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| 1 | Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013显示文摘 | Marie Ng Tom Fleming Margaret Robinson Blake Thomson Nicholas Graetz Christopher Margono Erin C Mullany Stan Biryukov Cristiana Abbafati Semaw Ferede Abera Jerry P Abraham Niveen M E Abu-Rmeileh Tom Achoki Fadia S AlBuhairan Zewdie A Alemu Rafael Alfonso | 2014 | The Lancet2014，，： | 7 |
| 2 | 文献快报(8):童年至成年期不同BMI变化轨迹预示心血管代谢风险的差异显示文摘生命历程中体质量指数(BMI)变化轨迹与成年期心血管疾病的关联尚未明确。来自澳大利亚塔斯马尼亚大学孟席斯医学研究中心、芬兰图尔库大学Magnussen教授带领的团队分析了著名的"芬兰青年人群心血管风险研究"(Cardiovascular Risk in Young Finns Study)的2 631名受试对象在1980年(6-18岁)和2011年随访期(34-49岁)BMI数据,并探讨了其与成年期(34-49岁)心血管疾病危险因素,包括2型糖尿病、高危脂蛋白水平、高血压和颈动脉内膜增厚的关联。 | BUSCOT M THOMSON R J JUONALA M 孙莹 | 2018 | 中国学校卫生2018，39，10： | 7 |
| 3 | Nutritional modulation of the inflammatory response in inflammatory bowel disease-From the molecular to the integrative to the clinical显示文摘Nutrient deficiencies are common in patients with inflammatory bowel disease (IBD). Both total parenteral and enteral nutrition provide important supportive therapy for IBD patients, but in adults these are not useful for primary therapy. Dietary intervention with omega-3 polyunsaturated fatty acids contained in fish oil may be useful for the care of IBD patients, and recent studies have stressed the role of PPAR on NFκB activity on the potential beneficial effect of dietary lipids on intestinal function. | Gary E Wild Laurie Drozdowski Carmela Tartaglia M Tom Clandinin Alan BR Thomson | 2007 | World Journal of Gastroenterology2007，13，1： | 6 |
| 4 | Mortality associated with gastrointestinal bleeding in children: A retrospective cohort study显示文摘AIM To determine the clinical characteristics of children with gastrointestinal bleeding (GIB) who died during the course of their admission.METHODS We interrogated the Pediatric Hospital Information System database, including International Classification of Diseases, Current Procedural Terminology and Clinical Transaction Classification coding from 47 pediatric tertiary centers extracting the population of patients (1-21 years of age) admitted (inpatient or observation) with acute, upper or indeterminate GIB(1/2007-9/2015). Descriptive statistics, unadjusted univariate and adjusted multivariate analysis of the associations between patient characteristics and treatment course with mortality was performed with mortality as primary and endoscopy a secondary outcome of interest. All analyses were performed using the R statistical package, v.3.2.3. RESULTS The population with GIB was 19528; 54.6% were male, overall mortality was 2.07%;(0.37% in patients with the principal diagnosis of GIB). When consideringonly the mortalities in which GIB was the principal diagnosis, 48% (12 of 25 principal diagnosis GIB mortalities) died within the first 3 d of admission, whereas 19.8% of secondary diagnosis GIB patients died with 3 d of admission. Patients who died were more likely to have received octreotide (19.8% c.f. 4.04%) but tended to have not received proton pump inhibitor therapy in the first 48 h, and far less likely to have undergone endoscopy during their admission(OR = 0.489, P < 0.0001). Chronic liver disease associated with a greater likelihood of endoscopy. Mortalities were significantly more likely to have multiple complex chronic conditions. CONCLUSION GIB associated mortality in children is highest within 7 d of admission. Multiple comorbidities are a risk factor whereas early endoscopy during the admission is protective. | Thomas M Attard Mikaela Miller Chaitanya Pant Ashwath Kumar Mike Thomson | 2017 | World Journal of Gastroenterology2017，23，9： | 6 |
| 5 | 健康领域的文化能力显示文摘1背景
尽管人类对其他社会的兴趣纵贯历史的各个阶段,但是检验不同文化概念对人类健康实践的影响从20世纪才开始,当时是伴随着长期的人类学田野调查产生的,这些田野调查揭露了不同文化之间相关卫生实践的多样性、复杂性和连续性。 | Napier A D Ancarno C Butler B Calabrese j Chater A Chatterjee H Guesnet F Home R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams AC Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，2： | 5 |
| 6 | 补体B因子是代谢综合征模型代谢与心血管特征的一个决定因素显示文摘补体B因子(complenment factor B,CFB)在2型糖尿病及心血管病患者脂肪组织及血清中水平升高,但与疾病发病机制的因果关系不明确。自发性高血压大鼠(spontaneously hypertensive rats,SHR)脂肪组织及血清中CFB也升高。为明确CFB在代谢综合征中的作用,研究者在SHR中敲除Cfb基因。 | 赵狄 练桂丽 Coan PM Barrier M Alfazema N Carter RN Marion de Procé S Dopico XC Garcia Diaz A Thomson A Jackson-Jones LH Moyon B Webster Z Ross D Moss J Arends MJ Morton NM Aitman TJ | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 7 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 8 | 文化、不平等性与卫生服务提供显示文摘1动态不平等性对基层医疗卫生人力的影响
政治、社会、文化、专业群体皆建立在一致且常规的人类行为之上。当遭受巨大变革和内外压力时,这些群体会变得十分脆弱。尤其在动荡时期,这些群体往往更关注社会和文化的差异性,而非二者的一致性。尽管社会中的个体思维和行为会呈现较大的差异,但对健康的感知具有统一性,并在更广范围人群内尤为突出,这主要归因于文化价值观的作用。广义的文化心态会随着时间和地理位置的不同而不同,就像健康的社会决定因素也会因文化类型的不同而产生差异。 | Napier A D Ancarno C Butler B Calabrese J Chater A Chatterjee H Guesnet F Horne R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams A C Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，3： | 2 |
| 9 | Morphological,kinetic,membrane biochemical and genetic aspects of intestinal enteroplasticity显示文摘The process of intestinal adaptation('enteroplasticity') is complex and multifaceted.Although a number of trophic nutrients and non-nutritive factors have been identified in animal studies,successful,reproducible clinical trials in humans are awaited.Understanding mechanisms underlying this adaptive process may direct research toward strategies that maximize intestinal function and impart a true clinical benefit to patients with short bowel syndrome,or to persons in whom nutrient absorption needs to be maximized.In this review,we consider the morphological,kinetic and membrane biochemical aspects of enteroplasticity,focus on the importance of nutritional factors,provide an overview of the many hormones that may alter the adaptive process,and consider some of the possible molecular profiles.While most of the data is derived from rodent studies,wherever possible,the results of human studies of intestinal enteroplasticity are provided. | Laurie A Drozdowski M Tom Clandinin Alan BR Thomson | 2009 | World Journal of Gastroenterology2009，15，7： | 2 |
| 10 | Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture显示文摘 | Amit M Carpenter MK Thomson JA | 2000 | Dev Biol2000，227，： | 1 |
| 11 | A custom microarray platform for analysis of microRNA gene expression显示文摘 | PARKER J PEROU C M | 2004 | Nat Methods2004，1，： | 1 |
| 12 | Laser ionization mass spectroscopy of single aerosol particles显示文摘 | Thomson D S | 1995 | Aerosol Science and Technology1995，22，： | 1 |
| 13 | Results of a multicenter randomized study to evaluate the safety and efficacy of combined immunotherapy with interleukin-2, interferon-{alpha}2b and histamine dihydrochloride versus dacarbazine in patients with stage Ⅳ melanoma 显示文摘 | Middleton M Hauschild A Thomson D | 2007 | Ann Oncol2007，18，10： | 1 |
| 14 | The promoter of a basic PR1-like gene,AtPRB1,from Arabidopsis establishes an organ-specific expression pattern and responsiveness to ethylene and methyl jasmonate显示文摘 | SANTAMARIA M Thomson C J Read N D | 2001 | Plant Molecular Biology2001，47，： | 1 |
| 15 | Results of a Summer Academy to Increase Minority Student Access to Allied Health and Other Health Professions显示文摘 | Thomson W A Denk J P Miller L M | 1991 | J Allied Health1991，21，1： | 1 |
| 16 | Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR- II , a receptor member of the TGF-beta famity显示文摘 | THOMSON J R MACHADO R D PAUCIULO M W | 2000 | Journal of Medical Gene- tics2000，37，10： | 1 |
| 17 | Analysis of uncertainties in instantaneous soot volume fraction measurements using two-dimensional, auto-compensat- ing, laser-induced incandescence (2D-AC-LⅡ) 显示文摘 | Crosland B M Johnson M R Thomson K A | 2011 | Appl PhysB2011，102，1： | 1 |
| 18 | Conceptualizing and measuring Collaboration 显示文摘 | Thomson A M PerryJ L Miller T K | 2009 | Journal of Public Administration Research and Theory2009，9，1： | 1 |
| 19 | Analysis of Speckle Noise Contribution on Wavelet Decomposition of SAR Images显示文摘 | Simard M Degrandi G Thomson K P B | 1998 | IEEE Transac-tions on Geoscience and Remote Sensing1998，36，6： | 1 |
| 20 | Numerical analysis of damage propagation and strength of countersunk composite joints 显示文摘 | Chishti M Wang W H Thomson R S | 2012 | Composite Structures2012，94，2： | 1 |
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