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| 1 | Impact of triple antithrombotic therapy in patients with acute coronary syndrome undergoing percutaneous coronary intervention in real-world practice显示文摘为在急性冠的症候群(交流) 和经皮的冠的干预(一种总线标准) 以后的口头的 anticoagulation (OAC ) 上的病人的 ObjectiveThe 最佳的 antithrombotic 政体仍然保持辩论。寻求回顾地在真实世界的 setting.MethodsWe 评估 OAC 正 clopidogrel 的功效和安全与或没有阿司匹林的这研究分析了数据从一国际,在 2003 和 2014 之间的多中心登记(n = 15,401 ) 。有在一种总线标准以后的交流和收到的 OAC 的病人被屏蔽。合成主要端点是 1 年的所有原因死亡,重新梗塞,或分析注册了 642 个病人包括的严重 bleeding.ResultsThe 期末考试有 OAC 和 clopidogrel (双治疗) 的 62 个病人(9.7%) ,和有阿司匹林, OAC 和 clopidogrel (三倍的治疗) 的联合的 580 个病人(90.3%) 。三倍的治疗上的病人更经常是女性的并且是更可能的有 comorbidities。关于在与三倍的治疗病人一起的双治疗之间的主要结束点没有重要差别[17.74% 对 17.24% ;unadjusted 危险比率(HR ) :1.035;95% 信心间隔(CI ) :0.556-1.929;调整 HR:1.026;95% CI:0.544-1.937 ] 。然而,重新梗塞率比三倍的治疗病人在双治疗是显著地更高的(14.52% 对 5.34% ;unadjusted HR:2.807;95% CI:1.329-5.928;调整 HR:2.333;95% CI:1.078-5.047 ) 。另外,在所有原因死亡和严重 bleeding.ConclusionsIn 的二政体之间没有差别有交流后面的一种总线标准并且与 OAC 的一个指示的真实病人,三倍的治疗没与双治疗相比与不利结果的增加的率被联系。而且,它减少了重新梗塞冒险并且没增加严重流血的风险。 | Yan YAN Xiao WANG Jing-Yao FAN Shao-Ping NIE SerGio Raooseiras-Roubin Emad Abu-Assi Jose P Simao Henriques: Fabrizio D'Ascenzo Jorge Saucedo Jose R Gonzalez-Juanate Stephen B Wilton Wouter J Kikkert Ivan Nunez-Gil Albert Ariza-Sole Xian-Tao SONG Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Morettil Zenon Huczek Toshiharu Fujii Luis cL Correia Masa-aki Kawashiri Sasko Kedev | 2017 | Journal of Geriatric Cardiology2017，14，11： | 6 |
| 2 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 3 | Improved outcomes of extremely premature outborn infants : effects of strategic changes in perinatal and retrieval services 显示文摘 | Lui K Abdel - Latif ME AUgood CL | 2006 | Pediatrics2006，118，5： | 1 |
| 4 | Interventional sialography: a single-center experience显示文摘 | Davies RP Whyte AM Lui CL | 1997 | Cardiovasc Intervent Radiol1997，20，： | 1 |
| 5 | Immediate and long-term outcomes of hepatectomy for hepatolithiasis显示文摘 | Chen DW Tung-Ping Poon R Lui CL | 2004 | Surgery2004，135，4： | 1 |
| 6 | Differenti- al expression of angiotensin type 1 and type 2 recep- tors at the maternal-fetal interface: potential roles in early placental development显示文摘 | Tower CL Lui S Charlesworth NR | 2010 | Reproduction2010，140，6： | 1 |
| 7 | Immunoglobulin G subclass concentrations and infections in children and adolescents with severe asthma显示文摘 | de Moraes Lui C Oliveira LC Diogo CL | 2002 | Pediatr Allergy Immunol2002，13，3： | 1 |
| 8 | Differential expression of angiotensin II type 1 and type 2receptors at the matemal-fetal interface : potential roles inearly placental development 显示文摘 | TOWER CL LUI S CHARLESWORTH N R | 2010 | Reproduction2010，140，6： | 1 |
| 9 | Subclinical central pontine myeli-nolysis following liver transplantation 显示文摘 | Lui CC Chen CL Chang YF | 2000 | Transplant Proc2000，32，： | 1 |
| 10 | Multiple uterine angioleiomyomas in a woman presenting with severe menorrhagia 显示文摘 | Hsieh CH Lui CL Huang SL | 2003 | Gynecol Oncol2003，90，3： | 1 |
| 11 | Rapid Sevoflurane Induction compared with thiopental显示文摘 | Michael CL Menno T Luis D | 2004 | J Clin Anesth2004，16，： | 1 |
| 12 | Soil compressibility and least limiting water range of a constructed soil under cover crops after coal mining in Southern Brazil显示文摘 | Cláudia Liane Rodrigues de Lima Ezequiel Cesar Carvalho Miola Luis Carlos Timm Eloy Antonio Pauletto Alvaro Pires da Silva | 2012 | Soil & Tillage Research2012，，： | 1 |
| 13 | Evaluation of the Structure–Activity Relationship of Rifabutin and Analogs: A Drug–Membrane Study显示文摘 | Marina Pinheiro Catarina Pereira‐Leite Mariana Arêde Cláudia Nunes Jo?o M. Caio Cristina Moiteiro Juan J. Giner‐Casares Marlene Lúcio Gerald Brezesinski Luis Camacho Salette Reis | 2013 | ChemPhysChem2013，，12： | 1 |
| 14 | Improved outcomes of extremely premature outborn infants:effects of strategic changes in perinatal and retrieval services显示文摘 | Lui K Abdel-Latif ME Allgood CL | | 0，，05： | 1 |
| 15 | hnproved outconms of extremely premature outborn infants: eft~ets of strategic changes in perinatal and retrieval services 显示文摘 | Lui K Abdel-Latif ME AIlgood CL | 2006 | Pediatrics2006，118，5： | 1 |
| 16 | Rapid Sevoflurane Induetio Compared with ThiopentaL显示文摘 | Michael CL Menno T Luis D | 2004 | Joumal of Clinica/ Anesthesia2004，，6： | 1 |
| 17 | Superior sagittal sinus thronbosis induced by thyrotoxicosis: Case report显示文摘 | Ra CS Lui CC Liahg CL | 2001 | J Neurosurg2001，94，： | 1 |
| 18 | Improved outcomes of extremely premature outborn infants:effects of strategic changes in perinatal and retrieval services显示文摘 | Lui K Abdel-Latif ME Allgood CL | | 0，，05： | 1 |
| 19 | Subclinical central pontine myelinolysis after liver transplantation显示文摘 | Lui CC Chen CL Chang YF | 2000 | Transplant Proc2000，32，7： | 1 |
| 20 | Immunoglobulin G subclass concentrations and infections in children and adolescents with severe asthma显示文摘 | de Moraes Lui C Oliveira LC Diogo CL Kirschfink M Grumach AS | 2002 | Pediatr Allergy Immunol2002，13，3： | 1 |
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