli C Flores-García Ricardo Ulises Macías-Rodríguez | 2021 | World Journal of Gastrointestinal Oncology2021，13，10： | 4 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Sedimentology and Shale Modeling of a Sandstone-Rich Fluvial Reservoir:Upper Statfjord Formation,Statfjord Field,Northern North Sea显示文摘 | Alister C Mac Donald Halland K | 1993 | AAPG1993，77，6： | 1 |
| 5 | 2D and 3D finite element a- nal ysis of a three stage forging sequence 显示文摘 | Mac Cormack C Monaghan J | 2002 | Journal of Ma- teri-als Processing Technology2002，，127： | 1 |
| 6 | De- termination of undegradable intake protein digestibility of forages using the mobile nylon bag technique 显示文摘 | HAUGEN H L IVAN S K MAC DONALD J C | 2006 | J Anita Sci2006，84，： | 1 |
| 7 | An apparently new transmissible disease of cattle显示文摘 | OLAFSON P MAC C A FOX F H | 1946 | Cornell Vet1946，36，： | 1 |
| 8 | On the diffusion of biological population显示文摘 | Gurtin M E Mac Cammy R C | | 0，，： | 1 |
| 9 | Preparation,electrical,mechanical and thermal properties of composite bipolar plate for a fuel cell显示文摘 | KUAN H C MAC C M CHEN K H | 2004 | Journal of Power Sources2004，134，： | 1 |
| 10 | Hydrogenolysis of glycerol to 1, 2-propanediol on the high dispersed SBA-15 supported copper catalyst prepared by the ion- exchange method 显示文摘 | ZHENG J ZHU W C MAC X | 2010 | Reaction Kinetics Mechanisms and Catalysis2010，99，2： | 1 |
| 11 | Global transcriptome profiles of Camellia sinensis during cold acclimation 显示文摘 | WANG X C ZHAO Q Y MAC L | 2013 | BMC Genomics2013，14，： | 1 |
| 12 | Morbidity in laparoscopic gynecological surgery:results of a prospective single - center study 显示文摘 | Mac Cordick C Lecuru F Rizk E | 1999 | Surg Endosc1999，13，1： | 1 |
| 13 | Myc-Max heterodimers acti- vate a DEAD box gene and interact with multiple E box-related sites in vivo显示文摘 | Grandori C Mac J Siebelt F | 1996 | EMBO J1996，15，16： | 1 |
| 14 | Positive cloud toground lightning in mesoscalc convective system显示文摘 | Rutledge S A C Lu D R Mac Gorman | 1990 | J Atmos Sci1990，47，： | 1 |
| 15 | Endochondral and intramembranous fetal bone development:osteoblastic cell proliferation,and expression of alkaline phosphatase,m-twist,and histone H4显示文摘 | Alborzi A Mac K Glackin C A | 1996 | J Craniofae Genet Dev Biol1996，16，2： | 1 |
| 16 | Merging photoredox catalysis with organocatalysis:the direct asymmetric alkylation of aldehydes显示文摘 | Nicewicz D A Mac Millan D W C | 2008 | Science2008，322，： | 1 |
| 17 | Performance test and flow visualization of ball valve 显示文摘 | CHERN M J WANG C C MAC H | 2007 | Experimental Thermal and Fluid Science2007，，31： | 1 |
| 18 | The Booroola(Fec B)phenotype is associated with a mutation in the bone morphogenetic receptor type 1 B(BMPRIB)显示文摘 | SOUZA C J Mac DOUGALL C CAMPBELL B K | 2001 | J Endocrinol2001，169，2： | 1 |
| 19 | ‘SPC136’(Suite NoteTM)sweet cherry显示文摘 | Hampson C Mac Donald R Mc Kenzie DL | 2014 | Canadian Journal of Plant Science2014，94，8： | 1 |
| 20 | Morbidity in lapa roscopic gynecological surgery:result of a prospective sin gle-center study显示文摘 | Mac Cordick C Lecuru F Rizk E | 1999 | Surg Endose1999，13，1： | 1 |
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