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| 1 | The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline显示文摘 | Gaspar LE Mehta MP Patchell RA Burri SH Robinson PD Morris RE Ammirati M Andrews DW Asher AL Cobbs CS Kondziolka D Linskey ME Loeffler JS McDermott M Mikkelsen T Olson JJ Paleologos NA Ryken TC Kalkanis SN. | 2010 | 中国神经肿瘤杂志2010，8，1： | 98 |
| 2 | CYP24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells显示文摘AIM:The effects of vitamin D3 have been investigated on various tumors, including colorectal cancer (CRC). 25-hydroxyvitamin-D3-24-hydroxylase (CYP24A1), the enzyme that inactivates the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 (1,25-D3), is considered to be the main enzyme determining the biological halflife of 1,25-D3. During colorectal carcinogenesis, the expression and concentration of CYP24A1 increases significantly, suggesting that this phenomenon could be responsible for the proposed efficacy of 1,25-D3 in the treatment of CRC. The aim of this study was to investigate the anti-tumor effects of vitamin D3 on the human CRC cell line Caco-2 after inhibition of the cytochrome P450 component of CYP24A1 activity. METHODS:We examined the expression of CYP24A1 mRNA and the effects of 1,25-D3 on the cell line Caco-2 after inhibition of CYP24A1. Cell viability and proliferation were determined by means of sulforhodamine-B staining and bromodeoxyuridine incorporation, respectively, while cytotoxicity was estimated via the lactate dehydrogenase content of the cell culture supernatant. CYP24A1 expression was measured by realtime reverse transcription polymerase chain reaction. A number of tetralone compounds were synthesized to investigate their CP24A1 inhibitory activity. RESULTS:In response to 1,25-D3, CYP24A1 mRNA expression was enhanced significantly, in a time- and dose-dependent manner. Caco-2 cell viability and proliferation were not influenced by the administration of 1,25-D3 alone, but were markedly reduced by coadministration of 1,25-D3 and KD-35, a CYP24A1-inhibiting tetralone. Our data suggest that the mechanism of action of co-administered KD-35 and 1,25-D3 does not involve a direct cytotoxic effect, but rather the inhibition of cell proliferation. CONCLUSION:These findings demonstrate that the selective inhibition of CYP24A1 by compounds such as KD-35 may be a new approach for enhancement of the anti-tumor effect of 1,25-D3 on CRC. | János P Kósa Péter Horváth János Wlfling Dóra Kovács Bernadett Balla Péter Mátyus Evelin Horváth Gábor Speer István Takács Zsolt Nagy Henrik Horváth Péter Lakatos | 2013 | World Journal of Gastroenterology2013，19，17： | 5 |
| 3 | Progression in melanoma is associated with decreased expression of death receptors for tumor necrosis factor-related apoptosisinducing ligand显示文摘 | Zhuang L Lee CS Scolyer RA | 2006 | Hum Pathol2006，37，10： | 1 |
| 4 | Use of the etonogestrelreleasing implant is associted with hypoactivation of the coagulation cascade显示文摘 | Vieim CS Ferriani RA Gacia AA | 2007 | Hum Reprod2007，22，8： | 1 |
| 5 | Treatment with a copper-zinc chelator mark-edly and rapidly inhibits β-amyloid accumulation in Alzheimers disease transgenic mice显示文摘 | Cherny RA Atwood CS Xilinas ME | 2001 | Neuron2001，30，： | 1 |
| 6 | The effect of dental probing on subsequent enamel demineralization显示文摘 | Van Dorp CS Exterkate RA ten Cate JM | 1988 | ASDC J Dent Child1988，55，5： | 1 |
| 7 | Preferential survival of CD4+ T lymphecytes engineered with anti-human immunodeficiency virus (HIV) genes in HIV-infectod individuals显示文摘 | Morgan RA Walker R Carter CS | 2005 | Hum Gene Ther2005，16，9： | 1 |
| 8 | Neoadjuvant chemo-therapy in the combined modality approach of locally ad-vanced non-metastatic breast cancer显示文摘 | Swain SM Sorace RA Bagley CS | 1987 | Cancer Res1987，47，14： | 1 |
| 9 | Neoadjuvant chemotherapy in the combined modality approach of locally advanced nonmetastatic breast cancer显示文摘 | Swain SW Sorace RA Bagley CS | 1987 | Cancer Res1987，47，12： | 1 |
| 10 | Müller glia as an active compartment modulating nervous activity in the vertebrate retina:neurotransmitters and trophic factors显示文摘 | de Melo Reis RA Ventura AL Schitine CS | 2008 | Neurochem Res2008，33，8： | 1 |
| 11 | The measurement of relative antibody affinity by ELISA using thiocyanate elution 显示文摘 | Macdonald RA Hosking CS Jones CL | 1988 | J Immunol Methods1988，106，2： | 1 |
| 12 | Prospective evaluation of cell kinetics,yields and donor experiences during a single largevolume apheresis versus two smaller volume consecutive day collections of allogeneic peripheral blood stem cells显示文摘 | Bolan CD Carter CS Wesley RA | 2003 | Br J Haematol2003，120，80： | 1 |
| 13 | Cardiovascular effects of relaxin:from basic science to clinical therapy显示文摘 | Du XJ Bathgate RA Samuel CS | | 0，，01： | 1 |
| 14 | Reversibility of acute B-cell leukaemia induced by BCR-ABL 1 显示文摘 | Huettner CS Zhang P Van Etten RA | 2000 | Nature Genet2000，24，1： | 1 |
| 15 | The spectrum of pancreatic exoerine and endocrine (beta-cell) function in tropical caleifie pancreatitis 显示文摘 | Yajnik CS Shelgikar KM Sabasrabudhe RA | 1990 | Diabetologia1990，33，7： | 1 |
| 16 | Reactive oxygen-mediated contraction in pulmonary arterial smooth muscle: cellular mechanisms 显示文摘 | Jin N Packer CS Rhoades RA | 1991 | Can J Physiol Pharmacol1991，69，3： | 1 |
| 17 | Ganglioneuroma of the mandible resulting from metastasis of neuroblastoma显示文摘 | Patterson AR Barker CS Loukota RA | 2009 | Int J Oral Maxillofae Surg2009，38，2： | 1 |
| 18 | American Cancer Society guidelines for the early detection of cancer显示文摘 | Smith RA Mettlin CS Davis KJ | 2000 | CA Cancer J Clin2000，50，1： | 1 |
| 19 | Production of a defensin-like antifungal protein NFAP from Neosartorya fischeri in Pichia pastoris and its antifungal activity against filamentous fungal isolates from human infections显示文摘 | Máté Virágh Dóra V?r?s Zoltán Kele Laura Kovács ádám Fizil Gergely Lakatos Gergely Maróti Gyula Batta Csaba Vágv?lgyi László Galgóczy | 2014 | Protein Expression and Purification2014，，： | 1 |
| 20 | A novel approach for the identification of unique tumor vasculature binding peptides using an E.coli peptide display library显示文摘 | Brown CK Modzelewski RA Johnson CS | | 0，，： | 1 |
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