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| 1 | 海洋中尺度涡与内波的地震图像显示文摘海洋反射地震通常用于调查、研究海底地质构造,勘探油气与天然气水合物资源.近期研究表明多道反射地震方法也可以对水柱的热盐细结构成像.中尺度涡与内波是重要的物理海洋现象,但是常规的物理海洋调查是在间隔若干公里的离散测站上进行的,水平分辨率较低,因此对中尺度涡的结构与内波的横向分布了解较差.本文利用在大西洋东部、南海采集的地震数据给出了低频反射地震可以对中尺度涡与内波清晰成像的新的证据.反射地震方法较传统海洋观测手段,具有明显的优势,主要体现在高的水平分辨率和短时间内对整个海水剖面进行成像方面.从地震剖面上,能够清楚地观测到中尺度涡、内波造成的反射特征变化,从而有助于改进对能量在不同尺度的海水运动之间传递过程的认识. | 宋海斌 Luis Pinheiro 王东晓 董崇志 宋洋 拜阳 | 2009 | 地球物理学报2009，52，11： | 21 |
| 2 | 地中海涡旋的垂向结构与物理性质显示文摘本文利用地震海洋学新的反演结果,对地中海涡旋的温度、密度、声速以及波阻抗等物理性质进行了详细的分析与讨论,特别对地中海涡旋的一些细结构、混合过程进行了相关描述.研究分析取得以下认识:(1)涡旋具有涡旋核心水与涡旋混合水双层结构,这种结构特征可以在温度图、声速图和波阻抗图中识别出来;(2)涡旋核心水并不是均匀的稳定结构,内部有微弱的混合作用;(3)在涡旋上部以及周围边缘区域,海水的混合比较复杂;在涡旋下部边缘区域,除了有小尺度的盐指混合,内波也是非常重要的动力混合作用;(4)海水密度在涡旋核心水的分布比较稳定,成层性较强,在混合水区域由于不同的混合作用及其强烈程度不同,会发生波动甚至反转;(5)涡旋本身并不是一个严格对称的结构,涡旋与背景海水的上部以及周围边界比较模糊和复杂,而涡旋下部边界则比较明显.地震海洋学反演提供的涡旋物理性质数据能够为涡旋进一步的研究提供更为准确、更高精度以及更高分辨率的参考数据,同时对涡旋的运动学以及动力学研究提供了更进一步的研究方法和研究方向. | 陈江欣 宋海斌 拜阳 Luis Pinheiro 黄兴辉 刘伯然 | 2013 | 地球物理学报2013，56，3： | 7 |
| 3 | Calcium isotope fractionation and its controlling factors over authigenic carbonates in the cold seeps of the northern South China Sea显示文摘In this study, we analyzed stable calcium isotope results of authigenic carbonates from two cold seep areas of the Dongsha area and the Baiyun Sag in the northern South China Sea. The stable isotopes of carbon and oxygen as well as the mineral composition of authigenic carbonates were used to investigate control calcium isotope fractionation. The δ44/40Ca ratios of the southwestern Dongsha area samples ranged from 1.21‰ to 1.52‰ and the ratio of the Baiyun Sag sample was 1.55‰ of the SRM915a isotope standard. X-ray diffraction analysis showed that the carbonate samples consisted of dolomite, calcite and aragonite, with small amounts of high-Mg calcite and siderite. The δ13C values of the carbonates of the southwestern Dongsha area varied between δ49.21‰ and δ16.86‰ of the Vienna PeeDee Belemnite (VPDB) standard and the δ18O values ranged from 2.25‰ to 3.72‰ VPDB. The δ13C value of the Baiyun Sag sample was 2.36‰ VPDB and the δ18O value was 0.44‰ VPDB. The δ13C values of the carbonates of the southwestern Dongsha area revealed there is methane seeping into this area, with a variable contribution of methane-derived carbon. The sampled carbonates covered a range of δ13C values suggesting a dominant methane carbon source for the light samples and mixtures of δ13C values for the heavier samples, with possibly an organic or seawater carbon source. The δ18O values indicated that there is enrichment in 18O, which is related to the larger oxygen isotope fractionation in dolomite compared to calcite. The results of the Baiyun Sag sample exhibited normal seawater carbon and oxygen isotopic values, indicating that this sample is not related to methane seepage but instead to precipitation from seawater. The relatively high δ44/40Ca values indicated either precipitation at comparatively high rates in pore-water regimes with high alkalinity, or precipitation from an evolved heavy fluid with high degrees of Ca consumption (Raleigh type fractionation). The dolomite samples from the Dongsha area revealed a clear correlation between the carbon and calcium isotope composition, indicating a link between the amount and/or rate of carbonate precipitation and methane contribution to the bicarbonate source. The results of the three stable isotope systems, mineralogy and petrography, show that mineral composition, the geochemical environment of authigenic carbonates and carbon source can control the calcium isotope fractionation. | WANG ShuHong YAN Wen MAGALHAES H Vitor CHEN Zhong PINHEIRO M Luis GUSSONE Nikolaus | 2012 | Chinese Science Bulletin2012，57，11： | 4 |
| 4 | Immunoexpression of inhibitors of apoptosis proteins and their antagonistSMAC/DIABLO in colorectal carcinoma: Correlation with apoptotic index, cellularproliferation and prognosis显示文摘 | Flávio De Oliveira Lima Henrique De Oliveira Costa Luis Barrezueta Celina Fujiyama Oshima José Silva Thiago Gomes Nathanael Pinheiro Ricardo Neto Marcello Franco | 2009 | Oncology Reports2009，，2： | 1 |
| 5 | Evaluation of the Structure–Activity Relationship of Rifabutin and Analogs: A Drug–Membrane Study显示文摘 | Marina Pinheiro Catarina Pereira‐Leite Mariana Arêde Cláudia Nunes Jo?o M. Caio Cristina Moiteiro Juan J. Giner‐Casares Marlene Lúcio Gerald Brezesinski Luis Camacho Salette Reis | 2013 | ChemPhysChem2013，，12： | 1 |
| 6 | Massive gas embolism during pulmonary nodule hook wire localization显示文摘 | Thomas A Horan Petrúcia M Pinheiro Luis M Araújo Flávia F Santiago Monica R Rodrigues | 2002 | The Annals of Thoracic Surgery2002，，5： | 1 |
| 7 | Immunoexpression of inhibitors of apoptosis proteins and their antagonistSMAC/DIABLO in colorectal carcinoma: Correlation with apoptotic index, cellularproliferation and prognosis显示文摘 | Flávio De Oliveira Lima Henrique De Oliveira Costa Luis Barrezueta Celina Fujiyama Oshima José Silva Thiago Gomes Nathanael Pinheiro Ricardo Neto Marcello Franco | 2009 | Oncology Reports2009，，2： | 1 |
| 8 | New avenues for the treatment of immunotherapy-resistant pancreatic cancer显示文摘Pancreatic cancer(PC)is characterized by its extremely aggressive nature and ranks 14th in the number of new cancer cases worldwide.However,due to its complexity,it ranks 7th in the list of the most lethal cancers worldwide.The pathogenesis of PC involves several complex processes,including familial genetic factors associated with risk factors such as obesity,diabetes mellitus,chronic pancreatitis,and smoking.Mutations in genes such as KRAS,TP53,and SMAD4 are linked to the appearance of malignant cells that generate pancreatic lesions and,consequently,cancer.In this context,some therapies are used for PC,one of which is immunotherapy,which is extremely promising in various other types of cancer but has shown little response in the treatment of PC due to various resistance mechanisms that contribute to a drop in immunotherapy efficiency.It is therefore clear that the tumor microenvironment(TME)has a huge impact on the resistance process,since cellular and non-cellular elements create an immunosuppressive environment,characterized by a dense desmoplastic stroma with cancerassociated fibroblasts,pancreatic stellate cells,extracellular matrix,and immunosuppressive cells.Linked to this are genetic mutations in TP53 and immunosuppressive factors that act on T cells,resulting in a shortage of CD8+T cells and limited expression of activation markers such as interferon-gamma.In this way,finding new strategies that make it possible to manipulate resistance mechanisms is necessary.Thus,techniques such as the use of TME modulators that block receptors and stromal molecules that generate resistance,the use of genetic manipulation in specific regions,such as microRNAs,the modulation of extrinsic and intrinsic factors associated with T cells,and,above all,therapeutic models that combine these modulation techniques constitute the promising future of PC therapy.Thus,this study aims to elucidate the main mechanisms of resistance to immunotherapy in PC and new ways of manipulating this process,resulting in a more efficient therapy for cancer patients and,consequently,a reduction in the lethality of this aggressive cancer. | Luis Guilherme de Oliveira Silva Fabian Fellipe Bueno Lemos Marcel Silva Luz Samuel Luca Rocha Pinheiro Mariana dos Santos Calmon Gabriel Lima Correa Santos Gabriel Reis Rocha Fabrício Freire de Melo | 2024 | World Journal of Gastrointestinal Oncology2024，16，4： | 0 |
| 9 | 阿尔沃兰海(Alboran Sea)中碳酸盐岩丘的发现:梅利利亚海山区显示文摘本文主要研究发现在阿尔沃兰海东南边缘(摩洛哥陆缘)的一群全新世海山——梅利利亚海山区(MMF)。我们通过条带测深、浅地层声学剖面、旁侧声纳、高分辨率地震调查以及沉积物取样等手段对MMF海山区进行了研究。该海山群位于陆缘下倾部分的上陆坡至陆坡中部,西北-东南走向,覆盖面积超过20km2。 | Menchu Comas Luis M. Pinheiro Nathalie Babonneau 陆红锋(译) 陈弘(校对) | 2008 | 海洋地质2008，24，3： | 0 |
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