|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Intravenous infusion of magnesium sulfate is not associated with cardiovascular,liver,kidney,and metabolic toxicity in adults显示文摘Background:Magnesium(Mg)deficiency contributes to the pathophysiology of numerous diseases.The therapeutic use of Mg has steadily increased over time.The increased in-hospital use of intravenous(IV)magnesium sulfate(MgSO4)warrants more extensive investigation regarding the safety of the therapy.The aim of this study was to determine the safety of IV MgSO4 infusion on cardiovascular,liver,kidney,and metabolic markers in adults.Methods:Twelve volunteers were randomized to one of two cross-over conditions:(a)IV infusion of MgSO4 in 5%dextrose followed by IV infusion of 5%dextrose 1 week later or(b)IV infusion of 5%dextrose followed by IV infusion of MgSO4 in 5%dextrose 1 week later.An electrocardiogram was recorded continuously during the infusions.Blood was drawn pre-and post-infusion for blood count(high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,and triglycerides).Results:Serum Mg increased from pre-to post-infusion in the MgSO4+5%dextrose group(p<0.0001).The QRS interval length increased from pre-to post-infusion in the MgSO4+5%dextrose group(p<0.04).Additionally,serum glucose concentration increased in the MgSO4+5%dextrose group(p=0.04).These significant findings were modeled with gender and age as covariates.No other significant differences were found.Conclusions:The administration of IV infusion of MgSO4(4 g/100 mL)in 5%dextrose over a 4-hour treatment period poses no significant deleterious effects on cardiovascular,liver,kidney,or metabolic function.Relevance for patients:IV infusion of MgSO4 may be used for certain treatment indications without significant concern for systemic or organ toxicity. | Elisa Karhu Steven E.Atlas Jinrun Gao Syed A.Mehdi Dominique Musselman Sharon Goldberg Judi M.Woolger Raul Corredor Muhammad H.Abbas Leopoldo Arosemena Simone Caccamo Ashar Farooqi Janet Konefal Laura Lantigua Vanessa Padilla Ammar Rasul Eduard Tiozzo Oscar L.Higuera Andrea Fiallo John E.Lewis | 2018 | Journal of Clinical & Translational Research2018，4，1： | 0 |
| 2 | Anti-cancer effects of aloe-emodin:a systematic review显示文摘Background:Anthraquinones are a possible treatment option for oncological patients due to their anti-cancer properties.Cancer patients often exhaust a plethora of resources that ultimately fail to provide fully curative measures.Alternative treatments are subsequently sought in the hope of finding a therapeutic remedy.Potential regimens include aloe-emodin and its related derivatives.This review therefore summarizes the effects of aloe-emodin and other aloe components in light of their anti-proliferative and anti-carcinogenic properties.Methods:A systematic search was performed in PubMed for aloe-emodin and cancer in humans.Sixty abstracts of in vitro studies were selected and reviewed with subsequent screening of the full text.Thirty-eight articles were summarized.Results:Aloe-emodin possesses multiple anti-proliferative and anti-carcinogenic properties in a host of human cancer cell lines,with often multiple vital pathways affected by the same molecule.The most notable effects include inhibition of cell proliferation,migration,and invasion;cycle arrest;induction of cell death;mitochondrial membrane and redox perturbations;and modulation of immune signaling.The effects of aloe-emodin are not ubiquitous across all cell lines but depend on cell type.Conclusions:On the basis of this systematic review,the multiple consistent effects of aloe-emodin in human-derived cancer cell lines suggest that aloe-emodin is a potential anti-cancer agent that acts on cancer cells in a pleiotropic manner.Relevance for patients:Cancer patients often utilize alternative therapies as a result of suboptimal efficacy of conventional treatments.Aloe-emodin might become a therapeutic option for cancer patients if the basic research is confirmed in clinical trials. | Brian Sanders Anna M.Ray Sharon Goldberg Tyler Clark H.Reginald McDaniel Steven E.Atlas Ashar Farooqi Janet Konefal Lucas C.Lages Johanna Lopez Ammar Rasul Eduard Tiozzo Judi M.Woolger John E.Lewis | 2017 | Journal of Clinical & Translational Research2017，3，3： | 0 |
| 3 | The effect of dietary supplementation on brain-derived neurotrophic factor and cognitive functioning in Alzheimer’s dementia显示文摘Background and Aim:The objective of the present study was to investigate the effect of an aloe polymannose multinutrient complex(APMC)on pro brain-derived neurotrophic factor(BDNF)and mature BDNF in persons with moderate to severe Alzheimer’s dementia.Methods:A 12-month open-label trial was utilized to evaluate the effect of the APMC on proBDNF and BDNF and their relationship to cognitive functioning.Thirty-four adults were enrolled and consumed 4 teaspoons/day of APMC for 12 months.Subjects were assessed at baseline and twelve months follow-up for proBDNF and BDNF and with a neuropsychological battery to measure cognitive functioning.Cognitive functioning was correlated with proBDNF and BDNF.Results:Few adverse effects were reported.While proBDNF(baseline M=6,108.9,SD=854.9 and 12 months M=5,799.2,SD=573.4;p=0.57)and BDNF(baseline M=5,673.8,SD=3,342.3 and 12 months M=6,312.9,SD=2,830.9;p=0.29)did not significantly change,the correlations between the ADAS-cog total score and BDNF(r=–0.53,p=0.04)and BDNF/proBDNF ratio(r=–0.58,p=0.05)became statistically significant after 12 months of dietary supplementation.Other correlations were noted for various cognitive functioning assessments and BDNF and/or BDNF/proBDNF ratio at both baseline and 12 months.Conclusions:These findings suggest that the relationship between cognitive functioning and BDNF and BDNF/proBDNF ratio improved in response to consumption of a dietary supplement in persons with Alzheimer’s dementia,which is consistent with our previous findings on cognitive functioning.Relevance for patients:Overall,our results showed modest improvements in clinical outcomes for a disease that otherwise has no standard conventional approach to treatment with proven efficacy. | Alicia Martin Jordan Stillman Maria-Jose Miguez H.Reginald McDaniel Janet Konefal Judi M.Woolger John ELewis | 2017 | Journal of Clinical & Translational Research2017，3，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员