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| 1 | Conversion from calcineurin inhibitors to mTOR inhibitors stabilizes diabetic and hypertensive nephropathy after liver transplant显示文摘AIM: To investigate if conversion to the mammalian target of rapamycin inhibitors(mTORi) improves renal function in diabetic and/or hypertensive liver transplant patients immunosuppressed with tacrolimus or cyclosporine.METHODS: The study included 86 liver graft recipients immunosuppressed with mTORi treatment after orthotopic liver transplantation(OLT), including all liver recipients with worsening renal function before conversion to mTORi(n = 55 patients) and recipients with normal renal function who converted to m TORi for other reasons(n = 31 patients). We identified patients with diabetes mellitus(n = 28), arterial hypertension(n = 27), proteinuria(n = 27) and all three factors(n = 8)(some patients have hypertension and diabetes and no proteinuria). The primary endpoint was evolution in renal function defined as the development in plasma creatinine as a function of diabetes mellitus(DM), hypertension(HT) or proteinuria. We required elevated serum creatinine for at least two weeks to define renal dysfunction.RESULTS: Only patients that converted because of renal failure with plasma creatinine levels > 1.5 mg/dL showed an improvement of renal function(2.14 to 1.77 mg/dL)(P = 0.02). Patients with DM showed no improvement of serum creatinine levels(1.31 mg/dL to 1.37 mg/dL) compared with non DM patients(1.31 mg/dL to 1.15 mg/dL)(P = 0.01), HT patients(1.48 mg/dL to 1.5 mg/dL) with non HT patients(1.21mg/d L to 1.08 mg/dL) and patients with proteinuria(1.44 mg/dL to 1.41 mg/dL) and no proteinuria(1.31 mg/dL to 1.11 mg/dL). CONCLUSION: In OLT recipients with diabetes or hypertensive nephropathy, conversion to m TORi does not improve renal function but stabilizes plasma levels of creatinine. Proteinuria is not a contraindication to conversion to m TORi; it also stabilizes renal function. Conversion to m TORi should only be avoided in patients with diabetes, hypertension and proteinuria. | José M álamo Claudia Olivares Lydia Barrera Luis M Marín Gonzalo Suarez Carmen Bernal Juan Serrano Jordi Muntané Francisco J Padillo Miguel A Gómez | 2015 | World Journal of Transplantation2015，5，1： | 6 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | The prevalence of bcl- 2, p53, and ki67 immunoreactivity in transitional cell bladder carcinomas and their clinicopathologic correlates 显示文摘 | Lydia N Christina V Anastasios Z | 1996 | Hum Pathol1996，29，： | 1 |
| 4 | High Anthocyanin Intake Is Associated With a Reduced Risk of Myocardial Infarction in Young and Middle-Aged Women显示文摘 | Aedín Cassidy Kenneth J. Mukamal Lydia Liu Mary Franz A. Heather Eliassen Eric B. Rimm | 2013 | Circulation2013，，2： | 1 |
| 5 | Corporate reputation in the People's Republic of China:A B2B Perspective显示文摘 | MICHAEL T E LYDIA W FIONA J N | 2010 | Industrial Marketing Management2010，，39： | 1 |
| 6 | A novel membrane-anchored rab5 interacting protein required for homotypic endosome fusion显示文摘 | Simon H Liu X Lydia N | 2000 | J Biol Chem2000，275，24： | 1 |
| 7 | Design and development of food safety knowledge and attitude scales for consumer food safety education 显示文摘 | Lydia C Medeiros PhD RD Virginia N HiRers PhD | 2004 | J Am Diet Assoc2004，104，： | 1 |
| 8 | Design and development of food safety knowledge and attitude scales for consumer food safety education显示文摘 | Lydia C Medeiros PhD RD Virginia N Hillers PhD | 2004 | J Am Diet Assoc2004，104，： | 1 |
| 9 | The prevalence of bel-2, p53, and ki67 immunoreactivity in transitional cell bladder carcinomas and their elinieopathologie correlates显示文摘 | Lydia N Christina V Anastasios Z | 1996 | Hum Pathol1996，29，1： | 1 |
| 10 | Premature deaths attributable to blood pressure in China: a prospective cohort study显示文摘 | Jiang He Dongfeng Gu Jing Chen Xigui Wu Tanika N Kelly Jian-feng Huang Ji-chun Chen Chung-Shiuan Chen Lydia A Bazzano Kristi Reynolds Paul K Whelton Michael J Klag | 2009 | The Lancet2009，，9703： | 1 |
| 11 | Mitochondria: pharmacological manipulatian of cell death 显示文摘 | Lisa B H Lydia L Donald D N | 2005 | J Clin Invest2005，115，10： | 1 |
| 12 | Club drugs as causal risk factors for H1V acquisition among men who have sex with men : A review 显示文摘 | Drumright Lydia N Thomas LP | 2006 | Substance Use & Misuse2006，41，10： | 1 |
| 13 | 儿童期哮喘病史与青年期无症状动脉硬化的关系:Bogalusa心脏研究显示文摘哮喘与各种心血管病风险相关。目前尚不清楚儿童期哮喘病史是否会导致成年动脉硬化(心血管事件的一种无创性替代指标)。为此,Dianjianyi对年龄20~51岁有儿童期哮喘病史的Bogalusa心脏研究参与者1746人进行前瞻性分析。 | 刘青 叶鹏 Dianjianyi S Xiang L Yoriko H Hoirun N Xiaoyun S Felicia R Tanika K Emily H Shengxu L Jiang H Lydia B Wei C Lu Q | 2018 | 中华高血压杂志2018，26，6： | 0 |
| 14 | Improving outcomes in pancreatic cancer: Key points in perioperative management显示文摘This review focused in the perioperative management of patients with pancreatic cancer in order to improve the outcome of the disease. We consider that the most controversial points in pancreatic cancer management are jaundice management, vascular resection and neoadjuvant therapy. Preoperative biliary drainage is recommended only in patients with severe jaundice, as it can lead to infectious cholangitis, pancreatitis and delay in resection, which can lead to tumor progression. The development of a phase Ⅲ clinical trial is mandatory to clarify the role of neo-adjuvant radiochemotherapy in pancreatic adenocarcinoma. Venous resection does not adversely affect postoperative mortality and morbidity, therefore, the need for venous resection should not be a contraindication to surgical resection in selected patients. The data on arterial resection alone, or combined with vascular resection at the time of pancreatectomy are more heterogeneous, thus, patient age and comorbidity should be evaluated before a decision on operability is made. In patients undergoing R0 resection, arterial resection can also be performed. | José M álamo Luis M Marín Gonzalo Suarez Carmen Bernal Juan Serrano Lydia Barrera Miguel A Gómez Jordi Muntané Francisco J Padillo | 2014 | World Journal of Gastroenterology2014，20，39： | 0 |
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