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| 1 | Current results of total endovascular repair of thoracoabdominal aortic aneurysms显示文摘 | Verzini F Loschi D De Rango P | 2014 | J Cardiovasc Surg (Torino)2014，55，1： | 1 |
| 2 | Isolation and characterization of two peroxidases from Cucumis sativus 显示文摘 | Battistuzzi G D'Onofrio M Loschi L | 2001 | Arch Biochem Biophy2001，388，1： | 1 |
| 3 | A Gibbs sampling scheme to the product partition model: an application to change-point problems显示文摘 | R.H. Loschi F.R.B. Cruz P.L. Iglesias R.B. Arellano-Valle | 2002 | Computers and Operations Research2002，，3： | 1 |
| 4 | Adipose stromal/stem ceils assist fat transplantation reducing necrosis and increasing graft performance 显示文摘 | Piccinno MS Veronesi E Loschi P | 2013 | Apoptosis2013，18，10： | 1 |
| 5 | Impact of eculizumab treatment on paroxysmal nocturnal hemoglobinuria: a treatment versus no -treatment study 显示文摘 | LOSCHI M PORCHER R BARRACO F | 2016 | Am J Hematol2016，91，4： | 1 |
| 6 | A Bayesian approach for estimating extreme flood probabilities with upper--bounded dis- tribution functions 显示文摘 | Fernandes W Naghettini M Loschi R | 2010 | Stochastic Environmental Research and Risk Assessment2010，24，8： | 1 |
| 7 | RNA granules: the good, the bad and the ugly 显示文摘 | Thomas MG Loschi M Desbats MA | 2011 | Cell Signal2011，23，2： | 1 |
| 8 | RNA granules: the good, the bad and the ugly 显示文摘 | Thomas MG Loschi M Desbats MA | 2011 | Cell Signal2011，23，2： | 1 |
| 9 | Isolation, Characterization, and Transduction of Endometrial Decidual Tissue Multipotent Mesenchymal Stromal/Stem Cells from Menstrual Blood显示文摘 | Filippo Rossignoli Anna Caselli Giulia Grisendi Serena Piccinno Jorge S. Burns Alba Murgia Elena Veronesi Pietro Loschi Cristina Masini Pierfranco Conte Paolo Paolucci Edwin M. Horwiz Massimo Dominici Thomas Skutella | 2013 | BioMed Research International2013，，： | 1 |
| 10 | A Gibbs Sampling Scheme to the Product Partition Model:An Application to Change Point Problems显示文摘 | Loschi R H Cruz F R B Iglesias P L Arellano-Valle R B | | 0，，03： | 1 |
| 11 | Effect of acute hyperglycemia on insulin secretion in human显示文摘 | loschi E Camastra S $ireni AM | 2002 | Diabetes2002，51，： | 1 |
| 12 | Extension to the Product Partition Model:Computing the Probability of a Change显示文摘 | Loschi R H Cruz F R B | | 0，，： | 1 |
| 13 | Current results of total endovascular repair of thoracoabdominal aortic an- eurysms显示文摘 | Verzini F Loschi D De Rango P | 2014 | J Cardiovasc Surg (Torino)2014，，： | 1 |
| 14 | Applying the product partition model to the identification of multiple change points显示文摘 | Loschi R H Cruz F R B | 2002 | Advances in Complex Systems2002，5，4： | 1 |
| 15 | Retinoic acid signaling acts as a rheostat to balance Treg function显示文摘Regulatory T cells(Tregs)promote immune homeostasis by maintaining self-tolerance and regulating inflammatory responses.Under certain inflammatory conditions,Tregs can lose their lineage stability and function.Previous studies have reported that ex vivo exposure to retinoic acid(RA)enhances Treg function and stability.However,it is unknown how RA receptor signaling in Tregs influences these processes in vivo.Herein,we employed mouse models in which RA signaling is silenced by the expression of the dominant negative receptor(DN)RARαin all T cells.Despite the fact that DNRARαconventional T cells are hypofunctional,Tregs had increased CD25 expression,STAT5 pathway activation,mTORC1 signaling and supersuppressor function.Furthermore,DNRARαTregs had increased inhibitory molecule expression,amino acid transporter expression,and metabolic fitness and decreased antiapoptotic proteins.Supersuppressor function was observed when wild-type mice were treated with a pharmacologic pan-RAR antagonist.Unexpectedly,Treg-specific expression of DNRARαresulted in distinct phenotypes,such that a single allele of DNRARαin Tregs heightened their suppressive function,and biallelic expression led to loss of suppression and autoimmunity.The loss of Treg function was not cell intrinsic,as Tregs that developed in a noninflammatory milieu in chimeric mice reconstituted with DNRARαand wild-type bone marrow maintained the enhanced suppressive capacity.Fate mapping suggested that maintaining Treg stability in an inflammatory milieu requires RA signaling.Our findings indicate that RA signaling acts as a rheostat to balance Treg function in inflammatory and noninflammatory conditions in a dose-dependent manner. | Govindarajan Thangavelu Gabriela Andrejeva Sara Bolivar-Wagers Sujeong Jin Michael C.Zaiken Michael Loschi Ethan G.Aguilar Scott N.Furlan Chrysothemis C.Brown Yu-Chi Lee Cameron McDonald Hyman Colby J.Feser Angela Panoskaltsis-Mortari Keli L.Hippen Kelli P.MacDonald William J.Murphy Ivan Maillard Geoffrey R.Hill David H.Munn Robert Zeiser Leslie S.Kean Jeffrey C.Rathmell Hongbo Chi Randolph J.Noelle Bruce R.Blazar | 2022 | Cellular & Molecular Immunology2022，19，7： | 0 |
| 16 | Exercise training as an intervention for frailty in cirrhotic patients on the liver transplant waiting list:A systematic review显示文摘BACKGROUND The existing literature suggests that exercise for cirrhotic patients is safe and favours significant improvement to their physical capacity.However,exercise training for this population and how to deliver activities,especially in severe stages of the disease and while waiting for a liver transplant(LT),remain undefined.AIM To review the existing exercise prescriptions for cirrhotic patients on the waiting list for LT,their results for frailty evolution and their effect on clinical outcomes.METHODS A systematic review was performed following the Preferred Reporting Review and Meta-Analysis guidelines and searching the PubMed,MEDLINE,and Scopus databases.The keyword“liver transplant”was used in combination with the free terms“frailty”and“exercise”for the literature review.Clinical studies that evaluated the effect of a regular training program,independent of supervision or the duration or intensity of physical exercise,in cirrhotic patients on the waiting list for LT were reviewed.The data on safe physical activity prescriptions following Frequency,Intensity,Time,and Type recommendations were extracted and summarised.RESULTS Nine articles met the inclusion criteria for this review.Various instruments for frailty assessment were used,frequently in combination.Five studies prescribed physical activity for patients,one in-person and four to be performed remotely and unsupervised.The remaining four studies only used a self-report instrument to assess the level of physical activity.None reported adverse events related to exercise training.The exercise frequency mainly varied from daily to a minimum of twice per week.The intensity depended on frailty and included increasing levels of activity.The type of exercise was predominantly a combination of aerobic and resistance training.The duration of exercise varied from 4 to 12 wk.Three articles evaluated the effect of the exercise program on clinical outcomes,reporting a reduction in 90-d readmission rates post-transplant and improved frailty scores,as well as improved survival of cirrhotic patients waiting for LT.CONCLUSION Routine frailty assessment is essential for this population.Although more robust evidence is required,the prescription of exercise is safe and can improve patients’functional capacity,improving pre-and post-LT outcomes. | Thais Mellato Loschi Melline D T A Baccan Bianca Della Guardia Paulo N Martins Amanda P C S Boteon Yuri L Boteon | 2023 | World Journal of Hepatology2023，15，10： | 0 |
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