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| 1 | Analysis of the Global Burden of Disease study highlights the trends in death and disability-adjusted life years of leukemia from 1990 to 2017显示文摘Background:The patterns of leukemia burden have dramatically changed in recent years.This study aimed to estimate the global trends of leukemiarelated death and disability-adjusted life-years(DALYs)from 1990 to 2017.Methods:The data was acquired from the latest version of the Global Burden of Disease(GBD)study.Estimated annual percentage changes(EAPCs)were calculated to estimate the trend of age-standardized rate(ASR)of death and DALYs due to leukemia and its main subtypes from 1990 to 2017.Results:Globally,the numbers of death and DALYs due to leukemia were 347.58×10^(3)(95%uncertainty interval[UI]=317.26×10^(3)-364.88×10^(3))and 11975.35×10^(3)(95%UI=10749.15×10^(3)-12793.58×10^(3))in 2017,with a 31.22% and 0.03% increase in absolute numbers from 1990 to 2017,respectively.Both of their ASR showed decreasing trends from 1990 to 2017 with the EAPCs being−1.04(95%confidence interval[CI]=(−1.10-−0.99)and−1.52(95%CI=−1.59-−1.44),respectively.Globally,the most pronounced decreasing trend of death and DALYs occurred in chronic myeloid leukemia with EAPCs of−2.76(95%CI=−2.88-−2.64)and−2.84(95%CI=−2.97-−2.70),respectively,while the trend increased in acute myeloid leukemia.The death and DALYs of leukemia decreased in most areas and countries with high socio-demographic index(SDI)including Bahrain,Finland,and Australia.Conclusions:The disease burden of death and DALYs due to leukemia decreased globally,and for most regions and countries from 1990 to 2017.However,the leukemia burden is still a substantial challenge globally and required adequate and affordable medical resources to improve the survival and quality of life of leukemia patients. | Zejin Ou Danfeng Yu Yuanhao Liang Wenqiao He Yongzhi Li Minyi Zhang Fangfei You Huan He Qing Chen | 2020 | Cancer Communications2020，40，11： | 4 |
| 2 | Comparison of PM_(2.5) and CO_(2) Concentrations in Large Cities of China during the COVID-19 Lockdown显示文摘Estimating the impacts on PM_(2.5)pollution and CO_(2)emissions by human activities in different urban regions is important for developing efficient policies.In early 2020,China implemented a lockdown policy to contain the spread of COVID-19,resulting in a significant reduction of human activities.This event presents a convenient opportunity to study the impact of human activities in the transportation and industrial sectors on air pollution.Here,we investigate the variations in air quality attributed to the COVID-19 lockdown policy in the megacities of China by combining in-situ environmental and meteorological datasets,the Suomi-NPP/VIIRS and the CO_(2)emissions from the Carbon Monitor project.Our study shows that PM_(2.5)concentrations in the spring of 2020 decreased by 41.87%in the Yangtze River Delta(YRD)and 43.30%in the Pearl River Delta(PRD),respectively,owing to the significant shutdown of traffic and manufacturing industries.However,PM_(2.5)concentrations in the Beijing-Tianjin-Hebei(BTH)region only decreased by 2.01%because the energy and steel industries were not fully paused.In addition,unfavorable weather conditions contributed to further increases in the PM_(2.5)concentration.Furthermore,CO_(2)concentrations were not significantly affected in China during the short-term emission reduction,despite a 19.52%reduction in CO_(2)emissions compared to the same period in 2019.Our results suggest that concerted efforts from different emission sectors and effective long-term emission reduction strategies are necessary to control air pollution and CO_(2)emissions. | Chuwei LIU Zhongwei HUANG Jianping HUANG Chunsheng LIANG Lei DING Xinbo LIAN Xiaoyue LIU Li Zhang Danfeng WANG | 2022 | Advances in Atmospheric Sciences2022，39，6： | 2 |
| 3 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 4 | The epidemiology of civilian inpatients’ burns in Chinese military hospitals, 2001–2007显示文摘 | Yuan Yao Yuncheng Liu Jihong Zhou Jun Qiu Liang Zhang Danfeng Yuan Liyu Zhou Zhengguo Wang Jiashun Ren Jianguo Shi | 2011 | Burns2011，，6： | 1 |
| 5 | Identification of two potential glycogen synthase kinase 3β inhibitors for the treatment of osteosarcoma显示文摘Osteosarcoma 是在与高死亡率世界范围的青少年之中的最普通的主要恶意的骨头肿瘤。肝糖 synthase kinase (GSK3 ) 3 是 serine/threonine kinase 并且在 osteosarcoma 被看作一个验证目标治疗。因此, GSK3 禁止者的学习是在 anti-osteosarcoma 药开发的最流行的领域之一。这里,生物信息学的工具被用来从锌药数据库屏蔽 GSK3 的新奇有效禁止者。分子的停靠、分子的动态模拟, MM/GBSA,和精力分解分析被执行识别禁止者。最后, ZINC08383479 和 ZINC08441251 作为潜在的 GSK3 禁止者被选择。这二个禁止者被 GSK3 kinase 抑制试金在 vitro 评估。房间增长的抑制在 vitro 在 osteosarcoma 房间线 U2OS 和 MG63 被测试。结果显示出那 ZINC08383479, ZINC08441251 对 GSK3 举办了高抑制活动。我们发现 CHIR99021 (一个已知的 GSK3 禁止者) , ZINC08383479,和 ZINC08441251 在 U2OS 房间和 MG63 房间举办了重要抑制活动。这些调查结果可以为 osteosarcoma 为更多的有势力 GSK3 禁止者和治疗学的目标的设计提供新想法。 | Kaimin Lu Xin Wang Yuyu Chen Danfeng Liang Hao Luo Li Long Zongyue Hu Jinku Bao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，5： | 0 |
| 6 | O-glycan profiling of serum glycan for potential renal cancer biomarkers显示文摘Serum was obtained from 25 male renal cell carcinoma(RCC) patients and 21 healthy males.O-glycans were released by a-elimination reaction and purified by graphitized carbon cartridge solid phase extraction,then profiled by matrix-assisted laser desorption/ionisation-time of flight mass spectrometry.After noise removal and peak alignment,1372 peaks were extracted from 200000 data points.Feature peaks were analyzed by calculation of differential sensitivity and specificity.The combination of two feature peaks was chosen as a biomarker and could clearly differentiate RCC and normal samples in our study group. | GAO Yi MA Fei ZHANG Wei ZHONG Fan TANG HaiLin XU DanFeng ZHAO Liang | 2013 | Science China(Life Sciences)2013，56，8： | 0 |
| 7 | Novel joint encoding/decoding algorithms of fountain codes for underwater acoustic communication显示文摘Fountain codes are considered to be a promising coding technique in underwater acoustic communication(UAC) which is challenged with the unique propagation features of the underwater acoustic channel and the harsh marine environment. And Luby transform(LT) codes are the first codes fully realizing the digital fountain concept. However, in conventional LT encoding/decoding algorithms, due to the imperfect coverage(IC) of input symbols and short cycles in the generator matrix, stopping sets would occur and terminate the decoding. Thus, the recovery probability is reduced,high coding overhead is required and decoding delay is increased.These issues would be disadvantages while applying LT codes in underwater acoustic communication. Aimed at solving those issues, novel encoding/decoding algorithms are proposed. First,a doping and non-uniform selecting(DNS) encoding algorithm is proposed to solve the IC and the generation of short cycles problems. And this can reduce the probability of stopping sets occur during decoding. Second, a hybrid on the fly Gaussian elimination and belief propagation(OFG-BP) decoding algorithm is designed to reduce the decoding delay and efficiently utilize the information of stopping sets. Comparisons via Monte Carlo simulation confirm that the proposed schemes could achieve better overall decoding performances in comparison with conventional schemes. | Mingshen Liang Jinjue Duan Danfeng Zhao Jiaxi Si Xiangyu Song | 2016 | Journal of Systems Engineering and Electronics2016，27，4： | 0 |
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