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| 1 | Fas stimulation of T lymphocytes promotes rapid intercellular exchange of death signals via membrane nanotubes显示文摘Fas/CD95 表面受体调停各种各样的房间的快速的死亡打字,包括有为触发 autoimmunity 的潜力的 autoreactive T 房间。这里,我们表明那的船边交货的现在的新奇方面定义一种“社会”的尺寸到导致受体的 apoptosis。船边交货刺激很快导致在附近的 T 房间之间的广泛的膜 nanotube 形成。这极其依赖于 Rho GTPases 然而并非在 caspase 激活上。包括活跃 caspases 的膜和 cytosolic 元素的双向转移能被观察经由这些 nanotubes 发生。Nanotube 形成和死亡信号的细胞间的交换在从有在船边交货受体的自体免疫的 lymphoproliferative 症候群 harbouring 变化的病人的 T 淋巴细胞是有缺点的。我们断定调停 nanotube 的交换组成扩充在附近的 T 房间之间发信号的死亡的繁殖的细胞间的通讯的一种新奇形式。 | Peter D Arkwright Francesca Luchetti Julien Tour Charlotte Roberts Rahna Ayub Ana P Morales Jose J Rodriguez Andrew Gilmore Barbara Canonico Stefano Papa Mauro Degli Esposti | 2010 | Cell Research2010，20，1： | 4 |
| 2 | Melatonin signaling and cell protection function显示文摘 | Luchetti F Canonico B Betti M | 2010 | FASEB J2010，24，10： | 1 |
| 3 | Early tracheostomy for primary airway management in the surgical critical care setting显示文摘 | Rodfiguez JL Steinberg SM Luchetti FA | 1990 | Surgery1990，108，4： | 1 |
| 4 | The effects of cobalt chromium upon macorphages显示文摘 | Horowitz SM Luchetti WT Gonzales JB | 1998 | J Biomed Mater Res1998，41，3： | 1 |
| 5 | Melatonin prevents apoptosis induced by UV-B treatment in U937 cell line 显示文摘 | Luchetti F Canonico B Curci R | 2006 | J Pineal Res2006，40，2： | 1 |
| 6 | Multiple roles of matrix metalloproteinases during apoptosis显示文摘 | Mannello F Luchetti F Faicieri E | | 0，，： | 1 |
| 7 | Impact of CF scan on treatment plan and fracture classification of tibial plateau fractures 显示文摘 | Chan PSH Klimkiewicz J J Luchetti WT | 1997 | J Othop Trauma1997，11，7： | 1 |
| 8 | Early tracheostomy for primary airway management in surgical critical care setting显示文摘 | Steinberg SM Luchetti FA | 1990 | Surgery1990，108，： | 1 |
| 9 | Matrix metalloprotoinases expression in HL-60 promyelocytic leukaemia cell during apoptosis显示文摘 | Gazzanelli G Luchetti F Burattini S | | 0，，： | 1 |
| 10 | Evalution of the triangular fibrocartilage complex tears by anhroacapy显示文摘 | Pederzini L Luchetti R Soragni O | 1992 | AJR1992，8，2： | 1 |
| 11 | Role of the N,N' -dimethylbiguanide metformin in the treatment of female prepuberal BALB/c mice hyperandrogenized with dehydroepiandrosterone显示文摘 | Sander V Luchetti CG Solano ME | 2006 | Reproduction2006，131，3： | 1 |
| 12 | Efficacy of interventions for bronchiolitis in critically ill infants: a systematic review and meta-analysis 显示文摘 | Davison C Ventre KM Luchetti M | 2004 | Pediatr Crit Care Med2004，5，5： | 1 |
| 13 | Structural specificities and significance for coeliac disease of wheat gliadin peptides able to agglutinate or to prevent agglutination of K562(S)cells显示文摘 | de Vincenzi M Stammati A Luchetti R | 1998 | Toxicology1998，127，13： | 1 |
| 14 | A multi-dimensional questionnaire quantifying quality of life in elderly osteoporotic women: the Italian Triple-Q Osteoporosis Study显示文摘 | Dario Maggio Carmelinda Ruggiero Sara Ercolani Maria Carmela Macchiarulo Nicola Palmari Filippo Luccioli Sonia Andreani Angela Mariani Emanuela Costanzi Antonio Cherubini Maurizio Luchetti Elena Zampi Giuseppe Girasole Gerolamo Bianchi Maurizio Rossini Ch | 2010 | Aging Clinical and Experimental Research2010，，4： | 1 |
| 15 | Adalimumab efficacy in enteropathic spondyloarthritis: A 12-mo observational multidisciplinary study显示文摘AIM To report adalimumab(Ada) efficacy on articulargastrointestinal disease and health-related quality of life(HRQo L) in patients with enteropathic spondyloarthritis(ES).METHODS A cohort of 52 patients with ES was evaluated in the departments of gastroenterology and internal medicine. At baseline, all patients underwent assessment by an integrated gastro-rheumatologic evaluation of articular and gastrointestinal activity, as well patient reported outcomes(PROs) of the HRQo L questionnaires. After this integrated evaluation and following a specific working flowchart, the Ada anti-tumor necrosis factor(TNF)-inhibitor was assigned to a cohort of 30 patients and its clinical efficacy was evaluated at baseline and after 6-mo and 12-mo treatment by the following tests:(1) Ankylosing Spondylitis Disease Activity ScoreC-Reactive Protein(ASDAS-CRP); Bath Ankylosing Spondylitis Disease Activity Index(BASDAI), Bath Ankylosing Spondylitis Functional Index(BASFI) and Bath Ankylosing Spondylitis Metrology Index(BASMI) for articular activity;(2) Inflammatory Bowel Disease Questionnaire(IBDQ), Crohn's Disease Activity Index(CDAI) and partial Mayo(p Mayo) score for gastrointestinal symptoms and activity; and(3) Health Assessment Questionnaire(HAQ), Patient Global Assessment(PGA) and Short Form-36 health survey(SF-36) questionnaires for PROs of the HRQo L.RESULTS Integrated evaluation and management of the patients affected by ES, carried out simultaneously by a gastroenterologist and a rheumatologist, allowed clinicians to choose the optimal therapeutic strategy. In a cohort of 30 ES patients affected by active articular and gastrointestinal disease, or axial active articular inflammation, Ada led to fast and sustained improvement of both articular and gastrointestinal disease activities. In fact, all the clinimetric evaluation tests exploring articular or gastrointestinal activity, as well as all the HRQo L scores, showed a significant improvement having been achieved at the earliest(6-mo) assessment. This important clinical improvement was maintained at the 12-mo follow-up. Importantly, global and gastrointestinal quality of life significantly correlated with articular disease activity, providing evidence to support that the integrated evaluation is the best option to manage patients with ES.CONCLUSION Ada treatment, upon multidisciplinary(gastrorheumatologic) evaluation, significantly improves both articular and gastrointestinal inflammation, thereby improving the HRQo L in patients affected by ES. | Michele Maria Luchetti Devis Benfaremo Francesco Ciccia Laura Bolognini Monia Ciferri Alessia Farinelli Matteo Rossini Piergiorgio Mosca Giovanni Triolo Armando Gabrielli | 2017 | World Journal of Gastroenterology2017，23，39： | 1 |
| 16 | Impact of routinemeasurement of serum calcitonin on the diagnosis and outcome ofmedullary thyroid cancer : experience in 10, 864 patients withnodular thyroid disorders 显示文摘 | EUSEI R BOTTICI V LUCHETTI F | 2004 | J Clin Endocrinol Metab2004，89，1： | 1 |
| 17 | The relationship between sleep and epilepsy:the effect oncognitive functioning in children显示文摘 | Parisi P Bruni O Pia Villa M Verrotti A Miano S Luchetti A | 2010 | Dev Med Child Neurol2010，52，9： | 1 |
| 18 | Matrix metalloproteinases expression in HL-60 promyelocytic leukaemiacell during apoptosis显示文摘 | LUCHETTI F BURATTINI S | 2000 | Apoptosis2000，5，1： | 1 |
| 19 | Reduced NREM sleep instability in benign children epilepsy with centro-temporal spikes 显示文摘 | Bruni O Novelli L Luchetti A | 2010 | Clin Neurophysiol2010，121，5： | 1 |
| 20 | Neurosteroidbiosynthetic pathways changes in prefrontal cortex in Al-zheimer's disease显示文摘 | Luchetti S Bossers K Van de Bilt S | 2011 | Neurobiol Aging2011，32，11： | 1 |
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