|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Subcurative radiation significantly increases cell proliferation, invasion, and migration of primary glioblastoma multiforme in vivo显示文摘Tumor cell proliferation, infiltration, migration, and neovascularization are known causes of treatment resistance in glioblastoma multiforme(GBM). The purpose of this study was to determine the effect of radiation on the growth characteristics of primary human GBM developed in a nude rat. Primary GBM cells grown from explanted GBM tissues were implanted orthotopically in nude rats. Tumor growth was confirmed by magnetic resonance imaging on day 77(baseline) after implantation. The rats underwent irradiation to a dose of 50 Gy delivered subcuratively on day 84 postimplantation(n = 8), or underwent no radiation(n = 8). Brain tissues were obtained on day 112(nonirradiated) or day 133(irradiated). Immunohistochemistry was performed to determine tumor cell proliferation(Ki-67) and to assess the expression of infiltration marker(matrix metalloproteinase-2, MMP-2) and cell migration marker(CD44). Tumor neovascularization was assessed by microvessel density using von-Willebrand factor(vWF) staining. Magnetic resonance imaging showed well-developed, infiltrative tumors in 11 weeks postimplantation. The proportion of Ki-67-positive cells in tumors undergoing radiation was(71 ± 15)% compared with(25 ± 12)% in the nonirradiated group(P = 0.02). The number of MMP-2-positive areas and proportion of CD44-positive cells were also high in tumors receiving radiation, indicating great invasion and infiltration. Microvessel density analysis did not show a significant difference between nonirradiated and irradiated tumors. Taken together, we found that subcurative radiation significantly increased proliferation, invasion, and migration of primary GBM. Our study provides insights into possible mechanisms of treatment resistance following radiation therapy for GBM. | Adarsh Shankar Sanath Kumar Asm Iskander Nadimpalli RS Varma Branislava Janic Ana deCarvalho Tom Mikkelsen Joseph A Frank Meser M Ali Robert A Knight Stephen Brown Ali S Arbab | 2014 | Chinese Journal of Cancer2014，33，3： | 5 |
| 2 | Outcone of hypospadias fistulas repair显示文摘 | Shankar KR Losty PD Hopper M | 2002 | BJU Int2002，89，： | 1 |
| 3 | Therapeutic applications of moloclonal antibodies 显示文摘 | Berger M Shankar V Vafai A | 2002 | Am J Med Sci2002，324，1： | 1 |
| 4 | A fuzzy goal programming approach for vendor selection problem in a supply chain 显示文摘 | Kumar M Vrat P Shankar R | 2004 | Computers & Industrial Engineering2004，46，3： | 1 |
| 5 | Solar photocatalyticdegradation of azo dye: Comparison of photocatalytic efficiency of ZnO and TiO2 显示文摘 | SAKTHIVEL S NEPPOLIAN B SHANKAR M V ARABINDOO B PALANICHAMY M MOORAGESAN V | 2003 | Solar Energy Materials & Solar Cells2003，77，： | 1 |
| 6 | Infection- derived Enterocoecusfaecalis strain mrfare enriched in esp, a gene encoding a novel surface protein显示文摘 | Shankar V Baghdayan A S Huyeke M M | 1999 | Infect Immun1999，67，： | 1 |
| 7 | Application of indigenous microbial consortia in bioremediation of oil-contaminated soils显示文摘 | Shankar S Kansrajh C Dinesh M G | 2014 | Int J Environ Sci Technol2014，11，36： | 1 |
| 8 | Anodic Growth of Highly Ordered TiO2 Nanotube Arrays to 134 fxm in Length显示文摘 | PAULOSE M SHANKAR K YORIYA S | 2006 | The Journal of Physical Chemistry B2006，111，16： | 1 |
| 9 | Severe plastic deformation (SPD) and nostructured materials by machining显示文摘 | Srinivasan Swaminathan M Ravi Shankar Balkrishna C Rao | 2007 | Journal of Materials Science2007，42，1： | 1 |
| 10 | Managing realtime database transactions in mobile ad-hoc networks显示文摘 | Le Gruenwald Shankar M Banik Chuo N Lau | 2007 | Distributed and Parallel Database2007，22，1： | 1 |
| 11 | Pathogenic enterocoeci: new developments in the 21st century显示文摘 | Tendolkar P M Baghdayan A S Shankar N | 2003 | Cell Mol Life Sci2003，60，12： | 1 |
| 12 | Transform domain LMS algorithm显示文摘 | S Shankar Narayan Allen M P M J Narsimaha | 1983 | IEEE Trans ASSP1983，31，3： | 1 |
| 13 | Evaluation of coatings on Ti-6Al-4V substrate under fretting fatigue显示文摘 | Wei R Shankar M Jeffrey H | 2004 | Surface and Coatings Technology2004，192，2： | 1 |
| 14 | Highly efficient solar cells using Ti02 nanotube arrays sensitized with a donor-antenna dye 显示文摘 | Shankar K Bandara J Paulose M | 2008 | Nano Lett2008，8，6： | 1 |
| 15 | Outcome ofhypospadias fistulas repair显示文摘 | Shankar KR Losty PD Hopper M | 2002 | BJU Int2002，89，1： | 1 |
| 16 | Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Aktl survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-inducedapoptosis显示文摘 | SHANKAR S L O'GUIN K KIM M | 2006 | J Neurosci2006，，： | 1 |
| 17 | Enhancement of photocatalytic activity by metal deposition:characterisation and photonic efficiency of Pt,Au and Pd deposited on TiO2 catalyst显示文摘 | Sakthivel S Shankar M V Palanichamy M | 2004 | Water Research2004，38，13： | 1 |
| 18 | A fuzzy programming approach for vendor selection problem in a supply chain显示文摘 | sKumar M Vrat P Shankar R | 2006 | International Journal of Production and Economics2006，101，： | 1 |
| 19 | The N-terminal domain of enterococcal surface protein, Esp, is sufficient for Esp mediated biofilm enhancement in Enterococcusfaecalis 显示文摘 | Tendolkar P M Baghdayan A S Shankar N | 2005 | JBacteriol2005，187，： | 1 |
| 20 | Enhancement of photocatalytic activity by metal deposition: characterisation andphotonic efficiency of Pt, Au and Pd deposited on TiO2 catalyst 显示文摘 | Sakthivel S Shankar M V Palanichamy M | 2004 | Water Research2004，38，13： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员