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| 1 | MicroRNA-135a Modulates Hepatitis C Virus Genome Replication through Downregulation of Host Antiviral Factors显示文摘Cellular microRNAs(miRNAs) have been shown to modulate HCV infection via directly acting on the viral genome or indirectly through targeting the virus-associated host factors. Recently we generated a comprehensive map of HCV–miRNA interactions through genome-wide miRNA functional screens and transcriptomics analyses. Many previously unappreciated cellular miRNAs were identified to be involved in HCV infection, including miR-135a, a human cancerrelated miRNA. In the present study, we investigated the role of miR-135a in regulating HCV life cycle and showed that it preferentially enhances viral genome replication. Bioinformatics-based integrative analyses and subsequent functional assays revealed three antiviral host factors, including receptor interacting serine/threonine kinase 2(RIPK2), myeloid differentiation primary response 88(MYD88), and C-X-C motif chemokine ligand 12(CXCL12), as bona fide targets of miR-135a. These genes have been shown to inhibit HCV infection at the RNA replication stage. Our data demonstrated that repression of key host restriction factors mediated the proviral effect of miR-135a on HCV propagation. In addition,miR-135a hepatic abundance is upregulated by HCV infection in both cultured hepatocytes and human liver, likely mediating a more favorable environment for viral replication and possibly contributing to HCV-induced liver malignancy.These results provide novel insights into HCV–host interactions and unveil molecular pathways linking miRNA biology to HCV pathogenesis. | Catherine Sodroski Brianna Lowey Laura Hertz T.Jake Liang Qisheng Li | 2019 | Virologica Sinica2019，34，2： | 5 |
| 2 | Eflqeaey of betaine ralative to choline as a dietary methyl donor显示文摘 | Lowey K R D H Baker | 1987 | Poultry Sei1987，66，： | 1 |
| 3 | Short of breath and dying: state of the science on opioid agents for the palliation of refractory dyspnea in older adults显示文摘 | Lowey SE Powers BA Xue Y | 2013 | J Gerontol Nurs2013，39，2： | 1 |
| 4 | Role of skeletal and smooth muscle myosin light chains 显示文摘 | Lowey S and Trybus K M | 1995 | Biophys1995，68，： | 1 |
| 5 | Synthesis and characterization of novel thermoresponsive-co-biodegradable hydrogels composed of N-isopropylacrylamide,poly(L-lactic acid),and dextran显示文摘 | Huang X Nayak BR Lowei TL | | 0，，： | 1 |
| 6 | Optimal number of features as a function of sample size for various classification rules显示文摘 | Hua J P Xiong Z X Lowey J | 2005 | Bioinformatics2005，21，8： | 1 |
| 7 | Acid detergent dispersible lignin in tropical grasses显示文摘 | LOWEY J B CONLAN L L SCHLINK A C | 1994 | J Sci Food Agri1994，65，： | 1 |
| 8 | The interaction of four genes in the inflammation pathway significantly predicts prostate cancer risk 显示文摘 | Xu J Lowey J Wiklund F | 2005 | Cancer Epidemiol Biomarkers Prev2005，14，111： | 1 |
| 9 | Cardiac myosin isoforms from different species have unique enzymatic and mechanical properties显示文摘 | Malmqvist LIp Aronshtam A Lowey S | 2004 | Biochemistry2004，43，15： | 1 |
| 10 | Light chains from fast and slow muscle myosins显示文摘 | LOWEY S RISBY D | 1971 | Nature1971，234，5324： | 1 |
| 11 | Failed eruption of the permanent canine following open reduction of a mandibular fracture in a child显示文摘 | Nixon F Lowey MN | 1990 | Br Dent J1990，168，5： | 1 |
| 12 | The use of three-dimensional techniques in facial esthetics显示文摘 | Moss JP Linney AD Lowey MN | 1995 | Semin Orthod1995，1，2： | 1 |
| 13 | White channel gravel alteration revisited 显示文摘 | Lowey G W Emond D S Weston L H | 2001 | Yokon Exploration and Geology2001，，： | 1 |
| 14 | A note on an inverse problem for nonnegative matrices显示文摘 | Lowey R London D | 1978 | Linear and Muhilinear Algebra1978，，6： | 1 |
| 15 | Protein measurement with the Folin phenol reagent 显示文摘 | Lowey O H Brough N J Farr A L | 1951 | J Biol Chem1951，193，1： | 1 |
| 16 | Spinal cord compression:an oneologie emergeney associated w ith metastatie can cer:evaluation and management for the home health clinician显示文摘 | Lowey SE | 2006 | Home Health Nurse2006，24，7： | 1 |
| 17 | Living with advanced heart failure or COPD:experieuces and goals of individuals nearing the end of life 显示文摘 | Lowey SE Norton SA Quinn JR | 2013 | Res Nurs Health2013，36，4： | 1 |
| 18 | Skeletal muscle myosin light chains are essential for physiological speeds of shortening显示文摘 | Lowey S Waller GS Trbus KM | 1993 | Nature1993，365，： | 1 |
| 19 | Architecture and algorithms for tracking football players with multiple cameras 显示文摘 | XU M ORWELL J LOWEY L | 2005 | Image and Signal Processing2005，152，2： | 1 |
| 20 | Copy number and targeted mutational analysis reveals novel somatic events in metastatic prostate tumors显示文摘 | Robbins CM Tembe WA Baker A Sinari S Moses TY Beckstrom-Sternberg S Beckstrom-Sternberg J Barrett M Long J Chinnaiyan A Lowey J Suh E Pearson JV Craig DW Agus DB Pienta KJ Carpten JD | | 0，，01： | 1 |
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