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| 1 | Hepatic steatosis is associated with an increased risk of carotid atherosclerosis显示文摘AIM: Although an association between helatic steatosis and vascular risk factors has been described, direct relationships between fatty liver and atherosclerosis have not yet been investigated. The aim of the present study has been to investigate those relationships.METHODS: The Study of Health in Pomerania examined a random population sample aged between 20 and 79 years.A study population of 4 222 subjects without hepatitis B and C infections and without liver cirrhosis was available for the present analysis. Hepatic steatosis was defined sonographically and intima-media thickness (IMT) as well as plaque prevalence were estimated by carotid ultrasound.RESULTS: The prevalence rate of hepatic steatosis was 29.9%. Among subjects aged ≥45 years, an association between hepatic steatosis and IMT of the carotid arteries was found in bivariate analysis, but not after adjustment for atherosclerotic risk factors. Individuals with fatty liver had more often carotid plaques than persons without fatty liver (plaque prevalence rate 76.8% vs 66.6%; P<0.001).This association persisted after adjustment for confounding factors and was predominantly present in subjects with no to mild alcohol consumption.CONCLUSION: There is an independent association between hepatic steatosis and carotid atherosclerotic plaques. Metabolic changes due to nonalcoholic fatty liver disease may explain this relationship. | Henry V(o|¨)lzke Daniel M.Robinson Volker Kleine Roland Deutscher Wolfgang Hoffmann Jan Lüdemann Ulf Schminke Christof Kessler Ulrich John | 2005 | World Journal of Gastroenterology2005，11，12： | 29 |
| 2 | Bioengineering bacterial encapsulin nanocompartments as targeted drug delivery system显示文摘The development of Drug Delivery Systems(DDS)has led to increasingly efficient therapies for the treatment and detection of various diseases.DDS use a range of nanoscale delivery platforms produced from polymeric of inorganic materials,such as micelles,and metal and polymeric nanoparticles,but their variant chemical composition make alterations to their size,shape,or structures inherently complex.Genetically encoded protein nanocages are highly promising DDS candidates because of their modular composition,ease of recombinant production in a range of hosts,control over assembly and loading of cargo molecules and biodegradability.One example of naturally occurring nanocompartments are encapsulins,recently discovered bacterial organelles that have been shown to be reprogrammable as nanobioreactors and vaccine candidates.Here we report the design and application of a targeted DDS platform based on the Thermotoga maritima encapsulin reprogrammed to display an antibody mimic protein called Designed Ankyrin repeat protein(DARPin)on the outer surface and to encapsulate a cytotoxic payload.The DARPin9.29 chosen in this study specifically binds to human epidermal growth factor receptor 2(HER2)on breast cancer cells,as demonstrated in an in vitro cell culture model.The encapsulin-based DDS is assembled in one step in vivo by co-expressing the encapsulin-DARPin9.29 fusion protein with an engineered flavin-binding protein mini-singlet oxygen generator(MiniSOG),from a single plasmid in Escherichia coli.Purified encapsulin-DARPin_miniSOG nanocompartments bind specifically to HER2 positive breast cancer cells and trigger apoptosis,indicating that the system is functional and specific.The DDS is modular and has the potential to form the basis of a multi-receptor targeted system by utilising the DARPin screening libraries,allowing use of new DARPins of known specificities,and through the proven flexibility of the encapsulin cargo loading mechanism,allowing selection of cargo proteins of choice. | Alexander Van de Steen Rana Khalife Noelle Colant Hasan Mustafa Khan Matas Deveikis Saverio Charalambous Clare M.Robinson Rupali Dabas Sofia Esteban Serna Diana A.Catana Konstantin Pildish Vladimir Kalinovskiy Kenth Gustafsson Stefanie Frank | 2021 | Synthetic and Systems Biotechnology2021，6，3： | 2 |
| 3 | Skewness and Kurtosis Implied by Option Prices: A Correction显示文摘 | Christine A.Brown David M.Robinson | 2002 | Journal of Financial Research2002，，2： | 1 |
| 4 | Adalimumab sustains clinical remission and overall clinical benefit after 2?years of therapy for Crohn’s disease显示文摘 | R.PANACCIONE J.‐F.COLOMBEL W. J.SANDBORN P.RUTGEERTS G. R.D’HAENS A. M.ROBINSON J.CHAO P. M.MULANI P. F.POLLACK | 2010 | Alimentary Pharmacology & Therapeutics2010，，12： | 1 |
| 5 | Problem behaviour, caregiver reactions, and impact among caregivers of persons with Alzheimer’s disease显示文摘 | Karen M.Robinson PamAdkisson SallyWeinrich | 2002 | Journal of Advanced Nursing2002，，4： | 1 |
| 6 | Anemia and mortality in hemodialysis patients:Accounting for morbidity and treatment variables updated over time显示文摘 | Bruce M.Robinson Marshall M.Joffe Jeffrey S.Berns | | 0，，： | 1 |
| 7 | 乡村转型——樱桃种植在中国关中平原以及澳大利亚阿德莱德山(英文)显示文摘This paper echoes a tradition in agricultural geography by focusing on a single crop:cherries. It illustrates how developments associated with globalisation and growing urban markets are re-shaping rural areas. The interplay between global and local is investigated in two different contexts. A Chinese example reflects transformations affecting the countryside following national economic reforms. Focusing on the hinterland of Xi'an, capital of Shaanxi Province, it examines farmers' responses to the changing socio-political context and the rising size and wealth of the local market. Individual initiatives backed by government support have spawned localised concentrations of cherry growing and increased horticultural production.Farm-based tourism is creating new relationships between farmers and consumers, with farms becoming more diversified and multifunctional. The second example is the Adelaide Hills, South Australia, where cherry growing is increasingly combined with direct sales to consumers and gastronomic tourism. The paper addresses contrasts and similarities between the two examples in the interplay between global and local, and a ‘multifunctional transition' in farming. Concluding remarks include reference to new economic links forged between China and Australia through relaxations on cherry imports to China and new patterns of Chinese foreign direct investment into Australian cherry production. A research agenda for future research is suggested. | Guy M.ROBINSON 宋冰洁 | 2019 | Journal of Geographical Sciences2019，29，5： | 1 |
| 8 | Long‐term risk of malignancy after treatment of inflammatory bowel disease with azathioprine显示文摘 | A. G.Fraser T. R.Orchard E. M.Robinson D. P.Jewell | 2002 | Alimentary Pharmacology & Therapeutics2002，，7： | 1 |
| 9 | 采用延迟片叠合技术的LCoS投影彩色处理显示文摘现今最新的分色和合色方案要数Colorlink公司开发的ColorSelect 滤色片了,它是利用偏振性而不是薄膜相干或吸收效应来控制彩色的。ColorSelect 产品基于Colorlink公司专有的延迟片叠加技术, 有效地把原基色光的偏振状态旋转90o,而互补色光仍保持输入的原偏振状态。PBS和我们的ColorSelect 结合组成了新的彩色处理系统,如ColorQuard , 它已成为高性能LCoS投影系统彩色处理的标准配置。本文将评述ColorSelect 的基本功能,并探索多种可行的彩色处理方案。 | 陈建民 M.Robinson G.Sharp. 朱锦林 | 2004 | 现代显示2004，，3： | 0 |
| 10 | Exploring the tectonostratigraphy of the Pakistan Himalaya with new detrital zircon geochronology and neodymium isotope data from the Kaghan Valley显示文摘In the central Himalaya,the Greater and Lesser Himalayan tectonostratigraphic zones can be distinguished from each other by combining detrital zircon U-Pb ages and whole-rock Nd isotopic data.In the Hazara-Kashmir syntaxis of northern Pakistan,rock units in the Kaghan valley have been variously assigned to the Tethyan,Greater,and Lesser Himalayan zones.To determine which tectonostratigraphic zones are represented,we sampled across the Batal thrust in the northern Kaghan valley because this structure is identified in some research as the Main Central thrust.Samples from the footwall yield Paleo-to Mesoproterozoic maximum depositional ages(-1.8-1.1 Ga)and an averageεNd(0)value of-14.3.Samples from the hanging wall yield Neoproterozoic maximum depositional ages(~1000-600 Ma)andεNd(0)values of-17.3.The contrasting detrital zircon ages show that the Batal thrust in the Kaghan valley is a major structural division.However,these data lack the characteristic detrital zircon age spectra andεNd(0)values of Greater and Lesser Himalayan rocks north and south of the Main Central thrust in the central Himalaya,respectively.Therefore,either the Batal thrust is not the Main Central thrust,or the Main Central thrust in the Kaghan valley cuts a different structural level and carries rock units not seen outside the Hazara-Kashmir syntaxis. | W.Joel Schiffer Delores M.Robinson Shah Faisal Harold H.Stowell | 2023 | Geoscience Frontiers2023，14，6： | 0 |
| 11 | Geochemistry and in-situ U-Th/Pb Geochronology of the Jambil Meta-Carbonatites, Northern Pakistan: Implications on Petrogenesis and Tectonic Evolution显示文摘The putative Jambil meta-carbonatites of Swat,northern Pakistan,occur as discrete intrusions into the Proterozoic Manglaur Formation,which are difficult to be distinguished from nearby calc-silicate marble because both rock types experienced regional metamorphism during Himalayan orogenesis that resulted in similar mosaic textures and mineral assemblages.Carbonatites are often significant repositories of economic mineral resources and,therefore,are important to be distinguished from calc-silicate marble.We present new geochemical and geochronology data to distinguish between the two rock types and interpret the petrogenesis and tectonic evolution of the Jambil metacarbonatites.Whole rock chemical data from the Jambil meta-carbonatites show characteristically high rare earth element(REE),Sr contents and lack of negative Eu anomaly,consistent with average calcio-carbonatite values worldwide and an igneous origin.More than 0.5 wt.% SrO in the metacarbonatites and SrO> 0.15 wt.% in constituent rock forming calcite are discriminating signatures of the Jambil meta-carbonatites.Chemically,the Jambil meta-carbonatites are relatively depleted in Rb,Nb,Ta,Ti,Zr and Hf,relatively enriched in Ba,Th,Sr,and have a high LREE/HREE ratio when normalized to primitive mantle.Their carbon and oxygen isotope compositions vary from-3.5‰ to-4.3‰and from 9.7‰ to 12.3‰,respectively.These geochemical characteristics indicate generation of the carbonatites through small degree of partial melting from a carbonated eclogitic source.In-situ,U/Pb analysis of titanite indicates that the Jambil meta-carbonatites were emplacement at 438 ±3 Ma.When combined with regional geological observations,we interpret the emplacement of the Jambil metacarbonatites to have taken place during the Silurian back arc extension within greater Gondwana and mark a transition from a compressional tectonic regime,brought about by collision of microcontinental blocks along the northern margin of Gondwana,to post-orogenic extension in the waning stages of the pre-Himalayan Ordovician orogeny.Finally,in-situ ^(208)Pb/^(232)Th monazite dates(40.3-27.6Ma) extracted from the meta-carbonatites are consistent with the Cenozoic metamorphism of the area. | Asad Khan Shah Faisal Kyle P.Larson Delores M.Robinson Huan Li Zaheen Ullah Mark Button Javed Nawab Muhammad Farhan Liaqat Ali Muhammad Ali | 2023 | Journal of Earth Science2023，34，1： | 0 |
| 12 | 无已知冠心病病人多层CT冠状动脉成像的费用和临床结果:与SPECT心肌灌注显像比较显示文摘目的相匹配的两组无已知冠心病(CAD)人群分别行多层CT冠状动脉成像及单光子发射计算机体层摄影(SPECT)心肌灌注显像。 | L.J.Shaw R.B.Devereux M.Robinson 郭欢仪 | 2008 | 国际医学放射学杂志2008，31，A06： | 0 |
| 13 | 椭圆封头和球形封头压力容器弹-塑性行为数据分析显示文摘本文是对椭圆封头和球形封头压力容器的弹性-塑性变化的研究。该研究采用的是有限元分析和低界限分析法,获得了不同几何参数下的第一屈服压力、极限压力和试运压力,并和以前的结果做出比较。 | 李波 范晴 D.J.Yeom M.Robinson | 1997 | 国外油田工程1997，13，12： | 0 |
| 14 | Dynamics of Submersible Mussel Rafts in Waves and Current显示文摘To investigate the dynamics of submersible mussel rafts, the finite element program Aqua-FETM, developed by the University of New Hampshire(UNH), was applied to rafts moored at the surface and submerged. The submerged configuration is used to reduce wave forcing and to avoid contact with floating ice during winters in northern waters. Each raft consists of three pontoons connected by a grid framework. Rafts are intended to support densely spaced mussel ropes hung from the framework. When submerged, the pontoons are flooded, and the raft is held vertically by floats attached by lines. The computer models were developed in Aqua-FE? to simulate the effects of waves and current. They were validated by comparison with wave tank results by use of a 1/10 scale raft physical model. Comparisons showed good agreement for the important heave(vertical) and pitch(rotational) motions, though there was a tendency towards conservative results for wave and current drag. Full-scale simulations of surface and submerged single raft and two rafts connected in tandem were performed. Submerged raft wave response was found to be reduced relative to that at the surface for both the single and two-raft configurations. In particular, the vertical motion of mussel rope connection points was significantly reduced by submergence, resulting in reduced potential for mussel drop-off. For example, the maximum vertical velocities of mussel rope attachment points in the submerged two raft case were 7%-20% of the corresponding velocities when at the surface. | WANG Xin-xin M.Robinson SWIFT Tobias DEWHURST Igor TSUKROV Barbaros CELIKKOL Carter NEWELL | 2015 | China Ocean Engineering2015，29，3： | 0 |
| 15 | 录像带的表面粗糙度与磁特性的关系显示文摘人们知道,磁记录介质的表面粗糙度影响记录和重放特性。我们用于涉法对一系列VHS 录像带表面进行了粗糙度测量。业已发现磁带的信号输出电平和噪声与其均方根(rms)表面粗糙度有密切的关系(相关系数>0.95)。并发现随着表面粗糙度的增加,高频 RF 输出降低。这种关系在某种程度上符合三种理论模型。均方根表面粗糙度干涉法测量值乘以2.7,恰好等于计算出的磁头与磁带的间距(以下简称头一带间距)。 | Glen M.Robinson Theodere J.Szczch Craig D.Englund Richard D.Cambronne 李正 | 1990 | 信息记录材料1990，0，4： | 0 |
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